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COMPARATIVE
EFFECT
OF AMPHETAMINE
CAFFEINE
ON S P O N T A N E O U S
ACTIVITY
CORTICAL
UNITS
RESPONSES
OF
THE
CAUDATE
AND THEIR
AND
OF
SENSOMOTOR
TO STIMULATION
NUCLEUS
~,. B. A r u s h a n y a n ,
a n d K. G. A i v a z o v
Yu.
A.
Belozertsev,
UDC 612.825.1.014.46':615.214.31
METHOD
RESULTS
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By the above c r i t e r i a no s h a r p d i f f e r e n c e s could be d e tected in the action o f a m p h e t a m i n e and caffeine, but n e v e r t h e l e s s it was not c o m p l e t e l y identical. The location of the s t i m u lating e l e c t r o d e s in the caudate nucleus is not always u n i m p o r tant for the effect of psychostimulants. Different p a r t s of its
head a r e known to affect m o t o r r e s p o n s e s and activity of s e n s o m o t o r c o r t i c a l neurons differently [5, 7, 10]: inhibition is
evoked m o r e often f r o m the v e n t r o - l a t e r a l region than f r o m
the d o r s o - m e d i a l and it is s t r o n g e r . C o m p a r i s o n of the action
of the d r u g s with r e s p e c t to r e s p o n s e s to stimulation of the
caudate nucleus and the location of the stimulating e l e c t r o d e s
showed that caffeine abolishes r e s p o n s e s to stimulation of all
p a r t s of the nucleus with equal s u c c e s s (Fig. 3). C o n v e r s e l y ,
a m p h e t a m i n e was c h a r a c t e r i z e d by definite selectivity of its
effect. It was f a r m o r e s u c c e s s f u l in s u p p r e s s i n g inhibition
f r o m the v e n t r o - l a t e r a l part. With this location of the s t i m u lating e l e c t r o d e s inhibition was m o r e often c o n v e r t e d into facilitation although the initial intensity of inhibition was 1.5
t i m e s higher than during stimulation of the d o r s o - m e d i a l p a r t
of the head. This tendency for caffeine and a m p h e t a m i n e was
found not only on aggregating the r e s u l t s of s e v e r a l e x p e r i m e n t s but also in a single e x p e r i m e n t using a multiple e l e c t r o d e by m e a n s of which 6 o r 7 points of the c a u date nucleus f r o m above downward could be tested consecutively (at intervals of 0.5-1 m m ) [5].
E.B.
E.B.
E.B.
E.B.
E.B.
(1972).
778
CITED
6.
7.
8.
9.
10.
E . B . Arushanyan, G. V. Stolyarov, and B. A. Tolpyshev, Zh. Nevropat. i Psikhiat., No. 9, 1384 (1970).
E. Grastyan, K. Lissak, and L. Molnar, Acta Physiol. Acad. Sci. Hung., 4, 262 (1953).
C . D . Hull, N. A. Buchwald, and J. Vieth, Brain Res., 6, 12 (1967).
M . R . Klee and H. D. Lux, Electroenceph. Clin. Neurophysiol., 19, 194 (1965).
S . L . Liles and G. D. Davis, J. Neurophysiol., 322, 574 (1969).
779