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Advances in the identification of the early signs of autism spectrum disorder (ASD) have occurred despite the heterogeneity of the disorder and its variable onset and presentation. Using various
methodologies including retrospective studies, community samples, and
sibling cohorts, researchers have identified behavioral markers of the disorder that emerge over the first 2 years of life. However, there are characteristics of ASD that overlap with other types of developmental delay
(DD), which may complicate differential diagnosis in young children. A
review of the literature was conducted to identify the most promising
behavioral markers that distinguish ASD from other types of DD in the
first 2 years of life. The review Identified profiles of behavioral markers in
the social realm by 12 months and in the communication realm by 18
months, which along with additional atypical motor behaviors could distinguish ASD from DD. This constellation of features coupled with a flat
or declining trajectory in specific aspects of social and communication
development, may assist clinicians in targeting early interventions to atrisk infants.
2013 Wiley Periodicals, Inc.
Dev Disabil Res Rev 2011;17:130-140.
Correspondence to: Shelly Mitchell, Hospital for Sick Children, 555 University
Avenue, Toronto, ON M5G 1X8, Canada. E-mail: Sheliy.Mitchell@Utoronto.Ca
Received 3 September 2012; accepted 5 October 2012
View this article online in Wiley Online Library (wileyonlinelibrary.com)
DOI: 10.1002/ddrr.llO7
131
132
iors.
Given
that
social
and
communication impairments are differentiated within current diagnostic
frameworks (i.e., DSM-IV-TR and
ICD-10), we examined group comparisons in each domain separately. Thus,
we summarize available data on early
markers, comparing groups with ASD,
DD and typical development (TD)
wherever possible, by age group (by 12,
18, and 24 months) and across developmental domains: social, communication,
motor, and temperament. Other relevant behaviors, including differences in
sensory seeking behavion, visual attention differences, and atypical object
exploration have been amalgamated
under the subheading Other behaviors
because of the limited number of studies examining these features. Key
findings in each age group are summarized in Table 1.
REVIEW FINDINGS
By 12 Months of Age
Social
ASD
2 Years
Communication/language
12 Months
18 Months
2 Years
Motor
12 Months
18 Months
2 Years
Temperament
0-2 Years
Other behaviors
12 months
18 months
2 Years
ASD compared with TD. In their retrospective study, Adrien et al. [1993]
described
unstable attention
and
increased distractibihty in infants who
niunication realm. Osterhng et al.
[Osterhng and Dawson, 1994; Maestro
went on to have a diagnosis of ASD
[2002] found that infants with ASD did
et al., 2001; Osterling et al., 2002], and
relative to infants with TD. Infants
not differ in frequency of gestures and
looked less at objects shown to them
with ASD were also reported to show a
vocalization from infants with DD. Bar[Osterhng et al., 2002].
pattern of lower activity level and
anek [1999] found that infants with DD
Prospective studies also reported
marked passivity at 6 months in prohad
increased
stereotyped
object
play
as
that infants with ASD show delays in
spective studies [Zwaigenbaum et al.,
well as increased stereotyped, inapprothe acquisition of communicative and
2005]. By 12 months, temperamental
priate play relative to infants with ASD.
symbolic gestures [Zwaigenbaum et al.,
differences from controls included
Therefore, to date, no communication2005; MitcheU et al., 2006; Iverson and
extreme distress reactions, decreased
related
markers
specific
to
ASD
were
Wozniak, 2007], reduphcated babbling
positive affect, reactivity, and irritability
confirmed for the first year of life.
[Iverson and Wozniak, 2007], directed
[Zwaigenbaum et al., 2005; Bryson
vocalizations [Ozonoff et al., 2010],
et
al., 2007]. No studies were identified
receptive
language
[Zwaigenbaum
Motor
that compared children with ASD with
et al., 2005; Ozonoff et al., 2010], and
expressive language
[Zwaigenbaum
ASD compared with TD. Retrospective those with DD in the first year of hfe.
et al., 2005; Iverson and Wozniak,
analyses of home videos have identified
2007; Ozonoff et al., 2010].
Other behaviors
hypotonia [Adrien at al., 1993] and unASD compared with DD. Few studies usual posturing [Baranek, 1999] in
compared infants with a later diagnosis
ASD compared with TD. Differences
infants with ASD relative to infants
of ASD to those with DD in the conibetween toddlers with ASD and TD
with TD. In a prospective case series.
DEV DISABIL RES REV- MITCHELL ET AL.
133
134
135
136
compared with
TD.
Although
Ventola et al.
137
138
139
140
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