Levocetirizine

In India,
levocetirizine is marketed by
GlaxoSmithKline under the brand name Vozet.
Torrent Pharma launched UVNIL for the rural
market.

Levocetirizine (as levocetirizine dihydrochloride) is a

third-generation non-sedative antihistamine, developed
from the second-generation antihistamine cetirizine.
Chemically, levocetirizine is the active enantiomer of cetirizine. It is the R-enantiomer of the cetirizine racemate.
Levocetirizine is an inverse agonist that decreases activity
at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever. It does not prevent the actual release
of histamine from mast cells.

In Pakistan levocetirizine was rst launched in a liquid formulation by Novartis Consumer Health Division under the name of T-Day Syrup.
In Nepal levocetirizine is available in tablet with
brand name Curin manufactured by Beximco
Pharma.[2]

The manufacturers claim it to be more eective with

fewer side eects than the second-generation drugs; however, there have been no published studies supporting
this assertion. A study part-funded by the manufacturer
UCB concluded it may be more eective than some other
second- and third-generation anti-histamines, but didn't
compare it to cetirizine.[1]

In Chile, it is marketed as Zival and made by Laboratorio Saval.

In Sweden, Xyzal was not granted subventions, and
was withdrawn from the market.[3]

3 Side eects
1

History

Brand names

Levocetirizine is called a non-sedating antihistamine as

it does not enter the brain in signicant amounts, and is
Levocetirizine was rst launched in 2001 by Belgian
therefore unlikely to cause drowsiness. However, some
pharmaceutical company UCB.
people may experience some slight sleepiness, headache,
mouth dryness, lightheadedness, vision problems (mainly
blurred vision), palpitations and fatigue.[4]

4 Research

It is sold under the brand names:

Xyzal /zazl/ in Australia, Austria, Croatia, Czech Latest research shows levocetirizine reduces asthma atRepublic, Finland, France, India, Ireland (also Ri- tacks by 70% in children.[5]
nozal), Lithuania, Netherlands, Portugal, Romania,
Taiwan, Turkey, The Philippines, Serbia, Slovakia,
Slovenia, South Africa and UK. On May 25, 2007,
the United States Food and Drug Administration ap- 5 Availability
proved Xyzal, where it is co-marketed by SanoThe drug is currently available by prescription in the
Aventis.
United States. Although the drug was only authorized
Xusal in Germany;
by the FDA on 25 May 2007, it was already available
in most European countries. Like many new drugs it en Xozal in Greece;
tered the market at a higher price than currently available
third and second generation antihistamines. In India, one
Cezera in Poland;
form of the drug is available as Crohist MK tablets and
Xazal in Spain;
syrup, a formulation of levocetirizine hydrochloride and
montelukast. In India, Crohist MK is a Schedule 'H' drug
Xuzal in Mexico;
and may only be prescribed by a registered medical prac In Hungary it is marketed as Zilola (made by Richter titioner. In Finland, Hungary, China, and Kuwait[6] the
Gedeon) and Histisynt (Actavis).
drug is sold over-the-counter.
1

Dierent brands (Actavis, Glenmark, UCB) Levocetirizine tablets

and oral solution.

References

[1] Grant, JA; Riethuisen, JM; Moulaert, B; DeVos, C;

Gamalero, C.; Descalzi, D.; Folli, C.; Passalacqua, G.;
Canonica, G.W. (February 2002). A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced
wheal-and-are response during 24 hours in healthy male
subjects. Ann Allergy Asthma Immunol. 88 (2):
190197. doi:10.1016/S1081-1206(10)61995-3. PMID
11868924.
[2] https://web.archive.org/web/20121022184859/http:
//beximco-pharma.com/allergic-disorders/147-curin.
html. Archived from the original on October 22, 2012.
Retrieved August 29, 2012. Missing or empty |title=
(help)
[3] http://www.fass.se/LIF/substance?substanceId=
ID11EHWRUFGBA53CSR
[4] XOZAL technical specications booklet.
[5] Pasquali, M; Baiardini, I; Rogkakou, A; Riccio, AM;
Gamalero, C; Descalzi, D; Folli, C; Passalacqua, G;
Canonica, GW (September 2006).
Levocetirizine
in persistent allergic rhinitis and asthma: eects on
symptoms, quality of life and inammatory parameters. Clinical & Experimental Allergy. 36 (9): 1161
7.
doi:10.1111/j.1365-2222.2006.02548.x.
PMID
16961716.
[6] On dierent names:
http://www.hazipatika.com/
gyogyszerkereso/termek/sefaller_5_mg_filmtabletta/
54120

External links
Full US prescribing information Xyzal (levocetirizine dihydrochloride) tablets and oral solution
(provided by UCB, December 2010, pdf le)

EXTERNAL LINKS

Text and image sources, contributors, and licenses

8.1

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