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Viruses

Particles composed of nucleic acid surrounded by protein


Some possess a lipid envelope & assoc. glycoproteins
No cellular structure; Absent:
Chromosomes
Cytoplasm
Cell membrane
Incapable of independent replication bec they dont contain needed enzyme to copy their

nucleic acids
Intracellular parasites that reproduce using metabolic prop. of their host cell
Smaller than bacteria
Can only be seen under electron microscope

Shape
Size
Nucleic acid
composition

Helical
Linear
Spherical
20-400 nm
Single-stranded
Double stranded
Linear (RNA or DNA)
Circular (RNA or DNA)

Viroids (virusoids)
-

Simpler than viruses


Infectious particles
Single-stranded RNA
No associated proteins
Plant pathogens
No human pathogens although human hepatitis D virus may have originated from
them

Prion
-

Unique bec. no nucleic acid


Simplest most recognized agents
Extreme resistance to steam, gamma radiation, & disinfectants
Atypical mammalian protein
Can interact w/ normal protein and make it a prion (undergoes conformational change)
Responsible for transmissible spongiform encephalopathies
Creutzfeldt-Jakob Disease (CJD)
Bovine spongiform encephalopathy (BSE)

Prokaryotes
-

Bacteria; archaea
No true nucleus
Normally only one chromosome not separated by other cell contents
Haploid
Reproduce asexually
o Rely on mutation to create genetic variety & new strains w/ advantageous charac
o Many bacteria can receive new genes from other strains or species

Eukaryotes
-

Cellular microorganisms (fungi, protozoa, algae)


Have a true nucleus
Chromosomes separated from cytoplasm by nuclear membrane
Diploid
Reproduce sexually

Bacteria
-

Essentially unicellular
Some are sheathed chains of cells

Eubacteria
-

Bacteria of interest in pharmacy & medicine


Rod shaped (bacillus), spherical (cocci), curved, or spiral
0.5-5.0 mm (longest)
Gram-positive or gram-negative

Arcaea

No pharmaceutical importance

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