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Proceedings of National Conference on

Recent Advances in Chemical Sciences

2016

11 & 12 November 2016

NAAC Accredited Grade A University

DEPARTMENT OF CHEMISTRY
MAHARISHI MARKANDESHWAR UNIVERSITY,
MULLANA, AMBALA-133207

PROCEEDINGS OF NATIONAL
CONFERENCE ON RECENT ADVANCES
IN CHEMICAL SCIENCES
Theme: Chemistry as the Central Science and its Implementation in Future Research
Fields

Dr. Rajshree Khare (Conference Director)


Dr. Kuldeep Singh (Convener)

DEPARTMENT OF CHEMISTRY, MMEC


MAHARISHI MARKANDESHWAR UNIVERSITY,
MULLANA, AMBALA-133207

NAAC Accredited Grade A University

Proceedings of National Conference on Recent Advances in Chemical Sciences


Convener: Dr. Kuldeep Singh
Editors: Dr. Rajshree Khare and Dr. Kuldeep Singh
Copyright 2016
ISBN 978-93-5267-361-2
First published in India by Chemistry Department, M M University Mullana 133207 India.
All rights reserved. No part of this publication may be reproduced or distributed in any form
or by any means, or stored in a data base or retrieval system, without the prior written
permission of the Convener/ department/University. However, Authors are allowed to
submit only their article to scientific repositories/ their website/Researchgate with giving
proper citation to this publication.
Cover (illustration) by Dr. Pankaj Kumar and Dr. Kuldeep Singh MRSC.
Printed in India.
This publication is designed to provide accurate and authoritative information for
Researchers and scientists working in chemical sciences. It is sold under the express
understanding that any decisions or actions you take as a result of reading this book must be
based on your commercial/scientific judgement and will be at your sole risk. The
authors/Editors/Conference Convener/ Organization committee/ Department/ University
will not be held responsible for the consequences of any actions and/or decisions taken as a
result of any information given or recommendations made. Authors has moral rights and
responsibility for their articles for plagiarism, trueness, correctness, reproducibility of
experiments, results.

NCRACS-2016 Organizing Committee


CHIEF PATRON
Sh. Tarsem Kumar Garg, Chancellor, M.M.U, Mullana
Prof. S. G. Damle, Vice Chancellor, M.M.U, Mullana
PATRON
Er. Sanjeev Garg, Secretary, MMUT Mullana
Dr. Vishal Garg, Treasurer, MMUT Mullana
Dr. L. C. Gupta, Managing Director, M. M. University Mullana
Prof. H. K. Sharma, Vice Chancellor, M.M.University, Sadopur
Prof. Sumit Mittal, Registrar, M. M. University Mullana
Prof. Vipin Saini, Director Research, M.M.U, Mullana
Prof. Avinash Sharma, Principal M.M.E.C, M.M.U, Mullana
Dr. J. K. Sharma, Dean, M M University Mullana
Dr. N. K. Batra, Dean (Acad), M M University Mullana
CONFERENCE DIRECTOR
Dr. Rajshree Khare (+91-80599-30792)
CONVENER
Dr. Kuldeep Singh, MRSC (+91-80599-30803)
MEMBERS
Dr. Pernita Dogra
Dr. A.K. Gupta
Dr. Nivedita Agnihotri
Dr. Jyoti Sharma
Dr. Nirankar Singh
Dr. Vinit Prakash
Dr Vinod Kumar
Dr. Avnish Arora
Dr. Joginder Singh

Dr. Nadeem Sharma


Dr. Mayank Kinger
Dr. Vivek Sheel
Dr. Raman Singh
Dr. Pooja Sharma
Dr. Vishal Mutreja
Dr. Pankaj Kumar
Dr. Shweta Mutreja

Technical Support: Mr. Deepak Sharma, Mr. Sanjeev Kumar, Mr. Akhilesh
Kumar, Ms. Mandeep, Mr. Sukhvir Kumar, Mr. Arun

ABOUT MAHARISHI MARKANDESHWAR UNIVERSITY, MULLANA,


AMBALA
Maharishi Markandeshwar University (MMU) is a leading University in North India and has become a
symbol of quality education in technical, medical and other professional streams. MMU has been
accredited by NAAC as Grade "A" university. Since its inception, the University is committed to excel
in research, innovation and skill development. Our Industry oriented education system helps us to make
our students leaders in the professional world.
The University is offering plethora of courses through its various teaching institutions spreading over
three different Campuses at Mullana, Sadopur and Solan. The constituent institutions of the University
are MM Engineering College; MM Institute of Computer Technology & Business Management
(MCA); MM College of Dental Sciences & Research; MM Institute of Physiotherapy & Rehabilitation;
MM Institute of Computer Technology & Business Management (Hotel Management); MM Institute of
Medical Sciences & Research; MM Institute of Management; MM College of Nursing; MM College of
Pharmacy; and MM Institute of Nursing, Mullana, Ambala. These institutes are also approved by the
regulatory bodies like Medical Council of India, Dental Council of India, Indian Nursing Council,
Indian Association of Physiotherapists, All India Council for Technical Education, DSIR etc .

ABOUT THE CHEMISTRY DEPARTMENT


The Department of Chemistry is a premier department of the university. It was initially established in
1995 as one of the Department under Applied Sciences. It started working as an independent University
Department in 2008. The Department offers Post Graduate (M. Sc. in Chemistry) and PhD programs.
The Department also caters to first year Engineering and Diploma-B.Tech., B.Sc., Integrated students,
Biotechnology Department for chemistry courses. The Department has 22 members team of dedicated
and competent faculty with aim to impart quality education among science students.

CONTACT ADDRESS:
Dr. Rajshree Khare
Professor & Head
Department of Chemistry, MMEC,
Maharishi Markandeshwar University
Mullana- Ambala, 133-207 (Haryana)
www.mmmumullana.org
www.mmu.ac.in

UNIVERSITY CONTACT NUMBERS


Toll-free No. 1800-2740-240
Landline: 01731-274475,76,77,78,
01731-304100 (For all users except BSNL customers)
Mobile : +91-8059930001, 02, 03, 04, 05, 06
Fax. No. 01731-274375

MESSAGES

Professor C. N. R. Rao

Dr. Tarsem Garg


CHANCELLOR

Message
It is a matter of great pleasure to know that the Department of Chemistry of this
University is organising a National Conference on Recent Advances in Chemical
Sciences on 11-12 Nov. 2016. I convey my best wishes to all the delegates of the
Conference being held at Maharishi Markandeshwar University, Mullana.
This Maharishi Markandeshwar University Trust, was founded with the objective
of social, educational and economic upliftment of society and the trust has
become a symbol of quality education in technical, professional and medical
streams in northern India and has been carrying on its lineage for over 23 years.
My cherished dream has been to provide value based education to the young
generation-the future creator of India. To attain this, the University has set up a
mission to develop a better than the best professionals for the economic
development of our country and my vision is to prepare students with an
integrated and technology oriented education for a better career and to be worth
citizens of a global society. I believe this conference is also a step in this direction.
I am sure that this two-day conference will go a long way in providing an
opportunity to the young scholars to explore their scientific talent.
I also congratulate the organisers of the conference and my best wishes for the
success of NCRACS-2016.

(Tarsem Garg)

Dr. S.G. Damle


VICE CHANCELLOR

Message
It is a matter of pleasure to know that the Department of Chemistry under the
aegis of Maharishi Markandeshwar University is organizing a National
Conference on Recent Advances in Chemical Sciences on 11th and 12th
November, 2016. I congratulate the organizing committee for selecting the theme
Chemistry as the Central Science and its implementation in Future Research
Fields. The conference aims to promote the interaction of researchers on the
latest issue of Chemistry. It is a known fact that the advances in Chemistry are
truly amazing and revolutionary. In todays world Chemistry as a science plays a
pivotal role in the development of scientific technologies and the new innovative
ideas in this subject have become the need of the hour.
I am also happy to know that the galaxy of renowned and eminent speakers are
participating in this conference to deliberate on latest developments and advances
in Chemistry. I am confident that these deliberations will inspire the young
scientists to achieve greater heights. This conference is also very significant for
bringing together the best scientific talents of the country to share and strengthen
their scientific and research attitude and aptitude. This event will provide an
opportunity to the postgraduate students to interact and learn from the best
intelligentsia.
I extend my best wishes to the Organizing Committee Members for the success of
this event.

(Dr. S.G. Damle)

Er Sanjeev Garg
SECRETARY, MMUT MULLANA

Message
It is a matter of pleasure to know that Department of Chemistry, Maharishi
Markandeshwar University, Mullana is organizing National Conference on
Recent Advances in Chemical sciences (NCRACS-2016) to be held on 11-12
November, 2016 and publishing a Souvenir to mark the occasion.
Maharishi Markandeshwar University being a leading University in North India
has become a symbol of quality education in technical, medical and other
professional streams. Since its inception, the University is committed to excel in
research, innovation and skill development.
The conference should serve as a platform for exchange of views and experiences
and a forum for sharing of knowledge of emerging trends. I hope that the
delegates, who are specialized in diverse fields of education / research fields /
academic sectors, will also interact on current problems and their remedies.
I hope that the outcome of this conference will prove to be beneficial for the
young scientists / researchers. I wish the conference and the souvenir all success.

(Er. Sanjeev Garg)

Dr. Vishal Garg


TREASURER, MMUT MULLANA

Message
It is a matter of delight for Maharishi Markandeshwar University, Mullana
Ambala that a National Conference on Recent Advances in Chemical Sciences (NCRACS2016) is being organized from 11-12 Nov, 2016.
This conference promises to be an excellent platform for eminent scientists,
academicians, entrepreneurs as well as students and young researchers across the
country to share their latest discoveries in the related areas of chemical sciences
and also providing learning opportunities to young students.
I am confident that the discussions among the renowned experts and participants
during the two days would be of immense use for the scientific fraternity to refine
their future pursuits. On this great occasion, I would like to extend a warm
welcome to all the delegates and participants on the conference. I extend my best
wishes for the success of such a mega event.

(Dr. Vishal Garg)

Dr. L. C. Gupta
MANAGING DIRECTOR

Message
It is a matter of immense pleasure to know that the Chemistry Department of the
MM University, Mullana-Ambala is going to organize a National Conference on
Recent Advances in Chemical Sciences with the theme of Chemistry as the Central
Science and its Implementation in Future Research Fields on 11-12 Nov. 2016.
I am sure the conference would provide a common platform to both those from
the academics and those coming from the industry to deliberate on different
theme areas related to the basic topic of the Conference and that the deliberations
at the conference would project new findings and fruitful results for the benefit of
the researchers and academic fraternity.
I also take this opportunity to convey my greetings to the delegates and best
wishes for grand success of the Conference.

(Dr. L. C. Gupta)

Prof. H. K. Sharma
Vice Chancellor, MMU Sadopur

Message
It gives me immense pleasure to know that Department of Chemistry is
organizing National Conference entitled Recent Advances in Chemical
Sciences.
A healthy discussion on a topic like Chemistry as the Central Science is certainly
a need of the hour, particularly when new viruses and diseases, environmental
pollution and need to device new green synthetic procedures are posing a
challenge to the mankind. I am sure that deliberations during the conference will
be academically rewarding for the participants and the recommendations will be
useful to all the stakeholders.
I congratulate the organizers especially Dr. Kuldeep Singh and his team for the
initiative and wish the conference a grand success.
With best wishes

(Dr. Harish K. Sharma)

Prof. (Dr.) Sumit Mittal


REGISTRAR

Message
It is a matter of pride and pleasure that Department of Chemistry of M.M.
Engineering College is organizing a National Conference on Recent Advances in
Chemical Sciences (NCRACS-2016) on 11th and 12th November, 2016. It is
heartening to note that delegates from all parts of the country shall be joining to
deliberate on areas of concern in the present context with a focus on recent
developments and research work in Chemistry.
From non-living to living, farming to aviation, fuel or food; every day we
encounter chemical phenomenon involved in our daily life. A chemical process
converts energy into food; while other process changes food into energy.
Chemistry overlaps physical, mathematical and biological sciences and truly,
central science.
To reap rich dividends from R & D activity, such Conferences / Seminars serve
the purpose of confluence by bringing together the students, researchers, scientists
and industrialists on a single platform which goes a long way in meeting and
fulfilling the aforesaid cherished aspirations through knowledge sharing and
management amongst intelligentsia.
I compliment the organizers in selecting the theme for the conference that will
help in providing a deep look in to the recent advances in the field of Chemistry.
I would like to convey my heartiest congratulations and best wishes for the
success of the conference.

(Dr. Sumit Mittal)

Prof. (Dr.) Vipin Saini


DIRECTOR RESEARCH

Message
I feel profound pleasure to know that Chemistry Department of M.M.
Engineering College, is organizing a National Conference on Recent
Advances in Chemical Sciences (NCRACS-2016), on 11th and 12th November
2016. The theme chosen for the Conference is best suited in the current
competitive world. I am sure during the Conference; the researchers across the
country in the field of Chemistry will present their scientific findings.
I encourage all scientists, academicians and persons working in across the region
to make the best of this opportunity to participate in the Conference.
I hope, this Conference will prove a mile stone in this direction.
I convey my good wishes for the success of the National Conference.

(Dr. Vipin Saini)

Dr. Avinash Sharma


PRINCIPAL, MMEC

Message
I am immensely happy that the Department of Chemistry, Maharishi
Markandeshwar Engineering collage, Mullana (Ambala) is organizing a
National Conference on Recent Advancement of Chemical Sciences
(NCRACS-2016) on November 11-12, 2016 and also publishing a Souvenir to
mark the occasion.
This will be the most celebrated chemistry conference at M. M. University and an
outstanding event for brand exposure to the thought leaders in the field of
chemistry and associated research areas. The innovations and researches in this
field are already impacting the society positively and hence we could expect more
innovations that will contribute to the sustainability of human beings in this
century. Main conference tracks being chemistry and bio-chemistry, and
biotechnology, bio-nanotechnology, natural products and other related research
areas, I have no doubt that this conference can promote such developments and
innovations in the field of Chemistry and its interdisciplinary research fields.
I hope that the outcome of this conference will prove to be beneficial for the
young researchers. I wish the conference and souvenir all success.

(Dr. Avinash Sharma)

Dr. Rajshree Khare


CONFERENCE DIRECTOR HEAD, CHEMISTRY DEPARTMENT

Message
Welcome to the first National Conference on Recent Advances in Chemical
Sciences (NCRACS-2016) which is organised by Department of Chemistry,
Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar
University, Mullana on 11th & 12th of November 2016.
Theme of conference Chemistry as the Central Science and its Implementation in Future
Research Fields emphasis on interdisciplinary collaborations. Scientists uses
chemistry as a tool in various areas of research.
We have received 106 articles and abstracts from various educational and research
institutes of India and abroad. All submissions were peer reviewed by Scientific
Advisory Board reviewers. This allowed us to compile an outside scientific
programme besides inaugural function which includes one key note, 3 plenary, 20
invited talks and 82 poster presentations. We are glad to provide an abstract book
(ISBN number- 978-93-5267-361-2) covering the presentations to be made during
NCRACS-2016. The most heartening feature of the Conference is that it provides
sufficient time for scientific exchange and discussion among young scientists and
research students. I extend warm welcome to all the participants
At this point I would like to thank sponsors Kamdhenu Paints, Tinchem
Enterprises, Target Enterprises, Drug De-addiction Centre- Ambala Cantt.,
Apurva Biotech-Karnal and Singhla Scientific for their financial support. Without
their contribution and timely help it was not possible to organise this conference
in such a short period of time. I take this opportunity to express my sincere thanks
and gratitude to all the members of organising team- Dr A K Gupta, Dr Pernita

Dogra, Dr Kuldeep Singh, Dr Nivedita, Dr Vinit Prakash, Dr Jyoti Sharma, Dr


Nirankar, Dr Vinod Kumar, Dr Avnish Arora, Dr Joginder Singh, Dr Nadeem
Sharma, Dr Mayank Kinger, Dr Pooja Sharma, Dr Viveksheel, Dr Raman, Dr
Vishal Mutreja, Dr Pankaj and Dr Shweta Mutreja, technical supporters- Ms.
Amita, Mr. Deepak Sharma, Mr. Sanjeev Kumar, Mr. Akhilesh Kumar, Ms.
Mandeep, Mr. Sukhvir Kumar, Mr. Arun for putting this conference together. I
extend my special thanks to Dr. Narender Chaudhry, Biotechnology Department
for his support and help.
I hope this Conference will become a meaningful experience in itself.

(Dr Rajshree Khare)

Dr. Kuldeep Singh, MRSC


CONVENER (NCRACS 2016)

Message
It gives me immense pleasure to welcome you all attendees, renowned speakers,
subject experts and distinguished guests to National Conference on Recent
Advances in Chemical Sciences (NCRACS 2016). The specialty of this
conference stems from the fact that the researchers from various research arenas
are participating. Chemical science is central to various research fields, thus
collaboration among diverse research areas is possible with a chemist.
The theme of conference is "Chemistry as the Central Science and its
Implementation in Future Research Fields". The major aim of the conference is to
provide a forum for scientists, teachers, and students from all over the world to
participate in and discuss the recent developments in chemical sciences, promote
the exchange of ideas, and create an opportunity for budding young scientists to
get exposed to the excitement of research in chemistry.
I am thankful to all speakers for accepting our invitation. I acknowledge support
and help extended by students, Head and all members of Chemistry Department,
university staff members, university administration and management. I
acknowledge support received from sponsors, advertisers.
I am so honored to be the convener for the NCRACS-2016 and welcome you all
to MMU, Mullana to have a great time and Chemistry.

(Dr. Kuldeep Singh)

CONTENTS
NCRACS-2016 Organizing Committee
MESSAGES
KEYNOTE
Dr. Rajender S. Sangwan, F.N.A.A.S., F.N.A.Sc.

1
2

Bio-Inspired Chemistry for Grand Challenges in Food, Energy and Environment- New Waves of
Enthusiasm and Innovations

PLENARY LECTURES
Prof. Ravi Bhushan, CChem, FRSC, FNASc
Resolution and Control of Enantiomeric Purity

5
6
7

Prof. N. K. Ralhan
Academia Industry Interaction

8
9

Dr. M. R. Maurya

10

Catalytic Aspects of Polymer Supported Vanadium Complexes and Their Future

11

Dr. Himadri B. Bohidar

12

Soft Interaction Induced Phase Separation in Biopolymers and Design of New Biomaterials

13

INVITED TALKS
Dr. Akash Deep

15
16

Application of Advanced Nanomaterials for Sensing Applications

17

Dr. Sonal Singhal

18

Magnetically Retrievable Nanocomposites: An Approach towards Green Catalysis

19

Dr. Amjad Ali

20

Chemical Transformation of Triglycerides and Glycerol Via Mixed Metal Oxide based Heterogeneous
Catalysts

21

Dr. Shaibal Banerjee

22

Azido Esters as an Energetic Plasticizers

23

Dr. Nitin Singhal

24

Immobilization of -Amylase on Magnetic Nanoparticles for Enhanced Reusability in Bio-Catalytic


Processes

25

Dr Uma Shanker

26

Green Synthesis Of Different Transition Metal Oxide Nanoparticles: Potential Catalysts For Removal Of
Organic Colorants From Water

27

Dr. Amardeep Singh

28

Evaluation of Metal-Organic Frameworks for Hydrogen Storage

29

Dr. Asish Kumar Sharma

30

Academic - Industrial Research Collaborations

30

Actuating Materials: Conversion of Light and Heat Energy into Mechanical Energy

31

ORAL PRESENTATIONS

33

Design and synthesis of modified amino acids and peptides

34

A Footstep Towards the Development of Eco-Friendly Lubricant Additives from Biomaterials

34

Extraction and Spectrophotometric Determination of Molybdenum (VI) using 3-Hydroxy-2-[-3-(4methoxyphenyl)-1-phenyl-4-pyrazolyl]-4-oxo-4H-1-benzopyran as a Chelating Agent
Waste Water Treatment Using Cuprous Oxide Nanomaterials

35

Nitric Oxide Dioxygenation Reactions and Their Mechanistic Insights

36

35

Biological Patents with Special Reference to Practical and Ethical Implications

37

Synthesis of Novel Ketomethylene N Domain Selective Ace Inhibitors

37

Anion Receptors-An Overview

38

Total volatile organic compounds (TVOCs) in Indoor and Outdoor Urban Atmospheres at a Terai Region Of
Northern India
Review on Catalytic Chemical Vapour Deposition (CCVD) Growth of Single Walled Carbon Nanotubes
and their Characterization

38

INVITED ARTICLES
Professor Sabyasachi Sarkar

41
42

Chemistry: Processing Everything Including Life

43

Natural Abenquines and Analogues as Potent Algicidal

45

Total Synthesis of the Antitumor Antibiotic Basidalin

46

Novel Non-Halogenated Flame Retardant For PCB

47

Dr. Soumita Ghosh

48

Exploring Biology Using Chemistry: Lessons from Metabolomics and Proteomics

49

A Novel Aspirin-Derived Small Molecule as A Potential Therapeutic for Colorectal Cancer

50

POSTER PRESENTATIONS

51

Electronic Structure Studies of L And D- Alanine.

52

PTSA Catalysed Solvent-Free Synthesis and Biological Evaluation of Some 5-Aminopyrazoles

53

CuO Nanostructures of Variable Shapes as an Efficient Catalyst for [3+2] Cycloaddition of Azides with
Terminal Alkyne
Spectrophotometric Determination of Pd(II) In Micellar Media by Sodium-1-Methyl-1-Propylthioxanthate

53

Elastic Behavior of La2-xSrxCuO4 (x=0.10-0.20)

54

Removal of Chromium III Ion from Waste Water using Gossypium herbacium as a Biosorbent

54

Structural Properties of Tb Incorporated ZnO Nanoparticles: An EXAFS And XPS Study

55

Heavy Metals in Environment and its Microbial Bioremediation

56

A Novel Method of The Synthesis of Titanium Dioxide Nps

56

Recent Innovative Approaches and Role of Microbes Towards Ecofriendly Remediation of Heavy Metals

57

Synthesis and Anti-Microbial Evaluation of Benzimidazole-1-Substituted Hydrazide Derivatives

57

Synthesis of Some Secondary Amines

58

Current Channelling Effect in Magnetotelluric Field Data

58

Lipid Based Peptidomimetics As Antimicrobial Agents

59

New Heterobimetallic Complexes and Their Interaction with DNA

59

The Field Study on The Discharge and Using of Agricultural Chemicals and Effects on The Agricultural
Environment
Point of Use Wastewater Treatment Using Agglomerated Nanoparticles of Titanium (IV) oxide and Blotter
Paper Impregnated with Silver Nanoparticles in Colum Mode
Effect of Solvents on Photo-catalytic Properties of SnO2 Nanoparticles Synthesized by Chemical Coprecipitation Method
Sulphate and Cerium Impregnated Ti/ZrO2 as Heterogeneous Catalyst for Glycerol Esterification

60

Inorganic Hybrid Materials Based on Mesoporous Silica Composites for Humidity Sensing Applications

61

Spectrofluorimetric Determination of Al3+ Using 3-hydroxy-2-(4-methoxy phenyl)-4H-chromen-4-one as


Analytical Reagent.
Well-defined Quantum Dots and Morphological Control of Nanomaterials

62

39

54

60
61
61

62

Perspective of Plant Based Home Made Organic Pesticides

63

Green Solvents for Organic Synthesis

63

Synthesis and Characterization of Peptide Derivatives of Quinazolinone

64

Synthesis and Characterization of Novel Zirconium Antimonoarsano- tungstate Zr[SbAsW] Salt

64

Biomass Generation from Sugarcane, Rice and Wheat Crops: Consequences of Removal Practices and
Alternatives
DFT Based Analysis for The Regio- and Stereoselective Synthesis of Tetrasubstituted Isoxazolidines From
Cinnamoyl Piperidine Derivatives
Potentiometric Determination of Lead (II) Ion using 2-[(4-Chloro-Phenylimino)-Methyl]-Phenol as an
electroactive Material
Transition Metal Complexes of 1-(2-Methylphenyl)-4, 4, 6-Trimethyl Pyrimidine-2-thione : Synthesis and
Biological Studies
A Review on Synthesis and Characterization of ZnO Nanoparticles

65

Clerodendrum serratum (L.) Moon. A Review on Conventional Uses and Scientific Findings

68

Destabilization Mechanism of Alzheimers A42 Protofibrils With a Small-Molecule Inhibitor: A


Molecular Dynamics Simulation Study
Synthesis and Antimicrobial Screening of Thiazolidinone Derivatives

68

Subchronic Toxicity Studies of Aqueous Extract of Alangium salvifolium Leaves in Rats

69

Synthesis, Characterization of Novel 3-(4-Substituted Phenyl)-1-(6-Substituted Benzothiazol-2-yl)-1HPyrazole-4-Carbaldehyde As Potential Antimicrobial Agent


Protective Effects of Linoleic acid on toxicity Caused by Acrylamide in Rats

70

Anodic Stripping Voltammetry of Anti-VI Antibody Functionalized CdTe Quantum Dots for Specific
Monitoring of Salmonella enterica serovar Typhi
Sonochemistry: The Non-Conventional Method of Organic Synthesis

71

Synthesis and Characterisation of Ce(III) Doped Polyvinylpyrollid-one Capped ZnS Nanoparticles

72

Electronic Structure Studies of Aspirin and Paracetamol.

72

Uniform Dispersion of Anisotropic CuO/SBA-15 Nanocomposites for Nitroaromatic Reduction

73

Evaluation of Phytochemicals and TLC optimization in Alstonia scholaris and Caesalpinia crista of Western
Himalayan Region
Assessing the Effect of DE-Loop Mutation (D59P) in the Amyloid Aggregation Propensity of 2Microglobulin with Molecular Dynamics Simulations
Synthesis and Characterisation of Molecularly Imprinted Polymer Nanoparticles for Streptomycin for Use
as Solid Phase Extraction Materials
Streptomyces albogriseolus as a Potential Bioremediation Agent for Sulfosulfuron

74

Synthesis of 3-substituted chromone derivatives for their antibacterial studies.

76

Synthesis, Characterisation and Analytical Applications of Novel Potentiometric Sensor Chromium (III)
Boratotungstophosphate
Formulation and Characterisation of Dual Drug Loaded Lipid Based Carrier System

76

Chemical Analysis of Municipal Water Samples of Gurgaon

77

To Study the Effect Of Urtica Dioica Extract On DiabetesMediated Alteration in Glucose Transporter.

78

Lipophilic peptide Multi-Nucleoside reverse transcriptase inhibitor conjugates synthesis to combat HIV
resistance
Crystallite Size Dependence on Photocatalytic and Antimicrobial Activity of Microemulsion Mediated
Synthesized ZnO Nanoparticles Annealed at Different Temperatures
Synthesis and Reactivity of Ru-DMSO Complexes

78

Wound Healing and Hemolytic Activity of Different Extracts of Arnebia benthamii

81

Synthesis of Nanomaterials by Fabricating AAO Membranes

81

Asias Fight Against Disasters: An Indigenous Approach

81

Synthesis, Characterization and Biological Evaluation of N- Substituted Heterocyclic beta-Lactam


Derivatives

82

66
67
67
67

69

70

71

74
75
75

77

79
80

iii

Preparation of some Benzo 1,5-Diazepine

82

Extractive Oxidative Desulfurization of fuels with Hydrogen Peroxide in presence of catalysts

83

Bacteriophage Conjugated Metal Organic Framework for Sensitive Detection of S. arlettae

84

A Novel Fluorescent Sensing Technique for Dipicolinic acid

84

CoMFA/ CoMSIA Studies on Peripherally Acting CB1 Receptor Antagonists as Anti-Obesity Agents

85

Nematode Paradoxical Activity of Naturally Occuring Biologically Active Compounds

86

2, 5-Disubstituted-1,3,4-Oxadiazoles as DNA Photo-Cleaving Agents

86

2-(3, 5-Dimethyl-1H-pyrazol-1-yl)-1-arylethanones as Potential Anticancer Agents

87

Azoles: Introduction, Current and Future Scope

87

Synthesis and Anticancer Activity of Some Novel 1,3,5-Trisubstituted pyrazolines using MDA-MB-231 and
Hep-G2 cancer cell lines
Graphene and Its Electronic Properties

88

Synergistic Effect of THF with Amines as Vapour Phase Corrosion Inhibitor for Mild Steel under
Atmospheric Conditions at High Temperature
Study of Magnetic Properties of Mixed Cobalt-Zinc Ferrites Synthesized By Solid State Reaction
Technique.
Solubility Behaviour of Cellulose-Reinforced Starch-PVA Blends with Insertion of Fly-Ash

89

Colorimetric Determination of Vitamin C Using Fe(II)-5-Chloro-7-Iodo-8-Hydroxyquinoline Complex

91

Conductance studies of Li+ and Na+ in Acetonitrile and Nitromethane binary mixtures at 298.15 K

92

Removal of Pesticides from Water Using Low Cost Adsorbents

93

Synthesis, Characterisation and Applications of 3D Transition Metal Oxide Nano Particles

93

Theoretical Studies On Structure Of Octacarboranes Dianions

94

Comparative study on modeling growth inhibition activity using physicochemical and connectivity indices

94

Flame retardant polymeric materials


Immobilization of Cadmium ions with ordinary Portland cement

95
95

UG/PG POSTER COMPETITION

99

Factors That Control the Reactivity of Cobalt(III)-Nitrosyl Complexes in Nitric Oxide Transfer and
Dioxygenation Reactions
Chemistry of Life

100

Mechanistic Insight into the Nitric Oxide Dioxygenation Reaction of Nonheme Fe(III)Superoxo and
Mn(IV)Peroxo Complexes
Nitric Oxide Dioxygenation Reactions and Their Mechanistic Insights

101

Clouding and Aggregation of Triton X-100 Micelles: Effect of Additives


Sugar Based Low Melting Mixtures as Green Solvents in The Hantzsch Synthesis of Substituted 1,4Dihydropyridines

AUTHOR INDEX

88

89
90

100

102
102
103
105

KEYNOTE

NCRACS-2016

Dr. Rajender S. Sangwan, F.N.A.A.S., F.N.A.Sc.


CEO, Center of Innovative and Applied Bioprocessing [CIAB],
Director, National Agri - Food Biotechnology Institute, Mohali
[A National Institute under Department of Biotechnology, Govt. of India]
C-127, Phase-8, Industrial Area, S.A.S. Nagar, Mohali-160071, Punjab, India
Email: edoffice@nabi.res.in
Phone:+91-172-4990300
Dr. Sangwan obtained his PhD from Haryana Agriculture
University Hisar and carried out postdoctoral research at
Queens University, Kingston, Ontario, Canada. His
interest in multidisciplinary research motivated work on
plant metabolites at CSIR- Central Institute of Medicinal
and Aromatic Plants, Lucknow-22601. His current
research interest involves Translational Biochemistry &
Biotechnology, Bioresource Science and Technology,
Medicinal, Aromatic Food and Industrial Plants,
Bioprocessing, Secondary Phytochemicals and Secondary
Metabolism, Secondary Agriculture Biotechnology,
Nutrients, Nutrition and Nutraceuticals. He is member of
DBT Taskforce, Management Committee CSIR-CMIAP,
Lucknow. He has published 130+ research papers in high
impact journals, 11 books/monographs, 7 Patents. He is currently serving Center of Innovative and
Applied Bioprocessing, and National Agri - Food Biotechnology Institute, Mohali as director.

NCRACS-2016

Bio-Inspired Chemistry for Grand Challenges in Food, Energy and


Environment- New Waves of Enthusiasm and Innovations
Rajender Singh Sangwan

Chemistry is considered as deep understanding of everything on earth, atmosphere and


cosmos. The chemistry of complexes in biological systems and in earth materials is most
arduous because it is difficult to recreate in the laboratory. To my mind this is most common
between the two. On other side co-ordination (self-aggregating and operating) of complex
systems in biology and static (largely) in geo-processes is the most contrast between them.
This is probably because early dynamics of chemical processes on the planet to reach to a geochemical environment that made the beginning of new chemistry- the chemistry of life. This
chemistry of life retained its key character same as in the origin but diversified into forms and
functions through growing chemistry of molecular aggregations and structural frames
expanding functions. This is current world of two chemistries. However, the two chemistries
hold a very strong principles many of which still envied by chemists because for generating
complexities of earth materials, those conditions are difficult to create, at least to that scale
and biological kind of precision, specificity and co-ordination is also equally envied by
chemists. However, scale and speed of industrialization of chemically designed processes is
envied by biologists. Catalysis is the major convergence as a path to progress in the two
systems. Biology exhibits the novelty but not the cues as clearly to design chemical
replication. Nevertheless, bio-inspired chemistry has now become much more than an
academic pursuits. The new waves of attraction originate from human needs for handling
current and forthcoming grand challenges related to food, energy and environment. These
attractions and needs have led to many astonishing achievements in chemistry of breaking
molecules as well as synthesizing molecules which are related to biology either as origin or as
impact on survivability or sustainability of future generations (future means1000 or 10,000
years from now) of mankind. The enthusiasm of research goes not only in mimicking
biological steps/processes but also in gainfully reversing biological processes to recover
energy invested in their production in biological systems like reverse photosynthesis,
photolysis etc. Some case examples and their applications would be presented from recent
researches globally.

NCRACS-2016

NCRACS-2016

PLENARY LECTURES

NCRACS-2016

Prof. Ravi Bhushan, CChem, FRSC, FNASc


Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667 India
E-mail: rbushfcy@iitr.ernet.in; rbushfcy54@gmail.com
Phone: 01332-285795 (O); 01332-271162, 285089 (R)
Prof. Ravi Bhushan has a throughout first class academic record (high school to MSc). Ravi Bhushan
obtained PhD in chemistry from University of Jodhpur, India and joined in 1979 the teaching faculty at
the University of Roorkee and was selected is a full professor of chemistry in 1996. He received the
Outstanding Teacher Award of the year 2007 of IIT Roorkee. He was elected Fellow National
Academy of Sciences India, (FNASc) in 2001.
Dr Bhushan has a research experience of 41 years. He received
prestigious Alexander von Humboldt fellowship of Germany in the
year 1988, and worked for research at the University of Oldenburg,
and at the University of Giessen, Germany. He received European
Economic Community Fellowship in 1992 and worked at University
of Bristol, UK, on Rye protein. He is an elected Fellow of the Royal
Society of Chemistry, London (including Chartered Chemist). He
also worked on establishment of primary structures of proteins of
Peanut, Brassica, and Soybean, and published several research
papers from Univ of Roorkee. He also worked as post doc fellow at
the Washington State University, USA.
At IIT Roorkee, he founded Intellectual Property Rights Cell in the
year 2000, organized several Conferences and Workshops on IPR till
2003 and formulated IPR Policy in Oct 2003, and also formulated Policy on Plagiarism in Dec 2012. He
served as Dean of Students Welfare; Member-Board of Governors; Member-Finance Committee; HeadChemistry Department; Chairman-Library Advisory Committee (Central Library), during the years
2005 to 2014.
He has 37 years of undergraduate and postgraduate teaching experience at University of Roorkee and
IIT Roorkee. He Produced 08 Educational TV films, telecast on UGCs Countrywide Classroom on
national TV network, and prepared 10 Educational Technology Packages under MHRD Scheme of
National Mission on Education in 2014, 2015. Besides, in 2016 he developed an 8 weeks e-course for
Organic Chemistry-I as Course Coordinator for the students of 1st semester of B.Sc. Chemistry and
B.Sc. Physical Science under Massive Open Online Courses (MOOC) hosted on SWAYAM-the India
Centric web portal under NME-ICT scheme of MHRD.
Dr. Bhushan is a Member of Editorial Board of Biomedical Chromatography, (John Wiley & Sons, UK,
since Jan 1996); Bioanalysis (Future Science Group, UK, Since 2011), and Acta Chromatographica
(Akademiai Kiado, Hungary, since 2012). He edited four Special Issues of Biomedical Chromatography
on Chiral Resolutions as Guest Editor.
His current area of research interest is enantiomeric resolution of compounds of pharmaceutical
importance using liquid chromatography. So far, he has guided 28 doctoral and 50 Masters theses,
published more than 230 research papers in international refereed journals including invited chapters in
books and encyclopedia. Besides, he authored two books.

NCRACS-2016

Resolution and Control of Enantiomeric Purity


Ravi Bhushan
Department of Chemistry, Indian Institute of Technology Roorkee,
Roorkee 247667, India
The regulatory agencies in the US, Japan and EC and certain other countries insist on registration of
single enantiomer of a new drug and ask the pharmaceutical companies to present full information on
the stereochemistry and stereoselectivity of both the enantiomers including the necessary stereoselective
analytical methods. Separation of enantiomers and determination of their purity has always been
challenging and important in the fields of chromatography, pharmacology, medicine, asymmetric
synthesis, mechanistic studies, extra-terrestrial chemistry, life sciences etc.
Efficient methods of enantioseparation are always required to control the enantiomeric purity, or to
separate the target molecule or one of its chemical precursors (obtained from conventional synthetic
procedures), or for monitoring the completion of enantioselective reaction process (since the production
of single enantiomer is a real difficult task).
This presentation covers some aspects of stereochemistry of the drugs that are marketed and
administered as racemic mixtures with an emphasis on status of analytical chemistry methods for
enantioseparation and control of enantiomeric purity. There is also a brief discussion on related
historical knowledge.
This report presents various methods developed primarily at our laboratory for chromatographic
resolution of racemates of several pharmaceuticals (e.g., -blockers, NSAIDS, anta-acids, DL-amino
acids, Bupropion, Baclofen, Etodolac, Carnitine, Mexiletine). Recently, we developed methods for
establishing molecular dissymmetry and determining absolute configuration of diastereomers (and thus
the enantiomers) of (RS)-Baclofen, (RS)-Betaxolol with complimentary application of TLC, HPLC, 1H
NMR, LCMS; this ensured the success of diastereomeric synthesis and the reliability of
enantioseparation.
Keywords: enantioseparation, racemic mixtures, single enantiomer of drug, chromatography,
chromatographic resolution.

NCRACS-2016

Prof. N. K. Ralhan
Professor and Dean Research
Akal University, Talwandi sabo
Bhatinda
Dr. N. K. Ralhan M. Sc.(Hons.), Ph. D from Panjab University
Chandigarh and Post-Doctoral From Louisiana State University
USA. Born in 1935 at Kapurthala, Punjab. After Serving for Two
Years at Department of Chemical Engineering and Technology
Panjab University Chandigarh joined Punjabi University Patiala as
Lecturer in Chemistry Department in 1965.
Retired as Professor and Head, of Chemistry Department in 1995
from Punjabi University Patiala.
Dr. N. K. Ralhan has given Guidance to 20 Nos. of Students for
Different fields of Ph. D. Chemistry.
He is having numerous Publications in National and International
Journals.
Department of Environmental Technology and Management was
Established by Him and successfully Headed for First Three years
of Establishment. He was also given additional Responsibility of Forensic Sciences Department of
Punjabi University. (i.e. Three Deptts. Were Headed at a Time.)
Through out of his career he has been interacting with Industry and Applied Research. He was Director
of Shri Ganesh Research Institute Ghaziabad(1980-83) ( On Deputation ) and Director Research and
Development Mahesh Udyog, UNA(H.P) (1995-2003).
He is having Three Patents to his Credit and same products are listed in Aldrich/Fluka/Sigma.
Presently heading as Chairman of Three Chemical and Mechanical Manufacturing Units Named as M/s
Tinchem Enterprises, M/s Target Enterprises and M/s Ralhan Enterprises at Patiala. These Companies
are involved in Manufacturing Surface Treatment and Surface Preservation Chemicals, Chemicals of
Tin, Nickel, Cobalt, Components of Indian Railways as well Exporting to USA, South Korea etc. In
2010, He was invited by the Eternal University Baru Sahib and worked in the capacity of Dean Post
Graduate Studies and guided Ph. D Students. Since August 2015 he is Dean Research at Akal
University Talwandi Sabo, Bathinda.

NCRACS-2016

Academia Industry Interaction


Prof. N. K. Ralhan
Since the last decade of the twentieth century to date, the IT industry assisted by internet and
electronic media has changed the face of the world. Especially it has affected the Industry and
Academia in the country. The students produced by the colleges and the Universities are
unemployable; due to lack of skill & information; the profitability of the industry has declined
for the lack innovation and improvement in the technical backup and services. Exception
being the IT industry.
The trend can be reversed, the day, the university Professors start interacting with the industry
and vice versa. The teacher will find ready supply of funds for its research and training
students. And the students will find their ready acceptability and receive attractive packages
from the industry. The industry in return will find skilled and trained manpower.
The teacher will never retire.

NCRACS-2016

Dr. M. R. Maurya
Professor, Inorganic Chemistry,
Department of Chemistry, Indian Institute of Technology
Roorkee, Roorkee 247 667 India
E-mail: rkmanfcy@iitr.ernet.in
Phone: (O): +91 1332 285327 (R): +91 1332 285113
Group web: http://www.iitr.ernet.in/chem/maurya/
Professor M. R. Maurya is currently heading the Department of
Chemistry, IIT Roorkee. He has more than 26 years of teaching and
research experience. He had worked in Loyola University of Chicago,
USA, Iowa State University, Ames, Iowa, USA, National Chemical
Laboratory, Pune, and Pune University Pune, before joining department
of Chemistry at IIT Roorkee in 1996 and became full professor in 2008.
His current area of research interests include structural and functional
models of vanadate-dependent haloperoxidases, coordination polymers
and their catalytic study, metal complexes encapsulated in zeolite cages
and their catalytic study, polymer-anchored metal complexes and their
catalytic study, and medicinal aspects of coordination compounds. So
far, he has guided 21 doctoral and 7 Masters theses, co-authored more
than 140 research papers in the international refereed journals.

10

NCRACS-2016

Catalytic Aspects of Polymer Supported Vanadium Complexes and


Their Future
Mannar R. Maurya
Solid supported catalysts or heterogenized homogeneous catalysts can go a long way in
developing catalyst based technology because of their high efficiency with recyclability and
easy separation from the reaction mixture. Immobilisations of homogeneous catalysts through
covalent bond with chloromethylated polystyrene cross-linked with divinylbenzene and
develop them as environmentally safe heterogeneous catalysts for oxidation reaction have
attracted attention in recent years. This method has now become a very specialized method
because polymer-anchored catalysts inherit the advantages of both homogenous as well as
heterogeneous catalysts as they are thermally more stable, selective and recyclable, and allow
their easy recovery from the reaction products at the end of the reaction. Recently, effort from
our research laboratory was to synthesize new recyclable polymer-supported vanadium
complexes based heterogeneous catalysts. Thus, chloromethylated polystyrene cross linked
with 5 % divinylbenzene was used as support to prepare variety of polymer supported
vanadium catalysts, these catalysts have been characterized with the help of various physicochemical techniques such as elemental, spectral (FT-IR, electronic, 1H- and 51V NMR, and
EPR), field emission scanning electron microscope coupled with an energy dispersive X-ray
analyses (EDAX), atomic force microscopy imaging and thermal analysis patterns. The
formulations of the polymer-anchored complexes are based on the respective neat complexes
and conclusions drawn from the various characterization studies.
These catalysts have successfully been used for the oxidation and oxidative bromination of
various organic substrates. The catalytic oxidative desulfurization of organosulfur compounds
(model of fuel diesel) has been carried out using supported vanadium complexes. The percent
conversion of substrate, analysis of reaction products and their selectivity were calculated
from gas chromatography data. The identity of the products was confirmed using a GC-MS by
comparing the fragments of each product with the library available. Oxidation of pyrogallol to
purpurogallin, a peroxidase mimicking property, catalyzed by polymer-supported
oxidovanadium (IV) complex has also been carried out.
Keeping in mind the industrial usage of the heterogeneous catalysts, the leaching and recycle
ability of all polymer-supported catalysts has also been tested. All these catalysts are stable
and do not leach during the catalytic reactions.
Keywords: Catalysis, polymer-supported oxidovanadium (IV) complex, Solid supported catalysts,
heterogenized homogeneous catalysts
References:
1. Maurya, M.R.; Kumar, A.; Costa Pessoa, J., Coord. Chem. Rev., 2011, 255, 2315-2344.
2. Maurya, M.R.; Costa Pessoa, J., J. Organometal. Chem., 2011, 696, 244254.
3. Maurya, M.R.; Costa Pessoa, J., Inorg. Chim. Acta, 2016, doi.org/10.1016/j.ica.2016.04.012.

11

NCRACS-2016

Dr. Himadri B. Bohidar


Professor,
School of Physical Sciences and Special Center for Nanosciences
Jawaharlal Nehru University, New Delhi, India
E-mail: bohi0700@mail.jnu.ac.in, bohidar@hotmail.com
Phone: (O): +9126704636/4699
Group web: http://www.jnu.ac.in
SPECIALIZATION: Polymer Science, Molecular Biophysics, Soft matter,
Physical Chemistry of Polymer solutions, Gels, networks, Colloids,
Nanoscience
ACADEMIC DETAILS:

Ph. D. (1982), Indian Institute of Technology, Delhi.

ACADEMIC POSITIONS HELD:


S. No.
1
2
3
4

Period
1982
1982-83
1984-88
1989-98

Jul.1999Jul.2002
Jul. 1998tildate
2006

6
7

Institution
IIT Delhi, India
Universite de Grenoble, France
University of Oslo, Norway
Jawaharlal Nehru University, New
Delhi
Purdue University, USA

Responsibility
Post. Doc.
Post. Doc.
Visiting Scientist
Assoc. Prof.

Jawaharlal Nehru University, New


Delhi
University of New South Wales,
Sydney, Australia

Professor

STUDENTS TRAINED: Ph.D: 18 +6 on-going: 24


PATENTS: 5
PUBLICATIONS: (Total=215) (as on 01 Nov 2016)
Average Impact Factor of Journals= 3.75
h-index of papers by the author=23

12

Visiting Prof.

Visiting Prof.

NCRACS-2016

Soft Interaction Induced Phase Separation in Biopolymers and


Design of New Biomaterials
H. B. Bohidar
Biopolymers like poly-aminoacids, nucleic acids and carbohydrates have signature physico-chemical
properties. At a given pH, these carry a specific net charge and a signature conformation. It has been
observed in many biopolymer systems that two such molecules can undergo associative interaction
even when both carry the net charge of same polarity. The heterogeneous charge distribution on
polyaminoacids facilitates such interactions in particular1-2. The resultant associative interaction arising
from charge neutralization and gain in solution entropy yields a new class of soft biomaterials called
coacervates. The microstructures of protein-polymer complexes gain flexibility from the cladding of
the complementary biomolecule which in turn cause partial charge neutralization of its surface. Raman
spectroscopy reveals differential hydration, rheology and small angle neutron scattering show localized
network formation of these matrices. Therefore, customization of these interactions widens the scope of
their application potential that may include biological applications. In principle, these studies can be
extended to a range of biopolymers to generate a tunable and biocompatible soft materials3-4. The
underlying intricacies of the soft chemistry involved will be discussed in this presentation.
Keywords: Polymer interactions, Raman spectra, hydration, rheology, neutron scattering.
References:
1. Bohidar et al. J. Phys. Chem. B. (2016)
2. Bohidar et al. RSC Adv. 5 (2015) 67066-76
3. Bohidar et al. RSC Adv. 4 (2014) 24710-18
4. Bohidar et al. J. Phys. Chem. B. 116 (2012) 14805-16

13

NCRACS-2016

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14

NCRACS-2016

Invited Talks

15

NCRACS-2016

Dr. Akash Deep


Scientist
CSIR- Central Scientific Instruments Organisation, Chandigarh.
Dr. Akash Deep is a Scientist at CSIR- Central Scientific Instruments Organisation, Chandigarh. He
received his Ph.D (Chemistry) degree in 2004 from the Indian Institute of Technology, Roorkee, India
after which he worked as a FCT postdoctoral research fellow at the chemical engineering department of
the Instituto Superior Technico, Lisbon, Portugal till 2008.
He joined CSIR-CSIO, Chandigarh in 2008. Dr. Deep has worked in
the fields of analytical chemistry, extractive hydrometallurgy,
separation chemistry, and nanosensors for environmental and health
applications. He has wide expertise in the synthesis and applications
of advanced materials, such as 2-dimensional layered materials,
fluorescent nanoparticles, metal organic frameworks, magnetic
materials, and conducting polymers. Dr. Akash Deep has also worked
as a Visiting Professor at the Hanyang University, Seoul, South
Korea. He has published more than 100 research articles in reputed
international journals. His research group includes Ph.D students from
interdisciplinary backgrounds, such as biotechnology, microbiology,
physics, chemistry, pharmaceutical sciences, and nanotechnology.
Research Interests
Separation chemistry, Extractive hydrometallurgy, Environmental nanotechnology, Waste
management, Nanosensors for environment and health (cancer antigens, pesticides, explosives, heavy
metals, bacteria), Porous materials, Adsorption, Advanced materials for solar cells, Metal organic
frameworks, Graphene, Conducting polymers, Transition metal dichalcogenides, CNTs

16

NCRACS-2016

Application of Advanced Nanomaterials for Sensing Applications


Akash Deep
The scientific activities of CSIR-CSIO, Chandigarh in the fields of nanoscience and nanotechnology are
mainly focused on the sensing of clinically and environmentally significant parameters. In the process,
several categories of nanomaterials are being explored, including graphene, carbon nanotubes, quantum
dots, ferrites, gold nanoparticles, etc. Employing electrochemical, fluorescence and optical fiber based
measurement techniques, different processes have been developed for the detection of disease antigens,
nitroaromatics, heavy metals, pesticides, fluorides, nitrates, food adulterants, VOCs etc. The future
target of CSIR-CSIO involves the translation of the research techniques to prototype gadgets.

17

NCRACS-2016

Dr. Sonal Singhal


Associate Professor
Department of Chemistry and Center for the Advanced Studies
Panjab University Chandigarh
E-mail: sonal1174@gmail.com; sonal@pu.ac.in
Dr. Sonal Singhal is associate professor in chemistry department, Panjab
University Chandigarh. She has a throughout first class academic record.
Dr. Singhal obtained PhD in chemistry from IIT Roorkee, India and joined
in 2003 the teaching faculty at the Panjab University, Chandigarh. Her
current area of research interests include synthesis and properties of nano
size ferrites/oxides and other materials and its industrial application in
various fields; preparation of the semiconductors such as pure and metal
substituted zinc oxide/tin oxide and their electrical and photo catalytical
properties; and formation of various types of nano composites materials
and their magnetic properties. She also worked on synthesis and
characterization of boron nitride nano tubes with different morphology
and sizes and their applications.

18

NCRACS-2016

Magnetically Retrievable Nanocomposites: An Approach towards


Green Catalysis
Sonal Singhal
Now-a-days green approach in the field of catalysis is a blistering area of research. Green catalysis aims
at minimizing waste hazards in the field of catalysis. It aims at the generation and use of clean and
easily recoverable and reusable catalysts so to avoid the wastage of energy and resources associated
with the production and recovery of catalysts. Magnetically recoverable nanocatalysts (MRNCs) have
emerged as very beneficial and effective as are associated with minimum energy, effort and time
required for the separation. MRNCs can be recovered out of the reaction mixture using an external
magnet.
Among the many available MRNCs, nanoferrites have proved to be most beneficial and widely
applicable. The catalytic activity of nano ferrites depends upon the distribution of metal ions in to the
octahedral and tetrahedral coordination sites of the ferrite sub-lattice. Insertion of different metal ions in
to the lattice of ferrites leads to alteration in the cation distribution, hence, affecting the catalytic
performance directly or indirectly. Also, owing to the inherent magnetic character ferrite nanoparticles
can be employed as efficient core materials for the synthesis of core-shell catalysts. Core-shell
structures also include immobilization of metal nanoparticles or other active catalysts where synergy of
each component contributes towards the catalytic performance. Different surface functionalizations can
be performed for ferrite nanoparticles which improve the dispersability and stability of the ferrite
nanostructures. These surface coatings can be inorganic metal oxides such as silica, alumina, titania
etc.; organic moieties such as dopamine, glutathione etc.; polymers such as polyethylene glycol (PEG),
polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) etc. which can be used as such or further
functionalized with acidic or basic moieties.

Figure 1
Keywords: Nanoferrites, Nanocomposites, Green Catalysis

19

NCRACS-2016

Dr. Amjad Ali


Associate Professor
School of Chemistry and Biochemistry, Thapar University Patiala-147004, India
Dr. Ali, PhD from IIT Bombay, joined Thapar University in 2006 as assistant
professor, and became associate professor in 2013. At Thapar university, he
started catalysis lab and completed several extramural research projects. His
current research interests are heterogeneous and bio-catalyst for biodiesel
production, synthesis of diesel fuel additives from vegetable oils, water treatment
technologies. He loves teaching - Coordination chemistry, Basic inorganic
chemistry, Bioinorganic chemistry, and Organometallics and Catalysis. He has
published 50+ research articles in various journal of international repute. Dr. Ali
has supervised 20+ PhD. And MTech students.

20

NCRACS-2016

Chemical Transformation of Triglycerides and Glycerol Via Mixed


Metal Oxide based Heterogeneous Catalysts
Amjad Ali
Triglycerides are nontoxic, biodegradable and renewable molecules which are being used as substrate
for the synthesis of a variety of useful molecules such as glycerol esters, fatty acid alkyl esters,
triacetin, ketals, acetals, glycerol carbonates, etc (Scheme 1).
H2C
OH
ROCOR'
H2C
OCOR'
+
Catalyst
ROCOR'' + HC
OH
HC
OCOR''
+ 3MeOH
+
Transesterification
OH
H2C
OCOR'''
ROCOR''' H2C
Alcohol

Triglyceride

Glycerol

Biodiesel

Catalyst CH3COOCH3

Catalyst

O
H2C

C
O

CH3

CH3COOR1

HC

C
O

CH3

CH3COOR1

H2C

CH3

CH3COOR1

H3CO

OCH3

Dimethyl carbonate

AcOH or Acetic Anhy


O
O

O
OH

Glycerol carbonate
Triacetin
Fatttyacidmethyl ester
Scheme 1: Synthesis of value added products from triglycerides and glycerol

In order to produce biodiesel, a renewable fuel, transesterification of triglyceride is performed in which


generate glycerol is produced as a byproduct. Application of this glycerol as a cost effective raw
material for the production of valuable chemicals could be advantageous from economical as well as
environmental point of view. Glycerol could be esterified with acetic acid to form triacyl glycerol ester
(triacetin) which has applications in cryogenics, plastics and fuel additives. Presently, triacetin is
usually produced by homogeneous acid or base catalyzed reaction. Although these reactions are fast
and yielded satisfactory conversion level in short reaction duration, however, after reaction catalysts
removal via water washing is mandatory which generate huge amount of industrial effluents. Moreover,
literature reported heterogeneous catalysts demonstrated poor stability and moisture sensitivity and
often led to the formation of a mixture of product.
In current research work, mixed metal oxide based heterogeneous catalysts were prepared and
employed for the triglyceride transesterification as well as glycerol esterification reaction to produce
triacetin and glycerol carbonate.
Keywords: Triacetin, transesterification, glycerol, triglyceride, biodiesel

21

NCRACS-2016

Dr. Shaibal Banerjee


Organic Synthesis Laboratory, Department of Applied Chemistry,
Defence Institute of Advanced Technology (DRDO), Girinagar, Pune-411025, India.
Tel: +91 20 2430 4164, Fax: +91 20 2438 9411
E-mail: banerjeess@diat.ac.in
Dr. Shaibal Banerjee obtained his Ph.D from Indian Institute of
Technology, Bombay. He persuaded postdoctoral research at Virginia
Tech, USA and The City College of New York, USA. He joined
DIAT, Pune in 2010, Dr. Banerjee has specialty in the synthesis of
energetic plasticizers and other high energy materials. His other
research interests involve synthesis and applications of Nano Energetic
composites and computational evaluation of energetic materials. Dr.
Banerjee published 34 articles in various peer reviewed journals of
high impact and 2 patents. He has guided two PhD students and five
postgraduate students. Currently four research scholars are working
under his supervision. He is principal investigator of projects of national importance, and Editorial
Board member of American Journal of Organic Chemistry.

22

NCRACS-2016

Azido Esters as an Energetic Plasticizers


Shaibal Banerjee
Plasticizer is one of the important ingredients in composite propellant. Energetic plasticizers (EP) [1] as
a replacement of commonly used inert plasticizers is another approach to improve the energy level of
propellants. A plasticizer is usually added to improve the mechanical properties of the binder itself by
lowering its glass transition temperature and ensuring that the material stays rubbery at the lowest
operational encountered temperature and that it never loses its physical integrity. Advanced solid
propellants are being developed these days to obtain higher thrust, eco friendliness by using powerful
oxidizers along with energetic binders like GAP (glycidyl azide polymer), BAMO (3,3
bis(azidomethyl)oxetane) and energetic plasticizers [2]. Therefore, recent approach has been to design
energetic plasticizers capable of enhancing physical and chemical compatibility along with minimizing
migration from the propellant [3] matrix. The talk will focus on the recent advances made in the field of
energetic azido plasticizers.
Keywords: Plasticizer, Energetic Plasticizers, Azido Plasticizers.
References:
1.
2.
3.
4.

Agarwal, J.P. and Hodgson, R.D., Organic Chemistry of Explosives. New York: Wiley, 2007.
Rachid, H.A., Lussier, L.S., and Ringuette, S., Propellants, Explos., Pyrotech., 2008, vol. 33, p.
301.
Akhavan, J., The Chemistry of Explosives, RSC, UK, 2004.
Kumari, D.; Balakshe, R.; Banerjee, S. and Singh, H. Review Journal of Chemistry, 2012, 2, 240
262.

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Dr. Nitin Singhal


Senior Scientist
Food Science, Nanobioscience
National Agri-Food Biotechnology Institute
Dr. Singhal received his PhD training at IIT Bombay. Before joining NABI, Mohali he was
postdoctoral fellow at Seoul National University (Nanobioscience), and Pennsylvania state University,
State college, USA (Chemical Biology). His research work is focused on application of
nanoscience/nanobioscience in food science. The objectives are enhancing the bioavailability of
micronutrients by encapsulation and development of nanobiosesnor for detection of food pathogens.
This approach incorporates all stages of the advance and manufacturing: the rational design of the
ingredients based on an understanding of the relationship between structure and function, the stability
of micronutrients during processing, development of delivery systems for micronutrients, the physicochemical properties of tailored foods, and the development of innovative technologies for nutritionally
enhanced foods. His current resercah intrest are micro &; Nano encapsulation paradigms for
micronutrients, and developing of nanobiosensor for detection of food borne pathogens

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NCRACS-2016

Immobilization of -Amylase on Magnetic Nanoparticles for


Enhanced Reusability in Bio-Catalytic Processes
Vishal Singh1, Nitin Kumar Singhal1
1

National Agri-Food Biotechnology Institute (NABI), S.A.S. Nagar, Punjab

Novel magnetic nanoparticles coated with silica and gold were successfully synthesized (Lyon et al.,
2004) and further functionalized with three carbon chain length linker i.e. 3-PPA (3Phosphonopropionic acid) for immobilization of -amylase enzyme via covalent amide linkage
between the carboxylic group of the linker and amine group of the -amylase (Sahoo et al., 2011).
Characterization was doneusingdifferent biophysical techniques such as Fourier transform infrared
spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy(SEM),
dynamic light scattering (DLS) and X-ray diffraction (XRD). Effect of various limiting factors such as
substrate concentration, temperature, and pH on the catalytic activity of enzyme was thoroughly
investigated. The optimum pH for free and immobilized enzyme was found unaffected (7.0), whereas
optimum temperature for the enzyme activity was increased from 60C for free enzyme to 80C for
immobilized counterpart. The gains in catalytic attributes concomitant to ease of recovery of the
enzyme reflect the potential of the approach and the product to be useful for the enzymatic
bioprocessing. The MichaelisMenten constant (Km) value of the immobilized -amylase was higher
than that of free -amylase,whereas maximum velocity (V max), and turn over number (Kcat), values were
almost similar. Immobilized -amylase maintained 60% of the enzyme activity even after recycling ten
times.

Fig.1 Graphical representation shows immobilized enzyme catalytic activity and their recovery after the
completion of the catalytic reaction using a simple magnet.
References:
1. Lyon, J.L., Fleming, D.A., Stone, M.B., Schiffer, P., Williams, M.E., 2004. Synthesis of Fe
oxide core/Au shell nanoparticles by iterative hydroxylamine seeding. Nano Lett. 4, 719-723.
2.Sahoo, B., Sahu, S.K., Pramanik, P., 2011. A novel method for the immobilization of urease
on phosphonate grafted iron oxide nanoparticle. J. Mol. Catal. B Enzym. 69, 95102.

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Dr Uma Shanker
Department of Chemistry, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar- 144011
E-mail: shankeru@nitj.ac.in
Dr Uma Shanker received his Ph D in Chemistry from
Department of Chemistry, Indian Institute of Technology
Roorkee, Roorkee, Uttarakhand-INDIA under the supervision of
Professor (Dr) Kamaluddin. Dr Shanker is working as Assistant
Professor in Chemistry at Dr B R Ambedkar NIT Jalandhar,
Punjab-INDIA. Dr Shanker has delivered many expert lectures in
National and International conferences. He is having good
number of publications in journals of International repute. The
major area of interest of Dr Shanker is synthesis of nanomaterials
using green techniques and exploring their applications in waste
water treatment.

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NCRACS-2016

Green Synthesis Of Different Transition Metal Oxide Nanoparticles:


Potential Catalysts For Removal Of Organic Colorants From Water
Uma Shanker
Novel green approach based on sunlight irradiation was employed to synthesize various transition metal
oxide (TMO) nanostructures (ZnO, CuO, Co3O4, NiO and Cr2O3) using water as a solvent.
Nanoparticles of different morphologies were obtained, such as nanotubes (ZnO; <35 nm), nanorods
(CuO; 7-50 nm), nanorods, triangles and hexagons (Co3O4; 45-90 nm), needle-shaped (NiO; 2-25 nm)
and nanobeads (Cr2O3; ~17 nm). The potential of nanoparticles synthesized was examined in treatment
of simulated water containing hazardous dyes: Alizarin Red S (ARS) + Methylene Blue (MB).
Interestingly, Cr2O3 nano-needles proved to be the best catalyst among all as it effectively degraded
88.24% of the dyes mixture (more or less completely) in a short period of 180 min, followed by 87.96%
(ZnO) > 86.86% (CuO) > 85.89% (NiO) > 80.35% (Co 3O4), depending on the sizes of respective TMO
nanoparticles. This is also supported by finding of small and non-toxic by-productssuch as but-2-enal,
sulfur trioxide and benzoquinone. With high potential observed in removal of dyes, TMO nanoparticles
can be used as important adsorbents in waste water treatment with a bright future.
Keywords: green synthesis, sunlight, TMO nanoparticles, morphology, dyes removal.
References:
1. U. Shanker, V. Jassal and M. Rani, RSC Adv., 2016, 6, 94989 -94999

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Dr. Amardeep Singh


Senior Scientist
R&D Centre, Indian Oil R&D Centre, Sector-13, Faridabad, India
Dr. Amardeep Singh received his M.Sc in 2003 & M.Phil in 2004 from Indian Institute of Technology
Roorkee (IITR), India. He obtained his PhD in 2009 from Indian Institute of Technology Guwahati
(IITG), India. He has more than 3 Yrs Post-Doc experiences in the field of Nanochemistry/Biosensor
from Pusan National University, Busan, S. Korea. He also visited USA and Japan for short term
programme. He published fifteen papers in highly impact International Journals. He is currently
working as Senior Research Scientist at R&D Centre, Indian oil Corporation Ltd, Faridabad. His
current research is focused on the development of Nanomaterials for CO 2 capturing and Hydrogen
storage.

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Evaluation of Metal-Organic Frameworks for Hydrogen Storage


A. Singh*, K. Semwal, T. Bera, J. Christopher, U. Srivastava, Alok Sharma
Indian Oil R&D Centre, Sector-13, Faridabad, India
Hydrogen (H2) has been considered as the fuel of future because it is environmental clean, abundant in
nature and ideal alternative to fossil-fuel systems. However, H2 storage has become the biggest
challenge in order to meet the requirements of U.S. Department of Energy (DOE). Various materials
like Metal hydrides, Zeolites, Carbon materials were studied to fulfill above requirements but none of
them could show satisfactory performance for commercial applications. Further, Metal-Organic
Frameworks (MOFs) and its sub-family Zeolitic Imidazolate Frameworks (ZIFs) are considered as
compatible H2 adsorbent due to extraordinarily high specific surface area, porosity, tunable pore size
and modifiable internal surface which differentiate large porous volume and thermal stability.
We report evaluation of Cu- and Zn-based MOFs and ZIFs for H2 adsorption using benzene
dicarboxylate (BDC) and 2-methyl Imidazole (mIm) as organic linkers. Various analytical techniques
such as X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM), Energy Dispersive
Spectrometer (EDS) and Thermo Gravimetric Analyzer (TGA) were used to study their structural,
morphological, elemental information and thermal stability. Powder XRD pattern of Cu-MOF, ZnMOF, Cu-ZIF and Zn-ZIF showed expected major peaks that match perfectly with reported values in
literature. Thermal stability of Cu-MOF, Zn-MOF, Cu-ZIF and Zn-ZIF were obtained from TGA.
SEM shows presence of roughly cubic and hexagon like-particles in Cu-MOF, Cu-ZIF and Zn-ZIF.
However, Zn-MOF indicates irregular shape. H2 adsorption and desorption using MOFs and ZIFs
were studied at 25 C at 100 bar. H2 adsorption for Cu-MOF, Zn-MOF, Cu-ZIF and Zn-ZIF were
found to be 0.47, 0.22, 1.18 and 0.94 wt%, respectively. It is concluded that higher uptake H 2 using
ZIFs may be due to basicity of imidazolate linkers and framework structure. Based on above studies, it
is evident that structural & surface properties of these adsorbents play important role in H2 adsorption
and desorption. Thus, development of efficient and cost effective H2 storage systems like MOFs will
definitely make a platform technology to increase the rate of uptake H 2.

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Dr. Asish Kumar Sharma


Senior Manager/ Sr. Scientis
Reliance Industrial Ltd, Navi Mumbai, India
A competent professional with 10 years of experience as Sr.
Research Scientist / Sr. Scientific Manager, Team lead in Research
& Development after doctorate degree from Premium Indian
Institute of technology, India and more than 5 years relevant
industrial experience in R&D from bench Scale to Pilot scale till
plant scale
in (Thermoplastic/ Thermoplastic elastomer)
elastomers / SBR (Styrene butadiene copolymer)- Solution,
SBR/PBR(poly butadiene) latex Emulsion technology, dipping
technology, Emulsion ABS (Acrylonitrile butadiene styrene), free
radical Solution Hybrid ABS technology
Currently associate with Reliance Industrial Ltd., Navi Mumbai India as Senior Manager Job role as
Senior Scientist since Jan, 2014. Reliance produce 140 KTA SBR -1502, 1712 through emulsion
technology and 115 KTA PBR by Solution based coordination technology. Associated with Samsung
Cheil Industries Inc., Yeosu, South Korea as Research Scientist/ Assistant manager for 3 years. Cheil
Industry is Mother Company of Samsung Group and produce ABS through emulsion and solution
technology.
Expertise in Emulsion Polymerisation , Solution polymerisation, Process, Product development,
Molecular Metal Catalyst and Elastomer,
High Values and behaviour in terms of Excellence, One team, Customer value, Integrity, Ownership
mind set, Proficient in analysing, handling and interpreting Instrument research results.
Adroit at identifying potential in the design phase of the project and solve problems associated with the
process; Demonstrated competence in executing a wide gamut of functions viz. analytical research,
validation, designing new experiments and co-ordination; Expertise in writing, executing, interpreting,
and evaluating validation documents in terms of acceptability to industry standards, procedures and
regulatory requirements.
Support the ongoing business of elastomer of the associated market segments and regions, Knowledge
of different type of rubber NBR (Acrylonitrile Butadiene rubber), SBR, PBR, EPDM, HSBR, HBR and
application in different filed like tire industries, plastic industries, Adhesive , An effective researcher/
manager with excellent designing and presentation skills

Academic - Industrial Research Collaborations


Dr. Sharma will discuss pits and falls of collaborations between industrial setups and academic
institutions.

30

NCRACS-2016

Actuating Materials: Conversion of Light and Heat Energy into


Mechanical Energy
Ahmad Husain
Department of Chemistry, DAV University Jalandhar, Punjab India
Email: ahmad.husain@outlook.com, ahmad10286@davuniversity.org
Materials showing mechanical response in presence of external stimuli are of relevance for the design
of nanoscale actuating devices for a variety of small-scale applications. More recently, the modern
analytical techniques for mechanical, structural, spectroscopic and kinematic characterization have
contributed to accumulate compelling evidence that under certain circumstances, even some seemingly
rigid single crystals can deform, bend, twist, hop, wiggle or perform other "acrobatics" that are atypical
for non-soft matter. When exposed to light/heat, certain single crystals can jump up to thousands times
their own size. Our efforts aimed at achieving rapid, reversible, maximum, and fatigueless response
with single crystals which can display optimum coupling between light/heat and the mechanical energy.

These examples contribute to a paradigm shift in our understanding of the elasticity of molecular
crystals and also provide direct mechanistic insight into the structural perturbations at the limits of the
susceptibility of ordered matter to internal and external mechanical force. As the relevance of motility
and reshaping of molecular crystals is being recognized by the crystal research community as a
demonstration of a very basic concept-conversion of thermal or light energy into work, a new and
exciting crystal chemistry around mechanically responsive single crystals rapidly unfolds.
References
1.
2.

Angewandte Chemie International Edition 2014, 126, 6017 6021.


Journal of the American Chemical Society 2015, 137, 1895-1902.

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Best compliments from

Apurva Biotech
Authorized distributor of Sigma-Aldrich & Fluka, Alfa Aesar
58-A, Model Town, Karnal-132001(INDIA)
Contact No.: +91-89500-24000,+91-89500-24001
E-mail: mittalrk1@gmail.com

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NCRACS-2016

ORAL PRESENTATIONS

33

NCRACS-2016

Design and synthesis of modified amino acids and peptides


Deepti Goyal
Department of Chemistry
Sri Guru Granth Sahib World University Fatehgarh Sahib-140406, Punjab, India
Peptides and proteins play an important role in various biological processes and these molecules are
useful as natural messengers of the living systems. Therefore they can be powerful therapeutic agents
with fewer side effects. However, their use is often hampered due to biodegradation, non-selectivity
and high conformational flexibility. Peptide based drugs are commonly used for osteoporosis, diabetes,
hypertension and dieresis, and the demand for peptide based drugs is likely to increase in near future.
To overcome the limitations associated with peptide drugs, introduction of modified amino acids can be
a useful alternative. On several occasions unusual -amino acids (AAAs) are incorporated into peptides
to modify the conformation and enhance the stability of the peptide. These modified peptides are found
to be biologically more active than the natural analogs. Motivated by such a need for post-assembly
peptide modification, we conceived several new strategies for unusual amino acids which are capable
of modification at the amino acid level as well as at peptide level.
References:
1. Kotha, S.; Chavan, A. S; Goyal, D. ACS Comb. Sci. 2015, 17, 253.
2. Kotha, S.; Goyal, D.; Chavan, A. S. J. Org. Chem. 2013, 78, 12288.
3. Kotha, S.; Goyal, D.; Thota, N.; Srinivas, V. Eur. J. Org. Chem. 2012, 1843.
4. Kotha, S.; Goyal, D.; Banerjee, S.; Datta, A. Analyst 2012, 137, 2871.

A Footstep Towards the Development of Eco-Friendly Lubricant


Additives from Biomaterials
Raj K. Singh
Chemical Science Division, CSIR-Indian Institute of Petroleum, Dehradun 248 005, India
E-mail: rksingh@iip.res.in
The high performance and multifunctionality of zinc dialkyldithiophosphate (ZnDDP) additive are the
reasons of continued use since its discovery in 1940s despite containing the harmful components like
P, S and heavy metals. The other reason of the persistent use of such toxic additives is the non
availability of the alternate ecofriendly additive technology for last few decades. Now due to
introduction of more and more stringent regulations by the governmental authorities towards the
restriction of the toxic industrial products, the researchers are trying to develop the novel ecofriendly
lubricant additives. Although some other factors like; depleting crude oil reserves; increasing demand;
the introduction of novel high performance synthetic base oils from vegetable oils and polyols etc. in
which the use of conventional toxic additives may deteriorate their biodegradability characteristics
despite showing good performance characteristics; are also responsible for growing attention towards
the development of novel ecofriendly additive options. One of the approaches towards this is the use of
biomaterials for developing the additives. The aim of this talk is to give an overview on the recent
efforts made to use biomaterials such as cellulose, amino acid, sugars and chitosan for application as
additives in lube base oil and biofuels. The synthesis and characterization were described through
desecrate reaction pathways in order to effectively disperse the biomaterials in the oils keeping the key
functional groups intact which provides inherent activity. Various performance characteristics will
bedescribed carried out on high frequency reciprocating rig, four ball test, rotatory bomb oxidation test,
34

NCRACS-2016

blotter spot test, panel coker test, universal oxidation test, rancimat test and standard corrosion test
protocols.

Extraction and Spectrophotometric Determination of Molybdenum


(VI) using 3-Hydroxy-2-[-3-(4-methoxyphenyl)-1-phenyl-4-pyrazolyl]4-oxo-4H-1-benzopyran as a Chelating Agent
A. Singha , Rajkamalb, R. Agnihotri c and N. Agnihotri a*
a

Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala - 133207,


Department of Chemistry, Kurukshetra University, Kurukshetra -136119, Haryana, India
c
Department of Applied Science, UIET, Kurukshetra University, Kurukshetra -136119, Haryana, India
b

An extractive spectrophotometric method has been developed for the trace determination of
molybdenum (VI) using a newly synthesized benzopyran derivative , 3-hydroxy-2- [-3- (4methoxyphenyl) -1-phenyl - 4 pyrazolyl ] - 4 - oxo - 4H 1 - benzopyran (HMPPB). The method
involves formation of a 1:2 ( M:L ) complex between Mo (VI) and HMPPB from 0.02 0.06 M
H2SO4 medium. The yellow Mo (VI) HMPPB complex is easily extractable into carbon tetrachloride
with 100 % extraction and exhibits maximum absorbance in the wavelength region 417 423 nm. The
method is made sensitive and selective to produce best extraction results by studying and optimizing
various parameters of acidity , reagent concentration , equilibration time and effect of diverse ions. The
optimized method shows a good range of linearity ( 0 1.4 g Mo (VI) ml-1) , sensitivity ( 0.0018 g
Mo(VI) cm-2) , limit of detection ( 0.104 g Mo ml -1 ), the correlation coefficient
( 0.9974 ) ,
accuracy and reproducibility ( 0.0020 absorbance units ). The proposed method is satisfactorily
applied to the extraction and determination of molybdenum (VI) from different synthetic and technical
samples including steel , flue dust and water samples.
Keywords: Molybdenum (VI) , 3-hydroxy-2- [-3- (4-methoxyphenyl)-1-phenyl-4-pyrazolyl]-4 -oxo - 4H1-benzopyran , solvent extraction , spectrophotometry, determination

Waste Water Treatment Using Cuprous Oxide Nanomaterials


Asar Ahmed*
Department of Applied Chemistry, Laxminarayan Institute of Technology, RTM Nagpur University,
Nagpur-440033 (M.S.), India
The cuprous oxide nanomaterials were synthesized by adopting a simple polyol method using SDS
and Tween 80 as the surfactants while ethylene glycol and diethylene glycol were used as
solvents. Surprisingly these nanomaterials doped with transition metal ions like Fe, Co, Ni and Mn
ions were found to exhibit ferromagnetic behavior at room temperature. Their ferromagnetic behaviors
were found to be dependent on the dopant concentration. It was suggested that ferromagnetic behavior
could have been originated from defects formed as cation vacancies in the material. Existence of these
defects has been further corroborated by photoluminescence and EPR spectra. The investigation of
photocatalytic activity of the various Cu2O nanomaterials for the degradation of different organic
pollutants like rhodamine B, methyl orange, methylene blue and phenol. For this, nanomaterials in their
fixed amounts were mixed with the aqueous solution of the organic dye and the solution was then
exposed to UV-visible or visible radiation. Methyl orange, methylene blue and phenol were found to be
photocatalytically degradable in the presence of visible light while rhodamine B was found to be
photocatalytically degradable only in the presence of UV-visible light. The concentrations of the
organic dye after every hour were measured by the UV-visible spectroscopy.
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References:
1. Asar Ahmed & N.S. Gajbhiye: Proceedings Of The International Conference Nanomaterials: Applications And
Properties 2014 Vol.3(2) p.02NAESF04 01-04
2. Asar Ahmed & N.S. Gajbhiye: Journal of Solid State Chemistry 2011 vol.184(01) p.30-35
3.Asar Ahmed & N.S. Gajbhiye: Journal of Solid State Chemistry 2010 vol.183(12) p.3100-3104
4. Asar Ahmed, N.S. Gajbhiye & S. Kurian: Journal of Solid State Chemistry 2010 vol.183(9) p.2248-2251

Nitric Oxide Dioxygenation Reactions and Their Mechanistic Insights


Pankaj Kumar*
Chemistry Department, M. M. Engineering College, Maharishi Markandeshwar University, Mullana,
pankaj.chem07@gmail.com, pankaj.chem.iitg@gmail.com
The main concern of this paper is to find out the differences in the reactivities towards nitric oxide
dioxygenation (NOD) of metal-peroxo and superoxo (M-O2) and metal nitrosyls (M-NOs) complexes,
having Mn, Fe and Co as metal centers. In this regards, the primary approach will be the syntheses of
M-O2 complexes derived from a new set of TAML and TMC ligands and their reactivity with nitric
oxide (NO), over a wide range of solvents and/or temperatures, to stabilize the intermediates formed in
different steps of the reaction. In the second part, we will discuss the generation of M-NOs and then
their reactivity with oxygen or/ superoxide to follow the reaction and various intermediates over a wide
range of solvents and temperature.

There are recent chemistries associated with M-O2 coordination complexes with NO 1 and the reaction
of M-NOs with oxygen or/ superoxide2, 3. But till now, no one determined the real mechanism of the
reaction, as there are only few reports available on the NOD reactions of M-O2, and why the different
products (NO3 and/or NO2) formed from M-PNs,? In addition to NOD reactions of M-O2 adducts, Mnitrosyls (M-NOs) will be synthesized and then allow to react with different oxidants to elucidate the
correct mechanism of NOD reactions. The NOD reactions, therefore, subdivided in two categories as
follows.
Keywords: Metal-Nitrosyls, Metal-Peroxo, Metal-Superoxo, Nitric Oxide Dioxygenation
References:
1. Hong, S.; Kumar, P.; Cho, K. B.; Lee, Y. M.; Karlin, K. D.; W. Nam Angew. Chem. 128, 2016,
12591.
2. Kumar, P., Lee, Y.M., Chen, J., Park, Y. J., Yao, J., Chen, H., Karlin, K. D., Nam, W. J. Am. Chem.
Soc., 138, 2016, 7753.

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2. Kumar, P., Lee, Y.M., Park, Y.J., Siegler, M.A., Karlin, K. D., Nam, W. J. Am. Chem. Soc., 137,
2015, 4284.

Biological Patents with Special Reference to Practical and Ethical


Implications
Raman Singh, * Kuldeep Singh
Department of Chemistry, MMEC,MM University Mullana Ambala
Raman.singh@mmumullana.org
A biological patent is a patent on an invention in the field of biology that by law allows the patent
holder to exclude others from making, using, selling, or importing the protected invention for a limited
period. The applicant for a patent must demonstrate novelty, utility or usefulness and non-obviousness.
An important distinction exists in patent law between discoveries, which are not patentable, and
inventions. In contrast to commodity patents, biological patents have ethical and social impact.
The scope and reach of biological patents vary among jurisdictions, and may include biological
technology and products, genetically modified organisms and genetic material. Biotechnology has
made rapid progress in the last few eras and this has allowed corporations and scientists to alter natural
biological matter for commercial profit. So In response to scientific breakthroughs in biotechnology,
the development of new technologies, and the demands of a capitalist marketplace, patent law has
expanded to accommodate a range of biological inventions. There has been much academic and public
debate as to whether gene patents have a positive impact upon research and development, health-care,
and the protection of the environment. The applicability of patents to substances and processes wholly
or partially natural in origin is a subject of debate.
Keywords: Biological Patent, Ethical implication, Biotechnology.

Synthesis of Novel Ketomethylene N Domain Selective Ace Inhibitors


Rajni K. Sharma1,2, Ross G. Douglas3, Kelly Chibale2,3 and Edward D. Sturrock3
1

Global Research Institute of Management and Technology, Radaur, Yamuna Nagar, Haryana, India
Department of Chemistry, University of Cape Town, Rondebosch, 7700, South Africa.
3
Institute of Infectious Disease and Molecular Medicine, Division of Medical Biochemistry, University
of Cape Town, Observatory, South Africa.
2

Human angiotensin-converting enzyme (ACE) is an important drug target because of its role in
cardiovascular disease and diabetic nephropathy. Somatic ACE comprises two homologous domains (N
and C) in which inhibition of N-domain could be useful in the treatment of conditions relating to
excessive tissue fibrosis without affecting blood pressure.1-2 In present work we synthesised some novel
ketomethylene analogues and evaluated for their in vitro inhibition activity. Keto-ACE analogues
having an aspartate residue at the P2 position resulted in a ~1000-fold change in N-selective inhibition
compared to the parent compound. In this work, we aim to extrapolate synthesis and biological
evaluation of ketomethylene derivatives.
Keywords: Ketomethylene analogues, ACE inhibitors
References
1. Anthony, C., Corradi, H., Schwager, S., Redelinghuys, P., Georgiadis, D., Dive, V., Acharya, K. and
Sturrock, E. (2010) J. Biol. Chem. 285(46):35685-35693.
2. Dive, V., Cotton, J., Yiotakis, A., Michaud, A., Vassiliou, S., Jiracek, J., Vazeux, G. et al. (1999)
Proc. Natl. Acad. Sci. U.S.A. 96:4330-4335.
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Anion Receptors-An Overview


Ritu Bala
Department of Chemistry, Guru Nanak Dev University
Amritsar-143005, Punjab (India)
rituhatta@yahoo.com
Anions play an important role in chemistry, biology and environment and as a result, the design and
synthesis of anion receptors, which can bind the anion, is a challenging area of research. This is because
of varied shape, size and charge of anions besides pH sensitivity. During last forty years, many organic
and few inorganic anion receptors have been reported. Here anion receptors are divided in to two
categories: (i) Organic and (ii) Inorganic. However, reports concerning the investigation of
bis(diethylenetriamine)- cobalt(III) cation as an anion receptor (binding agent) are scanty. It is
important to realize that bis(diethylenetriamine)cobalt(III) possesses all the characteristic features to act
as an potential anion receptor. In brief it has (i) presence of hydrogen bond donor groups, (ii) a
positively charged component for effective electrostatic interactions and (iii) a suitable framework onto
which these structural components can be assembled. This complex cation is tri-positively charged,
contains ten hydrogen bond donor groups, which can interact with properly oriented hydrogen bond
accepters (e.g., oxygens of oxoanions as well as water molecules) involving second sphere
coordination. The resulting molecular entity can also have a stable structural framework. So it is
pertinent to examine this well known cation in a different perspective i.e., as an anion receptor (binding
agent). Consequently, the work reported in the presentation explores bis(diethylenetriamine)cobalt(III)
as an anion receptor.

Total volatile organic compounds (TVOCs) in Indoor and Outdoor


Urban Atmospheres at a Terai Region Of Northern India
Amit Masih
Environmental Research Lab, Department of Chemistry, St. Andrews College, Gorakhpur, India
amitmasih10@yahoo.com
Aims: Volatile organiccompounds (VOCs), which are the main group of hydrocarbons in the
atmosphere, play an important role in the formation of ozone and other photochemical oxidants in the
troposphere1. Several effects of VOCs are recognized such as their contribution to toxic and
carcinogenic human health effects, and enhancement of the global greenhouse effect 2. VOCs are mainly
originated from the production processes, the storage tanks, and the waste areas. Once VOCs are
emitted into the atmosphere, they cause not only pollution problem on local scale but also play an
important role on regional scale like acid rain, photochemical ozone formation initiated by the reaction
with OH radicals in the troposphere in the presence of nitrogen oxides and sunlight3.Thus, an
investigation of indoor/outdoor TVOC was conducted at selected locations in Gorakhpur in order to
ascertain the contamination levels at two locations in the city of Gorakhpur, which covers residential
and roadside areas.
Methods: Samples were collected for the period of three consecutive days for indoors and outdoors, at
each microenvironment. Sampling duration was for 8 h from 10:00 am to 6:00 pm during all the
seasons. TVOC levels were measured using a portable data logging Ion Science PhoCheck+ photoionization detector (PID) equipped with 10.6eV ultra-violet lamp4. The sampling instrument was placed
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above 1.5 m (breathing zone) from floor level at indoor and outdoor locations. About 220 ml/min of air
was drawn through the instruments internal pump. The PID data logger was set for 1-sec measurement
interval.
Conclusion: TVOC concentration for combined indoor/outdoor air was 169.9 g m-3 and 420.8 g m-3
at residential and roadside site respectively. At residential site, the indoor and outdoor mean
concentration of TVOC was of 236.3 g m-3 and 103.5 g m-3 respectively. The average indoor
concentration at roadside site was 453.3 g m-3 whereas at outdoor it was 388.4 g m-3. At both the
sites, the indoor TVOC levels were higher than that at outdoors. Mean I/O ratio at residential site was
2.3 with a range of 1.7 to 2.7 while at roadside site I/O ranges from 0.9 to 1.3 with a mean value of 1.1.
At residential site, contribution of VOCs at indoor and outdoor was found to be 70% and 30%, clearly
indicating dominant indoor sources, whereas at roadside it was 54% and 46% for indoor and outdoor
respectively giving evidence of vehicular emission effect. Seasonal trend for TVOC at outdoors was in
the order of winter > summer > monsoon whereas for indoors it was winter > monsoon > summer at
both the sites.
References:
1. Cetin E, Odabasi M, Seyfioglu R. Sci Total Environ. 2003, 312, 103112
2. Kalabokas PD, Hatzianestis J, Bartzis JG, Papagianna Kopoulos P. Atmos Environ. 2001, 35, 2545
2555
3. Masih A. & Lall A.S. Proceedings of the International Conference on Sciences, Engineering and
Technical Innovations, June, 3-5, 2016, 2, 195-197. Jalandhar, Punjab, India,
4. NIOSH. Hydrocarbons, aromatic: method 1501. NIOSH Manual of Analytical Methods (NMAM).
2003.

New Methodologies for the Synthesis of Vinylic Fluoride Molecules


Dr. Girish Chandra*, Prof. Lak Shin Jeong
*Department of Chemistry, Central University of South Bihar, Gaya, Bihar-825301, girish@cub.ac.in
The introduction of a fluorine atom into an organic substrate can have a profound effect on its physical,
chemical and biological properties. And this has been applied very successfully to the development of a
number of fluorine containing pharmaceuticals. From the last few decades, there has been significant
development of fluorine chemistry which leads to discovery of many drugs which has at least one
fluorine atom in the molecule. So far, present 20% drugs belong to fluorinated drug category. Despite
importance of fluorinated compound, introduction of fluorine atom in organic molecule is very
difficult. Although many methods have been developed in last twenty years, but we are still waiting for
a reliable and universal method of introduction of fluorine in the organic molecule. And due to this
Fluorination Chemistry is one of the hot topics in synthetic organic chemistry. Recently, we have
established a new method for the synthesis of fluoro homoneplanocin A using a stereoselective
epoxidation, followed by regioselective and stereoselective fluorination and finally a simultaneous
oxidation-elimination reactions. It was observed in one case that hindered substituent near epoxide
group created problem during fluorination, but it was successfully solved by using more polar solvent
viz ionic liquids. This methodology for the synthesis of fluorinated organic molecule was further
explored for the synthesis of natural product neplanocin A analogues viz fluoroneplanocin and
homoneplanocin A which were found to show very good S-adenosylhomocysteine (SAH) hydrolase
inhibitors and anticancer activities.

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PivO

PivO
OH
O O

PivO
O

OH

O O

N
O

HO

NH2
N
N

O O
HO OH

References:
1. Girish Chandra et.al. J. Med. Chem. 2015, 58, 51085120.
2. Girish Chandra et.al. Organic Letters, 2012, 14, 2134.
3. W. J. Choi et. al. J. Med. Chem. 2012, 55, 45214525.
4. L.S. Jeong, US Patent, 2013/0310403 A1, 21, 2013.

Review on Catalytic Chemical Vapour Deposition (CCVD) Growth of


Single Walled Carbon Nanotubes and their Characterization
Pramendra Kumar Saini1, Mala Nath2 and A. K. Minocha1,*
1

EST- Division, CSIR-Central Building Research Institute, Roorkee-247667


Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667
prem.saini@gmail.com, minochaak@yahoo.com
2

Carbon Nanotubes (CNTs) have been extensively studied during the last two decades. Catalytic
Chemical Vapour Deposition (CCVD) is one of the most suitable methods for the synthesis of carbon
nanomaterials of various crystallographic configurations. The method is simple and economic for
synthesizing at low temperature and ambient pressure. CVD reactions are strongly affected by
experimental parameters, such as reaction temperature, pressure, precursor composition, catalyst and
concentration. The different morphologies of CNTs derived from same precursor are found by little
change in temperature and catalyst. Generally at low temperature (600-900 C) yields Multi Walled
Carbon Nanotubes (MWCNTs), whereas at higher temperature (900-1200 C) reaction forms Single
Walled Carbon Naotubes (SWCNTs) growth (Fig. 1) Bhattacharjee and et al [1]. In this paper, a typical
thermal CVD process for the synthesis of SWCNts and parameters such as catalysts, substrates (support
materials), carbon precursor and growth temperature are discussed. The methods of purification and
characterization are also described.
Keywords: Chemical Vapour Deposition (CVD), Single Walled Carbon Nanotubes (SWCNTs),
Catalyst.

Fig. 1 Structure of SWCNT

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Fig. 2 TEM image of SWCNT


References:
1.
Bhattacharjee, C. R.; Nath, A. J. Chem. and Pharmaceut. Res., 2012, 4, 706-713

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INVITED ARTICLES

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Professor Sabyasachi Sarkar


Former Senior Professor and Head, Chemistry , IIT Kanpur
Presently , Nanoscience and Synthetic Leaf Laboratory at Downing Hall, Indian Institute of
Engineering Science and Technology Shibpur, Botanic Garden-711103, Howrah, West Bengal
Professor Sabyasachi Sarkar (born in 17 May 1947) is an Indian Chemist. He has explored chemistry
passionately as a prospector to observe closely the clandestine activities of nature. He has worked and
continued working in the diverse branches of chemistry closely related to natural set up and as such his
research embraces functional models related to hyperthermophilic to mesophilic metalloproteins
enriching bioinorganic chemistry. A Replica of a Fishy Enzyme and the reduced xanthine oxidase also
have been made. Inhibition patterns in the Michaelis complex of low molecular weight hepatic sulfite
oxidase model complex have been exhibited. He demonstrated that carbon dioxide molecule does bind
to magnesium in chlorophyll in photosynthesis as proposed by
R. M. Willsttter hundred years ago and modeled hydrogenase
captioned as better than nature. The rare reaction of a Cu(II)
complex with aerial oxygen to generate superoxide anion and
Cu(III) has been shown addressing the native SOD reaction.
Similarly, the aspect of copper-molybdenum antagonism in
ruminant animals have been investigated. His research has
shown the architectural marvel in silk cocoon with the natural
thermostatic and humidity control with preferential oxygen
gating inside cocoon as greenhouse architecture. He proposed a
new magneto reception mechanism for nocturnal moth in
sensing the Earth's magnetic field to navigate with a stable pool
of carbon-centric free radicals along with ferromagnetic
components. He extended the work on nano carbon and
developed cheap sources of water soluble nano carbon including naturally formed graphene oxide from
low grade coal. These are used in the growth of young plants as promoters to slowly release micro
nutrients and adsorbed water. He explored these to explore bio-imaging and demonstrating that nontoxic carbon nano onion can cross blood brain barrier to carry drug as cargo and can be effectively be
excreted from the body. The utility of such nano carbon to control mosquito breeding in preventing
mosquito vectors of infectious dieseaes and the use of reduced graphene oxide to prevent hospital
pathogens have been demonstrated. On the environment aspect, the presence of damaged floating
carbon nano tubes in aerosols is shown to contribute global warming, winter smog and elevating
breathing problem. He demonstrated the adverse effect of soap and detergent discharge near tube well
in releasing arsenic and fluoride contaminated water. He also mapped the degradation of Heritage
monument, Taj Mahal.

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Chemistry: Processing Everything Including Life


Sabyasachi Sarkar
I shall not summarize the famous little book of Schrdinger, nor endeavor to define the laws of life, but
place in the limelight four processes that must be intimately associated in all living entities. They are:
metabolism, compartmentalization, memory and manipulation. The two former processes are organized
by small molecules, whereas the two latter are controlled by macromolecules. Thus, two spatial scales
are intertwined in living processes that develop at a mesoscopic scale. Before the formation of small or
macromolecules elements were made. The creation of this Universe following Big-Bang is viewed as
12-15 billion years old. From Star like the Sun the earth was created some 4.5 billion years ago.
The chemistry of elements starts from that date when all the elements were synthesized under the
thermonuclear conditions. From the fossil data one could get an idea about the primitive form of life,
which existed as back as 3.8 billion years ago in the earth.
The definition of life in Greek is pneuma means air. This air means to breathe .But 3.8 billion years
ago there was no air to breath. In Prasna Upanishad prana is deva or God and it says ,I alone,
dividing myself fivefold, support this body and keep it.
Understanding what life is to understand that one possesses a consistent representation of Nature.
Philosophers of Vedic order investigated founding principles, the five elements that permitted them to
understand the world. Comparing this the scientific understanding of the world culminates with the
convolution of four elements , matter, energy, space and time. It is summarized by the remarkably
short formula E = mc2 . There is also no privileged position in the universe, xp h/4 and this
could be the missing fifth element that completes with the Vedic founding principles.
The all-important question would be to know what is life and as per Carl Sagan , the astrophysicist, it
is physics as it contains all the elements created by Big-Bang and from supernova explosion of stars
and all these are in the domain of physics.
Is life came from outside? from asteroid ? or is it originated in Earth ? Anaxagoras, pre Socratic Greek
Philosopher, uses his Panspermia ( all seed ) theory as there is a common seed and that came from
outside. Noted Scientists like Berzelius, Helmholtz, Arrhenius, Hoyle, Wickramasinghe, and Stephen
Hawking believe such theory and argued that asteroid carried seed from outside the earth. But the
question remains that how the seed is created outside earth! Darwin in his famous book wrote in the
opening sentence, God first blew life into one or a few forms, and then evolution took over. 11 years
later, Charles Darwin in a letter to his botanist friend Joseph D. Hooker, suggested that life may have
had a chemical origin. Darwin could not directly ascertain this in his book out of fear as he witnessed
the fate of Galileo in speaking out the truth.
The answer to this query about life that could not be delivered either by the creation of elements or by
the evolution of life but by understanding that the non-living elements are assembled in a process by
which life evolved in the kitchen of chemistry. There are several experiments to show that simple
organic molecules can be created from plenty of primitive gases like CO2 , H2 N2 , H2S and water
using earth material as catalysts via the creation of simple aldehyde, pyrrole, thiols other than amino
acids, sugar, purine and pyrimidine bases just by invoking Fischer-Tropsch, Haber-Bosh type
reactions under hydrothermal and or solar energy. Such chemical assembly is continuing even today
where chemical evolution dictates newer biological evolution.

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Fig.1. The stairway time history of life. The bottom of the stairway represents the formation of
earth 4.6 billion years ago. The top represents the present or today.
We have to go back to the stage when after Big-Bang the earth separated out from the Sun some 4.6
billion years ago. Since then the stairway history of the earth or its progress in life can be traced from
several geological era ( Fig.1). 570 million years ago something happened to initiate the change of the
atmosphere of the earth. The primitive photosynthetic evolution started with the end of mineral origin
of chemical evolution .Chemists are still in all out search for combining all available elements and
compounds to get improved molecules and materials which will help and ease out the burden of human
on this earth by providing energy , food , medicine and also trying to rectify the mishap done earlier by
our poor knowledge with our environment .Presently we are improving the environment so that we can
sustain our lives with better air and water.
For our day to day use, from tooth paste to TV screen or mobile battery or BMW car or aircraft to
missile or anything we need are created by composite materials which we produced only by
chemical processes and this stresses the service of chemistry in human endeavor.

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Natural Abenquines and Analogues as Potent Algicidal


Amalyn Nain-Perez1, Luiz Claudio A. Barbosa1,2,Clia Regina lvares Maltha2
and Giuseppe Forlani3
1

Universidade Federal de Minas Gerais, Av. Pres. Antonio Carlos, 31270-901, Belo Horizonte, MG,
Brazil, anainperez@outlook.com
2
Universidade Federal de Viosa, P H Rolfs, 36570-000, Viosa, MG, Brazil
3
University of Ferrara, via L. Borsari 46, I-44121, Ferrara, Italy

Abenquines are natural quinones, bearing both an N-acetyl and an amino acid moiety (Fig. 1). These
compounds were recently isolated from the fermentation broth of a Streptomyces sp. found in the
Chilean highland of the Atacama desert [1], and were synthesized for the first time by our group [2].
Abenquines A, B2 and D in the concentracion range of 10 -6 to 10-4M were found to progressively
inhibit the growth of Synechococcus elongatus PCC 6301 [2].
In continuation to our studies in area the preparation and investigation of bioactive benzoquinones [2-4]
we report in this work the preparation and evaluation of algicidal activity of abenquines and new
analogues. With this aim, variations were introduced in their scaffold by either replacing the amino acid
substituent with different amines, or adding a bulky group through the substitution of the acetyl for a

benzoyl group (Fig. 1).


Figure 1. Structure of naturally occurring abenquines and variations in the abenquine scaffold for
analogues.
Analogues 4a-h and 5a-h were synthesized by a series of reaction as shown in Scheme 1.

Scheme 1. Preparation for abenquines and analogues.


Replacing the acetyl by a benzoyl group in the quinone core and also changing the amino acid moiety
with ethylpyrimidinyl or ethylpyrrolidinyl groups resulted in synthetic analogues 25-fold more potent
than the natural abenquines. The two most effective analogues inhibited the proliferation of all five
cyanobacterial strains tested, with IC50 values ranging from 0.3 to 3 M, whereas only a milder effect
was evident for Escherichia coli (IC50 values of about 20 M), and negligible effects were found for
plants and yeast (IC50 values > 100 M). The algicidal properties of these compounds might therefore
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represent a useful tool for the development of an effective strategy for the control of cyanobacterial
blooms.
References
D. Schulz, et al. J. Antibiotics, 2011, 64, 763.
A. Nain-Perez, et al. Tetrahedron Lett., 2016, 57, 1811.
L. C. A. Barbosa, et al. Molecules, 2010, 15. 5629.
A. Nain-Perez, et al. Chem. & Biodiversity, 2016, DOI: 10.1002/cbdv.201500340

Total Synthesis of the Antitumor Antibiotic Basidalin


Jaime A. M. Acosta1, Ramesh Muddala2, Luiz C. A. Barbosa1, and John
Boukouvalas2
1

Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antnio Carlos, 6627, Campus Pampulha,
31270-901, Belo Horizonte, MG, Brasil.E-mail: fitop6388@gmail.com
2
Universite Laval (UL), 1045 Avenue de la Mdecine, G1V0A6, Quebec City, QC, Canad

Basidalin 1 (Fig 1) is a small but richly functionalized antibiotic and cytotoxic, first isolated in 1983
from the fungus Leucoagaricus naucina [1], and also from Leucoagaricus cameifolia [2]. It has unique
tetronamide structure, including the Z-geometry of the formylmethylidene moiety. Notwithstanding the
frequent use of tetronamides in chemical, pharmaceutical, and agrochemical research, basidalin holds
the prominent position of being the first, and to date only, tetronamide known to occur in nature [3].
These attributes have stimulated considerable interest not only in the synthesis of 1 but also in a variety
of its analogues. However, while certain analogues have succumbed to synthesis, basidalin itself has so
far proven remarkably elusive [4].

Figure 1. Total ssynthesis of Basidalin 1].


In line with our work with butenolides {5,6], herein, we report the first synthesis of the tetronamide
antibiotic basidalin (Fig 1) in five steps and 39% overall yield from readily available 4-bromo-2triisopropylsilyloxyfuran and 2-formyl-1,3-dithiane. Highlights include: (i) regio- and stereocontrolled
assemblage of a pivotal (Z)--ylidene--bromobutenolide intermediate by stereodirected vinylogous
aldol condensation (SVAC), (ii) installation of the amino group via aza-Michael addition/elimination,
and crucially (iii) facile access to basidalin by late-stage dithiane removal.

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References:
1. H. Iinuma et al., J. Antibiot., 1983, 36, 448.
2. T. Huff et al., Naturforsch, 1994, 49c, 407.
3. J.A.M. Acosta, et al., J. Org. Chem., 2016.
4. A. Ear, V. Toum,; S. Thorimbert,; L. Dechoux, Synlett, 2014, 25, 1713.
5. L.C.A. Barbosa et al., Current Org. Synt. 2015, 12, 746.
6. M. Karak et al., Org. Biomol. Chem., 2016, 14, 4897

Novel Non-Halogenated Flame Retardant For PCB


Mayank Pratap Singh*
Phosphorus Research & Technology, ICL-IP America Inc. Tarrytown, NY USA 10591
Flame retardants are a class of chemicals which provides fire safety to other materials, polymers etc.
used in modern society. These fire retardants are highly diversified depending upon the requirements.
The flame retardant chemicals which are being used today fall into seven main chemical groups
including halogenated, phosphorus based, mineral fillers, nitrogen based, intumescent materials,
inorganic materials, and polymer nanocomposites. In this article, we will demonstrate the application of
flame retardants in epoxy applications particularly in printed wiring circuit boards. We have designed
and synthesized novel non-halogenated mono-, di- and poly-functionals Mannich-based flame
retardants. Their physical and chemical properties will be discussed in the present paper.

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Soumita Ghosh
Department of clinical Investigation, National Institute on Aging, Baltimore USA.
soumita84@gmail.com

Soumita Ghosh is a postdoctoral researcher in the Diabetes


section in National Institute on Aging, Baltimore. She is
involved in developing targeted proteomics technique for
cannabinoid proteins. During her PhD., she worked in field
of NMR metabolomics of murine cerebral malaria. She
obtained her doctoral degree from Tata Institute of
Fundamental Research in 2013. She obtained her MSc
from IIT Kharagpur in 2008 and BSc from Calcutta
university in 2006.

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Exploring Biology Using Chemistry: Lessons from Metabolomics and


Proteomics
Soumita Ghosh
Chemistry is the science of molecules. The structural and functional aspects of different molecules are
the key features dealt by all the different branches of chemistry. The biological system comprises of
millions of chemical reactions. Chemical processes in the laboratory takes place in setup created by the
experimentalist. In biological systems, cells provide the perfect environment for several reactions to
occur. Much like chemical reactions, which are controlled by external parameters, can be formulated
by a set of thermodynamic and kinetic equations, biological reactions can also be formulated. Metabolic
reactions are perhaps the closest analog of organic chemical reaction in biological systems. Metabolic
processes often involve a chain and/or cycle of organic reactions taking place within very well
regulated cellular systems. In most of the cases, the reactions are guided by proteins the catalysts of
biological reactions. Apart from individual cellular reactions, chemical processes are also responsible
for construction of intercellular/organ network via complex processes such as signal transduction.
Although the biological reactions are usually very tightly regulated owing to the organismal
homeostasis, external factors can indeed affect the thermodynamics/kinetics, hence the outcome of the
processes. At an organismal level, environmental stressor is one of the important external factor.
Examples of such stressors include disease, xenobiotics etc. Therefore, it is possible to gain mechanistic
information about those stressors by studying the biological reactions and their outcomes under such
stressors.
Thus, to understand biology of system under a special condition it is important to understand the
outcome of small molecule reaction taking place in the system. The small molecule comprises of
metabolite like glucose, amino acids etc. Metabolomics (1) thrives to study the complex mixtures of
molecules. It is the term applied to study the quantitative metabolic response to pathophysiological
stimuli or genetic modification. NMR spectra of biofuids like plasma, urine, cerebrospinal fluid are
subjected to statistical modelling with the idea to connect the metabolic markers to the diseased state. It
takes help of statistics to unravel the biomarkers of a particular disease/stressors which in turn relates to
the perturbation of the particular metabolic reaction in the system. One of the major analytical tool
used in metabolomics is Nuclear magnetic resonance (NMR) and mass spectrometry. While NMR is
sensitive to millimolar range concentration, mass spectrometry can pick up molecules of nanomole to
picomolar concentration. An important advantage of NMR being its robust nature, and its insight to the
structure elucidation of the molecules. Several different NMR methods are used in metabolomics
including 1D, 2D techniques. Once a group of biomarker is known to perturb a system, each of the
chemical reaction can be studied individually to understand the overall process. Metabolomics when
coupled to other omics techniques can unravel the entire re-wiring of biosynthetic pathway. One of the
other omics technology is targeted proteomics(2). Once a particular metabolic pathway is known to
be perturbed, the specific protein involved in the chemical reaction can be quantitatively profiled using
the technique.
Keywords: metabolomics, NMR, disease, targeted proteomics
References:
1. Nicholson, J.; Lindon, J.; Xenobiotica, 1999, 29, 1181-1189.
2. Boja ES, Rodriguez H., Proteomics, 2012, 12, 1093-110.

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A Novel Aspirin-Derived Small Molecule as A Potential Therapeutic


for Colorectal Cancer
Deepkamal N. Karelia, Manoj K. Pandey, Daniel Plano, Shantu Amin, Arun K.
Sharma*
Department of Pharmacology; Penn State Cancer Institute, CH72; Penn State College of Medicine, 500
University Drive, Hershey, PA 17033, USA.
aks14@psu.edu
Colorectal cancer (CRC) is expected to kill over 400,000 people worldwide this year. While the current
standard of care can extend the survival of the patients, CRC remains second in the number of cancer
related deaths in the industrialized world. Therefore, there is an urgent need to develop effective
therapies that will enhance the survival and improve quality of life of CRC patients. Non-steroidal antiinflammatory drugs (NSAIDs), particularly aspirin, have been shown to be effective in decreasing
cancer incidences including that of CRC and have shown promising chemopreventive potential.
However, prolonged usage and higher doses are associated with gastrointestinal toxicities. In addition,
aspirin is not potent enough to be used as a therapeutic agent.
Through extensive structure-activity relationship based on NSAIDs structures, we have recently
identified a novel aspirin derived selenium hybrid molecule, ASD-49, which is >100 times more potent
than aspirin in inhibiting the viability of cancer cells. We tested the cytotoxic potential of this novel
molecule against various cancer models including CRC. ASD-49 is effective against a variety of cancer
cells with an IC50 in the range of 1 to 2.5 M. Furthermore, it is selectively toxic to cancer cells as
compared to normal human dermal fibroblasts (nHDFs). Importantly, our results suggest that anticancer potency of ASD-49 is greater than the first line chemotherapeutic for CRC, 5-FU. ASD-49,
arrests CRC cells in G1 and G2/M phase of cell cycle, which is accompanied by reduction in cyclin
levels and an increase in cell cycle inhibitory protein, p21. Moreover, ASD-49 induces apoptosis in
CRC cells via activation of caspase 3/7 and PARP cleavage. Taken together ASD-49 has a potential to
be developed as a novel therapy for CRC.

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POSTER PRESENTATIONS

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Electronic Structure Studies of L And D- Alanine.


Pankaj,1 Anup Timsina,1 O. P. Singh2 and A. K. Sharma1*
1

Department of Physics, MMEC, MMU, Mullana(Ambala) 133207 (Haryana) India


Department of Physics, Paliwal (P.G.) College, Shikohabad 205135 (U.P.) India
anil67042@gmail.com
2

HF/6-31G calculations have been performed on the electronic structure of L and D-Alanine. Net atomic
charges, dipole moment and total energy of L and D-Alanine were compared in order to explore the
finer details of these molecules. Comparison shows that redistribution of charges on L-Alanine is over
larger range (- 0.852e to 0.852e) as compared to D- Alanine from this we concluded that L- Alanine is
more reactive as compared to D-Alanine as it offer more reactive sites and having more energy as
compared to D-Alanine. Further comparison of total energy from the ADMP calculations with DFT
(B3LYP) at 6-31G level explains the high reactivity of L-Alanine. From this study it is very clear that
why L-Alanine helps the body to convert glucose into energy and also helps to eliminate excess toxins
from the liver.

Keywords: Quantum chemical calculations, L-Alanine, D-Alanine, Electronic structure, Net atomic
charges, Bond length, Dipole moment. Fig. 1and Fig.2 are the optimized structure of L-Alanine and
D-Alanine with HF/6-31G

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PTSA Catalysed Solvent-Free Synthesis and Biological Evaluation of


Some 5-Aminopyrazoles
Anshul Bansal*1 and Ranjana Aggarwal2
1

S. A. Jain (PG) College, Ambala City-134002, Haryana


Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana
anshulbansal001@gmail.com
2

5-Aminopyrazoles have attracted considerable attention because of their enormous applications as


pharmaceuticals and agrochemicals as they have been found to exhibit antibacterial, anticonvulsant,
antidepressant and herbicidal activities. The most versatile method for the synthesis of 5aminopyrazoles involves the reactions of -ketonitriles, malononitrile, alkylidenemalononitriles and
their derivatives with hydrazines in the presence of hydrochloric or acetic acid using ethanol as a
solvent. Though these reactions afford 5-aminopyrazoles, they take 8-10 h for completion and the
workup is cumbersome. Recently, solvent-free synthesis has gained much attention due to advantage
over the conventional methods in terms of enhanced selectivity, efficiency, cleaner reaction profiles,
ease of manipulation and relatively benign conditions compared to their solution counterparts. In view
of these observations and in continuation of our work on solvent-free synthesis of heterocyclic
compounds, a solvent-free protocol was developed in the present study for the synthesis of 1-(4,6dimethylpyrimidin-2-yl)-5-amino-4H-3-arylpyrazoles using p-toluenesulfonic acid (PTSA) as a
catalyst. It has been observed that the acyl moiety, an integral part of many drugs, enhances the
biological activity e.g., acylation converts the natural painkiller morphine into the far more potent
heroin (diacetylmorphine). Therefore, with a hope to obtain better biological active analogues, 5aminopyrazoles were converted to the corresponding N-acetamide and N-trifluoroacetamide
derivatives. All the compounds were screened for their cytotoxicity and in vitro antibacterial activities.
Structure activity study showed that the amino derivatives are the most cytotoxic; the introduction of
acetyl group decreases cytotoxicity, while introducing trifluoroacetyl groups showed some
improvements. Antibacterial potency was mainly influenced by the substituents at positions 5 (NH2/
NHCOCH3/ NHCOCF3) and 3 (various aryl groups). While the introduction of an acetyl group results
in decrease or complete loss of activity, incorporation of the corresponding trifluoroacetyl group
restores or increases the activity; similarly to what was observed in the cytotoxicity assays. Also, the
substitution on the phenyl ring decreases the antibacterial activity in 5-aminopyrazoles, whereas these
substituents cause an increase in the activity of N-trifluoroacetamide pyrazoles.

CuO Nanostructures of Variable Shapes as an Efficient Catalyst for


[3+2] Cycloaddition of Azides with Terminal Alkyne
Anupamjeet Kaur, Sukhmani Mann, Bhupesh Goyal, Bhupender Pal* and
Deepti Goyal*
Department of Chemistry, School of Basic and Applied Sciences,
Sri Guru Granth Sahib World University, Fatehgarh Sahib140406, Punjab, India
anupam10992@gmail.com, deeptig@iitbombay.org
CuO nanostructures of variable shapes: CuO nanospheres (5-10 nm), CuO nanorods (WL = 24-27
nm124-140 nm) and CuO nanowires (WL= 8-10 nm230-270 nm) have been synthesised to study
the effect of shape of the catalyst on the Cu(I)-catalyzed click azidealkyne cycloaddition. Cu(I)
species were generated in situ by the reduction of CuO nanostructures in the presence of sodium
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ascorbate. CuO nanowires exhibited highest catalytic efficiency for the cycloaddition reaction between
azide and terminal alkyne, featuring short reaction time, soft reaction conditions and complete
regioselectivity. We have
Further extended the study by using azides with varying functional groups (OCH3 and NO2) and
studied the effect of shape of the nanostructures on the rate of the reaction and yield of the triazole
products. The activity trend observed was: CuO-NW> CuO-NR> CuO-NS, irrespective of the presence
of electron withdrawing or donating groups on the azide.
Keywords: Azidealkyne cycloaddition, triazoles, CuO-nanowires, CuO-nanorods, CuO-nanospheres
Reference:
1. Kaur, A.; Mann, S.; Goyal, B.; Pal, B.; Goyal, D. RSC Adv. 2016, DOI: 10.1039/C6RA20725A.

Spectrophotometric Determination of Pd(II) In Micellar Media by


Sodium-1-Methyl-1-Propylthioxanthate
Anupreet Kaur
Basic and applied Sciences, Punjabi university-Patiala
Email:anupreetchem@gmail.com
A direct method has been developed for the spectrophotometeric determination of Pd(II) with sodium1-methyl-1-propylthioxanthate as a complexing reagent in the micellar media. Beers law was obeyed
in the concentration range 0.84-7.5g/mL for Pd(II) under the optimized conditions. Calibration curve
was constructed at the absorption maxima (max) i.e. 370nm for Pd(II). Sandells sensitivity and molar
absorptivity have been found to be 0.0060g/cm2 and 8.6x104 L/mol/cm for Pd(II). The developed
method has been found to be quite simple, rapid, sensitive and reproducible results were obtained.

Elastic Behavior of La2-xSrxCuO4 (x=0.10-0.20)


Bhoopendra Singh
Bhaavya Technical Institute, Tehra, Gwalior Road, Agra
The expressions for elastic constant for high temperature superconductors, derived using MieGrneisen interaction potential, are used to analyze the elastic properties (bulk modulus, elastic
wave velocity) of La2-x Srx CuO4 for x = 0.10 to 0.20. The Debye temperature D has also been
computed which is found to decrease with increasing Sr concentration. The value of bulk modulus
in superconducting phase (Ks) is larger than the value in its normal phase (Kn=113.8 GPa) for x =
0.10 to 0.14. After this limit Ks decreases. A simple empirical relation between the difference in
bulk moduli in the two phases (superconducting and normal) and Tc is proposed. The value of Tc
for La1.85Sr0.15CuO4 obtained from the proposed relationship is in good agreement with the
experimental value.
Keywords: Phase transition temperature; Debye temperature; High-temperature superconductor.

Removal of Chromium III Ion from Waste Water using Gossypium


herbacium as a Biosorbent
Rupal Sharma1, Arvind Kumar Tiwari2, Prabha Mehta1 and Gajanan Pandey3
1
Department of Chemistry, Govt. Kamala Raja Girls College, Gwalior INDIA.
2
Defence Research and Development Establishment (DRDE), Gwalior INDIA.
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3

Dr. B.R. Ambedkar Central University, Lucknow INDIA.


rajarupalsharma11@gmail.com
In this study, we report removal of nickle (Ni) from waste water using flower of cotton plant,
Gossypium herbaceum as a biosorbent, collected from Gwalior region. Flowers are dried at room
temperature and crushed in electric grinder. The I.R. spectra of the biosorbent was recorded to
determine the various organic functional groups present in order to study the mechanism of sorption
experiments. The quantities of metal ion were measured by atomic absorption spectrophotometer and
UV-Vis spectrophotometer. Batch experiments were performed and effect of the contact time, pH etc
on the adsorption process were investigated. The isothermal studies were carried out with different
doses of biosorbent in 50 ml synthetic waste water at different metal ion concentration. The initial pH
of synthetic waste water was about 5 pH. The experimental results were examined using the Langmuir
and Freuindlich isotherms to obtain the appropriate model. The isotherm was found to be well
representing the measured sorption data. The goal for this research is to develop inexpensive, highly
available, effective metal ion adsorbent from nature or alternative to existing conventional adsorbents.
Keywords: Biosorption, Gossypium herbaceum, Heavy metal ions,Kinetics, Isotherm.

Structural Properties of Tb Incorporated ZnO Nanoparticles: An


EXAFS And XPS Study
A. Sharma1, J. K. Mishra2
1

Department of Sciences and Humanities, K. J. Somaiya College of Engineering, Vidyanagari,


Vidyavihar (E), Mumbai- 400077
2
Department of Physics and Material Science, Jaypee University, Anoopshahr, Bulandshahr-203390

A comparative study on the structural properties of Tb incorporated ZnO nanoparticles have been
performed. The structural properties were investigated using X-ray diffraction, X-ray Fine structure and
XPS studies. XRD studies performed on these samples reveals that the ZnO lattice systematically
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shows a contraction up to Tb mole fraction with x=0.04 beyond which the lattice expands with
increasing x [1]. The experimental EXAFS data is fitted with theoretically generated spectra assuming
that Tb ions have substituted Zn ions in a wurtzite lattice of ZnO. Tb-O bond lengths are found to be
more than the Zn-O bond length, which is due to higher ionic radius of Tb than Zn. The study also
indicates that Tb incorporates in different configuration than only substituting Zn ion in this case. This
study also show that the disorder factor decreases with the increase in the Tb doping concentration.
XPS result confirms the presence of many oxygen species attached to the surface of these ZnO
nanoparticles (in the form of Tb-O-Tb and Zn-O-Tb bonds) which accumulates on the surface on these
nanoparticles, further producing a contraction in the lattice [2,3]. It is noteworthy that according to the
XRD, EXAFS and XPS studies performed on these nanoparticles, the results confirm the presence of
Tb ions on the surface of the nanoparticles for Tb mole fraction up to x<0.04. Further increase in the Tb
mole fraction results in the core incorporation of these ions in the lattice.
Keywords: Tb ions, EXAFS, Surface strain, ZnO nanoparticles.
References:
1. Sharma A. et. al, Solid State Communications (2011) 151, 1885.
2. Yang L. L. et al, App. Surf. Sci. (2010) 256, 3592.
3. Wang . et al, Nanotechnology (2008) 19, 075607.

Heavy Metals in Environment and its Microbial Bioremediation


Ashwanti Devi, Indu Sharma and Vivek Singh
Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Haryana, India,
Increasing industrialization and anthropogenic activities have led to the accumulation of heavy metal in
the environment so Heavy metal pollution is nowadays one of the most important environmental
concerns as these metal toxicity cause serious morbidity and mortality. Recently, biological methods
are used for biotransformation of heavy metal, which are efficient, cost effective, environmental
friendly, easy to operate and do not produce secondary pollution. Bioremediation increasingly
considered for clean-up of metal contaminated and polluted ecosystem. This process can be carried out
both in aerobic and anaerobic condition. The isolation of heavy metal resistant microorganisms and the
understanding of the mechanisms they use in order to remove this kind of pollutants may contribute to
the development of improved bioremediation processes. Nowadays certain genetically engineered
microorganism are used which enhance the selectivity and accumulation of cells and metabolise toxic
heavy metals from industrial efluents. Molecular biotechnology, a potent tool to elucidate the
mechanism at molecular level, and to construct engineered organism with higher sorption capacity and
specificity for metal. Recent environmental pollution with heavy metals has increased the need for
research concerning microbial metal resistance as well as remediation. In recent years,
biotransformation has become an alternative approach and proven to be a promising technology for
removal of heavy metal from
Keywords: Biosorption, Heavy metal, Bioremediation, Biotransformation, Genetically modified
microbes

A Novel Method of The Synthesis of Titanium Dioxide Nps


Avnish Kumar Arora,* Vivek Sheel Jawal and Rajshree Khare
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NCRACS-2016

Department of Chemistry, Maharishi Markandeshwer University Mullana, Ambala - 133207


In this study, nanoparticles of titanium dioxide (TiO2) have been successfully synthesized by. reduction
method. These nanoparticles were characterized by using X-ray diffraction (XRD) and TEM
(transmission electron microscopy). XRD revealed the presence of pure TiO2 NPs. XRD studies
suggested that the titanium dioxide, TiO2 exists in anatase form. The nanostructured character of the
produced titania powders was characterised by Scherer method and TEM examinations. The TEM
images indicate that the crystalline size of titanium dioxide precipitates varies from 1.81 nm to 13.15
nm This shows that nanoparticles obtained from reduction method are in more nanorange as compared
to those obtained for precipitation method.

Recent Innovative Approaches and Role of Microbes Towards


Ecofriendly Remediation of Heavy Metals
Indu Sharma, Ashwanti Devi and Vivek Singh
Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana.
Heavy metal remediation of aqueous streams is of special concern due to recalcitrant and persistency of
heavy metals in the environment. Anthropogenic activities, such as mining, smelting, electroplating,
energy and fuel production, power transmission, intensive agriculture, sludge dumping, dying, drug
manufacturing and melting operations, typically contains metal which are the main contributor to heavy
metal contamination. Conventional treatment technologies like ion-exchange, membrane separation,
ultrafiltration, ion-floatation, electrocoagulation, electro-dialysis, sedimentation and reverse osmosis for
the removal of these toxic heavy metals are not economical and further generate huge quantity of toxic
chemical sludge. Biosorption is an emerging, innovative, ecofriendly and potential alternative approach
to the existing conventional technologies for the removal and or recovery of metal ions from water and
waste water. Biosorption is a physiochemical process which includes mechanism such as absorption,
adsorption, ion-exchange, surface binding and precipitation. This Process utilizes inexpensive live or
dead biomass for removal of heavy metals. Bioabsorbent are prepared from naturally abundant or waste
biomass of bacteria, fungi, algae, plant, agriculture and industrial waste. The major advantages of
biosorption over conventional treatment methods include; low cost, high efficiency, minimization of
chemical or biological sludge, regeneration of biosorbent and possibility of metal recovery. Waste
biomass being highly efficient, low cost and renewable source of biomass can be exploited for heavy
metal remediation. Biosorbents can be modified for better efficiency and multiple reuses to enhance
their applicability.
Keywords: Biosorption, Heavy metal remediation, Adsorbent, Industrial effluents, Agricultural waste
biomass.

Synthesis and Anti-Microbial Evaluation of Benzimidazole-1Substituted Hydrazide Derivatives


Bhupinder Kapoor, Rohit Manhas
Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
bhupipharma@gmail.com

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Benzimidazole is an important heterocyclic nucleus in the field of medicinal chemistry. The most
prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an
axial ligand for cobalt in vitamin B12. The versatile nature of benzimidazole makes it a highly explored
molecule in medicinal chemistry. A number of pharmacological activities are associated with
benzimidazole derivatives such as anthelmintic, antiulcer, antipsychotic, proton pump inhibitor, antianxiety, anti-emetic and sedative, vasodilator, anticancer, analgesic, antihistaminic, antifungal, antiviral
and antimicrobial.
Hydrazine and its derivatives are important class of organic compound that have wide applications in
the field of medicinal chemistry. A number of derivatives of hydrazones have been prepared and
evaluated for various pharmacological activities such as anticonvulsant, antioxidant, hormone
antagonist, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antitumor,
vasodilator, antiviral, and anti-trypanosomal. A novel benzimidazole-1-substituted hydrazide
derivatives have been synthesized from o-phenylenediamine by condensation with aromatic carboxylic
acids in acidic media followed by reaction with ethyl chloroacetate in the presence of base. The ester
derivatives were then reacted with hydrazine hydrate followed by reaction with aromatic aldehydes to
form benzimidazole-1-substituted hydrazides. The in vitro antimicrobial activity of synthesized
derivatives was evaluated by tube dilution method against E. coli and S. aureus. The antibacterial
studies revealed that the compound with p-hydroxy group on aromatic rings attached to benzimidazole
nucleus displayed more potency. The study revealed that these compounds have potential antibacterial
activity and the structure modification may lead to the development of more potent and safe
antimicrobial agents.
Keywords: Benzimidazole, Hydrazone, Anti-bacterial.

Synthesis of Some Secondary Amines


Sakshi Wadhava and Kuldeep Singh*
Department of Chemistry, M M University Mullana, Haryana 133207, India
research@orgsyn.in
Several Schiff bases were prepared by condensing substituted aromatic aldehydes with various aromatic
amines. The azomethines were reduced by action of sodium borohydride to produce secondary amines.
These products will be used to produce more complex molecules. We invite biologists for collaborative
research.
Keywords: reduction, Schiff bases, Sodium borohydride.

Current Channelling Effect in Magnetotelluric Field Data


Deepak Kumar Tyagi
Physics Department, MM University Mullana (Ambala)
Magnetotelluric (MT) is an electromagnetic geophysical exploration technique. The MT field data were
collected in period range 0.001 to 1000 s from Roorkee-Gangotric profile in Garhwal Himalaya of
Uttarakhand, India. The current channeling effect was analyzed on 6 MT sites of Higher Himalaya
region. The current channelling effect is explained as a high concentration of current induced in the
local conductor by external source fields. These currents are channeled by local conductor in a
frequency independent ohmic-like manner (i.e., anomalous DC currents). While analyzing
dimensionality of the MT data, one goal is to find out which part of the region can be explained with a
2D regional model overlain by local, shallow, horizontally elongated conductors oriented differently. In
our field data the current channelling effect have observed at 6 MT sites in the Higher Himalaya, the
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phases exceeding 900 above the period of 0.1 s. The Swift skew parameter for these 6 sites was
analyzed and it was observed that these 6 sites have Swift skew value greater than 0.2 at periods above
0.001 s. The Phase Sensitive Skew (PSS) parameter for these 6 sites was analyzed and it was observed
that only 4 sites have PSS value greater than 0.3 at periods above 0.1 s. The Groom-Bailey
decomposition was also used at these 6 sites. It was observed that shear was the more distorted
parameter at these sites. The twist and shear values in the entire period range (0.001 s to 1000 s) at
these sites are high. On the basis of these analyses, it can be inferred that these 6 MT sites show strong
current channelling effects and structure of higher Himalaya is complex.

Lipid Based Peptidomimetics As Antimicrobial Agents


Deepika Sharma and Gopal Singh Bisht*
Department of Bioinformatics, Biotechnology and Pharmacy,Jaypee University of Information
Technology,Waknaghat, Solan-173234, H.P.
bisht.gopal@gmail.com
Short cationic peptides with fatty acids chains have been found to have enhanced antimicrobial activity.
Keeping this in mind we have prepared lipid based peptidomimetics using non natural amino acid
ornithine. Prepared lipidated peptidomimetics were found to be proteolytically stable and non toxic
towards human blood cells. Antimicrobial activity of these peptidomimetics was evaluated against E.
coli, S. Aureus and P. aeruginosa. Among all peptidomimetics LPEP08 was found be most potent
against these microbes. Resistant strain of S. aureus was not able to develop resistance against LPEP08.
Pharmacokinetic study and in vivo antimicrobial study of this lead molecule is under progress. If this
molecule provides promising results in these studies, an antimicrobial formulation based on this
molecule may be designed in future for microbial infections.

New Heterobimetallic Complexes and Their Interaction with DNA


Girish Chandra Sharma
Jaypee University, Anoopshahr, Distt. Bulandshahr 203390, (U.P) India
The paper consists of the synthesis of novel tin (IV) complex [C26H28N2O6SnCl2] of the ligand
[C13H15NO3] derived from phenylglycine chloride hydrochloride and sodium salt of acetyl acetonate,
and its heterobimetallic complexes [C26H30N2O7SnCuCl2]Cl2 and [C26H28N2O6SnZnCl2]Cl2 were
subsequently synthesized and thoroughly characterized. The proposed structures of the complexes were
formulated based on elemental analysis, and other spectroscopic data (IR, 1H, 13C and 119Sn NMR,
EPR, UV-vis, ESI-MS) and analytical methods. The electronic absorption and electron paramagnetic
resonance parameters of the complex revealed that the Cu(II) ion exhibits a square pyramidal geometry
The 1H, 13C NMR in case of the ligand [C13H15NO3] and the complex [C26H28N2O6SnCl2] and 1H, 13C
and 119Sn NMR in case of the complex [C26H28N2O6SnZnCl2]Cl2. In-vitro DNA binding studies of the
complexes were employed to determine the DNA binding propensity as quantified by Kb values. In
presence of incremental amount of CT DNA, a significant hyperchromic effect with a slight
bathochromic shift was observed for all studied complexes. Complexes [C26H28N2O6SnCl2],
[C26H29N2O7SnCuCl4] and [C26H28N2O6SnZnCl4] displays a substantial bathochromic shift of ca. 2-3
nm which supports a higher degree of binding for this complex towards CT DNA. A concentration
dependent DNA cleavage activity of the complex [C26H30N2O7SnCuCl2]Cl2 with pBR322 DNA and
also in presence of different activators was employed to examine the cleaving ability of the complex.
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The Field Study on The Discharge and Using of Agricultural


Chemicals and Effects on The Agricultural Environment
Jaswant Ray1, Amit Kumar2, Pawan K.Bharti3, B .K. Aggarwal4
1

Department of Zoology, Mewar University, Chittorgarh, Rajasthan


Department of Toxicology, Institute for Industrial Research & Toxicology, Delhi NCR
3
Society for Environment Health Awareness of Nutrition & Toxicology, Delhi-110007
4
Department of Zoology, SSN College, University of Delhi, Alipur, Delhi
rayjaswant2012@gmail.com
2

In this study was focused on the effects of agricultural chemicals and fertilizers on the aquatic
ecosystem. Moreover it targeted the most prevalent and dangerous agricultural pollutants causes of the
pollution and the extent of the damages cause by these pollutants on the ecosystem as a whole.
Laboratory and field testing of water soil plants and animal samples using various and standard
methods of analysis proved that the level of the important heavy metals like lead nitrates phosphates
arsenic iron were above toxic limit which contributed to toxicity. The results proved that toxicity varied
linearly with the crop activities. With an increase in the toxicity the aquatic ecosystem was found to be
unstable and in deteriorated state. The study conclusively proves that the aquatic water bodies were
contaminated by agricultural pollutants (nutrient fertilizers and chemical fertilizers). Overflow of water
careless handling of chemicals by laborers spillage runoff and erosion lead to the toxicity of the heavy
metals hence affected the quality of the water soil and aquatic life.
Keywords: Agricultural Chemicals, Aquatic Ecosystem, Pollutants, Fertilizers, Toxicity

Point of Use Wastewater Treatment Using Agglomerated


Nanoparticles of Titanium (IV) oxide and Blotter Paper Impregnated
with Silver Nanoparticles in Colum Mode
Joginder Singh* and Amjad Ali
Department of Chemistry, M.M.E.C, M.M.U, Mullana, Ambala-133207 (India)
School of chemistry and biochemistry, Thapar University, Patiala 147004 (India)
jatsraw18@gmail.com
There is an urgent need for economical point of use methods to purify industrial wastewater. In the
present work, continuous two phase treatment of electroplating industrial wastewater was conducted in
column up flow mode. Two columns were packed with agglomerated nanoparticles of titanium (IV)
oxide and were joined in series maintained at different pH values. After percolation through columns,
the water was passed through the blotter paper impregnated with silver nanoparticles to deactivate the
pathogenic bacteria E. coli. The water obtained finally was free from the metal ions [Cu (II), Ni (II)],
color and E. coli. The E. coli was not filtered but was deactivated by the silver nanoparticles. The
nanoparticles were deposited by in situ reduction of silver nitrate on the cellulose fibers of an absorbent
blotter paper sheets. The silver-nanoparticles embedded in blotter sheets were tested for performance in
the laboratory with respect to bacteria inactivation. These results assured that percolation of industrial
wastewater containing metal ions, color and bacteria through agglomerated nanoparticles of titanium
(IV) oxide and paper embedded with silver nanoparticles could be an effective emergency water
treatment.

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Effect of Solvents on Photo-catalytic Properties of SnO2


Nanoparticles Synthesized by Chemical Co-precipitation Method
Harsimranjot Kaur, H. S. Bhatti and Karamjit Singh*
Department of Physics, Punjabi University, Patiala-147002, Punjab (India)
dhaliwalkaramjit@gmail.com
SnO2 nanoparticles have been successfully synthesized by chemical co-precipitation method using
ethanol, acetone, tetrahydrofuran (THF) and ether as solvents. X-ray Diffraction (XRD), Field Emission
Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM) have been used to study
the crystallographic and morphological properties of synthesized SnO2 nanoparticles, while their optical
properties have been studied by UV-Visible absorption spectroscopy. UV-Vis absorption spectra shows
a weak quantum confinement in all the synthesized SnO2 samples. The photo-catalytic activity of assynthesized SnO2 nanoparticles under UV irradiation has been evaluated using Methylene Blue (MB)
dye as a test contaminant in water. The results showed that solvents played a key role to control the
morphology and photo-catalytic activity of SnO2 nanoparticles.
Keywords: SnO2, nanoparticles, morphology, crystallography, photo-catalytic activity.

Sulphate and Cerium Impregnated Ti/ZrO2 as Heterogeneous


Catalyst for Glycerol Esterification
Km Abida and Amjad Ali*
School of chemistry and biochemistry, Thapar University, Patiala 147004
amjadali@thapar.edu
In present work, a series of sulphate and cerium impregnated on ZrO2TiO2 support was prepared via
two step method. During the catalyst preparation, metal concentration in ZrO2TiO2 support and
calcinations temperature have been varied in order to study the effect of the same on material
morphology and activity. The prepared catalysts were characterized by powder X-ray diffraction,
Fourier transform infra-red (FTIR), scanning electron microscopic and transmission electron
microscopic techniques and characterization of product was carried out by 1H-NMR. FTIR of catalyst
shows characteristic bands corresponding to the bi-dentate bridging of sulfate group with Zr4+ and/or
Ti4+. FTIR-DRIFT study demonstrate that maximum acidic sites were observed for the catalyst with 1
wt% cerium concentration and a further increase in cerium concentration was not found to enhance the
acidic sites on catalyst surface. This prepared catalyst has been employed as heterogeneous catalysts for
the esterification of glycerol with acetic acid to yield a mixture of di- and tri-acetin.
Keywords: Esterification, heterogeneous catalyst, powder XRD, SEM and TEM

Inorganic Hybrid Materials Based on Mesoporous Silica Composites


for Humidity Sensing Applications
Ekta Poonia1, Surender Duhan2 and Krishan Kumar1
1

Research Laboratory Chemistry, Department of Chemistry, D.C.R. University of Science and


Technology, Murthal, Sonipat, Haryana 131039, India.
2
Nanomaterials Research Laboratory, Department of Materials Science and Technology, D.C.R.
University of Science and Technology, Murthal, Sonipat, Haryana 131039, India.
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During the last decade mesoporous silica based hydrophilic materials composites were extensively used
in humidity sensing applications. Despite the fact that, earlier used chemical method for loading the
hydrophilic materials in the channel of mesoporous silicas is hard to guarantee their homogeneous
dispersion and there is no strong bonding between the host and guest materials. To unravel above
problems, mesoporous silicas were chemically modified with inorganic materials composites using
hydrothermal method. The chemical and porous structures of the obtained hybrid mesoporous materials
were characterized by High Resolution Transmission Electron Microscopy (HRTEM), Fourier
Transform Infrared Spectroscopy (FTIR), Low Angle XRD, High Angle XRD and N2 adsorption
desorption analysis including surface area analysis, pore size distribution and pore volume. The
humidity sensing applications of the sensors based on inorganic hybrid materials could effectively
enhance the sensing properties of mesoporous silicas.

Spectrofluorimetric Determination of Al3+ Using 3-hydroxy-2-(4methoxy phenyl)-4H-chromen-4-one as Analytical Reagent.


Kuldeep Kaur1*, Pooja Rani2
1

Department of Chemistry, Mata Gujri College Fatehgarh Sahib


Department of Chemistry, Punjabi University Patiala
shergillkk@gmail.com
2

The 3-hydroxychromones (3-HCs) derivatives are known to possess interesting fluorescence properties
due to the excited state intramolecular proton transfer (ESIPT). In the present study, the fluorescence
properties of 3-hydroxy-2-(4-methoxy phenyl)-4H-chromen-4-one were studied. The compounds
showed considerable native fluorescence when excited at 355 nm using a slit width of 5 nm. Interaction
with Al3+ resulted in significant enhancement of fluorescence intensity of the chromenone (3-Hydroxy2-(4-methoxyphenyl)-4H-chromen-4-one peak. Based on these interactions, method has been
developed for the spectrofluorimetric determination of microamounts of Al+3. The emission spectra as
well as synchronous spectra of the chromenone-Al3+ complexes were recorded. The synchronous
spectra were recorded using an excitation wavelength of 355 nm and value of 60. The various
parameters affecting the fluorescence intensity of the system including effect of pH, effect of addition
order of reagents, stability time were optimised. Calibration graph was plotted and regression equation
was determined. The fluorescence intensity F was found to vary linearly with concentration of Al3+ in
the range 1x10-7-1x10-6 M. Studies on the interference caused by other common metal ions on the
determination of the proposed metals were also carried out and change in fluorescence intensity due to
these metals was determined at fixed concentrations. The methods were applied for the determination
of Al3+ in environmental water samples. The recovery values were determined and they indicated that
the method can be successfully used for the determination of Al3+ in environmental water samples.

Well-defined Quantum
Nanomaterials

Dots

and

Morphological

Control

of

Deepika Jamwal, Pankaj Thakur


Shoolini University of Biotechnology & Management Sciences, Solan, India
Italian Institute of Technology (IIT@CRIB), Naples, Italy
In the context of the present talk, simpler methods have been presented for ordered and well defined
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nanostructures of semiconductor and biodegradable polymeric nanomaterials. However, suitably


spending various surface active agents as capping molecules, ordered morphologies of semiconductor
nanomaterials have been designed. A versatile and facile methodology is presented for size-controlled,
lead telluride nanoparticles in the presence of highly hydrophobic cationic gemini surfactants (12212,
14214 and 16216) as capping/stabilizing agents. The optical and electrical properties were
examined with attention focused on the cumulative diameter of lead telluride NPs for various
stabilizing agents. To explore the influence of surfactants' hydrophobicity on the shape and size of lead
telluride NPs, the microstructure of lead telluride NPs was investigated via transmission electron
microscopy (TEM).
References:
1. Lodge, T. P.; Rasdal, A.; Li, Z. B.; Hillmyer, M. A., Simultaneous, segregated storage of two agents
in a multicompartment micelle. Journal of the American Chemical Society 2005, 127, 17608-17609.
2. Li, Z. B.; Hillmyer, M. A.; Lodge, T. P., Control of structure in multicompartment micelles by
blending mu-ABC star terpolymers with AB diblock copolymers. Macromolecules 2006, 39, 765-771.
3. Riess, G., Micellization of block copolymers. Progress in Polymer Science 2003, 28, 1107-1170.
4. D. Jamwal, G. Kaur, P. Raizada, P. Singh, D. Pathak andP. Thakur, J. Phys. Chem. C, 2015, 119,
50625073.

Perspective of Plant Based Home Made Organic Pesticides


Dr (Ms.) Meena Rani
Chemistry Department, Govt. PG College, Hisar
meenachaba@yahoo.co.in
Pesticides are the toxic substances we intentionally release into our environment in order to kill living
organisms. These chemicals dont just harm their intended targets but also are responsible for
increasing number of human health problems ranging from headache and nausea to cancer, endocrine
disruption and neurological problems. Plants based pest control agents have long been treated as
alternatives to synthetic chemicals for integrated pest management. Plant products are biodegradable
leaving no residues on plants, effective against insects, plant pathogens, nematodes and noninsect pests
and cheaper, non-polluting, easy to prepare and compatible with several biopesticides and synthetic
pesticides. Ever wonder what farmers did hundreds of years ago to fight off crop pests? Long before the
invention of harmful chemical pesticides, farmers and householders came up with multiple remedies for
removing insect infestations from their garden plants. These plants based homemade organic pesticides
can also be used for large scale application in agriculture in general and plant protection in particular.
Keywords: plant based Home Made Organic Pesticides

Green Solvents for Organic Synthesis


Dr. Meera
Chemistry Department, FGM Govt. College, Adampur (Hisar).
meera@gmail.com
Solvents play an important role in organic synthesis. Choice of solvent is important in improving and
deciding the chemical process. Selection of solvents should be such that it has minimal effect on the
environment. Today chemists are interested in designing solvents which does not pose any risk to
human health and the environment. The reason why solvents are of great environmental concern is that
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they are used in large quantities compared to the amount of reactants and products. The reduction of
their use is one of the most important aims of green chemistry. In order for the solvent to be called
green, it must be biodegradable, non-toxic and capable of being burnt at the end of its life without
adding pollutants to the atmosphere. Solvents that have been suggested to be green solvents includes
water supercritical fluids, gas expanded liquids, ionic liquids, liquid polymers and solvents derived
from biomass. Vegetable oil obtained from plants have capability of replacing hazardous organic
solvents derived from petroleum. These vegetable oils extracted from plants are more ecofriendly.
Ethyl lactate green solvent derived from processing corn is commonly used in paint and coating
industry due to its high solvency power, high boiling point, low vapour pressure and low surface
tension. It has replaced solvents like toluene, acetone and xylene as it is 100% biodegradable, easy to
recycle, non-corrosive, non-carcinogenic and non-ozone depleting.
Key Words: Green solvents, organic Solvents, Vegetable Oil, Ethyl lactate

Synthesis and
Quinazolinone

Characterization

of

Peptide

Derivatives

of

Mukta Gupta, Arshid Nabi


Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab,144402
mukta_gupta2k@yahoo.com
During past two decades, heterocyclic compounds have gained much attention due to their
chemotherapeutic potential in the development of anti-microbial agents. Quinazolinone nucleus is
found in many bioactive natural products which promoted the chemical synthesis of its derivatives that
possess diverse biological activities such as anti-tumor, anti-microbial, anthelmintic, anti-convulsant,
anti-inflammatory, anti-cancer, analgesic, anaesthetic, sedative and anti-tubercular. Incorporation of
peptides into quinazolinone moiety results in compounds that exhibits potent bioactivities like
antibacterial, antifungal and anthelmintic. Peptides incorporation enhances the efficacy, reduce the
adverse effects and prolong the duration of action of the resulting compounds. Substituted quinazolinylsalicylic acid was synthesized by reaction of 2-(2-chlorophenyl)-4H-benzo[d]1,3-oxazin-4-one with 5aminosalicylic acid (5-ASA). Coupling of synthesized compound with different amino acid and
dipeptide ester hydrochlorides yielded novel quinazolinone-amino acid/peptide derivatives. The
synthesis of amide bond was carried out by N,N-dicyclohexylcarbodiimide (DCC) as coupling agent
and N-methyl morpholine (NMM) as base. The chemical structures of all synthesized compounds were
confirmed by FT-IR and proton-NMR.
Keywords: Peptide, quinazolinone, 5-amino salicylic acid, peptide

Synthesis and Characterization of Novel Zirconium Antimonoarsanotungstate Zr[SbAsW] Salt


H. K. Sharma,1 N. Sharma,2 P Dogra,2 Ritu2
1

Vice Chancellor, MM University Sadopur, Ambala, Haryana (India)


Department of chemistry, MMU, Mullana, Ambala, Haryana (India)

The present study focused on the structure elucidation of heteropolyacid salts named Zirconium
Antimonoarsanotungstate Zr[SbAsW] salt synthesised at variable pH using sol-gel route. Instrumental
technique, IR was used to assign the structural aspects to the compound. Physical characterisation
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involve ion exchange capacity and maximum value for this parameter is 0.40mg/eq. for sample no. 1.
Distribution coefficient values showed that the synthesized compound is preferentially selective for
Cu2+ ion. Membrane composition ZrSbAsW: epoxy resin as 40%:60% expressed linearity in the
concentration range 1.0x10-4 M to 1.0x10-1 M with slope of 20.0 mV/decade, with 101 M solution as
internal solution. The structure derived on the basis of above analytical techniques gave a picture of the
of Cu2+ selective electro-active moiety.
Keywords: Zirconium Antimonoarsanotungstate, synthesis, Kd values, ion exchange capacity

Biomass Generation from Sugarcane, Rice and Wheat Crops:


Consequences of Removal Practices and Alternatives
Nirankar Singh
Department of Chemistry, Maharishi Markandeshwar University, Ambala, Haryana
Email:nirankarsingh11@gmail.com
Sugarcane, rice and wheat are cultivated in a large agricultural area in Uttar Pradesh, Haryana and
Punjab. The crop residue produced after the harvesting of these crops is utilized up to some extent by
small farmers for their cattle. But, a large quantity still remains left in the fields. Farmers prefer open
burning of crop residues to clear their fields for the next crop which require no time, no manpower and
no direct cost in terms of money. According to IPCC the 25% of the crop residues are burnt in open
fields by farmers in India and 70%-80% residues produced during mechanized harvesting of rice and
wheat crops is burnt in Punjab and Haryana. These practices generate lots of air pollution in terms of
toxic gases (SOx, NOx, CO2, CO), organic compounds (VOCs, PAHs) and particulate matter (SPM,
PM10, PM2.5 or aerosols). During burning months, eyes irritation, suffocation and low visibility are
common and easily noticeable problems. The children and elderly are most affected by the burning
practices. Patients suffering from asthma, lungs infection and eyes problem face more difficulty during
crop residue burning days. The quality of the top layer of soil is also affected due to high heat generated
during burning. Farmers should adopt other alternatives for the removal of residues which can improve
the economy as well as the regional air quality.
Keywords: Crop residue burning, air pollution, aerosols
References:
1. American Thoracic Society, Committee of the environmental and occupational Health, Health
effects of outdoor pollution, American Journal of Respiratory and Critical Care Medicine, 15, 3-50
(1996)
2. Jose E. D. Canado, Paulo H. N. Saldiva, Luiz A. A. Pereira, Luciene B. L. S. Lara, Paulo Artaxo,
Luiz A. Martinelli, Marcos A. Arbex, Antonella Zanobetti and Alfesio L. F. Braga. The Impact of
Sugar Cane-Burning Emissions on the Respiratory System of Children and the Elderly,
Environmental Health Perspectives, Vol. 114, No. 5, pp. 725-729 (2006)
3. Mittal S.K., Singh N., Agarwal R., Awasthi A. and Gupta P.K., Ambient air quality during wheat
and rice crop stubble burning episodes in Patiala, Atmospheric Environment, 43(2), 238-244
(2009)
4. Orhan Sevimoglu, Wolfgang F. Rogge. Organic Compound Concentrations of Size-Segregated
PM10 during Sugarcane Burning and Growing Seasons at a Rural and an Urban Site in Florida,
USA, Aerosol and Air Quality Research, 15: 1720-1736, (2015)
5. Singh N., Agarwal R., Awasthi A., Gupta P.K. and Mittal S.K., Characterization of atmospheric
aerosols for organic tarry matter and combustible matter during crop residue burning and non-crop
residue burning months in North-western region of India, Atmospheric environment, 44 (10),
1292-1300 (2010)
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6.

Singh N., Mittal S.K., Agarwal R., Awasthi A. and Gupta P.K., Impact of rice crop residue burning
on levels of SPM, SO2 and NO2 in the ambient air of Patiala (India), International Journal of
Environmental Analytical Chemistry, 90 (10), 829-843 (2010)

DFT Based Analysis for The Regio- and Stereoselective Synthesis of


Tetrasubstituted Isoxazolidines From Cinnamoyl Piperidine
Derivatives
Sutapa Mandala, Avijit Banerjib, Nivedita Acharjeea*
a

Department of Chemistry, Durgapur Government College, Jawaharlal Nehru Rd, Durgapur, Dist.:
Burdwan, Pin Code: 713214, West Bengal
b
Centre of Advanced Studies on Natural Products Including Organic Synthesis, Department of
Chemistry, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700009, West Bengal.
nivchem@gmail.com; nivedita_acharjee@rediffmail.com.

(Fig. Optimized endo/meta transition state)


Regio- and stereospecific synthesis of cycloadducts from 1.3-dipolar cyclodditions of nitrones has
received sincere attention of chemists in the last decade since the resultant isoxazolidines have been
reported to possess important biological activities. The preferred reaction channel of the cycloadditions
can be analyzed by using different theoretical models at DFT level of theory. Failure of FMO theory in
many cases triggered the application of DFT based reactivity indices i.e. electronic chemical potentials,
global hardness, global softness, global electrophilicity indices, Fukui functions and nucleophilicity
indices to predict the electron demand character and hence the regiochemical mode of reaction.
Synthesis of tetrasubstituted isoxazolidines involve four center interactions and has limited reports in
literature to the best of knowledge. We hereby present a theoretical study at DFT/B3LYP/6-31G(d)
level of theory for the reactions of C-aryl-N-methyl nitrone and C-aryl-N-phenyl nitrone to cinnamoyl
piperidine. The global parameters indicated normal electron demand character for the cycloadditions
and the local properties from NPA and MK analyses predicted meta regioselectivity in complete
agreement with the experiments. The preferred generation of endo/meta isomer was reflected in their
lowest computed activation energies along the respective series for the investigated reactions. Time
gaps between the formations of C-C and C-O bonds were evaluated from single trajectory simulations.
The asynchronicity of bond formation process was analyzed from the wiberg bond indices, atom-atom
overlap weighted NAO bond orders and the asymmetry indices of the transition states.

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Potentiometric Determination of Lead (II) Ion using 2-[(4-ChloroPhenylimino)-Methyl]-Phenol as an electroactive Material


Jyoti Sharma, Pernita Dogra, Diksha
Department of Chemistry, Maharishi Markandeshwar University, Mullana (Ambala) India
Epoxy-based membrane of 2-[(4-chloro-phenylimino)-methyl]-phenol reveals a far Nernstian slope
of 43 mV per decade for Pb+2 over a wide concentration range (106 to 101 mol dm3). The response
time of the electrode is quite low (< 10 sec) and could be used for a period of 2 months with a good
reproducibility. The proposed electrode reveals very high selectivity for Pb(II) in the presence of
transition metal ions such as Cu2+, Ni2+, Cr2+ and Cd2+ at concentrations 1.0103 M and 1.0104 M.
Effect of internal solution concentration was also studied. The proposed sensor can be used in the pH
range of 2.50 - 9.0. It was used as an indicator electrode in the potentiometric titration of Pb+2 ion
against EDTA.
Keywords: ISE, Schiff base, Pb (II), Potentiometric titration.

Transition Metal Complexes of 1-(2-Methylphenyl)-4, 4, 6-Trimethyl


Pyrimidine-2-thione : Synthesis and Biological Studies
Pooja Sethi,* Rajshree Khare
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana.
drrajshreekhare@gmail.com
Transition metals Mn, Co, Ni, Cu and Zn were complexed with 1-(2-methylphenyl)-4,4,6-trimethyl
pyrimidine-2-thione as ligand (HL1) under solvent free conditions. Structures were confirmed on the
basis of elemental analysis, UVVisible, 1H NMR, IR, Mass spectroscopy, Magnetic moment and TGA
studies. The IR spectral data suggested that ligand behaves as a bidentate, coordinating through N
(endocyclic) and S (exocyclic) donor atoms. All compounds were screened for antibacterial and DNA
photocleavage ability. Ligands complexed with Mn and Ni metals has showed the effect of substitution
on their biological potentials.It was observed that p-substitution makes the ligand and complexes better
antibacterial and DNA photocleaving agents.
Keywords: DNA photocleavage, pyrimidine-2-thione, solvent free synthesis

A Review on Synthesis and Characterization of ZnO Nanoparticles


Priyanka, Avnish Arora*, Vivek Sheel Jaswal* and Rajshree Khare
Department of Chemistry, Maharishi Markandeshwar University, Mullana 133207, Haryana, India
Zinc oxide nanoparticles were synthesized using a simple precipitation method with zinc nitrate as
starting materials and taking ammonia as precipitating agent. The synthesized nanoparticles were
characterized by using XRD (X-Ray Diffraction) and TEM (Transmission electron microscopy). The
crystallite sizes of the synthesised zinc oxide was calculated from the full width at half maximum
(FWHM) of XRD peaks by using Debye-Scherrer's formula. The size of the obtained particles is
ranging from18 nm to 64 nm. Particle size was also measured by using TEM. TEM results show
particle size in the range from 44 nm to 65 nm and were observed to be supporting XRD results.

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Surface area of the synthesised NPs was measured by using BET surface area analysis and was
obtained as 4.3737m2/g.

Clerodendrum serratum (L.) Moon. A Review on Conventional Uses


and Scientific Findings
Raj Kumar Tiwari1 Udayabanu M 2 Silpi Chanda 3
1

Faculty, Dept of Pharmacy, Sunder Deep Pharmacy College, Dasna, Ghaziabad, UP-201001
Faculty, Dept of Pharmacy, JUIT, Waknaghat, Solan, HP-173234
3
Faculty, Pharmacy Institute, NIET, Greater Noida, UP-201010
2

Human being mostly depends upon plants and their related products for curing various diseases since
the origin of human civilization. There are big varieties of medicinal plants which are yet to be explored
for various ailments. In todays modern era lot of plants has been developed for drug discovery from
natural resources. Geographical distribution of plant and its usage in various communities provides
foundation for drug development process. Clereodendrum serratum is a perennial woody shrub native
to East India and Malaysia, up to 38 ft in height. Phytochemical studies reveal the presence of saponin
steroids, glycoside, alkaloids, and phenolic compounds. Review reveals the potential uses in the
traditional pattern along with scientific findings of Clereodendrum serratum.Traditionally plant is
known as bharangi mainly claimed for various ailments like fever, malarial fever, liver problems,
asthma, inflammations and wounds. Preclinical studies reveals for traditional claim along with active
constituents like ursolic acid, hispulidin, saponins etc.
Keywords: Clereodendrum serratum, Ethonobotany, Bharangi

Destabilization Mechanism of Alzheimers A42 Protofibrils With a


Small-Molecule Inhibitor: A Molecular Dynamics Simulation Study
Rajneet Kaur Saini, Suniba Shuaib, Bhupesh Goyal*
Department of Chemistry, School of Basic and Applied Sciences,
Sri Guru Granth Sahib World University, Fatehgarh Sahib140406, Punjab, India
rajneetkaur15@yahoo.com, bhupesh@iitbombay.org
Alzheimers disease (AD) is one of the most common types of dementia among elderly affecting part of
brain that control memory and language. However, the underlying inhibitory mechanism of protofibril
structure destabilization remains elusive. In the present study, we have performed molecular docking
and molecular dynamics (MD) simulations to elucidate the inhibitory mechanism of compound, D744,
reported for its potential inhibitory activity against A42 aggregation [1]. We find using molecular
docking that D744 interact with chain A of protofibril structure. Further, MD simulations reveal
destabilization of protofibril structure in presence of D744 due to the decrease in sheet content and
increase of coil structures, increase in the intrachain D23K28 salt bridge distance, decrease in the
number of backbone hydrogen bonds and increase in the average distance between C atoms of the
protofibril structure. The present study highlight that D744 inhibit protofibril aggregation by
destabilizing the sheet conformation of protofibril structure which will be of great significance as it
will prevent the A protofibril growth.
Keywords: Alzheimers disease, AD therapeutics, Molecular dynamics, Molecular docking
References:

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1.

McKoy, A. F; Chen, J; Schupbach, T; Hecht, M. H. Chem. Biol. Drug Des., 2014, 84, 505
512.

Synthesis and Antimicrobial Screening of Thiazolidinone Derivatives


Raman Singh,* Kuldeep Singh
Department of Chemistry, MMEC, M. M. University Mullana Ambala
raman@pundir .in
Thiazolidinone is considered as a biologically important active compound that possesses almost all
types of biological activities such as anti-tubercular, anti-bacterial, anti-fungal, anti-viral, anticonvulsant and anti-depressant activity, anti-histamines, anti-cancer, anti-inflammatory and
analgesic and industrial importance.. This diversity in the biological profile has attracted the
attention of many researchers and academicians to explore this bioactive molecule. A series of
novel thiazolidinones have been synthesized by reaction of various Schiff bases with thioglycolic
acid. They are formed by the attack of sulphur nucleophile on imine carbon and with elimination
of water intramolecular cyclization takes place. The Thiazolidinone have the heteroatoms such as
sulfur at position 1, an atom of nitrogen at position 3 and a carbonyl group at position 2, 4, or 5.
Due to the presence of such heteroatoms, it shows many biological activities.The structures of the
newly synthesized compound were monitored by TLC and confirmed by Spectral analysis (IR, HNMR, analysis). The SAR is established in the conclusion.
Keywords: Thiazolidinone, Structure activity relationship.

Subchronic Toxicity Studies of Aqueous Extract of Alangium


salvifolium Leaves in Rats
Reena Gupta, Gagandeep Kaur
Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
reenaph14@gmail.com
Medicinal plants and their isolated phytoconstituents have been used for the treatment and prevention
of various health disorders since time immemorial. Herbal medicines are claimed to be non-toxic and
generally regarded as safe because they are obtained from natural origin; but safety concern arise due to
a number of factors and poor quality control. Toxic effects have been attributed to several factors
including toxicity of chemical constituents, contamination of preparations by heavy metals or
microorganisms and adulteration. Toxic effects reported from herbal medicines include hepatotoxicity,
neurotoxicity, nephrotoxicity, cardiovascular toxicity and carcinogenic potential. Safety and quality of
herbal medicine should be ensured by regulatory bodies as these are routinely being used for
therapeutic purpose
Alangium salvifolium belongs to family Alangiaceae is wildly found in tropical forests of South India.
Different parts of the plant are used in traditional Indian system of medicine. Anti-rheumatic, antiasthmatic, anti-leprotic, anti-inflammatory, anti-cancer, anti-bacterial, anti-diabetic, and anti-tubercular
activities are reported for this plant. The present investigation was designed to evaluate the safety
profile of aqueous extract of Alangium salvifolium leaves, on oral administration for 13 weeks. The
NOEAL (No observed adverse effect level) and LOEAL (Lowest observed adverse effect level) after
90 day oral administration of the extract in rats was evaluated. It was concluded that long term
administration of the plant is safe and the aqueous extract of the leaves has shown potential
hypoglycaemic activity.
Keywords: Alangium salvifolium, Sub chronic toxicity studies, herbal drugs
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Synthesis, Characterization of Novel 3-(4-Substituted Phenyl)-1-(6Substituted


Benzothiazol-2-yl)-1H-Pyrazole-4-Carbaldehyde
As
Potential Antimicrobial Agent
Renu Bala1, Karan Singh1*, Poonam Dogra1, Sumit Sood1, Vinod Kumar2
1

Department of Chemistry, Akal College of Basic Sciences, Eternal University, Baru Sahib, District
Sirmour, HP-173101, India
2
Department of Biotechnology, Akal College of Agriculture, Eternal University, Baru Sahib, District
Sirmour, HP-173101, India
3-(4-substituted
phenyl)-1-(6-substituted
benzothiazol-2-yl)-1H-pyrazole-4-carbaldehyde
were
synthesized by treating 1-(4-substituted phenyl)ethanone (6-substituted benzothiazol-2-yl)hydrazones
with dimethyl formamide and phosphorous oxychloride (Vilsmeier-Haack reagent) undergo cyclization
forming pyrazole derivatives and undergo formylation on the pyrazole ring. The 1-(4-substituted
phenyl)ethanone (6-substituted benzothiazol-2-yl)hydrazones were synthesized by treatment of 4substituted acetophenone with 2-hydrazino-6-substituted benzothiazoles. The structures of these
compounds have been characterized from the rigorous analysis of their IR, NMR, MS and physical
analysis. These compounds were screened for their anti-bacterial and anti-fungal activity.
Keywords: Benzothiazoles, Pyrazole, Acetophenone, Vilsmeier-Haack reagent, antibacterial and antifungal activity.

Protective Effects of Linoleic acid on toxicity Caused by Acrylamide


in Rats
Sadhana Shrivastava and Anjana Jadaun
UNESCO satellite centre for trace element research
UGC-SAP School of Studies in Zoology, Jiwaji University, Gwalior (M.P.) India
Linoleic acid (LA) is a metabolic precursor for arachidonic acid synthesis and an essential fatty acids in
the human diet. LA have broad spectrum of biological activities like as antioxidant, anticancer and
antimutagenic activities. Acrylamide (AA) is an chemical with neurotoxic, carcinogenic and
reproductivetoxic effects in humans and has been known as an occupational hazard for decades.
However, in recent years, AA has been found to form in fried and baked starchy foods like potato
chips, french fries etc. Goal of the present investigation was to evaluate the therapeutic efficacy of LA
against AA induced toxicity in rats. AA was administered at the dose of 19.13 mg/Kg for 28 days days
to albino rats followed by therapy with 20 mg/Kg dose of Linoleic acid. Significant elevation in the
level of AST, ALT, ALPase and ALAS in brain with depletion in hemoglobin and blood ALAD after
AA exposure. Activities of AchE, GST, GR and GPx were also reduced whereas enhanced G-6-PDH
activity and microsomal lipid peroxidation in AA treated groups. AA also induced DNA damage.
Histopathological observations also supported biochemical studies. LA protect the effects of AA
induced toxicity.

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Anodic Stripping Voltammetry of Anti-VI Antibody Functionalized


CdTe Quantum Dots for Specific Monitoring of Salmonella enterica
serovar Typhi
Satish Kumar Pandey1, C. Raman Suri2, Aaydha C. Vinayaka2, Akash Deep1*
1

CSIR-Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30-C, Chandigarh


CSIR- Institute of Microbial Technology (CSIR-IMTECH), Sector 39-A, Chandigarh
dr.akashdeep@csio.res.in
2

Recent trends in electrochemical immunoassays have paved the way for metal nanoparticles bursting as
a very promising technique for sensitive evaluation. In this work, we report the competence of
bioconjugated CdTe quantum dot (QD) and gold nanoparticle (GNP) for the detection of Vi capsular
polysaccharide antigen of Salmonella Typhi. The QD and GNP were bioconjugated with anti-Vi
antibody and characterized to quantify the loading of respective nanoparticles. Cadmium chloride and
gold chloride reference standards were used for the evaluation of the respective metal atoms in the
nanobioprobes. The bursting of QD and GNP released 6.91 nmol of cadmium and 83.21 nmol of gold
ions in 1 L each, whereas, the anti-Vi nanobioprobe bursting resulted in the release of 17.29 nmol of
cadmium and 34.75 nmol of gold atoms per 1 g of antibody. The results are indicative of
conjugation of multiple QDs per antibody molecule in marked contrast to the GNPs which can interact
and bind with many antibodies owing to its larger size. CdTeIgG nanobioprobe was, therefore, made
use for developing a new sandwich type stripping voltammetry immunoassay in the presence of
polymyxin B, a cationic receptor molecule, as a capture molecule. The stripping response observed was
much convincing in the range 1 ng to 625 ng of Vi antigen indicating feasibility and reliability of the
QD based stripping assay. The results provided an insight into the governing factors of
immunostripping inferring the potency of biofunctionalized semiconductor/inorganic nanodots for
electroanalytical applications.

Sonochemistry: The Non-Conventional Method of Organic Synthesis


Dr. Satyender Kumar Yadav
FGM Govt. College, Adampur (Hisar).
skyadavgchisar@gmail.com
Sonochemistry i.e. use of ultrasonic waves to chemical reactions has huge potential for innovation in
eco-friendly and eco-efficient chemistry. The sonochemical phenomena originate from the interaction
between suitable fields of acoustic waves and a potentially reacting chemical system. The reaction takes
place through the intermediate phenomena of acoustic cavitations. Sonication enables the rapid
dispersion of solids, decomposition of organics including biological components, as well as the
formation of porous materials and nanostructures. Sonochemistry is also a technique for carrying out
solvent free organic reactions. High yields, low energy requirements, low waste, no use of solvents are
some of the fundamental advantages of these sonochemical techniques. Ultrasonic devices use less
energy than traditional heating systems and achieve superior processing results. Ultrasonication is an
alternative mechanism to heat, pressure, light or electricity to initiate chemical reactions. This
technology is nowadays widely used in fine chemistry and environmental chemistry. The use of
ultrasounds for carrying out chemical reactions proves to be an important tool to meet the goals of
green chemistry by reducing energy requirements and waste products. It has been found that ultrasound
can be used effectively in the treatment of sewage sludge and degradation of dangerous chemicals

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including chlorinated hydrocarbons, aromatic compounds, agrochemicals and pesticides from the
agricultural industry, explosives, dyes from the textile industry and surfactants. The advantages of using
sonochemistry in organic synthesis include milder reaction conditions with improved yields and
selectivities, easy generation of reactive species and replacement of hazardous reagents.
Keywords: Sonochemistry, Acoustic cavitation, Green Chemistry

Synthesis and Characterisation of Ce(III) Doped Polyvinylpyrollidone Capped ZnS Nanoparticles


Seema Maheshwari, Kuldeep Kaur*
1

Department of Chemistry, Mata Gujri College, Fatehgarh Sahib, Punjab


shergillkk@gmail.com
Optical properties of doped semiconductor nanoparticles are of considerable interest as their electronic
structure and electro magnetic elds are drastically modied due to quantum connement effects. In the
present study, Ce doped ZnS nanoparticles were synthesized using co-precipitation method. PVP
(polyvinylpyrrolidine) was used as capping agent. The existence of functional groups was identied
using Fourier transform infrared spectrometer. The optical properties of the synthesized materials were
studied. The doping of Ce3+ ions was found to show signicant inuence on the optical properties of the
synthesized nanoparticles. UV Vis absorption spectroscopy measurements have shown that the
absorption peak of doped ZnS was red shifted compared to undoped ZnS. Optical absorption studies
showed a blue shift in the absorption edge of capped ZnS nanoparticles as compared to uncapped
nanoparticles and hence the effective band gap energy was found to increase due to decreased particle
size which occurs as a result of capping. Photoluminescence measurements revealed that luminescence
intensity of Ce3+ was enhanced considerably by the energy transfer from ZnS. It was evident from
photoluminescence studies that the emission becomes more intensive as the size of the particles is
reduced as a result of capping agent.

Electronic Structure Studies of Aspirin and Paracetamol.


Shikha, Diksha1, O. P. Singh2 And A. K. Sharma1*
1

department of Physics, MMEC, MMU, Mullana (Ambala) 133207 (Haryana) India


department of Physics, Paliwal (P.G.) College, Shikohabad 205135 (U.P.) India
anil67042@gmail.com
2

HF/6-31G calculations have been performed on the electronic structure of aspirin and paracetamol. Net
atomic charges, dipole moment and total energy of aspirin and paracetamol were compared in order to
explore the finer details of these molecules. Comparison shows that redistribution of charges on aspirin
is over larger range (- 0.603e to 0.603e) as compared to paracetamol from this we concluded that
Aspirin is more reactive as compared to Paracetamol as it offer more reactive sites and having more
energy as compared to Paracetamol. Further comparison of total energy from the ADMP calculations
with DFT (B3LYP) at 6-31G level explains the high reactivity of Aspirin. From this study it is very
clear that why it inhibit the synthesis of prostaglandins responsible for pain and Paracetamol is a poor
inhibitor of prostaglandins synthesis.
Keywords: Quantum chemical calculations, Aspirin, Paracetamol, Electronic structure, Net atomic
charges, Bond length, Dipole moment.

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Fig. 1and Fig.2 are the optimized structure of Aspirin and Paracetamol with DFT/6-31G(d)

Fig. 3

Fig. 4
Fig.3 and Fig.4 are the time in trajectory vs energy curves of Aspirin and Paracetamol

Uniform Dispersion of Anisotropic CuO/SBA-15 Nanocomposites for


Nitroaromatic Reduction
Shweta Sareena, Vishal Mutrejab, Satnam Singha and Bonamali Pala
a

School of Chemistry & Biochemistry, Thapar University, Patiala-147004, Punjab, India


Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133207

Well dispersed CuO nanospheres (~ 5 nm) and nanorods were synthesized within the channels of
mesoporous SBA-15 (pore size ~8 nm) by a hydrothermal method using Pluronic P123 as a structure
directing agent followed by surface modification with APTMS. It was found that that the morphology
of embedded CuO nanospecies was strongly influenced by the extent of Cu impregnation. Different
characterization techniques viz., Powder XRD, BET, DRS, XPS, TEM and elemental mapping studies
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were used to characterize the prepared materials. Powder XRD and SEM studies studies confirmed the
presence of CuO nanoparticles within the mesoporous sieves. Elemental mapping depicted the uniform
distribution of CuO nanoparticles on the surface of SBA-15. Moreover, the catalytic activity was found
to increase as a function of Cu loading with an increase in Cu impregnation from 1-10 wt. %
respectively. Among the different synthesized composites, 10 wt. % CuO/ap-SBA-15 catalyst exhibited
the highest catalytic activity for the reduction of different nitroaromatics.

Evaluation of Phytochemicals and TLC optimization in Alstonia


scholaris and Caesalpinia crista of Western Himalayan Region
Raj Kumar Tiwari1, Silpi Chanda2
Asst. Professor, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad-201001
Associate Professor, Faculty, Pharmacy Institute, NIET, Greater Noida-201010 (U.P.)
Alstonia Scholaris is a widespread genus of evergreen trees and shrubs, of the dogbane plant family
Apocynaceae, well known for its anticancer and antimlarial potential. caesalpinia crista
(caesalpiniaceae) plant is well known for its medicinal and therapeutic values in Indian and in various
communities throughout the world, mostly claimed for therapeutic ailments like anthelmintic and antiamyloidogenic activity. The plant parts (bark and seed) were procured from New Delhi, Himachal
Pradesh and were authenticated by Himalayan Forest Research Institute, Shimla. Ethanol extract of
both the plants were prepared and screened for the presence of phytochemical by various color
reactions. Phytochemical screening revealed the presence of alkaloids, glycosides, tannins, flavonoids
and phenols etc. TLC optimization of these plants was also done which showed the presence of several
metabolites in visible and UV range.
Keywords: Alstonia scholaris, Caesalpinia crista, Phytochemicals, TLC

Assessing the Effect of DE-Loop Mutation (D59P) in the Amyloid


Aggregation Propensity of 2-Microglobulin with Molecular
Dynamics Simulations
Simranjeet Singh, Suniba Shuaib, Deepti Goyal, Bhupesh Goyal*
Department of Chemistry, School of Basic and Applied Sciences,
Sri Guru Granth Sahib World University, Fatehgarh Sahib-140406, Punjab, India
simranjeetsinghn@gmail.com, bhupesh22chem@gmail.com
Dialysis related amyloidosis (DRA) is a severe condition characterized by the accumulation of
amyloidogenic 2microglobulin (2m) protein around skeletal joints and bones. Recent studies
highlight the critical role of DE-loop region for the 2m stability and amyloid propensity [1]. Despite
significant efforts, mechanism of enhanced aggregation due to DE-loop mutation (D59P) is still not
well understood. In the present study, explicit solvent molecular dynamics (MD) simulation were
employed to study the changes in structure and dynamics of mutant D59P. MD simulations reveal that
fluctuations in the loop region and exposure of aggregation determining residues to the solvent are
responsible for the enhanced aggregation propensity of mutant D59P. The present study provides
theoretical insight into the mechanism of D59P mutant amyloid aggregation propensity.
Keywords: D59P mutation, Molecular dynamics, 2macroglobulin, DE-loop, Portein Aggregation
References:
1. Santambrogio, C.; Grandori, R. et al. Protein Science 2010, 19, 13861394.
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Synthesis and Characterisation of Molecularly Imprinted Polymer


Nanoparticles for Streptomycin for Use as Solid Phase Extraction
Materials
Simrat Kaur*
Dept. of Chemistry, Mata Gujri College, Fatehgarh Sahib-140406
chemsimrat@gmail.com
A Molecularly Imprinted Polymer (MIP) is a polymer that has been processed using the molecular
imprinting technique which leaves cavities in polymer matrix with affinity to a chosen "template"
molecule. Imprinted nanostructured materials are characterized by their small sizes, large reactive
surface area and, most importantly, with rapid and specific analysis of analytes due to the formation of
template driven recognition cavities within the matrix. These polymers have affinity for the original
molecule and have been used in applications such as chemical separations, catalysis, or molecular
sensors. Streptomycin antibiotic-selective molecularly imprinted polymer nanoparticles were
synthesized by polymerization of acrylic acid and ethylene glycol dimethacrylate in the presence of
streptomycin as template molecule. AIBN was used as initiator. The synthesis was carried out using
precipitation technique. The ratio of template to monomer to crosslinker was chosen to be 1:8:20. The
synthesised MIP molecules were characterised using Fourier Transform Infrared Spectrometer. The
binding experiments were carried out in aqueous solutions and followed using UV-Vis and
fluorescence techniques. Relative to non-imprinted polymer (NIP), the MIPs exhibited much higher
recognizable capacity and specificity to the streptomycin and negligible adsorption for other
compounds. The synthesised compounds could be used as solid phase extraction materials for
extraction of streptomycin from real complex matrices such as honey, milk and plasma.

Streptomyces albogriseolus as a Potential Bioremediation Agent for


Sulfosulfuron
Simrat Preet Kaur, Ridhima Arya, Navnit Kumar Mishra and Anil Sharma*
Department of Biotechnology, Maharishi Markandeshwar University, Mullana-133207, Ambala.
simratpreet1@gmail.com
Herbicides have been used extensively in agriculture which further percolate to the environment posing
a threat to living beings. The use of sulfosulfuron as a herbicide has been well established for years,
however, its excessive use has been a cause of concern because of its health hazards to the mankind.
We isolated a microbial strain identified as Streptomyces albogriseolus from the field soils which
exhibited an interesting phenotype of degrading sulfosulfuron from initial concentration of 10g/ml to
6.62g/ml after 20 hours of incubation. The metabolites were also identified using LC/MS as
aminopyrimidine and a rearranged amine. Hence, it could be concluded that the Streptomyces
albogriseolus strain is safer, cost-effective and holds potential to bio-remediate the harmful and toxic
hcerbicide, sulfosulfuron from the environment. However, a large cohort of field study is required to
truly access the promising bioremediation potential of this microbial strain.
Keywords: Bioremediation; Streptomyces albogriseolus; Sulfosulfuron; Degradation; Environment.

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Synthesis of 3-substituted
antibacterial studies.

chromone

derivatives

for

their

Savita Chahal, Sumit Kumar, Sonia Nain*


Department of chemistry,Deenbandhu Chhotu Ram Uni. Of Sci & Tech. Murthal Soneepat-131039
sonianain.chem@dcrustm.org
A series of 3-substituted chromone derivatives have been synthesized (as shown in scheme below). All
of the synthesized compounds have been characterized from their spectral data and testedfor their
antibacterial activity against both gram-positive andgram-negative bacteria. The activity results
revealed that all the compounds examineddisplayed good activity against all the pathogenic bacterial
strains studied with zone of inhibition between 16 and 20 mm andMICvalues in the range of 50
100g/mLascompared to the standard used.

Systemic pathway for synthesis of 3-substituted chromone derivatives


Keywords. Chromone.Antibacterial activity.Zone of Inhibition.MIC.

Synthesis, Characterisation and Analytical Applications of Novel


Potentiometric Sensor Chromium (III) Boratotungstophosphate
Dr. Harish K. Sharma1, Dr. Pernita Dogra1*, Anju Parmar1
1

Department of Chemistry, M.M.University, Mullana


microsil98@yahoo.com.in
The present research work is done to synthesis and characterise a novel electroactive to be used as a
sensor for the determination of hazardous metal ions .The novel exchanger has been prepared by sol-gel
method using Chromium Sulphate, Sodium tungstate, Orthophosphoric acid and orthoboric acid. The
characerisation of the sensor has been done with FTIR (Fourier Transform Infrared Spectroscopy),
SEM, EDS and X-Ray diffraction studies. XRD Studies showed that the exchanger is having
amorphous geometry. The active sites supporting the acidic character were investigated with the help of
IR spectroscopy. SEM and EDS studies have been done to show the presence of external water
molecules as well as to reveal topography and chemical composition of the exchanger. Membranes
containing different concentration of electroactive material and epoxy resin as binder were prepared.
The membrane with 60% electroactive material and 40% epoxy binder gives the best response. The
selected membrane can be successfully used in the concentration range of 10 -7 M to 10-1 M Hg(II) ions
with a Nernstian slope of 21.5 mV/decade. The electrode shows a fast response time of <10 sec. The
electrode works satisfactorily in the non-aqueous medium and effect of internal solution was also
studied. The sensor works well in the pH range of 2.6 to 9.30. So this pH range was selected as its
working range. Analytical applicapability of membrane sensor was tested by using it as indicator
electrode for determination of Hg2+ ions in the waste water released from batteries manufacturing
industry. FIM has been used for determining the selectivity coefficient with respect to different metal
ions like Pb2+, Cr3+, La2+, Cd2+, Co2+, Hg2+, As3+, Cu2+, Ni2+, Mn2+, SSm3+ etc.

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Keywords: Electroactive sensor, indicator electrode, selectivity coefficient, topography, Nernstian


Slope

Formulation and Characterisation of Dual Drug Loaded Lipid Based


Carrier System
Anikate Sood
LR Institute of Pharmacy, Solan
roouhaniananikate@yahoo.com
Aim of this work was to formulate a lipid based drug delivery system for delivery of dual drugs. Dual
drugs selected were antifungal drug clotrimazole as well as antibacterial drug ciprofloxacin. Dual drug
loaded lipid based drug delivery system was prepared by solvent diffusion method using stearic acid
and oleic acid as lipids. Both the drugs were efficiently loaded into carrier system. Prepared carrier
system was characterised by scanning electron microscopy, dynamic light scattering and FTIR for
surface morphology, size and stability. Developed carrier system was found to be spherical in shape
with size below 600 nm. Dual drug loaded lipid based nanostructure was found to release both the
drugs simultaneously. This kind of drug delivery system may be used to treat antibacterial as well as
antifungal disease simultaneously.

Chemical Analysis of Municipal Water Samples of Gurgaon


Charu Agarwal
Department of Applied Sciences, IILM Academy for Higher Learning, Greater Noida
charu.agarwal@iilm.ac.in
Various required parameters like Total dissolved solids, pH, Biological oxygen demand, hardness etc.
for water analysis were determined and results were compared with the standard values which are
required for drinking water approved by health agencies. Best quality municipal water is marked
through the studies and also the area which is best as per the quality of water. Municipal water was
having low BOD levels which were within the limits. It was observed through the analysis that in some
sectors tap water was not up to the mark but it may be changed into a better form after required
treatment.
Keywords: Chemical Analysis, Water Analysis, Municipal Water, Analytical Methods,
References
1. Mayur C Shah, Prateek Shilpkar and Sangita Sharma, Asian J Chem. 19(5), 3449-3454 (2007).
2. Ayibatele N.B.; First Seosun Environmerital Baseline Survey, In proc. of internal. conf. on water
and environ., 1, 4-26, (1992)
3. Mishra K.R., Pradip, Tripathi; S.P, Groundwater Quality of Open Wells and TubeWells, Acta
Ciencia Indica, XXXIIIC, 2, 179 (2002)
4. Gupta V., Agarwal J., Sharma S.; Adsorption Analysis of Mn(VII) from Aqueous Medium by
Natural Polymer Chitin and Chitosan, Asian J. of Chem., 20(8), 6195-98 (2008)
5. Tahir M.A., Rasheed H. and Malana A.;Method development for arsenic analysis by modification
in spectrphotometric technique, Drik. Water Eng.Sci. Discuss. 1, 135-154 (2008).

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To Study the Effect Of Urtica Dioica Extract On DiabetesMediated


Alteration in Glucose Transporter.
Sahil Gupta, Sita Sharan Patel, Dr.Udayabanu. M
Jaypee University of Information Technology Wkanaghat
Diabetes mellitus is metabolic disorder which results from insufficient insulin release or insulin
resistance. Diabetes mellitus cause functional abnormalities in the hippocampus and affect cognitive
function Animal models suggest that knock out of GLUT4 will result in insulin resistance whereas its
overexpression will restore glucose disposal and insulin sensitivity. Dysregulation of glucose
transporter 4 result in insulin resistance. Diabetes results in reduced expression of mRNA in
hippocampus. . Scopoletin a chemical constituent of Urtica dioica UD modulates the expression of
peroxisome proliferator-activated receptor- which is involved in the neuronal insulin receptor
functioning in the hippocampus and reduction of corticosterone level during diabetes. Streptozotocin
induced diabetes is a well documented model of experimental diabetes. STZ is a pancreatic cell toxin
that induces rapid and irreversible necrosis of cells. In the present we studied effect of UD extract on
diabetes mediated impairment in hippocampal GLUT4 translocation. Streptozotocin (STZ) (50 mg/kg,
i.p. consecutively for 5 days) was used to induce diabetes followed by UD extract (50 mg/kg, oral) for 8
weeks. By using western blot analysis we investigated the effect of hydro alcoholic extract of Urtica
dioica on hippocampus of diabetic mice. Herein, we observed that STZ significantly down regulated
the GLUT4 translocation in hippocampus. Further, we found that chronic UD treatment significantly
increased the GLUT4 translocation in hippocampus of diabetic mice comparable to rosiglitazone.
Modulation of GLUT4 protein in hippocampal plasma membrane might be responsible for glucose
homeostasis, learning and memory. UD might prove to be effective herbal drug for the treatment of
diabetes mellitus and its associated neurological disorder such as cognitive dysfunction. Present study
results demonstrate that chronic UD treatment increases the expression of GLUT4 in plasma membrane
of hippocampus which is isolated from STZ induced diabetic mice. It also been demonstrated that
chronic rosiglitazone treatment improve plasma membrane GLUT4 content.

Lipophilic peptide Multi-Nucleoside reverse transcriptase inhibitor


conjugates synthesis to combat HIV resistance
Bhupender S. Chhikara,1,2 Keykavous Parang2,3
1

Department of Chemistry, Aditi College, University of Delhi, Bawana, Delhi


Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI,
USA.
3
Pharmaceutical Sciences, Chapman University, Irvin, California, USA
The introduction of highly active antiretroviral therapy (HAART) in the mid-1990s resulted in a
significant decrease of morbidity and mortality in the human immunodeficiency virus-1 (HIV-1)infected patient population. A combination of nucleoside reverse transcriptase inhibitors (NRTIs) is
used in HAART to reduce the patients viral load. Each nucleoside analog, however, has different
cellular uptake rates and pharmacokinetics, and poor patient compliance during long-term use of
combination therapy and emergence of drug resistance compromise the sustained efficacy of HAART.
NRTIs succumb to newly-developed resistant virus. We have synthesized Mono-, di-, and trinucleoside
conjugates of natural moieties and peptide scaffolds containing nucleoside reverse transcriptase
inhibitors as anti-HIV agents. Among dinucleoside glutamate ester derivatives, N-myristoylated
2

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derivatives showed significantly higher anti-HIV activity than the corresponding N-acetylated
conjugates against cell-free virus. Myristoyl-Glu(3TC)-FLT (EC50 = 0.3-0.6 M) and myristoylGlu(FTC)-FLT ( EC50 = 0.1-0.4 M) conjugates were the most active glutamate-dinucleoside
conjugates. A trinucleoside glutamate derivative containing AZT, FLT, and 3TC (EC 50 = 0.9-1.4 M)
exhibited higher anti-HIV activity than AZT and 3TC against cell-free virus. This Compound also
exhibited higher anti-HIV activity against multi-drug (IC50 = 5.9 nM) and NNRTI (IC50 = 12.9 nM)
resistant viruses when compared with its parent nucleosides. These results where glutamate conjugates
of 2-3 nucleosides can be used to generate potent anti-HIV agents for therapeutic and preventive
purposes will be discussed.

Crystallite Size Dependence on Photocatalytic and Antimicrobial


Activity of Microemulsion Mediated Synthesized ZnO Nanoparticles
Annealed at Different Temperatures
Jyoti Sharma*1, Manu Vashishtha2 & D. O. Shah1
1

Shah-Schulman Center for Surface Science and Nanotechnology, Dharmsinh Desai University,
Gujarat, India
2
Department of Chemical Engineering, Indian Institute of Technology, Mumbai
shjyoti_06@yahoo.com
The synthesis of ZnO nanoparticles has attracted considerable interest because of their unique
properties and potential applications in a variety of solid state devices, catalytic media etc. By using
water-in-oil (w/o) microemulsions, nanodroplets of water were used as chemical reactor to synthesize
nanoparticles of zinc oxide. Addition of reducing agent NH4OH and zinc salt followed by heat
treatment results in the formation of zinc oxide nanoparticles (NPs).On increasing annealing
temperature of ZnO NPs, crystallize size increases which, in turn, decreases the band gap energy and
photocatalytic degradation efficiency of phenol. Furthermore, crystallize size also affects the
antimicrobial activity of ZnO NPs. It has been observed that on increasing annealing temperature,
crystallize size increases which results in the decrement of antimicrobial activity.
Keywords: microemulsion, ZnO nanoparticles, size-selective catalysis,antimicrobial activity

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Synthesis and Reactivity of Ru-DMSO Complexes


Kusum
K.M GOVT College Narwana
Kusumsagguchem@gmail.com
Platinum-group metal halide-sulfoxide complexes, and dimethyl sulfoxide (DMSO) complexes in
particular, have a rich chemistry and widely used as precursors in inorganic synthesis. Even though the
coordination chemistry of DMSO has been used as a subject in past. Most of the examples will concern
cis-RuCl2(DMSO)4. According to the accepted binding model DMSO coordinates through O induces a
decrease in the S=O bond order, while the opposite occurs through S. Thus the average S-O bond
distance for O-bonded sulfoxide is markedly shorter and longer than that of free sulfoxide. These
differences in bond length are reflected in the frequency of the SO stretching mode: vSO for dmso-S is
higher, and for dmso-O is lower compared to free DMSO. Beside X-ray crystallography and infrared
spectroscopy, H NMR spectroscopy also a powerful tool for determining the binding mode of DMSO
and the geometry of diamagnetic complexes. In the H NMR spectra, coordinates through oxygen
induces small downfield shift of dmso resonances compared to that of free DMSO, while coordinates
through sulphur induces larger downfield shift. In particular some of the precursors or their substituted
derivatives have antitumour and radiosensitizing properties, some have been used as a catalyst
precursors in several processes, such as air oxidation of thioethers to sulfoxides and sulfoxide to
sulfones oxidation of saturated hydrocarbons, alcohals, amines. In the view of current reports on the
ruthenium complexes containing diamino ligands and monocarboxylate, thiol group containing
containing biipyridine ligand.Initally 2-mercapto -4-methyl-5-thiozole acetic acid react with
Rucl2(dmso)4 which result to the formation of compound. This reaction occurs via attack of N,SH
donor. 1 mole of 2-mercapto-4-methyl-5-thiozoe acetic acid reacts with 2 mole of RuCl2 (DMSO) 4.
Similar reaction is performed with Zn, Ir, and Os. These complexes have antitumour and
radiosensitizing properties.

Wound Healing and Hemolytic Activity of Different Extracts of


Arnebia benthamii
M. A. Rather, Y. Singh, R. P. Singh, D. P. Pandey*
Department of Chemistry Govt. P. G. College, Uttarkashi-249 193, Uttarakhand India.

aslam.aslam2006@rediffmail.com , pandeydp_123@rediffmail.com
In present investigation it was revealed that the Chloroform extract of roots of Arnebia benthamii
showed maximum wound healing activity. The chloroform extract of roots & leaves possess minimum
hemolytic activity. Therefore, it would certainly help to ascertain the potency of the chloroform extract
of roots of A. benthamii as a potential source of natural wound healing remedy. Arnebia benthamii a
herbaceous perennial herb belonging to the family Boraginaceae is a high-value medicinal plant that
occurs in the alpine and subalpine Himalaya. The flowering shoots are used for making various
products such as syrup and jam. Gule Kahzaban a very costly medicine is isolated from it. It is
principally used in several cases of chronic constipation, fever, cough, cold and wound healing. Arnebia
benthamii plant is used in various diseases e.g. cardiac disorder, fungal infections, jaundice and urinary
problems. The Phytochemical screening of the` Arnebia benthamii plant extracts showed the presence
of alkaloids, phenols, anthraquinones and flavonoids in aerial part and root part extracts of the plant and
the root part extract showed the presence of terpenoids.
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Keywords: Arnebia Benthamii, wound healing, Hemolytic Activity.

Synthesis of Nanomaterials by Fabricating AAO Membranes


Manoj Kumar,1* Rajshree Khare,2 , Hardeep Singh Tuli,3 And Vinod Kumar4
1

Dept. of Chemistry, MM University Sadopur


Dept. of Chemistry, MM University Mullana
3
Dept. of Biotechnology, MM University Mullana
4
Dept. of Physics, Indus PG college, Kinana
2

Various nanoporous AAO membranes have been obtained by varying different parameters such as
applied voltage, temperature of electrolyte, electrolytic concentration and speed of rotation of
electrolyte in two step anodization process. SEM analysis performed for evaluation of results. The
relationship between pore size and variation of different parameters obtained. The synthesized
membranes have been used as template for the synthesis of carbon nanotubes of different nano
dimensions.

Asias Fight Against Disasters: An Indigenous Approach


Megha Bedi and Saniya Ahluwalia
Civil Engineering Department, MMEC, MM University Mullana
1
meghabedi@mmumullana.org, 2saniyaahluwalia@mmumullana.org
Asian communities are extremely vulnerable to disasters caused by natural hazards- such as
earthquakes, cyclones, tsunami, droughts, landslides, and floods along with environmental emergencies
such as deforestation, soil erosion, land degradation, loss of biodiversity, and environment pollution in
combination with social factors such as inequality and poverty. The 21st century has witnessed the
demise of more than 70,000 people annually by disasters caused by natural hazards in the region. It has
thus become necessary to develop strategies to tackle these threats and integrate them within wider
development contexts. Efforts to mitigate the impacts of hazards and climate change tend to focus on
infrastructure and scientific development. These solutions save lives when hazards strike, however,
they need to be complemented by actions to address risks surrounding the hazard and the underlying
components of vulnerability. Indigenous knowledge has become an important tool in this respect which
enables rural people and local communities to actively participate in the decision-making process. Up
until recently, Local and Indigenous Knowledge Systems have been regarded as inferior to science and
technology. It has been viewed as a factor that has hindered the development process of communities.
However, since the 1990s, such attitudes have largely shifted, and the positive contributions of Local
and Indigenous Knowledge Systems have become widely acknowledged. This paper provides the
insight to the efforts being made by local people using indigenous knowledge to promote sustainable
activities for combating disasters and improving livelihoods. Indigenous knowledge including the
observation of animal behaviour, celestial bodies and the environment are used to mitigate hazards. It
includes a series of natural phenomena learned through songs, stories, short poems and lullabies.
Communities have traditions and faith based on beliefs and practices that are embedded in their culture.
Local and indigenous knowledge can also be included in other forms of awareness-raising and
educational activities to increase community resilience as well as to preserve a communitys social
capital. The key is to find ways to combine local and indigenous knowledge with scientific knowledge.
In addition strategies that communities have developed to prepare for disasters based on their resources
and knowledge could be adapted by other communities who are beginning to face these conditions.

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Indigenous knowledge is a thus a powerful resource and therefore a key element in the fight against
humanitarian aspects of emergencies worldwide.
Keywords: Indigenous knowledge, disaster risk reduction, vulnerability, humanitarian crises .

Synthesis, Characterization and Biological Evaluation of NSubstituted Heterocyclic beta-Lactam Derivatives


Rajneesh Kaur, Raman Singh and Kuldeep Singh*
Department of Chemistry, MMEC, M. M. University Mullana 133207
Antibiotics are widely used in the prevention and treatment of infectious diseases. Many types of
antibiotics exist, but -lactam based antibiotics are still the most trusted line of defense as resistances to
other antibiotics has grown, dropping interest in novel antibiotics by pharmaceutical companies will
greatly hinder the development of new drugs to treat drug-resistant pathogens. While -lactam
antibiotics continue to be administered, it is clear that in recent years bacterial resistance has grown
remarkably quickly and new drugs are urgently needed. Keeping this view in mind, in this poster we
report our initial studies. We synthesized a number of azomethylene moiety containing pyridine
derivatives. These derivatives will be further modified to various systems. The synthesized molecules
showed good antibacterial activity.

Preparation of some Benzo 1,5-Diazepine


Kulbir, Raman Singh, Kuldeep Singh*
Department of Chemistry, M. M. University Mullana
research@orgsyn.in
A number of substituted chalcones were synthesised by base catalysed condensation of substituted
aromatic aldehyde with substituted acetophenone in good yield. These chalcones derivatives were
further condensed withortho-phenylene diamine to yield Benzo1,5-diazepine derivatives in moderate
yield. All the compounds were characterized by 1H-NMR spectral data. These compounds may have
good pharmacological activity against bacteria.

Extractive Oxidative Desulfurization of fuels with Hydrogen Peroxide


in presence of catalysts
Nisha,1 Pooja Yadav,1 B R Nautiyal, 1* and Rakesh Yadav2
1
CSIR-Indian Institute of Petroleum, Dehradun 248005, India,
2
Deptt. of Chemistry, DBS College, Dehradun-248001, Uttarakhand, India
nisha@iip.res.in, brnautiyal@iip.res.in
Sulfur in fuels causes pollution by emitting SOx and particulate matter (PM) from internal combustion
engines. Gas oil is the main stream which makes major transportation fuel such as diesel. In view of
environmental concerns more stringent specifications for sulfur in fuels are being implemented by
developed countries and put regulations to reduce sulfur to 15/10 ppm by 20091 in diesel fuel. Our
country will also adopt Euro VI specs (i.e. 15 ppm sulfur) of gasoline and diesel by April, 2020.
Conventional hydrodesulfurization (HDS) process reduces sulfur to the order of 350-500 ppm.
However, alkyl substituted dibenzothiophenes like 4,6-dimethyldibenzothiophene are refractory to
HDS due to steric hindrance and difficult to remove to a great extent 2. In order to produce ultra low
sulfur diesel (ULSD) fuel, deep HDS technique with severe operating conditions is to be adopted which
is expensive due to application of costly hydrogen (which in turn also responsible for green house gas
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(GHG) emission). Hence, alternative methods are gaining importance among which oxidative
desulfurization (ODS) has attracted worldwide attention due to inherent advantages like mild reaction
conditions and low cost.
In ODS, sulfur compounds present in fuels are oxidized to more polar sulfones / sulfoxides to facilitate
their removal by solvent extraction or adsorption. Various oxidation systems have been reported in the
literature for this transformation. Among these oxidants like hydrogen peroxide (H 2O2) and carboxylic
acid as catalyst 3-5. For the chemical industry, it becomes more and more important to develop cleaner
technologies. Solvent extraction processes are used to separate sulfones / sulfoxides from oxidized
fuels. These processes required suitable and selective solvents for separation of oxidized sulfur
compounds from petroleum feedstocks.
We, at IIP carried out certain oxidation studies and report the results on oxidation of sulfur compounds
present in gas oil using carboxylic acid / H 2O2 system. Extent of sulfur removal in gas oil after
oxidative desulfurization was monitored by sulfur analysis. Oxidation and solvent extraction reduced
sulfur in gas oil from 1.5% to 0.20% in single stage batch extractor.
Keywords : extraction, oxidation, fuels, hydrogen peroxide
References:
1. Gosling, C.D.; Gembicki, V. A.; Gatan, R. M.; Cavanna, A.; Molinari, D. National Petrochemical
and Refiners Association
2. (NPRA), Annual meeting, AM-04-48, March 21-23, 2004, San Antonio, TX.
3. Babich, I. V.; Moulijn, J. A. Fuel 2003, 82, 607-631.
4. Ishihara, A.; Wang, D.; Dumeignil, F.; Amano, H.; Qian, E. W.; Kabe, T. App.Catal. A; General
279(2005) 279-287.
5. Sampanthar, J. T.; Xiao, H.; Dou, J.; Nah, T-Y.; Rong, X.; Kwan W-P. App. Catal.B Environ
2006,63 85-93.
6. Shiraishi, Y.; Taki, Y.; Hirai, T.; Komasawa, I. Chem Commun. 1998, 2601-02.

Bacteriophage Conjugated Metal Organic Framework for Sensitive


Detection of S. arlettae
Neha Bhardwaj1,2, Akash Deep1,2*
1

Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30 C, Chandigarh, 160030, India


Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30 C, Chandigarh, 160030, India

Bacteriophages are obligate parasites that infect and hijack the cellular machinery of a host bacterium
for their own growth and multiplication. These are an important class of bio-recognition elements that
use their tail proteins to recognize the host bacterium with target specificity to the strain level. The
bacteriophages possess several advantages compared to the conventional antibodies used in biosensors,
including, high stability in variable environmental conditions (e.g., change in pH / temperature),
differentiation between the viable and dead cells, no requirement of sample pre-processing, self-signal
amplification and a favourable cost of device production. Recently, some researchers have proposed the
applications of bacteriophage immobilized carbon electrodes for electrochemical detection of bacteria
based on the bacterial lysis process requiring longer growth periods. Fluorescence based sensing of
bacteria has also been proposed using different bacteriophage conjugated nanomaterials, such as
nanoparticles, quantum dots, organic dyes, etc. However, since the size of bacteriophages is quite larger
than the small sized quantum dots or nanoparticles, they may not produce an effective design of a
fluorescent bacteriophage sensor. In the present work, we have proposed the development of a
bacteriophage conjugated MOF opto-sensor for rapid detection of Staphylococcus arlettae.
Luminescent metal organic frameworks (MOFs) have been proposed for several, biological
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applications, including molecular sensing, drug delivery, imaging, etc. The particle size properties of
the MOFs are tunable from nanosize to microsize based on different synthesis procedures. Further, the
large surface area and high stability (thermal and mechanical) of MOFs aid in higher biomolecule
loading. Here, a micron-sized fluorescent metal organic framework IRMOF-3 (amine group containing
MOF), which is made up of zinc ions (as metal unit) and amino terephthalic acid (as organic linker),
has been explored. The bacteriophageIRMOF biosensor may have advantageous properties, such as
low cytotoxicity, rapid response, high stability and favourable cost, it may be possible to advocate its
use as a real-world and practically viable bacterial sensor. The proposed bacteriophage based optosensor provided a low detection limit (100 cfu/mL) along with specificity in the detection with respect
to other some non-specific bacteria, e.g. S. aureus and E. coli.
Keywords: Metal organic framework, bacteriophage, bacteria, fluorescence, sensor.

A Novel Fluorescent Sensing Technique for Dipicolinic acid


Sanjeev K. Bhardwaj1,2, Neha Bhardwaj1,2, Jyotsana Mehta1,2, Amit L Sharma1,2,
Akash Deep1,2*
1

Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30 C, Chandigarh, 160030, India


Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30 C, Chandigarh, 160030, India

Dipicolinic acid (DPA, pyridine-2,6-dicarboxylic acid) is a major constituent of bacterial spores,


representing about 515% of spore dry weight. Several bacterial organisms such as B. cereus, B.
subtilis, Clostridium botulinum, Clostridium difficle, Bacillus anthracis etc produce spores (toxins) as
their dormant states under unfavorable environmental conditions. Such spores are highly resistant to
heat, biocides and radiation treatments and cause infectious diseases in animals and humans such as
anthrax, tetanus, food poisoning etc. Also, bacterial endospores are used as biowarfare agents which
poses a serious concern towards national security. Thus, rapid and ultrasensitive detection of the spores
is highly desirable for prevention and control of diseases caused by them. Various biological and
chemical methods have been developed by researchers for detection of bacterial spores. The biological
methods include polymerase chain reaction (PCR) and immunoassays, while the chemical methods
include surface-enhanced Raman spectroscopy (SERS), high-pressure liquid chromatography,
electrochemical detection and fluorescent detection. However, fluorescent sensors using lanthanide ions
is one of the promising method for detection of bacterial endospore marker i.e. dipicolinic acid (DPA)
due to the unique optical properties of lanthanide ion-DPA complex. Terbium ion based luminescence
assays have been largely developed by researchers for quantitative detection of DPA due to selective
energy transfer of DPA to terbium ions. Recently, metal organic frameworks (MOFs) are being used by
researchers for detection of DPA due to their porous crystalline structure and excellent properties such
as high surface area, tunable size and porosity, optical and electronic properties etc. In the present work,
a terbium based MOF has been green synthesized using terbium nitrate (metal ion) and trimesic acid
(ligand) at room temperature. The synthesized MOF was characterized using analytical techniques, viz.
UV-vis spectroscopy, FTIR, SEM and Confocal microscopy. Further, the synthesized MOF was used
for photoluminescence based sensing of different concentrations of DPA with LOD of 0.04 nM. The
results imply that the proposed approach can be extended further for development of nanoplatforms
which can detect DPA in a rapid and sensitive manner.
Keywords: Metal organic framework, bacteria, endotoxins, sensor.

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CoMFA/ CoMSIA Studies on Peripherally Acting CB1 Receptor


Antagonists as Anti-Obesity Agents
Mayank Kumar Sharma, Prashant Murumkar, Mange Ram Yadav
Faculty of Pharmacy, Kalabhavan Campus, The Maharaja Sayajirao University of Baroda, Vadodara
390 001, India
Obesity is a major health problem now a days and the number of overweight and obese population is
increasing day by day. Peripherally acting CB1 receptor antagonists could be a potential therapeutics in
the management of obesity. Thus, 3D-QSAR studies have been performed on 1,5-diaryl pyrazole
containing compounds to identify the essential structural requirement for the peripheral CB1 receptor
antagonists. The best CoMFA model was developed by using database alignment having cross
validated r2 = 0.552 with 6 components, non cross validated r2 = 0.973, SEE = 0.162 and F-value =
281.239. Further, the same alignment was utilized for the development CoMSIA model in which the
best results was obtained by a combination of steric, hydrophobic and hydrogen bond acceptor fields
showing cross validated r2 = 0.571 with 6 components, non cross validated r 2 = 0.960, SEE = 0.196 and
F-value = 188.701. The predictive r2 value of CoMFA and CoMSIA models was 0.528 and 0.679
respectively indicating that the CoMSIA model was better than the CoMFA model. Different validation
parameters were used to validate the best developed model for its accuracy and reliability. Thus, steric,
hydrophobic and hydrogen bond acceptor fields are the governing parameters for the CB1 receptor
antagonistic activity of 1,5-diaryl pyrazole derivatives. The developed model can be utilized for the
designing of novel peripherally acting CB1 receptor antagonists for the treatment of obesity.

Nematode Paradoxical Activity of Naturally Occuring Biologically


Active Compounds
Inderjeet, Anirban Deb, Jasveen Khanduja, Narender Chaudhry
Department of Chemistry, Maharishi Markendeshwar University, Mullana, Haryana-133203, India
narender@humanoid.net
Plant parasitic nematodes are known to be most challenging problem of crop plants to tackle. Beyond
the fact that these are very simple triploblastic animals having a hydroskeleton, it is cumbersome to
completely eliminate them from fields. They may hibernate for a very long period and may suddenly
cause a damage and the intensity of damage may be beyond any recovery. Though above ground
symptoms caused by these organisms are insufficient to detect the causal agent as a nematode and
hence it becomes more difficult to control the damage in time. Only solution to this problem is to
incorporate a biological compound in the soil which not only improves the fertility but also keeps the
population of this pest below threshold level of crop damage. For this purpose, neem i.e. Azadirachta
indica, datura and cannabis plants were taken into consideration. Their leaves were powdered and
mixed separately in soil samples (at the rate of 10 gram powdered mix in 100 grams of rhizosphere soil)
from heavily infested field of rice cyst . Resultant mixtures were kept at 22C in a BOD incubator for
48 hours and finally nematode extraction was done by using modified baermanns funnel method.
Nematode count was done under a stereomicroscope in triplicate for 1 ml of homogenous water sample
collected . It was noted that nematode count per gram of soil in control mixture (untreated) was 8,000
however in case of neem treated soil was 2500, in datura it was 6000 and in cannabis it was 5000.
Though initially it seems, neem powder acts as a nematicidal agent, however role of temperature and
pH of the soil in increasing or decreasing the activity of the neem powder can not be ruled out. It can
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also be the possibility that nematodes lose their motility in such soils having neem extract, because
baermanns funnel method chosen to extract nematodes is based on active movement of nematodes.
Hence it cannot be said that whether the nematodes were killed or were immobilized. To determine,
whether leaf powder of plants exhibited nematicidal or paradoxical activity, similar experiment as
above was carried with an exception that decanting and sieving method was followed to obtain total
nematodes in the soil samples. When extracted nematodes from such samples were examined under
stereomicroscope, it was found that most nematodes from control soil sample(untreated) exhibited
sigmoidal movements and were vermiform. However nematodes from neem treated samples, exhibited
sluggish movement and were J shaped. Nematode count having straight slender body was nearly
equivalent in both the treated and non treated samples. Present study though is not aimed at increasing
the mortality of nematodes or nematicidal activity of biologically active compounds, however
strengthens our belief in using plant products as amendment to soil in order manage nematode attack
beyond parasitic threshold limits.

2, 5-Disubstituted-1,3,4-Oxadiazoles as DNA Photo-Cleaving Agents


Kumar Sunil1, M. Kumar2, V. Kumar2, V. Beniwal3
1

Department of Chemistry, Govt. College for Girls, Hisar, INDIA


Department of Chemistry, Maharishi Markandeshwar University, Mullana-Ambala 133207, INDIA
3
Department of Biotechnology, Maharishi Markandeshwar University, Mullana (Ambala) 133207
chahal_chem@rediffmail.com, vinodbatan@gmail.com
2

Some 2,5-disubstituted-1,3,4-oxadiazole derivatives have been synthesized conveniently via oxidative


cyclization of various newly synthesized aryl/heteroaryl hydrazones by diacetoxyiodobenzene in
dichloromethane under mild reaction conditions. In addition, the effect of electron
withdrawing/releasing group on the formation of products has also been studied. Compounds were
obtained in good yields and their structures have been established on the basis of their FT-IR, 1H, 13C
NMR and mass spectral data. Here, total forty-two compounds (hydrazones as well as oxadiazoles)
were synthesized and investigated for their DNA photocleavage potential using plasmid DNA. It has
been observed that benzoylhydrazones showed good DNA photocleavage activity in comparison to
their corresponding oxadiazoles.

2-(3, 5-Dimethyl-1H-pyrazol-1-yl)-1-arylethanones
Anticancer Agents

as

Potential

Vinod Kumar*
Department of Chemistry, M. M. University, Mullana-Ambala, 133207, India
vinodbatan@gmail.com
In continuation of our efforts to find new biologically active agents, a regioselective synthesis of a
series of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-arylethanones 4a-k has been achieved under facile,
extremely mild and greener reaction conditions with excellent yields. The structures of the compounds
were established on the basis of a combined use of IR, NMR (1H, 13C) spectroscopy, mass
spectrometry and elemental analysis. All the compounds were evaluated for their anticancer activities.
To explore the biological potential, the compounds were screened for their cytotoxic activity on colon
(HCT116 and HT29), prostate (DU145), ovarian (SKOV3) and lung (A549) cancer cell lines. The
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compound 4j was found to be cytotoxic to all the cancer cell lines, except SKOV3, with more
selectivity towards the colon cancer cell lines (HCT116, HT29) and A549 lung cancer cell line. On
A549 lung cancer cell line, 4j and 4k exhibited similar potency as carboplatin in inhibiting cell
viability. The details of the work will be presented in the poster presentation session.
Keywords: Regioselective synthesis, anticancer activity, Pyrazoles, NMR spectroscopy.

Azoles: Introduction, Current and Future Scope


Vinod Kumar*, Anil Kumar
Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India
vinodbatan@gmail.com
Azoles are five-membered nitrogen containing heterocycles and some of them are widely distributed in
nature. Owing to diverse biological properties they have gained much more attention in different fields
of science. Most of the drugs are either originally natural products or their biomimetic compounds
bearing different types of azoles. In view of these mentioned facts, we pursued the research study on
some important Azole derivatives, particularly, Pyrazole, Imidazole, Triazole, Isoxazole, Oxadiazole
and thiazole compounds. Globally, though a large number of compounds belonging to azole family
have been designed and synthesized, our lab also contributed significantly to add some new highlights
in this field. Our main focus centers on the establishment of the structures of a wide variety of novel
azoles on the basis of their NMR (1H, 13C and 19F) spectral characteristics besides to explore their
biological potential. Research interests focusing on the structural reinvestigations, greener approaches,
synthetic, and mechanistic aspects of azoles of medicinal interests also remain the parts of the core
areas of research. In recent past, our group has synthesized some novel anti-cancer, DNA photocleaving
agents, anti-inflammatory and antimicrobial azole derivatives. In future, the design and synthesis of the
hybrids of these heterocycles may generate a lot of opportunities in the field of medicinal chemistry.

Synthesis and Anticancer Activity of Some Novel 1,3,5-Trisubstituted


pyrazolines using MDA-MB-231 and Hep-G2 cancer cell lines
Mayank Kinger,a* Sushil Kumar,a Sang Wook Kim,*b
a

Department of chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana,


Department of Advanced Materials Chemistry, College of Science & Technology, Dongguk
University-Gyeongju, 780-714, Republic of Korea.
b

A novel and extensive set of 1,3,5-trisubstituted pyrazolines has been synthesized from
1,3diaryl/heteroarylprop-2-ene-1-ones and evaluated for their in vitro cytotoxicity against two cancer
cell lines, one human breast cancer cell line MDA-MB-231 and hepatocarcinoma cell line Hep-G2. The
structure-activity relationship studies of the synthesized compounds revealed that modifications at R 1
and R2 positions of the pyrazoline ring affects the binding of acetyl pyrazoline derivatives with these
cell lines. All the tested compounds showed good anticancer activities. Amongst the compounds, 1acetyl-5-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-(thien-2-yl)-2-pyrazoline and 1-acetyl-5-(3-methyl-1phenyl-1H-pyrazol-4-yl)-3-(4-nitrophenyl)-2-pyrazoline strongly inhibited the progression of MDAMB-231 and Hep-G2 cell lines with IC50 value of 1.46 & 3.17 and 5.7 & 3.9 m respectively.
Therefore, structural modification or as such these1,3,5-trisubstituted pyrazoline would act as
promising anticancer agents in future.
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Keywords: Prop-2-ene-1-ones, heteroaryl, pyrazolines, pyrazoles, anticancer.

Graphene and Its Electronic Properties


Sharad Sharma,1* Sakshi Nagpal,2 Vinit Mishra,2 Kuldeep Singh2*
1

Electronics and Communication Engineering Department, M. M. Engineering College, Maharishi


Markandeshwar University, Mullana, Ambala - 133207
2
Chemistry Department, M. M. Engineering College, Maharishi Markandeshwar University, Mullana,
Ambala - 133207
Sakshinagpal005@gmail.com,vinit1996mishra@gmail.com, sharadpr123@rediffmail.com
Grahene is most sought after material to construct next generation electronic circuitry. Graphene based
transistors have developed rapidly and are new considered an option for post silicon electronics.
Graphene transistor include opening a sizable and well defined band gap in Graphene making large
area. Graphene also enables flat speakers for mobile audio system. Researchers have used grapheme to
produce a speaker that does not require acoustic box. Atomically thin transistors and circuits made of
graphene and molybdenum disulfide (molybdenite) can now be chemically assembled on a large scale.
Researchers hope that atomically-thin grapheme based devices will allow Moores Law to
continue once it becomes impossible to make further progress using silicon. Graphenes remarkable
heat conductivity has led to a lot of research into using it to for thermal management in electronics. It
has been observed that the electrostatic interactions between electrically charged particlesknown
as Coulomb interactionsin different layers of multi-layered graphene offers a key mechanism for
dispersing heat. This occurs despite the fact that all electronic states are strongly confined within
individual 2D layers.
Keywords: Bandgap, conductivity, thin transistors

Synergistic Effect of THF with Amines as Vapour Phase Corrosion


Inhibitor for Mild Steel under Atmospheric Conditions at High
Temperature
V. Saini, H. Kumar*b and S. K. Sainic
a

Dept. of Chemistry, Janta Girls P.G. College, Ellenabad, Haryana 125102, India.
Dept. of Chemistry, Ch. Devi Lal University, Sirsa, Haryana 125055, India.
c
Dept. of Physics, M.D. College Rawatsar, Rajasthan 335524, India.
dony84@rediffmail.com, harimoudgil1@gmail.com
*b

Industrialization and modernization has made a strong demand of steel and their maintenance for a
strong infrastructure for every country in the race of survival, stabilization, growth and competition.
Atmospheric corrosion may cause some dangerous and expensive damage to everything from
automobiles, home appliances, water systems to pipelines, bridges and public buildings like other
natural hazards such as earthquakes or several weather disturbances. Atmospheric corrosion can
aggressively accelerate the rate of degradation of steel during their manufacturing, processing, storage
and transportation. In these cases, traditional methods to prevent corrosion are not suitable which
provide scope of vapour phase corrosion inhibitors in industries, defense and daily life. Synergistic
effect of Tetrahydrofuran (THF) was tested for mild steel in different aggressive conditions like
atmospheric condition, SO2 environment and salty environment with aliphatic (Tetramethylenediamine
and 1-Benzylimidazole) and aromatic amines (N-Ethylaniline, 1-Benzylimidazole) by Vapour Pressure
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Determination Test, Weight loss test, Eschke test, Salt spray test and Sulphur dioxide test at 50oC.
Mechanism of inhibition of corrosion and surface study of mild steel was also studied by Metallurgical
Resesarch Microscopy and Scanning electron Microscopy.
Keywords: Synergistic effect, Eschke test, Salt spray test, Vapour phase corrosion inhibitor, Weight
loss test, Sulphurdioxide test, TU, Aliphatic amines, Aromatic amines.
References:
1.
2.

K. I. Bolotin, K. J. Sikes, Z. Jiang, M. Klima, G. Fudenberg, J. Hone, P. Kim, and H. L. Stormer,


Solid State Commun., 2008, 146, no. 9/10, 351355.
X. Li, X. Wang, L. Zhang, S. Lee, and H. Dai, Science, 2008, 319, 1229.

Study of Some Physico-Chemical Characteristic Properties of


Ground Water in the Villages of Uchana Block in Jind District,
Haryana.
Dr. Sunita Lega
Assistant Professor,Department of Chemistry, Dayanand College Hisar
legasunita@gmail.com
Pure and safe drinking water is a basic need of human development, health and well being. In India
85% rural population solely depends on the ground water, which is depleting at a fast rate, Drinking
water affects the health of human beings due to the presence of various dissolved chemical constituents.
Problems arising out of chemical constituents in drinking water are different from the problems of
microbial contamination. Therefore, consumers should have at least minimum knowledge on quality of
drinking water. Ground water is a major source, so based on the importance of the matter; a research
topic is taken up on the assessment of quality of groundwater in the selected areas of villages in Uchana
block of Jind District, Haryana. This preliminary study assessed the quality of physical and chemical
characteristic properties of underground water in the selected locations of 8 villages in Uchana block of
Jind District. Some physico- chemical characteristic parameters are estimated in the samples and the
results obtained are compared with the available standard values such as WHO and India.
Keywords: Ground water, physico- chemical characteristic, Uchana, Jind.

Study of Magnetic Properties of Mixed Cobalt-Zinc Ferrites


Synthesized By Solid State Reaction Technique.
Leena Thakur1*, Brijesh Singh2
1

Kz Hema & Rup Bhawan, Near Sub Judge Residence, Sunder Nagar ,HP 175018,
Department of Physics, RKMV Shimla, HP
leenathakur26@gmail.com
2

The spinel ferrites were fabricated by solid state reaction technique.Cobalt and Zinc ferrites
CoxZnyFe2O4,(x=0.7,0.3,0.4,0.2 and y=0.3,0.7,0.6,0.8) were prepared by solid state reaction
technique. The crystalline structure of the sample was investigated by X-ray diffraction(XRD). All
samples show cubic spinel structure. The lattice parameter decreases with increasing cobalt content.
Magnetic properties shows that the prepared sample exhibit ferromagnetic behaviour at room
temperature. The saturation magnetization increases with increasing cobalt content. Curie temperature
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of various samples were calculated. The Curie temperature increases with increasing content of Cobalt
ions. The variation of initial perme ability and magnetic loss with frequency are explained with the help
of established models.
Keywords: XRD; Magnetic Properties; Magnetization; Curie Temperature.

Solubility Behaviour of Cellulose-Reinforced Starch-PVA Blends with


Insertion of Fly-Ash
Satish Kumar
University College Kurukshetra, Haryana-136119
chauhanchem83@gmail.com
In the homogenous mixture of Starch and Polyvinyl alcohol (PVA), 30 % of plasticizer was mixed to
make Pure blend. Then 10 % cellulose was mixed into above mixture followed by removal of extra
water gave Cellulose-Reinforced starch-PVA blends. The different proportions of Fly ash were mixed
into mixture of Cellulose-Reinforced starch-PVA blends to get various fly ash inserted CelluloseReinforced starch-PVA blends. Solubility, swelling behaviour and water absorption studies of Fly ash
blends were measured at different time intervals at relative humidity of 50-55%. The insertion of
Cellulose into starch-PVA blend decreases the solubility of blends due to the hydrophobicity of
cellulose, but the solubility further increases by insertion of Fly ash into starch-PVA matrix that
indicating the mechanical stability enhancement of blends. The water absorption behaviour of fly ash
blends increases rapidly upto 150 min and then no change. The optimum concentration of Fly ash into
Cellulose-Reinforced starch-PVA blend was 4%.

Colorimetric Determination of Vitamin C Using Fe(II)-5-Chloro-7Iodo-8-Hydroxyquinoline Complex


Ashwani Kumar
Department of Chemistry, Kurukshetra University, Kurukshetra -136 119 India
vihanaashwani@gmail.com
An extractive spectrophotometric procedure based on the complexation of reduced Iron(II) with 5Chloro-7-iodo-8-hydroxyquinoline (CIHQ) for the estimation of micro amounts of vitamin C. The
resulting brown colored complex was extracted into chloroform to give a reddish brown extract which
shows an absorption band at 485 nm. This chelate was formed immediately and the apparent molar
absorptivity and Sandells sensitivity for vitamin C was found to be 8.5 105 dm3 mol-1 cm-1 and
2.072x10-4g cm-2. Linear relationship between absorbance and concentration of ascorbic acid is
observed up to 0.8 g ml-1. Interference studies of different substances including sugars, vitamins and
amino acids, metal ions and organic acids were carried out. The utility of the method was tested by
analysing some of the marketed products of vitamin C

Conductance studies of Li+ and Na+ in Acetonitrile and Nitromethane


binary mixtures at 298.15 K
Hardeep Anand*, Narender singh*1 and Suresh Kumar2
*Department of Chemistry, Kurukshetra University, Kurukshetra 136119
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2

Department of Chemistry, M N College, Shahabad (M) Kurukshetra-136135


suresh980980@gmail.com
Molar conductance of Lithium perchlorate (LiClO4), Sodium perchlorate (NaClO4), Sodium
tetraphenylborate (NaBPh4), Tetrabutylammonium perchlorate (Bu4NClO4) and Tetrabutylammonium
tetraphenylborate (Bu4NBPh4) have been measured in range 0.005-0.2 mol kg-1 in binary mixtures of
Acetonitrile (AN) and Nitromethane (NM) containing 0, 10, 20, 40, 60, 80 and 100 mol % of NM in
AN at 298.15 K. The experimental data of conductance has been analyzed using Shedlovsky method to
evaluate limiting molar conductance (o) of these electrolytes which were further split to obtain
limiting ionic conductance (o) of various ions present in salts. The ionic radii (ri) of ions in solutions
were calculated using a modified form of Stokes law and were analyzed in the aspects of ion-solvent
interactions. The solvated radii (ri) of Li+ and Na+ ions were found to be greater than rest of the ions in
the entire solvent composition range which indicates strong solvation of the ions. Bu 4N+ and Ph4B- ions
were found to show poor solvation due to solvophobic interaction. Solvated radii (ri) values indicate
preferential solvation of Li+ and Na+ ions in the intermediate solvent composition range than in pure
AN and NM. Li+, however, is found to be better solvated than Na+.

Removal of Pesticides from Water Using Low Cost Adsorbents


Ajay Kumar*1, Prashant Singh2 and Parminder Kumar Saini3
1

Department of Chemistry, D B S. (P.G.) College, Dehradun (Uttarakhand)


Department of Chemistry, D. A. V. (P.G.) College Dehradun (Uttarakhand)
3
Central Building Research Institute, Roorkee, Haridwar (Uttarakhand)
E-mail:ajaykdcy@gmail.com
2

Ground water and surface water sources being used for drinking purpose get contaminated due to
industrialization waste, hazardous waste, dyes, toxic chemicals, heavy metal along with pesticides.
Crop protection measures in agriculture and horticulture utilize large amount of pesticides, which are
widely used as insecticides, fungicides, nematocides, herbicides or sprout inhibitors on agricultural
crops and on residential lawns and gardens by homeowners and professionals. Due to leaching, the
movement of pesticides takes place with water downward through soil or rock. When water moving
downward from the surface, comes into contact with hazardous chemicals like pesticides, these are
carried along with the water until they eventually reach the groundwater and pollutes it. Exposure to
pesticides both occupationally and environmentally causes a range of human health problems and hence
there is challenge to remove the pesticides from water. In the paper, an overview of pesticides in water
in India is presented. The current scenario of pesticides in water and its various treatment as well as
removal methods are discussed. Each method has been described with advantages and limitations in
terms of removing the pollutants, efficiency and economical effectiveness. The main focus of the study
is on pesticides removal by adsorption using low cost adsorbents developed from cheaply available
bulk industrial wastes, owing to low energy requirement and high efficiency for pollutants uptake for
producing pure water.
Keywords: Pesticides, Water, Low Cost Adsorbents, Human health, Environment

Synthesis, Characterisation and Applications of 3D Transition Metal


Oxide Nano Particles
Poonam Rana
Research Scholar, School of Sciences IGNOU,, Maidan Garhi New Delhi
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Nano particles are of ample interest for researchers from a wide range of fields including magnetic
fluids, catalysis, biotechnology/biomedicine. There are number of methods which have been developed
for the synthesis of nanoparticles of various sizes, shapes and compositions having successful
application in the areas listed above is highly dependent on the stability of the particles under different
conditions. In most of the cases , the particles perform best when the size of the nanoparticles is below
a critical value, which is dependent on the material but is typically around 1020 nm. Synthesis of
metal oxide nanoparticles have been achieved through Co-Precipitation, Thermal Decomposition,
micro-emulsion , hydrothermal synthesis and many other processes . The synthetic approach can be any
one of the methods given above synthesizing nanoparticles which give good yield and controlled sized
nanoparticles. In our work we have synthesised cobalt and iron nanoparticles stabilized using a bio
polymer. Some results are still awaited to reveal the name of the biopolymer used in the synthesis.
Characterisations are mainly done using UV visible double beam spectrophotometer, TEM, SEM and
XRD.

Theoretical Studies On Structure Of Octacarboranes Dianions


Vibha Kumari and H. Singh
1

Department of Chemistry, Govt. P. G. College, New Tehri, Uttarakhand, India,


e-mail: vibhasingh25@gmail.com
e-mail:hitensingh25@gmail.com
Only cage structures of octacarborane have been reported in literature[1-3], some stable non-cage
structures for the same have been found for the first time in this work. A complete isoelectronic
dianion series of carboranes of B8H82- have been investigated, each time a B-H unit being replaced by
a bare carbon hence forming a dianion series of general formula C nB8-nH8-n2- (n=1-8). The work has
been carried out using Gaussian98 software at Hartree-Fock and DFT levels using 6-31G basis sets
both with and without polarization functions.
References:
1. Schleyer, P. v. R. and Najafian, K., Inorg. Chem., 37, 3454 (1998).
2. Bausch, J. W., Prakash, G. K. S., Williams, R. E., Inorg. Chem., 31(18), 3763 (1992).
3. Gimarc, B. M. and Ott, J. J. J. Am. Chem. Soc., 109(5), 1388 (1987).

Comparative study on modeling growth inhibition activity using


physicochemical and connectivity indices
Basheerulla Shaik, Suresh Kumar, Vijay K Agrawal
Dept. of Applied Sciences, National Institute of Technical Teachers Training & Research, Shamla
Hills, Bhopal-462002, Madhya Pradesh, India
E-mail: basheerulla.81@gmail.com,vermasuresh98@gmail.com, apsvka@yahoo.co.in
Attempt is made for modeling growth inhibitory activity (log 1/C) of 44 derivatives of benzoxazine-3ones using physicochemical parameters as well as connectivity indices. The multiple regression
analysis has shown that a single physicochemical parameter viz Molecular weight (MW) is best for
modelling the activity of benzoxazine-3-ones. The results are critically discussed using variety of
statistical parameters.

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General structure of benzoxazine-3-ones


Keywords: Growth inhibition activity, QSAR, physicochemical parameters, connectivity indices, MLR

Flame retardant polymeric materials


Dr. Sweety Monga
Asst. prof. of chemistry, F.G. M. Govt. College, Mandi Adampur, Hisar-125052, Haryana, India
sw.chemistry@gmail.com
The research and development on novel polymeric materials belongs to an important field of material
science. The polymeric materials are replacing the traditional inorganic engineering materials due to
their wide range of useful properties and ease of process ability. The diverse use of polymers in daily
life has made polymers an integral part in the modern life style. The fire safety is an important issue as
the fire at any place has the potential to cause harm to the people and severe damage to property. Fire
accidents across the world lead to extensive loss of life and property every year. In India, on an average
about 25,000 persons die every year due to fires and related causes. Since, polymers are widely used in
many applications, therefore, the development of ame retardant polymers is of great importance for
safety from fire hazards. The addition of conventional fire retardant additives is the most common
approach to improve the flame retardancy of a polymer. These conventional flame retardants (FRs)
vary from hydrated fillers such as alumina trihydrate, magnesium hydroxide to halogen, phosphorous,
nitrogen and boron based compounds. They interact physically and chemically with the polymer during
different stages of combustion thereby reduce the flammability of the polymer. Despite the advantages
of these conventional FR additives, there are many drawbacks as they often require high levels of
loading (40-50 %) for adequate flame retardancy that leads to additional costs, processing difficulties
and deterioration of polymer mechanical properties. Also, halogen based compounds generate toxic and
corrosive combustion products like dioxin which draw the concerns over their environmental impact. In
the past two decades, much attention has been diverted to use nanoscale fillers as flame retarding
additives in polymers because a very small amount of nanoclay can significantly enhance barrier
performance, mechanical, thermal and fire properties of the polymer significantly.

Immobilization of Cadmium ions with ordinary Portland cement


Amit Bhardwaj, Nadeem Sharma, A.K. Minocha*
CSIR-Central Building Research Institute Roorkee 247667
Department Of Chemistry, Maharishi Markandeshwar University, Mullana -133 207, Ambala (India)
mtbhrdwj39@gmail.com, sameeksha20002@gmail.com, minochaak@yahoo.com
The disposal of toxic wastes containing heavy metals may cause a peculiar environmental problem
especially when these metals are present in water soluble form. In the present research varying
concentration of cadmium ions have been studied for their effect on physical, chemical and engineering
properties of 43 grade Ordinary Portland Cement like initial and final setting time, compressive
strength, bulk density, leaching studies, microscopic studies etc. our Efforts have been made to
establish a quantitative corelation between the different concentrations of cadmium ions used and the
intensity of any change in above properties of the cement. Nitrate salt of cadmium has been taken in
the concentration range 1000-5000 ppm and the results of these investigations are presented in this
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paper. The results show that Cd improves the Compressive strength as well as the bulk density of the
mortar samples. The leaching studies shows that the concentration of cadmium is almost negligible in
the leachate analysed by the Atomic Absorption Spectrophotometer and as the concentration increases
in the mortar samples the leaching of cadmium ions decreased it shows all the added cadmium ions gets
adsorbed on the surface of cement. Scanning electron microscopic studies shows that the C-S-H gel
phases are denser than that of control samples and C-S-H phases are responsible for the improved
compressive strength of cement samples.
Keywords:

Heavy metals, cement, setting time, cadmium, waste management.

References:
1.

2.

3.

4.

5.
6.

7.
8.
9.

10.
11.
12.
13.
14.

96

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Aqueous Waste Using a Dynamic Leaching Test", Hazardous Waste and Environmental
Emergencies, Houston TX, 1984.
P. Cote', T. Constable, J. Stegemann, R. Dayal, S. Sawell, R. Caldwell and J. McLellan,
"Guide for the Selection of leaching tests" (in preparation), prepared for USEPA, Risk
Reduction Engineering Laboratory, Cincinnati, OH, by the Waste Water Technology Center,
Burlington, Ontario, 1988.
M.J. Cullinane, L.W. Jones and P. G. Malone, Handbook for Stabilization/Solidification of
Hazardous Waste, EPA/540/2-86-001, USEPA, Risk Reduction Engineering Laboratory,
Cincinati, OH, 1986.
L.W. Jones and P. G. Malone, "Physical Properties and leach Testing of Solidified / Stabilized
industrial Waste,"EPA-600/2-82-099 (NTIS PB83-147983), USEPA, Municipal Environmental
Research Laboratory , Cincinati, OH, 1982.
P.K. Mehta, Concrete Structure, Properties and Materials, Prentice Hall, Inc., Englewood
Cliffs, NJ, 1987.
T.E. Myers, "A Simple Procedure for Acceptance Testing of Freshly Prepared Solidified
Waste", Hazardous and Industrial Solid Waste Testing: Fourth Symposium, ASTM STP 886,
J.K. Petros, Jr. , W.J. Lacy and R.A. Conway, eds., American Society for Testing and
Materials, Pheladelphia, P.A., 1986.
U.S. Environmental Protection Agency," Test Method for Evaluating Solid Wastes", SW-846,
3rd ed., Office of Solid Waste and Emergency Response, Washington, DC, 1986.
H. Woods, Durability of Concrete, ACI Monograph 4, American Concrete Institute, Detroit,
MI, 1968.
L.W. Jones, "Interference Mechanism in Waste Solidification/ Stabilization Processes," EPA600/S-89/067 (NTIS No. PB90-156209/AS), USEPA, Risk Reduction Engineering Laboratory,
Cincinati, OH, 1989.
J. Deja, "Immobilization of Cr6+, Cd2+, Zn2+ and Pb2+ in alkali activated slag binders," Cement
and Concrete Research, 32, 1971, 2002.
C. Park, "Hydration and solidification of hazardous wastes containing heavy metals using
modified cementitious materials," Cement and Concrete Research, 30, 429, 2000.
J.R. Loebenstein. In: Proceedings, Workshop on Removal, Recovery, Treatment and Disposal
of Arsenic and Mercury, USEPA Report EPA/600/R-92/105, 89, 1992.
Landrett RE. Guide to the disposal of chemically stabilized and solidified waste. ERA SW-872.
Cincinatti (OH). US Environmental Protection Agency, 1986.
TEPA, Study to Minimize the Materials for Solidification of Hazardous Fly Ash. Taiwan
Environmental Protection Administration, Taipei, Taiwan, 2001.,

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15. J.F. Artiola, D. Zabcik and S.H. Johnson, In situ treatment of arsenic contaminated soil from a
hazardous industrial site: Laboratory studies. Waste Manage. 10 1, 7378, 1990. .
16. V. Dutre and C. Vandecasteele, Solidification/stabilization of arsenic-containing waste: leach
tests and behaviour of arsenic in the leachate. Waste Manage. 15 1 5562, 1995.
17. V.Alunno Rosseti, F. Medici, Inertization of toxic metals in cement matrices: effects on
hydration and hardening, Cem . Concr. Res 25(6), 1147-1152, 1995.
18. S.wang. C.Vipulanandan, Solidification/Stabilization of Cr(VI) with cement. Leachability and
XRD analysis,Cem. Concr. Res 30 (3), 385-389, 2000..
19. J.R. Corner Chemical Fixation and Solidification of Hazardous wastes, Van NostrandReinhold, New york, 1990.
20. W.Nocun, J.Melolepsxy, Studies on Immobilization of heavy metals in Cement Paste-C-S-H
leaching behaviour, Procedings of the 10 th international congress on the chemistry of cement,
Goteborg, Sweden, .4iv 043, 1997 .
21. A.Macias. A. Kindness, F.P. Glasser, Impact of carbon Dioxide on the immobilization
potential of cemented wastes: Chromium,Cem.Concr.Res.27 (2), 215-225, 1997.
22. S.Sprung . Trace elements-concentration build-up and measure for reduction, Zem-Kalk-Gips
( Wisebaden) 41
23. H.F.W Taylor, the chemistry of cement,Vol.(II) Academic press, New york, 1964.
24. Implication of the structure of cementitious wastes containing Pb(II), Cd(II) As(V) and Cr(VI)
on the leaching of metals CCR 34, 1093-1102, 2004.
25. A. K Minocha, Pankaj Kumar, Manish K. Goyal, CL Verma, Immobilization of Toxic Metals
in cement based system- case studies. New Build. Mater. and Const.. World, 10 , 44-51, 2004.
26. A.K. Minocha, Pankaj Kumar, Jaswinder Singh, Manish K. Goyal, L.K. Aggarwal, Influence
of copper(II), lead(II) and cadmium(II) metal ions on the setting time of ordinary Portland
cement. Indian J. Env. Prot, 25 , 365-368, 2005.
27. A.K. Minocha, Pankaj Kumar, Jaswinder Singh, L.K. Aggarwal, C.L. Verma, Effect of
molybdate (II), chromium (III) and (VI) metal ions on the setting time of ordinary Portland
cement. Indian J. Env. Prot. , 24, 771-774, 2004.
28. C. Gervais, and S. K. Ouki, Performance study of cementitious systems containing zeolite and
silica fume: Effects of 4 metal nitrates on the setting time, strength and leaching
characteristics. J. Hazard. Mater., 93,187-200, 2002.

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Factors That Control the Reactivity of Cobalt(III)-Nitrosyl


Complexes in Nitric Oxide Transfer and Dioxygenation Reactions
Ramanpreet Kaur, Narinder Kaur and Nidhi Dahiya
Chemistry Department, M. M. Engineering College, Maharishi Markandeshwar University, Mullana
indunain50@gmail.com, priyanka01april1993@gmail.com
Metal-nitrosyl complexes are key intermediates involved in many biological and physiological
processes of nitric oxide (NO) activation by metalloproteins. In this study, author reported the
reactivities of mononuclear cobalt(III)-nitrosyl complexes bearing N-tetramethylated cyclam (TMC)
ligands, [(14-TMC)CoIII(NO)]2+ and [(12-TMC)CoIII(NO)]2+, in NO-transfer and dioxygenation
reactions. The Co(III)- nitrosyl complex bearing 14-TMC ligand, [(14-TMC)CoIII(NO)]2+, transfers the
bound nitrosyl ligand to [(12-TMC)CoII]2+ via a dissociative pathway, {[(14-TMC)CoIII(NO)]2+
{(14-TMC)CoNO}2+}, thus affording [(12-TMC)CoIII(NO)]2+ and [(14-TMC)CoII]2+ as products.
The dissociation of NO from the [(14-TMC)CoIII(NO)]2+ complex prior to NO-transfer is supported
experimentally and theoretically. In contrast, the reverse reaction, which is the NO-transfer from [(12TMC)CoIII(NO)]2+ to [(14-TMC)CoII]2+, does not occur. In addition to the NO-transfer reaction,
dioxygenation of [(14-TMC)CoIII(NO)]2+ by O2 produces [(14-TMC)CoII(NO3)]+, which possesses an
O,O chelated nitrato ligand and where, based on an experiment using 18O-labeled O2, two of the three
O-atoms in the [(14-TMC)CoII(NO3)]+ product derive from O2.

The dioxygenation reaction is proposed to occur via a dissociative pathway, as proposed in the NOtransfer reaction, and via the formation of a Co(II)-peroxynitrite intermediate, based on the observation
of phenol ring nitration. In contrast, [(12-TMC)CoIII(NO)]2+ does not react with O2. Thus, the present
results demonstrate unambiguously that the NO-transfer/dioxygenation reactivity of the cobalt(III)nitrosyl complexes bearing TMC ligands are significantly influenced by the ring size of the TMC
ligands and/or the spin state of cobalt ion..
Keywords: Metal-Nitrosyls, Nitrosyl Transfer, Metal-Peroxynitrite, Nitric Oxide Dioxygenation
References:
1. Kumar, P., Lee, Y.M., Park, Y.J., Siegler, M.A., Karlin, K. D., Nam, W. J. Am. Chem. Soc., 137,
2015, 4284.

Chemistry of Life
Priya Yadav, Diwakar Aggarwal and Anil K. Sharma
Department of Biotechnology, Maharishi Markandeshwar University, Mullana-133207

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Consuming food without table salt would be unthinkable for most of us. But had any one thought does
salt just enhance taste or sodium and chloride ions, have other important roles in our body as well. The
contraction and relaxation of heart muscle cells is precisely regulated by electrical pulses generated as
sodium, potassium and calcium ions that pass through complex molecular channels inside the cell.
Similarly there are numerous example in nature where chemical ions are known to play key body
functions and they are the important constituents of various body parts and organelles. In fact 99 % of
human body is made up of just four elements i.e. hydrogen, oxygen, carbon and nitrogen. Others like
copper, cobalt, zinc and iron etc. are present on much smaller quantities. Dietary deficiency of chemical
ions or their improper regulation leads to diseases like potassium deficiency (hypokaemia). Likewise
anaemia is associated with iron deficiency. Nature has selected both organic and inorganic constituents
to build the living organisms. With the progress of science we are now increasingly becoming aware of
the growing interface of chemistry and the living world.
Recent research highlights the
multidimensional role of various chemical elements in biological systems. A lot still remains to be
unravelled though. In conclusion numerous elements around us play an important role in chemistry of
life. As research will progress we will have better understanding of their role at a molecular level which
will help in better tomorrow.

Mechanistic Insight into the Nitric Oxide Dioxygenation Reaction of


Nonheme Fe(III)Superoxo and Mn(IV)Peroxo Complexes
Shiwani, Lata Taneja
Chemistry Department, M. M. Engineering College, Maharishi Markandeshwar University, Mullana,
shiwanisingh270@gmail.com, tanejalata2@gmail.com
In this paper, author reported the reactivity of newly synthesized FeIIIsuperoxo and MnIVperoxo
complexes with nitric Oxide (NO) to follow nitric oxide dioxygenation reactions. Reactions of
nonheme FeIIIsuperoxo and MnIVperoxo complexes bearing a common tetraamido macrocyclic igand
(TAML), namely [(TAML)FeIII(O2)]2- and [(TAML)MnIV(O2)]2-, with NO afford the FeIIINO3
complex [(TAML)FeIII(NO3)]2- and the MnVoxo complex [(TAML)MnV(O)]- plus NO2 , respectively.

Mechanistic studies, including density functional theory (DFT) calculations, reveal that M III
peroxynitrite (M = Fe and Mn) species, generated in the reactions of [(TAML)Fe III(O2)]2- and
[(TAML)MnIV(O2)]2- with NO, are converted into M IV(O) and NO2 species through O-O bond
homolysis of the peroxynitrite ligand. Then, a rebound of Fe IV(O) with NO2 affords

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[(TAML)FeIII(NO3)]2, whereas electron transfer from MnIV(O) to NO2 yields [(TAML)MnV(O)] plus
NO2.
Keywords: Metal-Peroxo, Metal-Superoxo, Metal-Peroxynitrite, Nitric Oxide Dioxygenation
References:
1. Hong, S.; Kumar, P.; Cho, K. B.; Lee, Y. M.; Karlin, K. D.; W. Nam Angew. Chem. 128, 2016,
12591.

Nitric Oxide Dioxygenation Reactions and Their Mechanistic Insights


Vaibhav Wadhwa, Sunil Kumar, Umesh Yadav
Chemistry Department, M. M. Engineering College, Maharishi Markandeshwar University, Mullana,
yadavumesh6776@gmail.com
In this paper author reported the reactivity of newly synthesized Co(III)-nitrosyls complexes with
superoxide radical to follow nitric oxide dioxygenation. Two new Co(III)nitrosyl complexes bearing
N-tetramethylated cyclam (TMC) ligands, [(12-TMC)-CoIII(NO)]2+ (1) and [(13-TMC)CoIII(NO)]2+ (2),
were synthesized via [(TMC)Co II(CH3CN)]2+ + NO(g) reactions. Spectroscopic and structural
characterization showed that these compounds bind the nitrosyl moiety in a bent end-on fashion.
Complexes 1 and 2 reacted with KO2/2.2.2-cryptand to produce [(12-TMC)CoII(NO2)]+ (3) and [(13TMC)CoII(NO2)]+ (4), respectively; these possess O,O-chelated nitrito ligands.
Mechanistic studies using 18O-labeled superoxide (18O2) showed that one O atom in the nitrito ligand
is derived from superoxide and the O2 produced comes from the other superoxide O atom. Evidence
supporting the formation of a Coperoxynitrite intermediate is also presented.

Keywords: Metal-Nitrosyls, Metal-Peroxynitrite, Nitric Oxide Dioxygenation


References:
1. Kumar, P., Lee, Y.M., Park, Y.J., Siegler, M.A., Karlin, K. D., Nam, W. J. Am. Chem. Soc., 137,
2015, 4284.

Clouding and Aggregation of Triton X-100 Micelles: Effect of


Additives
Divyam Semwal,1* Indrani Das Sen,2 Radha Jayaram3
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1

National Initiative On Undergraduate Science (NIUS) Chemistry Fellow, Homi Bhabha Centre For
Science Education (HBCSE), Mumbai, Maharashtra 400088, India
2
Homi Bhabha Centre For Science Education (HBCSE), Mumbai, Maharashtra , India
3
Institute of Chemical Technology (ICT), Matunga, Mumbai, Maharashtra 400019,
divyam.semwal123@gmail.com
The present work is a study of the phenomenon of clouding and aggregation behaviour of nonionic
surfactant, Triton X-100 (TX-100) in presence of additives. Non-ionic surfactants are known to
undergo phase separation when heated called as cloud point. The property of cloud point (CP) allows us
to understand the underlying complex behaviour of the surfactant system. The effect of various ionic
liquids (IL), complexing agent, 18 crown ether and the electrolyte, CsNO 3 on the cloud point of TX100 has been studied and compared to understand the salting in/salting out ability of these additives.
Further, the thermodynamic parameters such as standard free energies (G), standard enthalpies (H)
and standard entropies (S) of clouding have also been calculated from the data obtained. A distinct
change in CP and thermodynamic values for different systems helped us in interpretation of the changes
and interactions occurring in the surfactant system. CP for TX-100 was found to be decreasing with
increasing concentration but after a certain point, it continued to increase. Addition of CsNO 3 lowered
the CP of TX-100 noticeably which is an example of salting out effect. An increase in CP was visible
on addition of 18-Crown-6 and ionic liquids (IL) which further increased on o increasing the chain
lengths of ILs having the same counterion. G values for all the systems were positive that depicts the
non-spontaneity of clouding phenomenon. Enthalpy values varied from largely negative to largely
positive for different systems.
Keywords : Triton X-100, Thermodynamic Parameters, Cloud Point, Ionic Liquids, Aggregation.

Sugar Based Low Melting Mixtures as Green Solvents in The


Hantzsch Synthesis of Substituted 1,4-Dihydropyridines
J. Ashwin Kumar,a Gomathi Shridhar,b Savita Ladage,c Lakshmy Ravishankard*
a

National Initiative on Undergraduate Science (NIUS) Chemistry programme fellow,


Homi Bhabha Centre for Science Education, Mankhurd, Mumbai-400088, INDIA.
b
Department of Chemistry, V. K. Krishna Menon College of Commerce & S. S. Dighe College of
Science, Bhandup (E), Mumbai - 400042, INDIA.
c
Homi Bhabha Centre for Science Education (TIFR), Mankhurd, Mumbai-400088, INDIA.
d
Department of Chemistry, K.E.Ts V. G. Vaze College of Arts, Science and Commerce, Mithagar
Road, Mulund- (E), Mumbai- 400081, INDIA.
lakshravi@yahoo.com.
Low melting mixtures (LMMs) consisting of carbohydrates, suitable hydrogen bond donors and /or a
salt have been used to create new green reaction media for organic transformations. The present paper
discusses the preparation of several LMMs. These were further used in the synthesis of a series of 1,4dihydropyridines in a one pot, three component reaction involving an aldehyde, a 1,3-dicarbonyl
compound and a nitrogen source. Efficient and easy workup, good yields, low reaction times,
recyclability of LMMs, wide applicability of the method and catalyst free methodology are some of the
highlights of this protocol.
Keywords: Low melting mixtures, sugars, multi component reactions, green solvent, 1,4
dihydropyridines.

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Author Index
Bonamali Pal 75
Brijesh Singh 91

A
A. K. Sharma 54, 74
A. Sharma 57
A. Singh 29, 35
A.K. Gupta 4
A.K. Minocha 95, 97
Aaydha C. Vinayaka 73
Ahmad Husain 31
Akash Deep 16, 73, 85, 86
Amalyn Nain-Perez 47
Amardeep Singh 28
Amit Bhardwaj 95
Amit Kumar 62
Amit L Sharma 86
Amit Masih 38
Amjad Ali 20, 21, 62, 63
Anikate Sood 79
Anil K. Sharma 100
Anil Kumar 89
Anil Sharma 77
Anirban Deb 87
Anjana Jadaun 72
Anju Parmar 78
Anshul Bansal 55
Anup Timsina 54
Anupamjeet Kaur 55
Anupreet Kaur 56
Arshid Nabi 66
Arun K. Sharma 52
Arvind Kumar Tiwari 56
Asar Ahmed 35, 36
Ashwani Kumar 92
Ashwanti Devi 58, 59
Asish Kumar Sharma 30
Avijit Banerji 68
Avnish Arora 4, 69
Avnish Kumar Arora 58

B
B .K. Aggarwal 62
B R Nautiyal 84
Bhoopendra Singh 56
Bhupender Pal 55
Bhupender S. Chhikara 80
Bhupesh Goyal 55, 70, 76
Bhupinder Kapoor 59

C
C. Raman Suri 73
Clia Regina lvares Maltha
47
Charu Agarwal 79

D
D. O. Shah 81
D. P. Pandey 82
Daniel Plano 52
Deepak Kumar Tyagi 60
Deepika Jamwal 64
Deepika Sharma 61
Deepkamal N. Karelia 52
Deepti Goyal 34, 55, 76
Diksha 69, 74
Divyam Semwal 102
Diwakar Aggarwal 100
Dr.Udayabanu. M 80

H. Singh 94
Hardeep Anand 92
Hardeep Singh Tuli 83
Harish K. Sharma 14
Harsimranjot Kaur 63
Himadri B. Bohidar 12

I
Inderjeet 87
Indrani Das Sen 102
Indu Sharma 58, 59

J
J. Ashwin Kumar 103
J. K. Mishra 57
Jaime A. M. Acosta 48
Jasveen Khanduja 87
Jaswant Ray 62
Joginder Singh 4, 62
John Boukouvalas 48
Jyoti Sharma 4, 69, 81
Jyotsana Mehta 86

Edward D. Sturrock 37
Ekta Poonia 63

Karamjit Singh 63
Karan Singh 72
Kelly Chibale 37
Keykavous Parang 80
Km Abida 63
Krishan Kumar 63
Kulbir 84
Kuldeep Kaur 64, 74
Kuldeep Singh 2, 3, 4, 14, 20,
37, 60, 71, 84, 90
Kumar Sunil 88
Kusum 82

G
Gagandeep Kaur 71
Gajanan Pandey 56
Girish Chandra 39, 40, 61
Girish Chandra Sharma 61
Giuseppe Forlani 47
Gomathi Shridhar 103
Gopal Singh Bisht 61

L
H
H. K. Sharma 4, 14, 66
H. Kumar 90
H. S. Bhatti 63

Lak Shin Jeong 39


Lakshmy Ravishankar 103
Lata Taneja 101
Leena Thakur 91

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Luiz C. A. Barbosa 48
Luiz Claudio A. Barbosa 47

M
M. A. Rather 82
M. Kumar 88
M. R. Maurya 10
Mange Ram Yadav 87
Manoj K. Pandey 52
Manoj Kumar 83
Manu Vashishtha 81
Mayank Kinger 4, 89
Mayank Kumar Sharma 87
Mayank Pratap Singh 49
Meena Rani 65
Meera 65
Megha Bedi 83
Mukta Gupta 66

N
N. Agnihotri 35
N. K. Ralhan 8
N. Sharma 66
Nadeem Sharma 4, 19, 95
Narender Chaudhry 87
Narender singh 92
Narinder Kaur 100
Navnit Kumar Mishra 77
Neha Bhardwaj 85, 86
Nidhi Dahiya 100
Nirankar Singh 4, 67
Nisha 84
Nitin Singhal 24
Nivedita Acharjee 68
Nivedita Agnihotri 4

O
O. P. Singh 54, 74

P
P Dogra 66
Pankaj 54
Pankaj Kumar 3, 4, 36
Pankaj Thakur 64
Pawan K.Bharti 62
Pernita Dogra 4, 69

106

Pooja Rani 64
Pooja Sethi 69
Pooja Sharma 4
Pooja Yadav 84
Poonam Dogra 72
Prabha Mehta 56
Prashant Murumkar 87
Priya Yadav 100
Priyanka 69

R
R. Agnihotri 35
R. P. Singh 82
Radha Jayaram 102
Raj K. Singh 34
Raj Kumar Tiwari 70, 76
Rajender S. Sangwan 2
Rajkamal 35
Rajneesh Kaur 84
Rajni K. Sharma 37
Rajshree Khare 2, 4, 5, 18, 19,
58, 69, 83
Rakesh Yadav 84
Raman Singh 4, 37, 71, 84
Ramesh Muddala 48
Ranjana Aggarwal 55
Ravi Bhushan 6
Reena Gupta 71
Renu Bala 72
Ridhima Arya 77
Ritu 38, 66
Ritu Bala 38
Rohit Manhas 59
Ross G. Douglas 37
Rupal Sharma 56

S
S. K. Saini 90
Sabyasachi Sarkar 44
Sadhana Shrivastava 72
Sahil Gupta 80
Sakshi Nagpal 90
Sakshi Wadhava 60
Sang Wook Kim 89
Saniya Ahluwalia 83
Sanjeev K. Bhardwaj 86
Satish Kumar 73, 92
Satish Kumar Pandey 73
Satnam Singh 75
Satyender Kumar Yadav 73
Savita Chahal 78

Savita Ladage 103


Seema Maheshwari 74
Shaibal Banerjee 22
Shantu Amin 52
Sharad Sharma 90
Shikha 74
Shiwani, 101
Shweta Mutreja 4
Shweta Sareen 75
Silpi Chanda 70, 76
Simranjeet Singh 76
Simrat Kaur 77
Simrat Preet Kaur 77
Sita Sharan Patel 80
Sonal Singhal 18
Sonia Nain 78
Soumita Ghosh 50
Sukhmani Mann 55
Sumit Kumar 78
Sumit Sood 72
Suniba Shuaib 70, 76
Sunil Kumar 102
Surender Duhan 63
Sushil Kumar 89
Sutapa Mandal 68

U
Udayabanu M 70
Uma Shanker 26
Umesh Yadav 102

V
V. Beniwal 88
V. Kumar 88
Vaibhav Wadhwa 102
Vibha Kumari 94
Vinit Mishra 90
Vinit Prakash 4
Vinod Kumar 4, 72, 83, 88, 89
Vishal Mutreja 4, 75
Vivek Sheel 4, 58, 69
Vivek Sheel Jaswal 69
Vivek Singh 58, 59

Y
Y. Singh 82

Proceedings of National Conference on Recent Advances in Chemical Sciences

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