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Antibiotic MOA
Inhibition of
cell wall synthesis
Inhibition of
nucleic acid synthesis
Inhibition of
protein synthesis
Cell wall
Disruption of cell
membrane function
Cell
membrane
DNA
Folic acid
Ribosome
Gram Positive
Outer membrane
Lipoproteins
Peptidoglycan
Periplasmic
space
Cutoplasmic
membrane
Lipopolysaccharides
Gram +
Porin
Protein
Gram + and -
Penicillins
(Amoxicillin)
Gram + (Strep, Syphillis)
Disrupts synth of peptidoglycan
Tetracyclines
(tetracycline, doxycycline)
Broad spectrum (Gram +/-, atypicals)
Inhibit protein synth
Sulfonamides
(TMP-SMZ)
UTIs
Inhibit DNA synth
Macrolides
(azythromycin, erythromycin)
Gram + (URIs, Strep, Staph)
Inhibits protein synth
Cephalosporins
Disrupts synth of peptidoglycan
1st gen: Gram + (Keex)
2nd gen: Gram - > Gram + (Cefzil)
3rd gen: Gram - > Gram + Pseudomonas (cefdinir)
4th gen: Pseudomonas (Cefepime)
5th gen: MRSA (Ceftobiprole)
Carbapenems
(meropenem)
Broad spectrum
Disrupts synth of peptidoglycan
Fluoroquinolones
(Ciprooxacin, Levooxacin)
Broad spectrum
Inhibit DNA synth
Metronidazole
(Flagyl)
Anaerobes, protozoa
Disrupts DNA
Lincosamides (clindamycin)
Step, Staph
Inhibit protein synth
Gram Aminoglycosides
(streptomycin, tobramycin, gentamicin)
Gram - Psuedomonas - TB
Inhibit protein synth