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I i --i-,-icu::gLi;:ac:9g--:-

T flLA

jLITdr)
ny_'t?:'`_

-----i-Qd-P9-ten,`ng

-fini+in---

tpBln

____ _____j: __Ala_ ____.___.

-T------

)/1:

+/-,i\-ji:i-i':'G,a:,"-r-:,

.,.-.-----------.-.-_`.`--

1eQc)

i Pst^j
A,

------

.--.

J-9PGl-

__-,
',L' -

st_._

1 flLfl

. __.

\)/

---T`-----i-i3foia-i-6J-ph,i-tin--

+.fj_i:-f__pro_t9ip_yp_h.8_"_`_n_

----i--Then-e---RBc crm m`ctoH+c

ty

Heyy\e-

nLLL:___________-_ __ _-_____L!
i t^``cyoc8h.c hbpoche"i`cR8c .

Tmti:i`;Qh`aQfun'`d
#4P:Pf|S__CiYi=F:__~..Hrfe+pvlan&-bttfr------PesT'.+.;i-f-0-:I:-i-I-i:'`Oru-|`l'_-.-.|'`

i~l-ulfn-girt-8-q-in-,JQ|-fo-----.,,

-12fledL__

fo::i

A_^\i_ |^

..., ^ I

4l_.,_.`,,`_.L__\_:\..

.L~_.h

__~__i_ieifLishaphili.rfuppng:A &8C

Qap~p+ill.strip_j'J':ng-----

:`c">to__jr\.nib_chondii`.ci__.
le co``ib-\\fo

p6\-;i;-a- I ___ Lento iT>_._\eaJ _pal.53_Q._no_ -~~-_`-I

caJ\\ed R\u

Sid!id_eso_b_\_ed`_~

-be=H-.

t_.

teen ``f\ b6``c3~ ttlarfu.

+

1NH

71.. V-\T

.ic,i
a'

\euffl
rfu'GD

r-astfiT'-therqt-c~---\Eaa-~58~-i-oT-A---.-

0,`Q`oetez`u i`s rlc) -i

cp`cJJ!cl

ArvL\`t\o

find

Ac.I`ds

jAtn-\no

c5+

netJ+OfQth8

P6le!`ns .

+ ftci`J

a c,-I ( - c a o `i )

am,-no
c_-tjH_ij

C~nin

A-S`.aeLchou`n.

CH3

3Ntla`fl
JF

\
AIQn,`ne`

Au ami-no_Qci`d have A_Qme

bQ/}i`c

AitluchoyTe , the altFrene

lafm#Tu=o:n=-Qtw,.StR;,us:fech4"
__,_,_ -,-:- .i -------tl3 ----,--------,-,--- i,--- fllariin ---------

__I_+enifuo____8Iop_`=s~_giv2ed+Qm_a_\Qoi._n__,~its____ffifLfe__.Qc_I:a___
__f_____!he* ._amino_ _a.ci`d ___coed_a _._iron _____4_\smi.r&..-_

`ji=-

.H`,`-c-cf=
/

H
-----------

\oH

--C-u3---./
-\

------------------------{-H-3------------H3-

J9_i _ _\euc_i_n_e

___,_1So_-__\e5ct`_nc

Ntl2~~C ~ C oo H _

Nui-i-C9_oH _

----,-----`-++------------.----,------------.

____I_u_3--

Lib_3

CH3
-------

--- 1

` --.-.--..--..----------.-------- 1 -----------.--------.-- ` ------

a____8{girty_che_a___hgj_a__curAiLfl{>._Qj:\`_do_:=y_cline___.____.
\euc:'-T\e
I.-_

-r ---------- I

--.-----...-- I .-.------..--.----.--.------.--------------. I .--.

I .--.---.-. I
`\Sc> I-I
\euc\n&

.__~_`._.~__
ctl3-

Am\`no clc.{`de

zr

\i`-sh-a!njL ~3

NHi ~ a.-Coon
t3H,`shdtlitlTng

Phenb\ Q\cht.ne

Nt{L-i~ CcoH

idtos`L-VletthL~ cL ~ C-a-OH
I

---

CH3-`.:.i--`

c)H

_TYbpbpr=_n
c_oc)I

N-a-2i---=

__All_usoe_oninc>__._a.ci`_d~Q=e____
1\~ece_.___Q_e____hthJy_e_P_\_\-_c__aici_(_

.
-'`i,---:

* _ .AtAinjo_ _ .Qcj-dz>.

SeJiir\e-I

..a-. __OH_. ~

(hrdf_o_fyi_\`-a.__a_y_F\Qfr ) _

.N . tl 3 _i .Ci_ ~ . CO Q_H _
\

--

ctL=QH-

-i.:..I

-T+ ------------------.- __--___

1\eot\l.ne

Nu+ -'c ~ coo H

(

c-H
I

,J

J+

SCH+/H`c>~\\`nkel3\ttcos8\ahn
PO\aY

!9]: .0++ t`s--I p\dit 8yoL>p,

i+ @iveA
u
'
u
' pe\crfuiha
U

peTfa`fKfff:dle`?8\tt;So8|:iq:CSti:i-u-,vi:a:#cLh:`;c#edfo
O=\iqng_a__ q\ucp_solq=h+qm

8le_ .E_ _Q_-\j_n_ts_ _3\acosd\cih`gn .i.s _@o\8i- QffxlTQho

S_est-mcL Qr\d thYeon``ncL

t
__.a

A_tniap_____qT_c`=_de ___ a-

Q\\ocu

c@\dcos8\CIL`an

sd\phith_._

ossle`ne (tQ.n_ mcitte d`sulphi`Jc bc>nds ift proleino

NtlQ+I _C,=_. Ccoth
1

--ctl3----- I--S-D--

r`ftyt-c>r\{ne .( ls+ a-a Ot__ Qti

pyole`.two.)

i__________N_\]_i__i_c~__-__coon
I

ctl3

_ _

._--

cH3 - `,H
-;-:_~u\i:-9_Lne_ _c-qn~ lo;a_i:_its fA_th_tll atodp

h b odd i+s a a\`ecL

-_Pet}u\_4onQfty.

f\e_thtc>t``\nq cQ:n-+ ink;- d\`sd\pri`aer .bo.q_de -ii` :ts ^o\thLth ``s Qn8Qtfa ttE>m

\c)h AdeD

r
C

rteth``c>nine td;Thoufr I-is

~CH3 I-s -bxin tcil(ed

horyrocusbne
I

Ntli~CL~ Coon .
I

:H3
CH3

f J\ife.oT`.`ne ed
\t)mcLti
f

fo

`S-

metha-ot\``y& cite impossi`ble to be made b8

ee.\\s.

theAe~ clTCL

cssenL`Q|

ci-cL

i "cLA+ be peAenfli`n Fob.

+ 1f thetr ciTa ro+ ttlken \-n trom foa pyolem |jnthe^``s cd`l( 4
+ iheLSe Qyzf
+

i<

..

"

:`nf`.\`nc`

pdQj\ bcLfr not chanoed

htrofh`-\I`c,

ic{`!

make

pyolet-in

e+ty'3`

~,z_C)9Li,

iLrQflch Ao\ub\eL.

a RSPL-c f\a-a
rdHL~ c,- cc>O\+
\

CH3

c-H3 G\\uhaTy`c a.cT`d

tut+1-i-.coc>H
clH3

cH3

iH3|hej>e. crve

Cc)Oli

Qc.``J\`c o ~ve\b cleh8ed

ibhar\ Nut_ \-e, tevyioved tom

i`c act-d , i+ fQfro o4\oacg_h`G_c]c\`d ,

rietyvea
Nt+1 -CHi-cot)H
'

-,

L;cl.>s

i ----

_-----I-I_-_------:::I----_I
--------

~~fequ_9_y_a___titli ram 3\utwt`c Qcl-a

~ ----- ` tit-fl-;--i---i-i -c c>aii7-<~d-\{ eio 3\uitqu`<2 cicl`J..
_ ------------------------------- I -----.

_ -'.

CH1

__

Frj_i a-\1

rLttL=___I__..Q.QH
I

_ ___i_T3_ _ _. _ .. '
.--1--i---.---'

- C-I - Cc,a lJ
4ib___iri}ELco_Sd_leL`9-a
I

I+srdl_pr2_ngL`_a_:~re_h`c!!Qm_.

rL`\uiQmir\@

hjH.
-i-CCx3ti
`2.I_.___.__

..

:-I--3------

___(hi________.______

=JL----co--a-,I,

9TgT|~QLdr__n_a_i_changel_(a-egtflqu-i

rbeieLcjiiife_V~e_\3_._q
-NLEL= c-- COO\|

--u3-'

--------lcH-?------I

-----klltz:i--------------------------------------------

nd

1bee ci+a

+ve-\% chQfl8ed.

qT@

+k=h in - \`s{ne

Qnd

Qy{8ini-ne - S0 Thei a+a ives

CA#ch:i:le{#Q;=d~:\uDNcflti-e{dto,CprfJrDNA
L`t`sL i`T`a isq+r=i\':uo 3=: :t;a'db f;a

iocLaajJo

Qtc{dJSl`S

?y?\{n& is

f\c>+ci pyolern
C--

I illH-

CC)oH

c,H3

EL-S\-de

C-H3

C\ci{r\ bind to citni`nD

'

3ap.

o cQrdEL usa pvalein # .

cH3

the3rfu QjtQ. to a:m``no

eici`de .

ed

+
cLJD\`C-

ssch`Ql ci-_-

Qyy\.,flo cLc,de
h{

4c.'.dl-c}

'

NeLu+y{u

1NIH2~=2C00H

ihq9 \cpag cQit+ tnQte. .qj;? _i_c>.

F-__
`fi ---- I i -

`-----__
_----__

L|Ar6in!-a_a_ io+ grxpth_ i`n chtiJ

i_@~\ngifl.q _t_pug \ongeAt _.qr_a_ ngdp_ h-.)/ifr ib be.. mQci a

3henc~ 2_ Clfe bcso\-a

a--i cltcl

eJnenL`qj . _A1__ A(`sh`di.fry

caslei`nc

,`s

---------- _
r
S -T\eth.``or\l-_n.cL.
-----` _.I

+ CO 0-ear thtoni-ne

nc>+

GryHnLi`Q

t\c)+ SeJti`lzuL_ .

:=a_T::`i:;=,_`,a
-+--I `-so-\eucrse J i byc`nchca cL..
i_3_ P::nptl!pQh\Qqnn'-ne nor it)tosi`ne
:i: + Hish-dine
ng ___.__I-._ ----r!
Thej}e Q-a Shou\J 6e kke-n
E-ill

up iLj,`th al-egaA boda

ntheDi.ze. The.yyi

1-

c_-cooH
I

i-=Qffi/:-ftdii=--:-ly::ie-i,,uco8en,c
ulu
1,

___

--------------,- i:-E-j`-:-------- AeJ,+d

___.~ ___.. i%si_ro____ _ __...__leo_ci:iAjL__

__._

rl

deb-_cm

R#:s!:;_:
lhitcoriyle

Q\-CtTu`Jl-e,

fe:tin-e-ilengh-

cQnnaL

r
tulH2~~ C~ ~ COoH

i.

5T~ HudYo*8

N\`acin

or

h8Pbmi-ne

(Sehtani-n )

r\\.ccknani`de

( V`.i -83)

pyoduced item trtlpk>phQn.

/`imino

Ac\`c]r

Mettiboiisrvl
KetocLcicl .

!ts \iKe

CchchudaL clnd fQfl .

{+

ul#y3uR
Cor\tdinA

> T%tovde

A\apine -rlH+

+ . Ci\otam{ne i Nu. -8\u+cuni`c aci`a ~ NH. --ed-Kds8luhmi-c Qci`d

I -Asp

iLn4_~ ttHt - A5prh-c Qc.i`J -tyH2_-> Oxalo QceL-c Qc].a

+A:gh\ufu#th+edfiha\`bTo#--=nA::i:oiv#dioftehaltofl
lkefone)

kek>neA..,.

iELs,c,ne1keJcgr,;act
i

93
theo
Qhflverfea
called inh
idosen`-c
ajs thaiQm\:flo
bwhn Qcide.._
iD ptodrce
Some
`a;Te
8\ocosc.cimt`to
sb cal\eaacl`do
S\uco8enic
_
the\}

{nch}ac. uttl+ all, e{Gp+

bme cal\ be bah

|edcl`ne Qfld (86in4_

called @\Ucokckffnl`c.

rty&b`#::"ifh.3IJ.i
c>\eua`ne.

Phent)\QIQni`ne

+ lf no 8\ucosa Then a-ciQ

cal\eJ

used io proJuce 8lucose

jts

S\uCo-f\eo-8eneAi-s

~Ntti group can be

freMoveJ in 1

utids .

tiroved
cind mcLde

- i - cot,H

--+ee,cciiled
'\+I,`-I,
Dc`QniflQh`on

'

fpe

cunmoni`Q i`s ioxl`c le btain

Z-

nctTmQ\

brain

jL lecHch fo a ron-funcL.oflQ'

givtjcitJe .

1\`-s ammon``a \` combi`ned

QC-,`d .

Z~

flo p+ i,

q\OtQm,-nJ1

q\utQmi`c Qc`.a

+-cimmc>n``ci

h\i)fawine Stlntleho

I+s Qn enoLhST,` dapenckrf pr6ce~ .

`ed<

fAost a+ i+a tboa# calls

ry`aKco

@\uLQmi`yu .

Io chec.i NH31ejvel, S\uhm\`vt4 level

NH3

can be checked, `+ ialls

\evel.

i_=`\Utamiir @oct fo urfu in+eLDh-ne .

tt|Uhmt`yfuL -> NHS + G\Ukmi.c

uYeJI

NqucoA

r_+

-- L- r

I--i

L`-:='+
`Lj

IEl1-

f}acbia ot .inhifle pVov\6co\ `\Uhm-mcute

: is_:js\Ud?:i: b;:=
t
-I_ _ _I
A

\.

------ |^ `\f\hohne.,
,`,`_,-`.-_,
\hotqTttine
u`_
i; convexdi
-------- u'\

{nfo
"

ammco``~ chl-do_b"`C
^_

''-_

.'1.

~-~-"is___fstH3_eTtleys_p__al_ch_li`ve7+_._l\y_ct___ev_eth_this_tJt3ic>_

ELBE\

-c,-rr-`" '=

K``dfte8 tool veA itun\`th iLhinl.

ife`ane% atohi\eA

-, 3uhm,-c- a

cheo halve 3luharrinan

ihl`s 8\dr``wlfroe bvenke 9lutQrrini fa

-.----.--,-- qidttlm,-n a
>Nt,4t-

3hoha``c &` on! ielefl^c NH3 un

combine^ a

H+

fo Pm

NHi+-Jhu^ y"aviw#

H+inthi`s ranne^

iyot" bal8 -

:e`:V;ijd;Sbi;:j;\hai\{::n;::ct;i::hb:S8n[sfi:i;ceK
quha`-vtr ho bg bvofen ac>uln
3DeA le
t

if,,

byQ\.n

h\`3he^+

via

tfr5ti'L

r\ei`J,dr,

i,,i:\,veJLl

Aut us;ng
+

-QnJ wlea/be

conc-

NHS. A5Thi`s NH3

te+ qo dexLdn] , e!Sf t\c`du

U

eiQ
a+ tJH3 '`s ?n

PV.

:tiha;Q::\::,skinnekihenhaNHH3qui`cnd~ch#Fulrizrd
t,

TL

ifa\`Jdich Qm`;n St?i

Nut

d-idfo8\ohai`c a -3\ohm``c a
+

ueue thou \.s `o ixee NHS on its trQThprea ho d-keto8\ulemif c+ .

1\n\`s is

cci\\ed

TVQ{\scunif\ch`on .

1b\`s ?ocgivu need. vit

Bc

cana

hart;tor"yian

AQ+dKhQcKfl+ hfl
th\`S bafi~ ;fi al\

be!tl cei(!s

They& ore

1 SkyJ .

in:,i;eel:juafce--3\o#TQmn,:
I.

o\\uha`c a + pwOvcLle ha:-I;;Qfri-intro-+ ed-KenguAt::::e ? +

han^qu-a
NH3 8cxgr) io a pgruqle peduci-iig citgLn[IAa_._
v\`t-B(

QT\a

enttlry\g

i-A-LT) _ _

Q\clni`ncL cim{nQ iITQRA_

A,

o\d ncirwjL ujanu ejioiyL S\okeQfle _F6yuvQ.Ie_ _er"`no___haJ\A

(SGPT)------------------

5ts F{eSut in TyiuncleA

Noel ch`:s Q\Qj\i`n covyva/`_

Jn

|ivegt

3Ya

ou+ a+ mcu}c.{ez> QfuJ_ yacL !i`vefi .

Tyajr\;>ajminciL`on.',_~_

q\cir\ I-Wl
Aa
NH-5

ticrft?

,-r`iLt,`'t C I, &.:I

(ordoQaetqJ) .

CIA

iDuyuyQbe_

\jirfefo

a,

//fli`fv, Jq9icf`d + cil_thfrrfe.

E====
t + c ~ KehalL`,harafe

::=\``--

HflD

:Feng#flDH|

'-`''jL' r`fc?dr.: rQc_i`n

g| 1itoh.n_Qnr.cr:a ________

i+\`{:j-:i:{ochj*:a;iH`ca;:,`:%d:n:\:fa(=edrenQ_L;:+-n.-iann~+
Iw rue_ @\Qcse
____I__

QuLcl_utcL_ _ de_ combine.i _I

exaLQ_acefafe-___._______`___. __.. .___ _.

_~____ouo+nrrfe__+.__DXQLo_aefe-L!!{isi-ffi#ha[===-I
Hehe,_er\zgryu.aJ3fap+eoning__tr=+r_:=_t~i|2..`.S__ape
+

_a_sFftdte- !`s q`_ed._te,a_

i rl \.wch .

so t}yzrfu:__C8_(_._happ__erIA

r
UQ Ct)c[e
+. #u th``S NH3 is aconveifea -fnfe ~ .
*

NH3 I-s bxi`c., utQfi t-s no+ thafl ioxi.c

!f to cucICI Att>P,

!le On\tr in \``vdh.

tNHt>,

+uAA4L

rriie NH3 + to+ + flTP

j cap Stlnthehoe
Fu`TjptlTim``d``neA)

(cchbenti|phasphcde)

fl/fosxth8mi`atra
c>Tc`L.C-

TulH3+

yl\thn-

C02~ +

-i,;{Cici,-! .''' i

flTP

i, C.QF s3f`*`clLiirfe

# cQi>ped Oyn\.tl\``, i^
c``trui\i-ruL #

NH1 - i - -`''J`-l!`J,`
E=-,

_._/I..._`.-------------

~-r'Jvt,-aet=
'

i i-f:`_:iu_+ Qtut _ cj2>mco +em cL^pqrfe ._

___._.__ .---------.- : -------.-.-------- `_-. _I-__ -.

`c=__i_I_i:.:_`_:.-i

1_-. .1 ..-..------------------- `r__.--`-

+_?_chLg_le_q__\.i_v_qu_d_z___9E_Q_f_tloctedg_gig_#Le_:_

_ __ ---.-.-.----------- i ------------.---------- ` -------- ___.-_ _ -

1jtsDe,\;n\nu"in:le:ey,`Q
ap sO"thdrc
. _oTc
---.-__--

Con\`th\.y\fl ira.vD cchbc|mtllcoe)

----__.
+

A mi`fochondiL

hQ/I i`ts

--.-_----.

~~_J_aThed _.

Odn

EN#, SO

M\.kehorby``dfl___8_eneA

i+s

ierIA cQn#

cenn_c>L_ _be,_ izepQt-tied_i._

i--oCTflcfdsgnFth:h::ra8tcc#iJL=flfpooh`cact`d
----J/
~_~J_b\`s_ i`s _. jti\.fochondTi.`cLL. a

t -uJtac'|

i__a_\_L _qli kjchordri:~ _@que/i t4_ryt _ _t]^Ja_ELeA _.___SQ__.in+fochQ.ndI`dfl

deFct ion:;a r;:thch

,?N H3 /, l}ret|f#C?,`CL?Q:=i':i C-

.)u4~__ le _th\:s _ n_a_ _ u_dr caclc { i u y=`

ih-ehji` I-S ofoh`G Qc.d
i`ft uti`nj2,
3 otoh-c
-_cq-dutch
i #f _:iyoLift_ i+ecg___a``efl__co_a_ _prde_``n_ t\4a.keA __NH 3_

___t_ de_Th`-s

_ \9At a+

|i.vejL trncl

QnJ

l``veLEL

\`5 nQtma4

_--.---------.--I-.----..-----.----.---'--...-..

~+___pbenu\ _ra"ife---- J1 :- -tr^voe^ Np:-:ut

1

-''.

vrNtt3
PhenuL al Q:ni`MjL

uJbeJ, N-tl-3
Q\an`.nJL.

co2__(:i __

phend-L

I
CQi.boo

ha#`fcllclr\ine
OH

Skeleton f]m{flo

f]ci`J

mpr#XalcocdrlevflcefuitoitL\euctn:s`;o|:\;::a

f.`.ru^i^4xp
C)````f
isougnTnQfe
J#e

Y06\r\e

f`.hr^Le
cJtrQle

Jz

pyop`ontllcbfl.~

\Surmqidsfl#eto8tohrfe
vethtl+uid`:;r`n8~to:3=rty,`cca`avl+B,2
Mchu\^ th\ontll rcfl
odd C.\"`rl F.fl
T`

vchine

SvaTnd chen`fl

lso

cfl

;I Ptop`ofl!l

kal a n

if tidatra8c6cun

tsfl Co.Ybo*3la+Ae

r BohayQb
thtlcoT\\u,

1
CBstdrEL,``;nsele\`fle

c8sbthi`oyuH8ttth \'`+ Bt

s-fta+u\c~H:fQujt`ne
ife.nos\-,

'hono Qb

Crt3

shoe

s-Ach

U\

wl8th\`om`vu

Meth\`o-niyl

xpsfLQctd"T#q\fa_hail:ri`iifej
fo\\t
clc.t`a jpwick
ronro c6Sletya unTh\ h~dJLbpien :

(Oaa chou`n 'tQng QadJ

va`li`yth
--.__.

\L

{ i`sc>let/cf vt4

_____-.._

___.____

f_r_3__=?_P_\,.`:=c_'-f

------------

i=-iriiin8I--~;c4c

propt`6ntol C-a fl ~J"e~thul ralofltll teft

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