8/25/2015

CommonsideeffectsofAEDs

OfficialreprintfromUpToDate
www.uptodate.com2015UpToDate

Commonsideeffectsofantiepilepticdrugs
Drug

Systemicsideeffects

Neurotoxicsideeffects

Carbamazepine

Nausea,vomiting,diarrhea,
hyponatremia,rash,pruritus

Drowsiness,dizziness,blurredordouble
vision,lethargy,headache

Clobazam

Increasedsalivation,nausea,vomiting,
constipation

Somnolence,aggression,irritability,
ataxia,insomnia

Eslicarbazepine

Nausea,vomiting,diarrhea,fatigue,
rash

Dizziness,drowsiness,headache,
diplopia,vertigo,ataxia,attention
disturbance,blurredvision,tremor
(Note:Dizziness,diplopiaandataxia
reportedmorefrequentlyin
combinationwithcarbamazepine)

Ethosuximide

Nausea,vomiting

Sleepdisturbance,drowsiness,
hyperactivity

Ezogabine

Nausea,fatigue,changeincolorof
urine,dysuria,urinaryhesitancy,
weightgain

Dizziness,somnolence,confusion,
vertigo,blurredordoublevision,tremor,
abnormalcoordination,inattention,
memoryimpairment

Felbamate

Nausea,vomiting,anorexia,weightloss

Insomnia,dizziness,headache,ataxia

Gabapentin

Infrequent

Somnolence,dizziness,ataxia

Lacosamide

Nausea,vomiting,fatigue

Ataxia,dizziness,headache,diplopia

Lamotrigine

Rash,nausea

Dizziness,tremor,diplopia

Levetiracetam

Infection

Fatigue,somnolence,dizziness,
agitation,anxiety,irritability,depression

Oxcarbazepine

Nausea,rash,hyponatremia

Sedation,headache,dizziness,vertigo,
ataxia,diplopia

Perampanel

Weightgain,fatigue,nausea

Dizziness,somnolence,irritability,gait
disturbance,falls,aggression,mood
alteration

Phenytoin

Gingivalhypertrophy,rash

Confusion,slurredspeech,double
vision,ataxia

Pregabalin

Weightgain,peripheraledema,dry
mouth

Dizziness,somnolence,ataxia,tremor

Primidone,
phenobarbital

Nausea,rash

Alterationofsleepcycles,sedation,
lethargy,behavioralchanges,
hyperactivity,ataxia,tolerance,
dependence

Rufinamide

Nausea,vomiting,fatigue

Dizziness,somnolence,headache

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CommonsideeffectsofAEDs

Tiagabine

Abdominalpain

Dizziness,lackofenergy,somnolence,
nausea,nervousness,tremor,difficulty
concentrating

Topiramate

Weightloss,paresthesias

Fatigue,nervousness,difficulty
concentrating,confusion,depression,
anorexia,languageproblems,anxiety,
moodproblems,tremor

Valproate

Weightgain,nausea,vomiting,hair
loss,easybruising

Tremor,dizziness

Vigabatrin

Visionloss

Drowsiness,fatigue,dizziness

Zonisamide

Nausea,anorexia

Somnolence,dizziness,ataxia,
confusion,difficultyconcentrating,
depression

Graphic59755Version11.0

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