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Inner Secrets of the Respirasome
Andrew Melber1 and Dennis R. Winge1,*
1University of Utah Health Sciences Center, Salt Lake City UT 84132, USA
*Correspondence: dennis.winge@hsc.utah.edu
http://dx.doi.org/10.1016/j.cell.2016.11.025
Curie, PSL Research University, Chemical Biology of Membranes and Therapeutic Delivery unit, INSERM U 1143, CNRS UMR 3666,
26 rue dUlm, 75248 Paris Cedex 05, France
*Correspondence: ludger.johannes@curie.fr
http://dx.doi.org/10.1016/j.cell.2016.11.026
Membrane trafficking from endosomes to the trans-Golgi network or the plasma membrane is
driven by the retromer complex. Through structural analysis of the cargo-bound complex, Lucas
et al. describe a mechanism by which endosomal membrane recruitment and cargo recognition
are integrated through cooperative interactions between retromer subunits.
Early maturing endosomes serve as
central sorting hub in eukaryotic cells
from which cargo molecules are directed
to three destinations: lysosomes via the
late endocytic pathway, the trans-Golgi
network via the retrograde pathway,
and the plasma membrane via the recycling pathway. The retromer complex
is an evolutionarily conserved protein
synaptic transmission. It is not surprising therefore that mutations in retromer proteins are linked to pathologies,
including neurodegenerative disorders
such as Alzheimers and Parkinsons
disease. New work by Lucas et al. looks
at the overall structure of the retromer
complex and offers insights into how it
recognizes and directs cargo.