Académique Documents
Professionnel Documents
Culture Documents
in Poultry
By
Mohamed Hossany Negm
Senior Technical Support Specialist
and Marketing
Masters Degree, Poultry Science, very good
TEL:00201123223874
Faculty of Agriculture Zagazig University
Immunosuppressive Disease
-General Indicators Increased incidence of complicated
respiratory disease
Increased E. coli problems
Increased condemnations-- airsacculitis and
Septicemia/Toxemia
Immunosuppressive Disease
-General Indicators Increased mortality and poor performance
Decreased serologic response to
vaccination
Increased incidence of secondary disease
Gangrenous dermatitis
Inclusion body hepatitis
Necrotic enteritis
Immunosuppressive Disease
-Specific Indicators Early/permanent damage to bursa of Fabricius
<2 weeks of age
chickens
General lymphoid cell depletion
Failure to respond immunologically to antigens
Vaccines
Experimental antigens- sheep red blood cells,
Brucella abortus
Immunosuppressive Disease
-Specific Indicators Failure to respond to vaccination as
Immunosuppression
-Confusing Factors Introduction of new pathogen for which
Immunosuppression
-Confusing Factors Inappropriate or ineffective vaccination programs
Use of virulent vaccine
hot Gumboro vaccine
Immunosuppression
-Confusing Factors Development of resistance to commonly
used antibiotics
Environmental factors
Sanitation
Biosecurity
Ventilation
Bird density
Down time between flocks
Breed differences
Thymus (T-lymphocytes)
Liver
Spleen
Bone marrow
Lymphoid cell aggregates
Blood
AVIAN IMMUNITY
HARDERIAN
GLAND
LYMPHOID
PATCH
CECAL
TONSILS
THYMUS
BURSA of
FABRICIUS
HEART
SPLEEN
BONE
MARROW
YOLK OR
YOLK
REMNANT
Dietary toxins
Mycotoxins
Biogenic Ammines
Rancid fat
Reovirus
Interactions
IBDV
Challenge
1 day
NDV
Vaccine
28 d
NDV
Challenge
49 d
# dead/total
7 day
28 d
49 d
13/31
14 day
28 d
49 d
3/31
21 day
28 d
49 d
3/31
None
28 d
49 d
3/35
None
----
49 d
33/33
27/31
Avian Reoviruses
Specific ReovirusesMiss-B Reovirus
Isolated from bursa of SPF sentinels
Antigenically similar to S1133 Reovirus
High mortality and reduced body weights in
broilers infected at 1 day of age
Bursa and thymic atrophy
Liver necrosis, tenosynovitis
Virus widely disseminated in tissues for
several weeks post infection
Avian Reovirus
Avian Reovirus (Miss-B isolate) can suppress
immune responses to NDV and IBV
Susceptibility to CAV is increased by prior
Reovirus exposure
CAV, IBDV, and Reovirus interact to induce
more severe disease
immunosuppressive agents
IBDV
CAV
Mareks Disease virus
Interactions