sinaro17 Endeshelal function and oxgave ses in carctovascular diseases - PubMed - NCBI PubMed ” Format: Abstract Full text links con J 2000 Marat, pun 2000 Fan STAC sce Endothelial function and oxidative stress in cardiovascular diseases. Higashi Y", Noma K, Yoshizumi M, Kihara Y. Author information Abstract The vascular endothelium is involved in the release of various vasodilators, including nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor, as well as vasoconstrictors. NO plays an important role in the regulation of vascular tone, inhibition of platelet aggregation, and suppression of smooth muscle cell proliferation. Endothelial dysfunction is the initial step in the pathogenesis of atherosclerosis. Cardiovascular diseases are associated with endothelial dysfunction. It is well known that the grade of endothelial function is a predictor of cardiovascular outcomes. Oxidative stress plays an important role in the pathogenesis and development of cardiovascular diseases. Several mechanisms contribute to impairment of endothelial function. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One mechanism by which endothelium-dependent vasodilation is impaired is an increase in oxidative stress that inactivates NO. This review focuses on recent findings and interaction between endothelial function and oxidative stress in cardiovascular diseases, PMID: 19194043 [PubMed - indexed for MEDLINE] Free full text Publication Types, MeSH Terms, Substances LinkOut - more resources PubMed Commons PubMed Commons home 0 comments How to join PubMed Commons Fipsshwwrw ni rim ri.govipdomed! 19194043 wesnign0%7 Enedeshelal function and oxgave sre in carcovascular diseases - PubMed - NCBI Fipsshwerw nc rim rh govidomed 19194043