Adve rtise m e nt

Ente r Your Em ail Addre ss

Search

Email Print-Friendly Glossary PDF Adve rtise m e nt

The 16th Annual

Headache, and Nausea, and Fatigue. Oh, My! HIV Drug Guide

More on HIV
A Look at the Possible Side Effects That Can Result From HIV Medications
Medication Side
Updated by Renata Smith, Pharm.D., and Enid Vzquez Effects
From Positively Aware

March/April 2012

Click on the name of each drug for further details, or refer to the manufacturer's package insert for
a comprehensive list of potential drug side effects. Remember that side effects may or may not occur.
Some are more common than others, and individuals react differently to the same drug. A drug
regimen cannot be chosen solely on the basis of minimal potential for side effects. Discuss any
symptoms, however minor, with your health care providers, including your pharmacist, since small
reactions may become serious. There may also be management techniques for side effects.

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Potential drug class side effects Rare but potentially serious toxicity with all NRTIs: enlarged,
fatty liver (hepatomegaly with steatosis) and lactic acidosis
(accumulation of lactate in the blood and abnormal acid-base

open in browser PRO version Are you a developer? Try out the HTML to PDF API pdfcrowd.com

C ombivir (lamivudine/zidovudine)
Emtriva (emtricitabine, or FTC )
Epivir (lamivudine, or 3TC )
Epzicom (abacavir/lamivudine)
Retrovir (zidovudine, AZT, or ZDV)
Trizivir (abacavir/lamivudine/zidovudine)
Truvada (emtricitabine/ tenofovir)
Videx EC and Videx (didanosine, or ddI)
Viread (tenofovir DF, or TDF)
Zerit (stavudine, or d4T)
Ziagen (abacavir, or ABC )
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
Potential drug class side effects
open in browser PRO version
balance). Lactic acidosis may cause persistent fatigue,
abdominal pain or distension, nausea/vomiting, difficulty
breathing or shortness of breath, and enlarged liver.
See Epivir and Retrovir.
"You don't have to
A very tolerable drug, but side effects may include headache, fight this fight by
diarrhea, nausea, and rash. Darkening of the skin on the yourself." Watch
palms and the soles of the feet has also been reported. Susan's Story >
A very tolerable drug, but side effects may include headache,
nausea, vomiting, diarrhea, fever, fatigue, hair loss,
insomnia, malaise, nasal symptoms, and cough.
What's at Stake in
See Epivir and Ziagen. Trump's America?
HIV C ommunity
Headaches, fever, chills, muscle soreness and/or damage, Leaders Share
fatigue, nausea, lipodystrophy, fingernail discoloration, Their Opinions
anemia (low red blood cell count), and neutropenia (low white
blood cell count). The End of AIDS?
Advocacy in and TheBody.com App
See Epivir, Retrovir, and Ziagen. Beyond 2016
See Viread and Emtriva. Abdominal distension/pain. Get Our
Stigma in Action:
Newsletters
10 Infuriating HIV
Peripheral neuropathy, upset stomach, diarrhea, headache,
C riminalization
pancreatitis (inflammation of the pancreas), eye changes and
Stories My Health Tracker
optic neuritis, increased uric acid levels, insomnia, and body
fat redistribution.
C harlie Sheen Medication and
Overall fairly well tolerated; however, side effects may Achieves Health Reminders
include nausea, diarrhea, vomiting, flatulence (gas), bone Undetectable Viral
changes, kidney toxicities, decreased bone mineral density, Load With Weekly Assess Your Risk
and low blood phosphate. Injectable HIV for HIV
Treatment
Headache, diarrhea, nausea, rash, peripheral neuropathy, Follow Us:
lipoatrophy (including facial wasting), mitochondrial toxicities Newly Diagnosed Facebook, Twitter,
(a variety of symptoms caused by cell damage), and With HIV, Jennifer RSS
elevated cholesterol levels. Vaughan Rises to
YouTube
Hypersensitivity reaction, nausea, vomiting, diarrhea, fatigue, Prominence
headache, fever, rash, and loss of appetite.
Rash. Immune Reconstitution Inflammatory Syndrome (IRIS)
may occur as the immune system regains strength; signs and
symptoms of inflammation from previous infections may
occur soon after anti-HIV treatment is initiated. Report
Are you a developer? Try out the HTML to PDF API pdfcrowd.com

Edurant (rilpivirine, or RPV)
Intelence (etravirine, or ETR)
Rescriptor (delavirdine, or DLV)
Sustiva (efavirenz, or EFV)
Viramune XR and Viramune (nevirapine, or
NVP)
Protease Inhibitors (PIs)
Potential drug class side effects
Aptivus (tipranavir, or TPV)
(must be taken with Norvir)
C rixivan (indinavir sulfate, or IDV)
open in browser PRO version Are you a developer? Try out the HTML to PDF API
symptoms of illness, such as shingles and TB, to a health
care provider.
Insomnia, headache, rash, and depressive disorders.
Rash, diarrhea, nausea, nasopharyngitis (symptoms like a
common cold), headache, hypersensitivity, and increased
liver enzyme levels.
Increased liver enzyme levels and itchy skin or rash.
C entral nervous system (C NS) and psychiatric symptoms.
Rash, nausea, vomiting, diarrhea, fever, insomnia, and
increases in triglycerides, bad cholesterol (LDL), good
cholesterol (HDL), and liver enzyme levels. False positive
tests for marijuana. Birth defects.
Headache, nausea, vomiting, fever, rash, Stevens-Johnson
syndrome, increased liver enzyme levels, liver damage, and
drug-induced hepatitis.
Seen with protease inhibitors (except unboosted Reyataz) are
increased levels of cholesterol and triglycerides, which may
be associated with an increased risk of heart disease. Other
possible side effects are lipodystrophy (body fat changes,
including thinning of the face, arms, and legs, with or without
fat accumulation in the stomach, breasts, and upper back),
onset of new cases or worsening of diabetes (see your doctor
promptly), and increased bleeding in hemophiliacs. Immune
Reconstitution Inflammatory Syndrome (IRIS) may occur as
the immune system regains strength; signs and symptoms of
inflammation from previous infections may occur soon after
anti-HIV treatment is initiated. Report symptoms of illness,
such as shingles and TB, to a health care provider.
Mild diarrhea, nausea, vomiting, and abdominal pain.
Headaches, fever, fatigue, dry mouth, rash (including
sensitivity to sun), dizziness, liver toxicity, and bleeding in
the brain. Aptivus has a sulfa component; use with caution in
patients with allergies to sulfa drugs. Also see Norvir.
Headache, fatigue or weakness, malaise, nausea, diarrhea,
stomach pain, loss of appetite, yellowing of skin/eyes,
changed skin color, dry mouth/sore throat, taste changes,
painful urination, indigestion, joint pain, hives, liver toxicity,
kidney stones, increased bilirubin, itchy/dry skin, ingrown
pdfcrowd.com

Invirase (saquinavir, or SQV)
(must be taken with Norvir)
Kaletra (lopinavir/ritonavir, or LPV/r)
Lexiva (fosamprenavir calcium, or FPV)
Norvir (ritonavir, or RTV)
Prezista (darunavir, or DRV)
(must be taken with Norvir)
Reyataz (atazanavir sulfate, or ATV)
Viracept (nelfinavir, or NFV)
Integrase Inhibitors (INSTIs)
Potential drug class side effects
Isentress (raltegravir, or RAL)
dolutegravir (or DTG) (investigational drug)
open in browser PRO version Are you a developer? Try out the HTML to PDF API
toenails, and hair loss.
Diarrhea, abdominal discomfort, vomiting, and nausea. Also
see Norvir.
Rash, diarrhea, nausea, vomiting, stomach pain, headache,
muscle weakness, increased cholesterol and triglycerides,
and increased liver enzyme levels. Also see Norvir.
Nausea, rash, diarrhea, headache, vomiting, fatigue, and
abdominal pain. Lexiva has a sulfa component; use with
caution in patients with allergies to sulfa drugs.
Weakness, stomach pain, upset stomach, tingling/numbness
around the mouth, hands or feet, loss of appetite, taste
changes, weight loss, headache, dizziness, pancreatitis,
alcohol intolerance, liver problems, increased muscle enzyme
levels, and uric acid.
Rash, diarrhea, nausea, headache, abdominal pain, and
increased liver enzyme levels. Prezista has a sulfa
component; use with caution in patients with allergies to sulfa
drugs. Also see Norvir.
Dizziness, lightheadedness, rash, kidney stones, and
elevated liver enzyme levels, including elevated levels of
unconjugated bilirubin.
Diarrhea, stomach discomfort, nausea, gas, weakness, and
rash.
Immune Reconstitution Inflammatory Syndrome (IRIS) may
occur as the immune system regains strength; signs and
symptoms of inflammation from previous infections may
occur soon after anti-HIV treatment is initiated. Report
symptoms of illness, such as shingles and TB, to a health
care provider.
A very tolerable drug, but side effects may include diarrhea,
nausea, vomiting, headache, fever, abdominal pain, fatigue,
weakness, dizziness, lipodystrophy, increased levels of liver
enzymes and creatine kinase, allergic reaction, and
cerebellar ataxia.
Seen in clinical study: nausea, diarrhea, headache, dizziness,
fatigue, weakness, and upset stomach or indigestion.
pdfcrowd.com

elvitegravir (or EVG) (investigational drug)
Entry Inhibitors
Potential drug class side effects
Fuzeon (enfuvirtide, T-20, ENF)
Selzentry (maraviroc, or MVC )
Single-Tablet Regimens (STRs)
Atripla (efavirenz/emtricitabine/tenofovir)
C omplera (rilpivirine/emtricitabine/tenofovir)
The "Quad"
(elvitegravir/cobicistat/emtricitabine/tenofovir)
(investigational drug)
PK Enhancer
C obicistat (or C OBI) (investigational drug)
open in browser PRO version Are you a developer? Try out the HTML to PDF API
Available data is limited due to investigational status at press
time.
Seen in clinical study: diarrhea, upper respiratory tract
infection, bronchitis, back pain, depression, sinusitis, joint
pain, nausea, and urinary tract infection. Available data is
limited due to investigational status at press time.
Immune Reconstitution Inflammatory Syndrome (IRIS) may
occur as the immune system regains strength; signs and
symptoms of inflammation from previous infections may
occur soon after anti-HIV treatment is initiated. Report
symptoms of illness, such as shingles and TB, to a health
care provider.
Injection site reactions (ISRs), pneumonia, diarrhea, nausea,
and fatigue. Hypersensitivity reactions are possible.
C ough, fever, cold, rash, muscle and joint pain, stomach
pain, dizziness, liver toxicity, allergic reaction, low blood
pressure, and possible increased risk of infections and
cancer.
See Sustiva and Truvada (Emtriva and Viread). Atripla dose
cannot be adjusted for people with kidney problems. Nausea,
diarrhea, rash, insomnia, abnormal dreams, and depressive
disorders.
See Edurant and Truvada (Emtriva and Viread). C omplera
dose cannot be adjusted for people with kidney problems.
Insomnia, headache, nausea, dizziness, rash, abnormal
dreams, and depressive disorders.
See elvitegravir, cobicistat, and Truvada (Emtriva and
Viread). The Quad dose cannot be adjusted for people with
kidney problems. Nausea, diarrhea, and rash. Available data
is limited due to investigational status at press time.
Seen in clinical study: diarrhea, nausea, lipid elevations
(increases in cholesterol and triglycerides), creatine kinase,
red blood cells in urine, increased serum creatinine, and
decreased estimated glomerular filtration rate (e-GFR).
pdfcrowd.com
 Available data is limited due to investigational status at press
time.

Got a comment on this article? Write to us at publications@tpan.com.

Similar Efficacy and a Few Gender-Related 20% People Switch Atripla Due to Efavirenz Side
Differences in Side Effects With Rilpivirine Versus Effects: Late Switches Are C ommon
Efavirenz at 96 Weeks

Email Print-Friendly Glossary PDF

This article was provided by Positively Aware. It is a part of the publication Positively Aware. Visit
Positively Aware's website to find out more about the publication.

The 16th Annual HIV Drug Guide

More on HIV Medication Side Effects

GOP: Don't Be Starting HIV Please Sign My

Penny-Wise Treatment Petition for
and Dollar- Soon After C lemency and
Foolish With Diagnosis Help End HIV
Our Health Trims Time to C riminalization
C are Viral

2017 Remedy Health Media, LLC . All Rights Reserved

The Body: About The Body | C ontact The Body | Site Policies | C ontent Providers | Advertise With Us | Site Map

Remedy Health Media: About Remedy Health Media | C ontact Remedy Health Media | Terms of Use | Privacy Policy

The Body is a service of Remedy Health Media, LLC , 750 3rd Avenue, 6th Floor, New York, NY 10017. The Body and its logos are trademarks of Remedy Health Media,
LLC , and its subsidiaries, which owns the copyright of The Body's homepage, topic pages, page designs and HTML code. General Disclaimer: The Body is designed
for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body should not be used

open in browser PRO version Are you a developer? Try out the HTML to PDF API pdfcrowd.com
 for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body should not be used
for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult
your health care provider.

open in browser PRO version Are you a developer? Try out the HTML to PDF API pdfcrowd.com