B.

PATHOPHYSIOLOGY OF NEONATAL JAUNDICE

Predisposing Factors:
8 days old
Female
Preterm borderline neonate

RBC lifespan of 120 days

RBC will become fragile

Cellular content will be release

Macrophages will phagocytized it

Hemoglobin will split into

Heme Globins

Iron Biliverdin Breakdown into amino acids

Will go to the bone marrow Reduct into bilirubin (indirect, unconjugated) fat soluble
for new RBC production

Transport to the liver with the help of albumin

Absence of glucuronyl transferase produced by liver

Unconjugated to convert

Increase unconjugated bilirubin

To the blood stream

HYPERBILIRUBINEMIA
Yellow discoloration of sclera, skin, conjunctiva

HYPERBILIRUBENIA

MANAGEMENT:
Bilirubin light