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Immuno TB Flashcards Unit 3
joints, chronic runny nose, and coughing up blood. Chest x-ray shows
pulmonary nodules. Cortisol is increased; ESR is slightly elevated.
Tests for autoantibodies are positive for cytoplasmic antineutrophil
cytoplasmic antibodies. This patient has:
8) The CREST variant of which disease is associated with the presence progressive
of an anticentromere antibody? systemic sclerosis
(scleroderma)
9) A 40-year-old female patient has increased TSH and decreased rT3
and T4 levels with a normal T3 level. Antithyroglobulin is measured Hashimoto's
as 1:1280, and the antimicrosomal level is reportedly 1:6400. This thyroiditis
patient most likely has:
10) What lab findings would be most likely to indicate multiple sclerosis? several bands on
electrophoresis of
CSF
11) Systemic lupus erythematosus can be characterized by all of the
following EXCEPT:
A) butterfly rash
D
B) joint pain
C) presence of circulating immune complexes
D) presence of reagin antibody
12) In the slide agglutination for lupus, what is detected? anti-DNP
13) An autoimmune disease characterized by pain and progressive
rheumatoid
destruction of the joints, weight loss, morning stiffness, and presence
arthritis
of an antibody directed against IgG best describes:
14) Reasons for autoimmunity may include all of the following EXCEPT:
A) inheritance of certain HLA antigens
B) molecular mimicry D
C) polyclonal B cell activation
D) normal antibody production
15) The characteristic ANA pattern produced by antibody to DNA-histone
homogeneous
complex is:
16) A disease characterized by hypoactivity of the thyroid with weight
Hashimoto's
gain and a sluggish metabolism due to destruction of thyroglobulin
thyroiditis
best describes:
17) In the RF test for rheumatoid arthritis, what is being detected? IgM directed
against IgG
18) 18. What are characteristic of cold autoimmune hemolytic anemia? The antibody
reacts as an anti-I.
19) The fluorescent antinuclear antibody test for lupus is an example of indirect fluorescent
what? testing
20) What would be an indicator of systemic lupus? anti-Sm antibody
21) In which one of the following autoimmune diseases are antibodies to myasthenia gravis
acetylcholine receptors produced, thereby blocking the signal to
muscles?
22) Lupus can be distinguished from rheumatoid arthritis on the basis of deposition of
what? immune
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Immuno TB Flashcards Unit 3
complexes in the
kidney
23) A 25-year-old female sees her physician because of swelling in the rheumatoid
joints of her hands and generally feeling tired and run down. A slide arthritis
agglutination test for antibody directed against IgG is positive. What is
the most likely cause of her symptoms?
24) Antibodies directed against thyroglobulin represent a significant Hashimoto's
finding in what autoimmune diseases? thyroiditis
25) What would be an indicator of systemic lupus? anti-
deoxynucleoprotei
n antibody
26) A 35-year-old female experiences difficulty in walking, and her hands multiple sclerosis
and feet are numb from time to time. Suspecting a disease involving
the central nervous system, her physician orders an MRI. The MRI
reveals lesions on the myelin sheath. What is the most likely disease?
27) All of the following findings would be useful in the diagnosis of D
Graves' disease EXCEPT:
A) presence of antibodies to thyroid-stimulating hormone receptors
B) hyperthyroidism
C) symptoms of nervousness and weight loss
D) increase in allergic IgE
28) Homogeneous staining of the nucleus in an ANA test indicates: antibody to DNA-
histone complex
29) A 16-year-old male goes to his physician for an annual checkup. A Goodpasture's
routine urinalysis indicates the presence of blood, an increase in syndrome
protein, and an increase in urea. The young man reports that he has
been feeling tired and has a persistent cough. The doctor orders
additional lab testing, including a serum test for rheumatoid factor,
antinuclear antibody testing, anti-streptolysin O testing, and testing for
the presence of anti-basement membrane antibodies. Only the latter
test was positive. What is the most likely cause of the symptoms?
30) A CBC, differential, and flow cytometry were performed on a patient B-cell chronic
with the following results (normal values): WBC = 8.0 th/uL (5.010.0 leukemia
th/uL), diff = 90% lymphs (2040%), CD3 = 5% (6080%), CD5 =
95% (6080%), CD19 = 95% (520%), CD10 = 0% (0%), surface Ig
= pos (positive), and cytoplasmic Ig = neg (negative). What disease
does this patient have?
31) What is the interpretation of the following patient results? (normal T-cell chronic
values) WBC = 90.0 th/uL (5.010.0 th/uL,), with 89% lymphs (20 leukemia
40%); CD3 = 90% (6080%); CD5 = 87% (6080%); CD10 = 0% (<
1%); CD4 = 88% (3065%); CD20 = 12% (520%); CD34 = 0% (<
1%); CD8 = 3% (1040%); kappa = 10% (315%); lambda = 5% (2
10%); CD19 = 15% (520%).
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Immuno TB Flashcards Unit 3
32) What is the interpretation of the following patient results? (normal T-cell acute
values) WBC = 25.0 th/uL (5.010.0 th/uL), with 78% blasts; CD3 = leukemia
83% (6080%); CD5 = 90% (6080%); CD10 = 2% (< 1%); CD4 =
85% (3065%); CD20 = 1% (520%); CD34 = 0% (< 1%); CD8 =
87% (1040%); kappa = 1% (315%); lambda = 0% (210%); CD19
= 2% (520%).
33) What is the interpretation of the following patient results? (normal B-cell acute
values) WBC = 7.0 th/uL (5.010.0 th/uL), with 89% blasts; CD3 = leukemia
10% (6080%); CD5 = 9% (6080%); CD10 = 89% (< 1%); CD4 =
6% (3065%); CD20 = 0% (520%); CD34 = 94% (< 1%); CD8 = 3%
(1040%); kappa = 0% (315%); lambda = 0% (210%); CD19 =
90% (520%).
34) Which immunoproliferative disorder is a cancer of the plasma cells multiple myeloma
and results in secretion of light chains into the urine?
35) A 55-year-old male presents with symptoms that include weakness, Waldenstrm's
loss of appetite, and anemia. Immunofixation electrophoresis reveals a macroglobulinemia
heavy IgM band. What is the most likely diagnosis?
36) What is the main difference between leukemias and lymphomas? Lymphomas arise
mainly in lymph
nodes, the spleen,
or other lymphoid
tissue.
37) What best describes the difference between chronic and acute Acute lymphocytic
lymphocytic leukemias? leukemias have a
high response rate
to chemotherapy.
38) Decreased CD3-positive lymphocytes and a lack of responsiveness to DiGeorge
phytohemagglutinin (PHA) in the circulation would typically be syndrome
associated with:
39) What statements about severe combined immunodeficiency (SCID) may be associated
are true? with a signal
transduction defect
40) A 9-month-old boy was suspected of having an immune deficiency X-linked
because he had many recurrent infections with Streptococcus agammaglobuline
pneumoniae. Laboratory tests revealed a normal percentage of T cells mia
and T-cell subsets but a lack of mature B cells and immunoglobulins.
This boy most likely has:
41) A patient with hereditary angioedema will present with swelling in the C1 inhibitor
tissues and has what deficiencies?
42) A 7-month-old boy is seen by a specialist because of hypocalcemia, DiGeorge
viral pneumonia, a history significant for recurrent diarrhea, and oral syndrome
candidiasis. An x-ray reveals the lack of a thymic shadow. This boy
most likely has:
43) An autosomal recessive disease characterized by the presence of Chdiak-Higashi
abnormally large granules primarily affecting the function of syndrome
lysosomes is known as:
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Immuno TB Flashcards Unit 3
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Immuno TB Flashcards Unit 3
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78) How does complement help in defense against bacterial invasion? It promotes
phagocytosis.
79) Antibodies detected by reacting rickettsial antigens with specific Rocky Mountain
antibody followed by use of an anti-immunoglobulin with a spotted fever
fluorescent tag could be used to diagnose: