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Lymphatic System

Spleen
Capsulated
Secondary
Largest accumulation
of lymphoid tissue
Very vascular
(macrophage removing
effete RBC)
Circulation in the Spleen
*Feline Spleen. The Schweigger-Seidel sheath is hard to find in reality.

Sheathed arterioles

Schweigger-Seidel sheath
(sleeve-like sheath)
Penicillary artery
(a.k.a. Brush arterioles)
Branching out

Follicular artery
Through follicle
Central artery
Spleen
Spleen

Labeled with doc


Spleen
Spleen

CA= central artery


Labeled with doc
Spleen

Labeled with doc


Spleen
Collagen capsule

Trabeculae

Follicular (Central) artery

Germinal Center

Corona or mantle zone

Lymph follicle
B-cell outside ( Cortex)
T-cell inside ( Medullary)
Trabecular vessel
Spleen
Follicular (Central) artery
Casule -> Trabeculae

Trabecular vessel

Vascular sinus (sinusoids)


-Yung spaces especially at the margin
-between red and white pulp
RED PULP
Sinusoids=Space
Splenic Cords
(Cord of Billroth)
Rich in
macrophage and
lymphocytes
Splenic Cords
(Cord of Billroth)
Rich in
macrophage and
lymphocytes
White Pulp
Lymphoid nodule
Periarteriolar
lymphoid sheaths
Thymus

Capsulated
Primary
Bilobed
@ mediastinum;
overlying the heart
Lobule

Cortico- Septa
medullary Continuation
junction of capsule
gives
division to
incomplete
lobules

C = Cortex
M = Medulla
CT = Connective tissue (Capsule)
Thymus, L-section
Lobules

Cortex
stained blue-violet
high cell density

Medulla
stained lighter and reddish
low cell density

THYMUS, x-section
Zoom,
cortex

Thymocytes/
Cortex maturing
stained blue-violet lymphocytes
high cell density

Medulla thymocyte/
stained lighter and reddish immature
low cell density lymphocytes

Zoom,
MIGRATION OF THYMOCYTES medulla

BONE ENTERS @ CORTICO- MIGRATION TO


MARROW MEDULLARY JUNCTION OUTER CORTEX
THYMUS, x-section
Intralobular septa/Septa/ trabecula
Continuationn of the capsule
Divides the thymus into lobes.

Zoom
Capsule
Cortex
Medulla Outer region
Inner region

Hassal body/ thymic corpuscle


seen in the medullary region

Capsule
Capsule
Cortex
Medulla Outer region
Inner region

capillary

Hassals bodies
-concentric layers of the
reticulum cells Capsule
-

Zoom, medulla
Hassal corpuscle/ Hassals bodies/
Thymic corpuscle
Cortex Cortex Formed by
-higher cell
density = darker
concentric layers
of reticulum cells
Stain intensely
with eosin (pink)

Medulla
-lower cell Medulla
density = lighter
Credits to: http://www.bu.edu/histology/m/index.htm

Orange = thymocytes ( maturing lymphocytes)


Red = mitotically active cells ( pyknotic nucleus= dark condensed chromatin)
Green = Macrophage
Purple = epithelioreticular cells
Credits to: http://www.bu.edu/histology/m/index.htm
Credits to: http://www.bu.edu/histology/m/index.htm

Green = blood vessels ( capillaries)


Red = epithelioreticular cells
Orange = Hassal corpuscle
Blood vessels

Credits to: http://www.bu.edu/histology/m/index.htm


Adulthood of Ye Thymus

A = Adipose tissue
L = Lymphoid tissue remnants
CT = connective tissue, also where
the capsule is.
Adipose

Lymphoid tissue

Medulla with Hassals corpuscle

Residual
Cortex
tissue

Adult Thymus showing fatty involution ( age involution)


Adipose
Residual thymus tissues Hassals body

Adipose

Adipose
Hassals body
Adipose
Lymp Node

Encapsulated
Secondary
Lymph Node in Theory
Cortex
B-cells predominate

Lymphatic nodule Subcapsular sinus


Germinal center Capsule
Mantle zone
Trabecula

Medulla
Efferent
Medullary sinus
lymphatic
Medullary cord vessel
T-cells predominate

Paracortex

Artery
High endothelial venule Vein
Afferent
lymphatic Blood capillaries
vessels around lymphatic
nodule
Paracortex
High-endothelial
venules
Entry point of
lymphocytes to
the circulation
Medulla
Medullary cords
Medullary sinus
Plasma cells
Lymphocytes

Zoom
Lymph Node
Cortex
Secondary follicle
Medullary cord

Medullary sinus
paracortex
Afferent Lymphatic vessels?

Primary follicle

Trabecular sinus/
cortical/marginal
sinus
Subcapsular sinus

Lymph Node
Primary Secondary
follicle follicle
Tonsils
Partly Encapsulated
Secondary
Part of MALT
According to location:
Palatine
Pharyngeal
Lingual

*See powerpoint notes for full name of MALT.


B-lymphocytes nasa loob

Palatine Tonsils
GC T-cell zone nasa
interfollicular
zone
E LN
C
E

LN

LN LN

GC
E CT CT
E E = Stratified Squamous Epithelium
C LN = Lymphoid nodules
GC = Germinal Centers
CT = Connective Tissue Capsule
C = Crypts
Tonsils Infiltration of lymphocytes in
the epithelium covering the
crypts

Salivary corpuscles C
Yung remnants na nasa crypts daw sabi
ni Doc.
Palatine Tonsils
CT

E = Stratified
GC Squamous Epithelium
GC LN = Lymphoid
C nodules
C GC = Germinal
Centers
E LN CT = Connective
Tissue Capsule
C = Crypts

C LN
Palatine Tonsils
Follicle cap (B-lymphocyte cap)
-ung nag surround sa nodule

Epithelial covering
Stratified squamous non-
keratinized epithelium

Capsular covering:
Connective tissue
Kaya siya partially encapsulated
Lingual Tonsils
Epithelium

Crypts

Lymphoreticular
tissue part of
Lamina propia

Mucus glands
of the Tongue

Connective tissue capsule


Lingual Tonsils
Epithelium

Crypts

Lymphoreticular with the


germinal centers

Connective tissue capsule

Mucos Glands

Tongue Muscles
Pharyngeal Tonsils
multilayered ciliated epithelium Crypts

Goblet cells
Connective
Tissue
( Blue)

Lymphoreticular tissue
(Lymphocytes and reticular
fibers)
Intestine
NOT Encapsulated
Secondary
Still with MALT
GALT (Gut-associated
lymphoid tissue)
GALT
Peyers Patch (Plaques)

Intestinal Villi

Lymphoid Nodules

Germinal Center
Peyers Patches
Peyers Patches
Thymus MALT Lymph Nodes Spleen

Cortex/medulla Distinctly present Absent Present Absent

Lymphoid nodules Absent Present Present (in cortex Present (in white pulp
only) only)

Lymphatic vessels No afferents; few No afferents; Afferents at capsule, No afferents; efferents


efferents in septa efferents present emptying into in trabeculae
subcapsular sinus;
efferent at hilum

Unique features Hassall (thymic) Crypts lined by Thin paracortical Minor white pulp
corpuscles in surface mucosa in region between component, with
medulla; tonsils; epithelial M cortex and central arterioles;
epithelialreticular cells in mucosa medulla, with high major red pulp
cells in cortex and over Peyer endothelial venules component, with
medulla Patches (HEV); medullary many sinusoids
cords and sinuses