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DNA
DNA
Through an intermediate
RNA!
DNA
RNA!
Translation!
protein!
Function!
Replica)on, Transcrip)on and
Transla)on
Informa)on stored in RNA can be
transferred to DNA
Modica)on to the central dogma
protein
Class of RNA!
T h e n u c l e o t i d e i n R N A a r e j o i n e d b y
phosphodiester linkage between 3`carbon of one
nucleotide and the 5` carbon of another!
All known living cells use DNA rather than RNA to store genetic
information!
DNA is chemically more stable than RNA!
!
!
Structure of RNA!
Purine and Pyrimidine are flat and planar, so they can stack on top of one
another. The Van der Waals and electrostatic interactions between stacked
bases contribute to the strong interaction !
Structure of RNA!
The backbone phosphate group are negatively charge and will tend to
repel each other!
Both monovalent (Na+ and K+) and divalent (Mg2+) ions have been found
to shield the negative charge of RNA!
RNA cannot adopt the standard Watson-Crick
double helical structure!
C2` and C5` are in same plane C3` and C5` are in same plane
Found in B-form of double-helix Found in A-form of double-helix
What are A-form and B-form of helix?!
Major groove
Minor groove
C2`-edo