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3/2/2017

Thursday, March 2nd, 2017


Agenda:
What you must know
Meiosis Notes The difference between asexual and sexual reproduction.
The role of meiosis and fertilization in sexually reproducing organisms.
Sordaria Mini Lab
The importance of homologous chromosomes to meiosis.
More movie from yesterday if time
How the chromosome number is reduced from diploid to haploid
Quiz for chapter 12 and 13 due tomorrow night at through the stages of meiosis.
11:59 Three important differences between mitosis and meiosis.
All homework from chapter 12 and 13 is due by The importance of crossing over, independent assortment, and random
fertilization to increasing genetic variability.
Monday
Not accepted for a grade after I leave school Monday!

Genes: segments of DNA that code for basic Types of Reproduction


units of heredity
ASEXUAL SEXUAL
Offspring acquire genes from parents by
inheriting chromosomes Produces clones (genetically Meiosis produces gametes
identical) (sex cells)
Single parent 2 parents: male/female
Little variation in population Lots of variation/diversity
- only through mutations Slower and energy
Fast and energy efficient consumptive
Eg. budding, binary fission Eg. humans, trees

Asexual vs. sexual reproduction Chromosomes


Somatic (body) cell: 2n = 46 chromosomes
Each pair of homologous chromosomes includes 1
chromosome from each parent
Autosomes: 22 pairs of chromosomes that do not determine
sex
Sex chromosomes: X and Y
Females: XX
Males: XY
Gametes (n=23): 22 autosomes + 1 sex chromosome
Egg: 22 + X
Sperm: 22 + X **or** 22 + Y

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Homologous Chromosomes in a Somatic Cell Karyotype: a picture of an


organisms complete set of
chromosomes
Arranged from largest
smallest pair

Making a karyotype unsorted chromosomes 22 pairs of autosomes + 1 pair of sex chromosomes

Male or female?

Male or female? Karyotype - used to determine genetic abnormalities

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Cancer cells
Breast Cancer Cell Karyotype
Some have abnormal #s of chromosomes

Karyotype of
Metastatic
Melanoma

HeLa Cells
HeLa Cells Immortal cells do not die after a
Oldest and most commonly used few divisions
human cell line Active version of telomerase
Cervical cancer cells taken from
Henrietta Lacks (d.1951) Used in research:
Develop vaccine for polio
Cancer, AIDS, virus, radiation
research

Estimated that cells produced in


culture exceeded # cells in
Henriettas body

HeLa Cell Karyotype

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HeLa Cells Ethical Concerns


Controversy: Cells harvested without
patient consent
Discarded tissues can be
commercialized sold for profit
Genome published in 2013 without
familys consent

The Immortal Life of Henrietta Lacks by


Rebecca Skloot

Life cycle: reproductive history of organism,


from conception production of own Varieties of Sexual Life Cycles
offspring
Fertilization and meiosis alternate in sexual life cycles
Meiosis: cell division that reduces # of chromosomes (2n
n), creates gametes
Fertilization: combine gametes (sperm + egg)
Fertilized egg = zygote (2n)
Zygote divides by mitosis to make multicellular diploid
organism

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Human Life Cycle

Animals

Alternation of
Generations
Plant and some algae
Sporophyte (2n):
makes haploid spores
by meiosis
Spore gametophyte
by mitosis
Gametophyte (n):
makes haploid
gametes by mitosis

Varieties of Sexual Life Cycles

Fungi, protists,
algae

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Meiosis I (1st division)


Meiosis = reduction division Interphase: chromosomes replicated
Prophase I:
Cells divide twice
Synapsis: homologous chromosomes pair up
Result: 4 daughter cells, Tetrad = 4 sister chromatids
each with half as many Crossing over at the chiasmata
chromosomes as parent Metaphase I: Tetrads line up
cell Anaphase I:
Pairs of homologous chromosomes separate
(Sister chromatids still attached by centromere)
Telophase I & Cytokinesis:
Haploid set of chromosomes in each cell
Each chromosome = 2 sister chromatids
Some species: chromatin & nucleus reforms

Meiosis II (2nd division) = create gametes


Prophase II:
No interphase
No crossing over
Spindle forms
Metaphase II:
Chromosomes line up
Anaphase II:
Sister chromatids separate
Telophase II:
4 haploid cells
Nuclei reappear
Each daughter cell genetically unique

Events Unique to Meiosis I (not in mitosis)

1. Prophase I: Synapsis and crossing over


2. Metaphase I: pairs of homologous
chromosomes line up on metaphase
plate
3. Anaphase I: homologous pairs separate
sister chromatids still attached at
centromere

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Sources of Genetic Variation: Sources of Genetic Variation:


1. Crossing Over 2. Independent Assortment of Chromosomes
Exchange genetic Random orientation of homologous pairs in Metaphase I
material
Recombinant
chromosomes

Sources of Genetic Variation:


Mitosis Meiosis
3. Random Fertilization
Both are divisions of cell nucleus
Any sperm + Any egg
Somatic cells Gametes
8 million X 8 million = 64 trillion combinations!
1 division 2 divisions
2 diploid daughter cells 4 haploid daughter cells
Clones
Genetically different-less than 1 in
From zygote to death 8 million alike
Purpose: growth and repair
Females before birth follicles are
No synapsis, crossing over formed. Mature ova released
beginning puberty
Purpose: Reproduction

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