Académique Documents
Professionnel Documents
Culture Documents
ANATOMY
1. In the chart below, checkmark which types of blood cells are derived from myeloid vs. lymphoid
stem cells. (p. 342)
2. List the types of white blood cells in order of decreasing prevalence. (pp. 342-343) _____________
______________________________________________________________________________
6. B lymphocytes are produced in the _______________ (bone marrow/thymus) and mature in the
_______________ (bone marrow/thymus). T lymphocytes are produced in the _______________
(bone marrow/thymus) and mature in the _______________ (bone marrow/thymus). (p. 344)
PHYSIOLOGY
7. Why are Rh-negative mothers given RhoGAM ? (p. 345) _________________________________
8. In the chart below, checkmark which coagulation factors are in the intrinsic vs. extrinsic coagulation
pathways. (p. 345)
10. Describe the four steps of primary hemostasis and platelet plug formation. (p. 346) ____________
______________________________________________________________________________
PATHOLOGY
11. Identify each cell type and its associated pathology. (pp. 348-349)
A. B. C. D E. F.
A. _______________________________ D. ______________________________
B. _______________________________ E. ______________________________
C. _______________________________ F. ______________________________
12. Indicate whether the lab findings in the chart are elevated, decreased, or normal. (pp. 349-353)
Anemia of
Hemochroma- Iron Pregnancy/
Lab Value Chronic Thalassemia
tosis Deficiency OCPs
Disease
Ferritin
Serum iron
Transferrin
% Transferrin
13. In -thalassemia, what is the condition called when all four -globin genes are deleted? When
three are deleted? When one or two are deleted? (p. 349) ________________________________
______________________________________________________________________________
14. What are the major history and physical exam findings of lead poisoning? (p. 350) _____________
______________________________________________________________________________
15. What clinical findings differentiate megaloblastic anemia due to folate deficiency versus that due to
vitamin B12 deficiency? (p. 350) _____________________________________________________
16. What are four causes of aplastic anemia? (p. 351) ______________________________________
______________________________________________________________________________
17. Match the intrinsic hemolytic normocytic anemia with its characteristic. (p. 352)
_____ A. G6PD deficiency 1. GLU LYS mutation
_____ B. HbC defect 2. GLU VAL mutation
_____ C. Hereditary spherocytosis 3. Heinz bodies
_____ D. Paroxysmal nocturnal hemoglobinuria 4. Howell-Jolly bodies
_____ E. Pyruvate kinase deficiency 5. Increased hemosiderin in urine
_____ F. Sickle cell anemia 6. Rigid RBCs
18. Which autoimmune hemolytic anemias are associated with warm agglutinins? With cold
agglutinins? (p. 353) ______________________________________________________________
______________________________________________________________________________
19. What are the 5 Ps of acute intermittent porphyria? (p. 354) ______________________________
______________________________________________________________________________
20. Indicate whether the lab findings in the chart are elevated, decreased, or normal. (pp. 355-356)
Platelet Bleeding
Disorder PT PPT
Count Time
DIC
Glanzmanns thromboasthenia
Hemophilia
ITP/TTP
Vitamin K deficiency
von Willebrands disease
22. Which type of Hodgkins lymphoma is more common in women? (p. 357) ____________________
23. What will serum protein electrophoresis reveal in a patient with multiple myeloma? What will be
seen in the urine? (p. 358) _________________________________________________________
24. Match the disease with the genetic translocation most closely associated with it. (pp. 358-360)
_____ A. Burkitts lymphoma 1. t(8;14)
_____ B. Chronic myelogenous leukemia 2. t(9;22)
_____ C. Ewings sarcoma 3. t(11;14)
_____ D. Follicular lymphoma 4. t(11;22)
_____ E. M3 type of AML 5. t(14;18)
_____ F. Mantle cell lymphoma 6. t(15;17)
25. What are the four major groups of leukemias? Which type is associated with Auer rods? (pp. 359-
360) __________________________________________________________________________
26. Indicate whether the lab findings in the chart are elevated, decreased, or normal. (p. 361)
Chronic
Myeloproliferative Platelets RBCs WBCs
Disorder
CML
Essential
thrombocytosis
Myelofibrosis
Polycythemia vera
PHARMACOLOGY
27. Indicate how the drugs in the chart affect the lab findings. (pp. 362-363)
Bleeding Platelet
Drug PT PTT
Time Count
Aspirin
Clopidogrel/abciximab
Heparin
Warfarin
28. What is the mechanism of action of heparin? How is overdose treated? (p. 362) ______________
______________________________________________________________________________
29. What is the mechanism of action of warfarin? How is overdose treated? (p. 362) ______________
______________________________________________________________________________
31. Match the patient with the drug he or she is most likely taking. (pp. 365-366)
_____ A. Patient preparing for bone marrow transplantation has 1. Bleomycin
PFTs consistent with restrictive lung disease 2. Busulfan
_____ B. Patient with colon cancer has myelosuppression 3. Cyclophosphamide
not reversible with leucovorin 4. Doxorubicin
_____ C. Patient with non-Hodgkins lymphoma is having 5. 5-Fluorouracil
hemorrhagic cystitis 6. Methotrexate
_____ D. Patient with leukemia is having myelosuppression
reversible with leucovorin
_____ E. Patient with solid tumor is having dilated cardiomyopathy
_____ F. Patient with testicular cancer has PFTs consistent with restrictive lung disease
Answers
ANATOMY
1.
PHYSIOLOGY
7. To prevent the development of anti-Rh IgG, which can cause erythroblastosis fetalis in a
subsequent fetus.
8.
Factor Extrinsic Pathway Intrinsic Pathway Both Pathways
I
II
V
VII
VIII
IX
X
XI
XII
10. Injury: Endothelial damage prompts vWF binding to exposed collagen. Adhesion: Platelets bind
2+
vWF and release ADP/Ca . Activation: GpIIb/IIIa is expressed. Aggregation: Fibrinogen binds
GpIIb/IIIa and links platelets.
PATHOLOGY
11. A = Bite cell: G6PD deficiency. B = Ringed sideroblast: sideroblastic anemia. C = Schistocyte:
microangiopathic hemolytic anemia (DIC, TTP, HUS). D = Teardrop cell: bone marrow infiltration or
myelofibrosis. E = Target cell: HbC disease, asplenia, liver disease, thalassemia. F = Heinz bodies:
-thalassemia, G6PD deficiency.
12.
Anemia of
Hemochroma- Iron Pregnancy/
Lab Value Chronic Thalassemia
tosis Deficiency OCPs
Disease
Ferritin normal normal
Serum iron normal normal
Transferrin normal
% Transferrin normal to normal
13. Four deletions: Hb Barts; three deletions: HbH disease; one or two deletions: asymptomatic.
14. History reveals abdominal colic and confusion. Physical exam shows wrist and foot drop and
Burtons lines on gingiva.
15. Megaloblastic anemia due to vitamin B12 deficiency is associated with neurologic symptoms.
16. Idiopathic, radiation and drug exposure, viral infection, and Fanconis anemia.
18. Warm agglutinins (IgG): SLE, chronic lymphocytic leukemia, and certain drug reactions. Cold
agglutinins (IgM): chronic lymphocytic leukemia, Mycoplasma pneumoniae infection, and infectious
mononucleosis.
19. Painful abdomen, Pink urine, Polyneuropathy, Psychological disturbances, and Precipitated by
drugs (alcohol, barbiturates).
20.
Platelet Bleeding
Disorder PT PPT
Count Time
DIC
Glanzmanns thromboasthenia normal normal normal
Hemophilia normal normal normal
ITP/TTP normal normal
Vitamin K deficiency normal normal
von Willebrands disease normal normal
23. An M-spike, representing a monoclonal antibody; IgG light chains (Bence-Jones proteins).
25. AML (associated with Auer rods), ALL, CML, and CLL.
26.
Chronic
Myeloproliferative Platelets RBCs WBCs
Disorder
CML
Essential
thrombocytosis
Myelofibrosis variable variable
Polycythemia vera
PHARMACOLOGY
27.
Bleeding Platelet
Drug PT PTT
Time Count
28. Heparin activates antithrombin, decreasing thrombin and Xa. Treat heparin overdose with
protamine sulfate.
29. Warfarin interferes with normal synthesis and -carboxylation of vitamin K-dependent clotting
factors. Treat warfarin overdose with intravenous vitamin K and fresh frozen plasma.
30. A-5, B-1, C-9, D-8, E-3, F-2, G-4, H-7, I-6, J-10.