TopicsforMastersThesisinSummerSemester2015

BIOTEC

GroupofKonstantinosAnastassiadisGeneticEngineeringofStemCells

1.AnalysisoftheUtyknockoutphenotypeduringmouseembryonicdevelopment
(embryology)

2.MechanisticinsightintotheregulationofearlygrowthresponsegenesbyInterferon
gammainbonemarrowmesenchymalstromalprogenitors.(Molecularbiology)

Contact:konstantinos.anastassiadis@biotec.tudresden.de

GroupofMichaelBrandDevelopmentalBiology

1.GenerationofknockinallelesinzebrafishusingCRISPR/Casteachnology

2.SmallmoleculescreentoidentifycompoundsaffectingzebrafishCNS/retinaregeneration

Contact:michael.brand@biotec.tudresden.deandstefan.hans@biotec.tudresden.de

GroupofCarloVittorioCannistraciBiomedicalCybernetics

SystemsandNetworkBiology:

1. Unsupervisedexplorativeanalysisoftissuegeneexpressionprofilesbymachinelearning
fordetectionofcommondevelopmentalpatternsinvertebratesandinvertebrates.

2. Decoupling linear and nonlinear associations of gene expression in genome wide

expressionstudies.

3.Investigationoftopologicalwiringmodelsinbrainnetworks

4.Studyingstructureandtopologyofneuronglianetworkinteractionnetworks.

5.Miningthetopologicalpropertiesofdomainresolvedproteininteractionnetworks

6. Characterizing a biochemical universal space of representation for tissue protein

expressionfunctionalnetworks

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PersonalisedMedicine:

1.Geneexpressionbasedmachinelearningpredictionofclinicaloutcomeforcancerpatients
treatedwithchemotherapy
2. Integrating molecular networks and genomic profiles for the definition of personalised
therapeuticalplansandindividualiseddrugtreatmentsincancer

3.Usingmolecularnetworksandgenomicprofilestostudygutmicrobiotapatternsinheart
attack,diabetesandneurodegenerativedisease.

4.Studingthenetworkofgrowthdifferentiationfactorsabletocontrastagingandage
relateddisease.

5.Machinelearningmodelsforstudyingantibioticresistantbacteriapropagationand
dynamics

Othersubjectsareavailable,andwearealsoopentolistentoexcitingsubjectproposals
fromthestudents.
ContactdirectlyCarloVittorioCannistraci:carlo.cannistraci@biotec.tudresden.de

GroupofJochenGuckCellularMachines

1.Highthroughputcellmechanicsmeasurementswithrealtimedeformabilitycytometry

2.Deformationofcellsandvesicleswithanopticalstretcher

3.Durotaxisofmacrophages

Contact:jochen.guck@biotec.tudresden.de

GroupofJrgMansfeldProteolysisinCellFateDecisions

InvestigatingthetemporalspatiallocalizationoftheAPC/Cduringmitoticentry

Formoredetails,seeattacheddescription
Contact:joerg.mansfeld@biotec.tudresden.de

GroupofMariaTeresaPisabarroStructuralBioinformaticsand
ComputationalBiology

PleasecontactdirectlyMaytePisabarroorSergeySamsonov:mayte.pisabarro@biotec.tu
dresden.deandsergey.samsonov@biotec.tudresden.de

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GroupofFrancisStewartGenomics

1. Analysisofahistonemethyltransferaseinmousedevelopmentanditsimplications
forepigeneticregulation.

2. AnalysisofanMll4mousemutantwithrespiratoryfailure

3. Derivationofdoublemutantmouseembryonicstemcelllinesfromblastocystculture

4. Measuringtheflexibilityofchromatininlivingcellsusingsitespecificrecombination

Contact:francis.stewart@biotec.tudresden.de

BCUBE

GroupofStefanDiezMolecularTransportinCellBiologyand
Nanotechnology

1.Singlemoleculestudiesonmotorproteinswithnmaccuracyin3D
(involves:surfacestructuring,microtubules,kinesinand/ordyneinmotors,imagiing
techniques,fluorescencemicroscopy)

Contact:diez@bcubedresden.de

CRTD

GroupofChristianBkelStemCellNichesinDrosophila

Please,contactdirectly:christian.boekel@crtdresden.de

LeibnizInstituteofPolymerResearchandMaxBergmannCenterfor
Biomaterials

GroupofHansGeorgBraunPolymermicroandnanostructure

WithinalongtermcooperationwiththeCenterofNanoscienceandEngineeringatthe
IndianInstituteofScienceMagneticcontrolledspiralmicroswimmers(1,2)willbeexplored
as
- A) Bionalyticaltools
- B) Nanoreactionsites
- C) Transportersacrossliquid/liquidphaseboundariesandmembranes

Themotionofspiralmicroswimmerscanbecontrolledbyexternalmagneticfields.
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 A) Appropriatefunctionalizationoftheswimmerswithfunctionalentitiesusedin
chemiluminescentanalyticalassays(HorseradishPeroxidase)willbeexploredin
ordertotesttheswimmersystemsfordetectingandmeasuringanalytesinan
microenvironment.
B) Thefunctionalizationofswimmerswithcatalyticsites(appropriateenzymes)will
allowtocatalyzechemicalreactionsattheswimmerslocationandtotriggerlocalself
organizationsuchasthepHinducedselforganizationofoligopeptidegelators(3)
C) Thebehaviorofmicroswimmersatliquid/liquidphaseboundarieswillbestrongly
dependentoninterfacialpropertiesbothoftheliquidcomponentsbutalsoonthe
solidliquidinteractionsbetweenswimmersurfacesandsurroundingliquids.Of
particularinterestisthetransferofswimmersacrosslipidmembranebilayers
separatingtwoaqueouscontainments.Appropriatemembranesystemsshouldbe
realizedaccordingtomethodsdescribedinliterature(4,5)

Alltopicscan/willincludealsothepreparationofspiralswimmersonthescaleof30
to50micrometerby2photonlithography(6)

Formoredetails,seeattacheddescriptionContact:Braun@ipfdd.de

GroupofCarstenWernerBiofunctionalPolymerMaterials

1.Causeandconsequenceofadhesiveinteractionsofhematopoieticstemcells

2.Developmentofafeedbackcontrolledanticoagulanthydrogelbasedonadirectthrombin
inhibitor

3. Synthesis and characterization of a peptide functionalized hydrogel for delivery of

neuroprotectiveagentsforapplicationsinneurodegenerativediseases

4.Exploringthepotentialofpolymerstoinhibitthefibrillationofalphasynucleinthemis
foldedproteininParkinsonsdisease

Contact:werner@ipfdd.de

InstituteofMaterialsScienceTUDresden

GroupofDieterScharnweberBiomaterials

1.InfluenceofchemicallymodifiedhyaluronanontheVEGFmediatedproliferationof
humanendothelialcells

2.DevelopmentofaconjugationandpurificationprotocolforBMP2conjugatedto
oligonucleotidesforapplicationsinamodularDNAbasedimmobilisationsystem

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Formoredetails,seeattacheddescription
Contact:dieter.scharnweber@tudresden.de

GroupofGianaurelioCunibertiMaterialsScienceandNanotechnology

1.Transportpropertiesofmolecularswitches

2. Modeling Electron Transport In Boron Nanotubes Studying the materials properties of

novelboronnanostructures

3.ModelingofPolymerWrappingAroundCarbonNanotubes

4.SynthesisofDopedCarbonNanostubesforApplicationsinBiosensorsandGasSensors

5.OnChipCharacterisationofOneDimensionalNanomaterialsForBiosensorsApplication

6.SynthesisofNovelBoronbasedNanostructures

7. Efficient energy conversion at the molecular level Theoretical study of thermoelectric

figureofmeritofmolecularjunctions

8. STMstudiesofmoleculesformolecularelectronicsExperimentalstudyofsingleorganic
moleculesbyScanningTunnelingMicroscope(STM)andspectroscopyatlowtemperature

9.BiomaterialSilicaNetworkingGrowthmechanismsinbiomaterialsilicananostructures

10. Organically coated Silica Nanoparticles Dispersed in Glass Material modelling of

nanoparticlesrandomlydispersedinanamorphousmatrix

11. Pyroelectrocatalytic disinfection of bacteria cells Experimental study of

disinfectionwithPyroelectricmaterials

12. Screening of bacterial slayer proteins for metal binding Experimental study of metal
bindingbehaviorofnativeandbiochemicallymodifiedslayerproteins

13. CharacterizationoftargetsurfacesforphotocatalysisExperimentalstudyofmicroand
nanoscopicproperties

14. Characterization of immobilized photocatalysts Experimental study of degradation

properties

15.Modelingandcharacterizationoffieldeffecttransistorsforchemicalsensorapplications

16. Biochemical Functionalization of SiO2 Impedance spectroscopy on bound receptor

biomolecules

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17. NanowireGrowthfromSolutionUsingDielectrophoresisExperimentalinvestigationof
theeffectofprocessparametersonwiregrowthtooptimizetheirmorphology

18. Functionalization of metallic nanowires Transfer of a routine lab protocol for gold
surfacestogoldnanowires

19.ElectrochemicalfunctionalizationofnanowirebiosensorsExperimentalinvestigationof
electrochemicaldepositionwithsiliconnanowirefieldeffecttransistorsforbiosensorics

20.Onchipintegrationofreferenceelectrodesforsiliconnanowirebasedbiosensors

21.FlexibleinterconnectionsformedicalelectronicsExperimentalStudies

22.ImpedancesensorforchronicwoundsmonitoringExperimentalStudies

23.DesignofmetaloxidenanowiresforamultifunctionalgassensorExperimentalStudies

24.BacterialnanowiresforbiosensoringdevicesExperimentalStudies

25.ElectronicandTransportPropertiesof2DMaterials

26.ChargeTransportthroughTopologicalInsulators

27.Organicelectronicmaterials

Formoredetails,seeattacheddescription
Contact:teaching@nano.tudresden.deand/org.cuniberti@tudresden.de
Fortopicsnumber25to27,pleasecontact:Frank.Ortmann@nano.tudresden.de

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