aneoi7 ‘Ahihaus Ulcers Mescation: Corcosteraids, Oral Rinsas
Medscape
Aphthous Ulcers Medication
Updated: Jan 20, 2017
Author: Crispian Scully, MD, MRCS, PhD, MDS, CBE, FDSRCS(Eng), FDOSRCPS, FFDRCSI,
FDSRCSE, FRCPath, FMedSci, FHEA, FUCL, FSB, DSc, DChD, DMed(HC), Dr(HC); Chief Editor:
Arlen D Meyers, MD, MBA more...
MEDICATION
Medication Summary
TCs remain the mainstay of treatment for recurrent aphthous stomatitis (RAS). TCs reduce the
number of ulcer days compared with controls, but they have no consistent effect on the frequency
of ulceration. TCs may reduce the ulcer duration and pain. Amlexanox oral adhesive pellicles or
oral adhesive tablets appear to reduce ulcer pain and duration.
Chlorhexidine gluconate mouth rinses reduce the severity and pain of ulceration but do not affect
the frequency.
The range of systemic medications available is of variable or unproven efficacy or may have
serious adverse effects; such agents include systemic corticosteroids, colchicine, clofazimine, and
thalidomide (and many others). [131
Corticosteroids
Class Summary
A spectrum of different TCs can be used. All can reduce symptoms, and neither hydrocortisone nor
triamcinolone preparations cause adrenal suppression. Ulcers still recur.
Hydrocortisone topical (Cortaid, Dermacort, Westcort)
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Decreases inflammation by suppressing migration of PMNs and reversing increased capillary
permeability
Triamcinolone topical (Aristocort, Flutex, Kenalog)
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Decreases inflammation by suppressing migration of PMNs and reversing capillary permeability.
Betamethasone topical (Alphatrex, Diprolene, Maxivate)
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For inflammatory dermatoses responsive to steroids. Decreases inflammation by suppressing
migration of PMNs and reversing capillary permeability.
hitpvlemecicina medscape.convartcl/857080-medicaiontshouall 1aneoi7 Aphihaus Ulcers Mescation: Corticosteroids, Oral Rinsas
Fluocinolone (Synalar, Fluonid)
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High-potency topical corticosteroid that inhibits cell proliferation and is immunosuppressive,
antiproliferative, and anti-inflammatory.
Fluocinonide (Fluonex, Lidex)
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High-potency topical corticosteroid that inhibits cell proliferation and is immunosuppressive and
anti-inflammatory.
Clobetasol (Temovate)
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Class | superpotent topical steroid; suppresses mitosis and increases synthesis of proteins that
decrease inflammation and cause vasoconstriction.
Oral Rinses
Class Summary
Mucoadhesive action reduces pain by adhering to the mucosal surface of the mouth.
Bioadherent oral (Gelclair)
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This agent adheres to the mucosal surface of mouth and forms a protective coating that shields
exposed and overstimulated nerve endings. Ingredients include water, maltodextrin, propylene
glycol, polyvinylpyrrolidone (PVP), sodium hyaluronate, potassium sorbate, sodium benzoate,
hydroxy ethylcellulose, polyethylene glycol (PEG)—40, hydrogenated castor oil, disodium edetate,
benzalkonium chloride, flavoring, saccharin sodium, and glycyrrhetinic acid
Follow-up
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