Académique Documents
Professionnel Documents
Culture Documents
Pain thresholdLevel of
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Relief of pain
Analgesics
Anaesthetic agents
General anaesthetics
Local anaesthetics
Narcotic analgesics
Properties
Morphine
Papaver somniferum
prototype of opioids
PA
CNS depression
Sedation
Respiratory depression
Analgesia
CI
Asthma
drug allergy
Paralytic ileus
Morbid obesity with sleep apnea
Patients with severe head injuries
ADE
Naloxone
Codeine
Natural alkaloid
Generalized CNS depression
mild to moderate pain
combination with other analgesics Tylenol with codeine
Methadone
Synthetic opioid
Physical dependence
agonist
Drug of choice for detoxification treatment for opioid addiction
Meperidine(Pethidine)
Non-narcotic analgesics
Classification
Salicylate
PA
Analgesia
Anti-inflammatory action
Antipyretic action
Antiplatelet effect Inhibit platelet aggregation/adhesion
Uses
Systemic administration:
Non-specific relief of certain types of pain headache
To reduce inflammation acute rheumatic fever
Prophylaxis of thromboembolic diseases coronary heart disease
Local application:
ADE
Nausea/vomiting
Salt-water retention
Increased bleeding tendency
hypersensitivity reaction
Reyes Syndrome(Caused by aspirin & other salicylates)
PARACETAMOL
ADE
INDOMETHACIN
ADE
DICLOFENAC
Uses
Long-term symptomatic t/m in moderate pain & inflammation
rheumatoid arthritis
Orally
Short-term treatment in MSK disorders
CELECOXIB
ADE & CI
INFLAMMATION
CORTICOSTEROID
ADE
Fat redistribution
Hypertension
Glucose intolerance
Risk of infection
Cataracts
CI
Infection
Peptic ulcer
Heart disease
GOUT
Acute Treatment
NSAIDS (indomethacin)
Corticosteroids
Chronic Treatment
Allopurinol
Uricosuric drugs
Low-dose colchicine
RA
auto-immune
Causes inflammation & swelling
Disease-modifying anti-rheumatic drugs (DMRDs) are recommended
for almost all RA patients within 3 months of diagnosis to reduce joint
damage, preserve joint structure & function, improve patients
symptoms & lower health care costs
Steroids are often used along with DMARDs DMARDs may take weeks
to months to have effects. Prednisolone is most often used with
DMARDs