Académique Documents
Professionnel Documents
Culture Documents
:Definition
:I ms of studying of biochemistry
Microbiology-1
Immunology-2
Pharmacology-3
Toxicology-4
Pathology-5
Physiology-6
. Diagnosis of diseases-1
.Treatment of diseases-2
.Preventation of diseases-3
1
:Examples
C)Lipids Arteriosclerosis
: B)Macromolecules (polymers)
Proteins 3-Lipids -1
2
:A)Proteins
:B)Carbohydrates
monomers : monosaccharide-
:C)Lipids
: D)Nucleic acids
monomers : nucleotides-
Elements-1
Simble molecules-2
Macro molecules-3
3
Cells-5
Tissues-6
Organs-7
Body-8
:Elements of life
:Atoms
(-) = electrons
(+) p= proton
n= neutron (o)
:Example
:NaCl
of 1
an electron
4
The remaining 4% consist of ca, p , k , Na , Cl , Mg -
.and S
: Compounds-
5
: Electro negativity and polarity
: Electro negativity
; Example
HF , CH3- C = N
N.B
The bond between two different atoms called polar -
bond , except the bond between ( C, H ) in
hydrocarbons such as : alkane called non polar
.bond
: Examples
O
HF , H C =N , CH3- C O H ,
CH3 CH3
6
The bond between two atoms (non metals ) have -
equally electronegativity called non polar covalent
. bond
: Examples
N. B
O=C=O
7
: Chemical Bonds
: Types of bonds-
. Ionic bonds-1
.Covalent bonds-2
8
. Ionic bond occurs between metal and nonmetal -
:Example
NaCl
Na loss of an 1 Na+
-
e + Cl Gain of an 1e Cl
:B)Covalent bonds
Covalent bond result from the sharing of electrons -
.between two atoms
: Example
O=O N=N
single bond double bond
triple bond H-H
9
; Non covalent bond -2
Equal attraction of bond electrons ( they have
same electronegativity)
e.g ; H H , FF, O =O , N=N
:Chemical interaction
:Types of interactions
.Vandderwaals forces-1
.Dipole-Dipole interaction-2
.Hydrogen bonding-3
or
10
Example : CH4 , CH3 - CH3 , CH=CH2
Dipole -Dipole -2 ;
forces
:
Dipole Dipole interactions occurs between the -
.permanent dipoles of two polar molecules
:Examples
:Hydrogen bonding -3
e.g
11
O
H H. O H
Hydrogen bond
: Example
Electrostatic bonds
Result from the electrostatic attraction between-
two ionized groups of opposite charge such as
carboxyl ( - COO- ) and
12
amino ( - NH3 +
)
:Hydrophobic interaction -
Cause non polar groups such as hydrocarbons -
chains to associate with each other in an aqueous
. environment
Chemical equations
Reactants products
:Balancing equations
:Example
4Na + O2 2Na2O
13
Two or more simple substances combine to form a single -
.new substance
:Examples
C + O2 CO2
S + O2 SO2
:Examples
2H2O2 O2 + 2H2O
AB + CD AD + BC
:Examples
:Examples
CH3 CH2CH2CH3
aliphatic
:Functional groups-4
15
The properties of the major classes of organic compounds -
(carbohydrates , lipids , proteins and nucleic acid ) are
.determined mostly by their functional groups
.Physical properties-3
.Nome clature-4
.Chemicla reactive-5
O
2-Carbonyi group ( C )
O
3-Carboxyl group ( C O H)
16
: hydroxly groups -1
: Examples
CH3 OH (methanol )
CH3CH2CH (ethanol )
O
: 2-Carbonly (- C - )
O O
-Ketone ( R C R ) and aldehyde ( C H ) contain
.carbonyl groups
O O
CH3 C CH3 CH3CH2 C H
17
acetone
propanal
O
- ( C OH ) has both carbonyl and hydroxyl group attached
.to the same of carbon atom
O O
+
COH CO +H
-
18
.Found in cell in the ionized form-
:Examples
H
-Glycine H 2N C C OOH
H
H
-Alanine 2HN C COOH
CH3
H+
N H + H+ N H
H H
:Sulfhydryl group ( S H ) -5
:Examples
.group is polar ( S H )-
19
In some amino acids and proteins, sulfer is present in the -
form sulfhydryl groups or disulfide groups which
.help stabilize protein structure
:Examples
O O
R O P O H R O P O - + 2H+
-OH O
Non ionized
Ionized
20
:Methyl group ( CH3 ) -7
: Examples
methylbenzene
O
RCOR RO
R
Ester
ether
:Examples
O
CH3 C O CH2CH3 CH 3 CH2 - O-
CH3
O O
CH3 C NH2 R C NH 2
ethanamide amide
21
Identification of functional groups in compounds
Alkanes: ( C-1
C)
:Examples
CH3
CH3CH2CH2CH3
CH3 C CH2 CH3
un branched
branched
22
n= Number of carbon atom
:Some of alkanes-4
Methane CH4
Ethane C2H6
Propane C3H8
Butane C4H10
Pentane C5H12
Hexane C6H14
Heptane C7H16
Octane C8H18
Nonane C9H20
Decane C10H22
:Example
CH3
CH3 CH2 C CH2 CH3
H
:Example
23
CH3 Cl CH2CH3
CH3 C -------- C ------- C ------ C CH3
H H H Br
:Example
Cl
1- CH3 CH2 CH2 CH2 CH3
1 2 3 4 5
C hloro Pentane 2
Br CH3
2- CH3 C CH2 C CH2 CH3
H H
1 2 3 4 5 6
:Example
Cl Cl
CH3 C C CH2 CH3
24
Cl H
1 2 3 4 5
:Example
Br CH3
1- CH3 C CH2 C CH3
H H
1 2 3 4 5
Br CH3 Cl
2- CH3 CH CH2 C CH CH3
H
1 2 3 4 5 6
:Propenteis of alkanes
25
:Example
:Example
CH3 CH 3
CH3 C CH2 CH3 > CH3 C CH3
Higher b.p H CH 3
Combustion-1
Hologenation-2
Pyrolusis (cracking)-3
:A)Combustion
:B)Hologenation
:Example
26
CH4 + Cl2
CH3Cl + HCl
:C)Pyrolysis (cracking)
Alkenes: ( C = C )-2
General molecular formula (CnH2n)-
C C
C C
Alkynes: (C C )-3
27
General formula (CnH2n -2 )-
:Examples
CH3 C H = CH C CH3 -1
1 2 3 4 5
methyl 2 pentene 4
1 2
CH2 CH3
2- CH3 C = CH CH2 CH2CH3
3 4 5 6 7
methyl 3 3
heptene
28
Alkenes and alkynes are very active they can react-2
with many compounds , because of the presence of double
.and triple bonds in their molecule
Addition reactions -
oxidation
reactions
:Addition reactions-1
:Examples
H Br
1- CH3 CH = C H2 + HBr CH3 C C
H
:Examples
Br Br
1- CH3 C = C C H3 + Br2 CH3 C C
CH3
29
C) Hydration : is addition of water to an alkenes and
. alkynes to form an alcohol
:Examples
OH H
O 1- CH3 C CH CH 3
C CH CH3 C CH3
OH
2- CH3 CH CH2 + H2O CH3 C CH3
H
Oxidation
RC = CR C = C RC
30
CH
H H
Reduction
Oxidation
H H H
H HCH HCH
C O C O O C H
H H OH
: Aromatic hydrocarbons
:Benzene structure-2
.Should be planar-
31
Compounds containing two or more benzene rings that -
share (C C ) bonds called polycyclic aromatic
.hydrocarbons
: Examples
:Examples
32
: Properties of aromatic hydrocarbons
Non polar-1
Insoluble in H2O-2
CL2 No reaction + -4
33
Formation of complexes such as phospholipids -1
(important for formation of cell membrane) and
prostaglandins (control blood pressure and cause
.inflammation)
.Diseases-1
34