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What is This?
Julie C. Stout
Indiana University
Rebecca E. Ready
Janet Grace
Paul F. Malloy
Brown University
Jane S. Paulsen
University of Iowa
The Frontal Systems Behavior Scale (FrSBe), formerly called the Frontal Lobe Personality
Scale (FLOPS), is a brief behavior rating scale with demonstrated validity for the assess-
ment of behavior disturbances associated with damage to the frontal-subcortical brain cir-
cuits. The authors report an exploratory principal factor analysis of the FrSBeFamily
Version in a sample including 324 neurological patients and research participants, of which
about 63% were diagnosed with neurodegenerative diseases (Huntingtons, Parkinsons,
and Alzheimers diseases). The three-factor solution accounted for a modest level of vari-
ance (41%) and confirmed a factor structure consistent with the three subscales proposed on
the theoretical basis of the frontal systems. Most items (83%) from the FrSBe subscales of
Apathy, Disinhibition, and Executive Dysfunction loaded saliently on three corresponding
factors. The FrSBe factor structure supports its utility for assessing both the severity of the
three frontal syndromes in aggregate and separately.
Damage to the prefrontal cortex is associated with a lies and on society at large. Neuropsychological methods
wide range of behavioral changes, including disinhibition, for assessing cognitive changes associated with frontal
irritability, apathy, decreased initiation, emotional lability, systems damage have been a focus of study for many
distractibility, irresponsibility, as well as problems with years, and neuropsychological tests are available that ef-
executive functions, working memory, attention, abstract fectively address many of these cognitive disturbances
thinking, mental flexibility, and recall (for a recent review, (Lezak, 1995; Spreen & Strauss, 1998). Fewer measures
see Lichter & Cummings, 2001b). These symptoms pose a are available to assess behavioral disturbances lying out-
threat to personal autonomy and increase burden on fami- side of the cognitive realm, although recent years have
Jessica Jones at Indiana University provided excellent assistance in preparation of this manuscript. We gratefully acknowledge the
contributions of Mary Wyman at Indiana University, who assisted in compiling data. We thank Drs. Guerry Peavy and David Salmon at
the University of California, San Diego Alzheimer Disease Research Center, for providing data from patients with Alzheimers disease.
Beth Turner and Laura Stierman provided assistance in data compilation at the University of Iowa. The project was supported by National
Institutes of HealthNational Institute of Aging AGO-5131 (UCSD-ADRC) and T32AG00214 (predoctoral fellowship to second au-
thor). Correspondence concerning this article should be addressed to Julie C. Stout, Department of Psychology, Indiana University, 1101
E. 10th St., Bloomington, IN 47405-7007; e-mail: jcstout@indiana.edu.
Assessment, Volume 10, No. 1, March 2003 79-85
DOI: 10.1177/1073191102250339
2003 Sage Publications
seen an increase in the availability of such measures (the & Salloway, 2001; Paulsen et al., 1996, 2000; Zawacki
Neuropsychiatric Inventory, Cummings et al., 1994; the et al., 2002). The Family Version of the FrSBe has been
Frontal Systems Behavior Scale [FrSBe], formerly re- used in the majority of the reports, including the primary
ferred to as the Frontal Lobe Personality Scale [FLOPS], validity study of the FrSBe (Grace et al., 1999).
Grace, Stout, & Malloy, 1999; the Frontal Behavior In- The FrSBe has been shown to have high internal consis-
ventory, Kertesz, Davidson, & Fox, 1997; the Apathy tency reliability, and there is growing evidence for the
Evaluation Scale, Marin, Biedrzycki, & Firincioguliari, tests validity for assessing behavioral changes associated
1991). Accurate conceptualization and measurement of with frontal systems damage (Boyle, Grace, Zawacki, Ott,
frontal behavior disturbances are essential steps for de- & Stout, 2001; Grace et al., 1999). The clinical utility of
termining their prevalence and their impact on activities the instrument is indicated by the fact that it measures
of daily living. Furthermore, the precise measurement of characteristics that are at least partly independent of cog-
treatment efficacy depends on the availability of nitive dysfunction and thus is not redundant with cognitive
psychometrically sound scales for measuring specific be- measures (Paulsen et al., 1996; Stout, Wyman, Peavy, &
havioral disturbances. Salmon, 2001; Zawacki et al., 2002). Ratings on the FrSBe
Of the scales listed above, the FrSBe is of particular in- also are associated with important outcome criteria, such
terest for characterizing behavior disturbances related to as functional status (Norton et al., 2001; Stout et al., 2001;
frontal system dysfunction.1 The FrSBe is a behavior rat- Zawacki et al., 2002).
ing scale designed to provide a total frontal disturbance Evidence is beginning to accrue that the FrSBe
score and three subscale scores made up of items devel- subscales are differentially associated with clinical fea-
oped to assess particular behavioral disturbances. Apathy, tures. For example, the Apathy Subscale of the FrSBe was
disinhibition, and executive function were chosen by the more strongly related to activities of daily living in vascu-
scales authors following an extensive search of the clini- lar dementia (Zawacki et al., 2002) and mixed dementia
cal research literature that revealed these three categories groups (Norton et al., 2001). Furthermore, Ready,
of behavior as the most frequently cited behavioral distur- Stierman, and Paulsen (2001) reported evidence of eco-
bances associated with damage to the frontal lobes and logical validity for the various subscales in a healthy un-
frontal-subcortical brain circuitry. In fact, these three fron- dergraduate student sample; the Disinhibition Subscale
tal behavior syndromes have been linked to regional dis- showed differential relationship to engaging in risky and
turbances in frontal lobe function. Specifically, damage to aggressive behaviors (Ready et al., 2001). Sufficient data
the dorsolateral prefrontal cortex has been linked to prob- from neurological patients and research participants has
lems with executive function, the mesial frontal and ante- now accumulated so that it is possible to conduct a factor
rior cingulate cortex with apathy and akinesia, and the analysis of the scale items and to determine if the factor
orbitofrontal cortex with disinhibited behavior and emo- structure of the instrument corresponds to the hypothe-
tional outbursts. These behavioral disturbances are found sized three-subscale structure. This is an essential step for
in individuals who have frontal lobe damage and in indi- determining whether the psychometric features of the
viduals whose damage is at the subcortical levels in brain scale support the intended use of the measure for assessing
structures known to be linked in a regionally specific fash- overall frontal behavior disturbance, as well as differential
ion to frontal cortex (Levin, Eisenberg, & Benton, 1991; presentation of the three frontal syndromes of apathy,
Lhermitte, Pillon, & Serdaru, 1986; Lichter & Cummings, disinhibition, and executive dysfunction.
2001a; Mega & Cummings, 1994; Stuss & Benson, 1986). The goal of this study was to determine whether the fac-
The FrSBe is a 46-item behavior rating scale (Grace & tor structure of the FrSBe supports the subscale structure
Malloy, 2001). Parallel forms exist for use by a family of the scale. For this purpose, we evaluated data from a
member or close caregiver (Family Version), a staff mem- mixed group of neurological patients and research partici-
ber caring for a patient in a professional setting (Staff Ver- pants regarding the frequency ratings of recent behaviors
sion), and for self-ratings by the patient/subject (Self on the FrSBeFamily Version. The study sample was de-
Version). The FrSBe is designed to allow ratings to be signed to include a wide range of neurological disorders
made of recent behavior, and for comparison, an optional that is representative of those for whom the scale will be
retrospective rating of behavior prior to accident, injury, or used in clinical and research settings. Diagnostic heteroge-
treatment. The majority of the studies that have used the neity in the sample ensured that a wide and comprehensive
FrSBe have focused on ratings only of recent (post- range of FrSBe item scores would be represented in the
accident, postinjury, or posttreatment) behavior (Hulver- data, as is recommended for optimal factor analysis
shorn, Stout, Paulsen, & Siemers, 1999; Norton, Malloy, (Gorsuch, 1997; Reise, Waller, & Comrey, 2000).
TABLE 1
Descriptive Statistics for Age, Education, and FrSBe Scales by Diagnosis (N = 324)
AD HD PD FLD Dem, NOS HI CVA
M SD M SD M SD M SD M SD M SD M SD
Age 75.4 7.8 46.5 12.2 68.2 7.8 69.9 8.8 70.7 11.8 41.8 17.5 60.0 19.2
Education 13.1 3.6 13.1 2.3 14.0 2.8 12.5 2.6 11.4 3.7 12.6 3.2
Apathy 41.6 10.7 39.0 11.8 34.8 10.7 48.6 7.9 35.6 12.2 32.3 10.3 36.0 11.5
Disinhibition 27.4 8.9 29.1 9.0 23.8 7.5 34.5 11.0 27.7 9.8 29.5 7.6 29.2 10.3
Executive dysfunction 55.9 12.9 46.1 14.3 40.0 11.1 57.8 13.5 48.8 16.3 41.3 10.4 44.3 15.6
Total 124.9 27.9 114.2 31.0 98.63 23.3 140.9 27.0 112.1 34.6 103.1 25.5 109.6 33.6
N 76 91 38 13 27 29 50
NOTE: AD = probable Alzheimers disease; HD = Huntingtons disease; PD = Parkinsons disease; FLD = frontal lobe dementia; Dem, NOS = dementia,
not otherwise specified, Lewy Body Variant, vascular dementia, traumatic dementia, dementia due to multiple sclerosis; HI = head injury; CVA = cerebral
vascular accident.
and 5 = almost always. The 5-point scale on the last page TABLE 2
(containing the final 11 positively stated scale items) was Pattern Matrix From Principal
reversed so that 1 = almost always, 2 = frequently, 3 = Factor Analysis With Oblique Rotation
sometimes, 4 = seldom, and 5 = almost never, and a rating to Simple Structure (N = 324)
scheme was maintained such that higher ratings corre- A Priori Factor 1 Factor 2 Factor 3
sponded to relatively more abnormal behavior. Item Abbreviation (number) Scale E D A
same factor, and thus, it was possible to make substantive the subscale to which they were theoretically assigned
interpretations of the factors based on item loadings. were Neglects personal hygiene from the Apathy sub-
The first factor, which we labeled Executive Dysfunc- scale, which cross-loaded on the Apathy and Disinhibition
tion, accounted for 29.1% of the variance. Twelve of the factors, and Has difficulty starting an activity, lacks ini-
original 16 Executive Dysfunction subscale items as well tiative, motivation, which cross-loaded on the Apathy and
as 1 item developed for the Apathy subscale had salient Executive Dysfunction factors.
loadings on the Executive Dysfunction factor. The second
factor, which we labeled Disinhibition, accounted for
7.2% of the common variance. It included salient loadings DISCUSSION
by 8 of the original 15 items from the Disinhibition
subscale as well as 1 item from the Apathy subscale. The The exploratory principal factor analysis of the FrSBe
third factor, which we labeled Apathy, accounted for 4.4% confirmed a factor structure consistent with the three
of the common variance, and 9 of the 15 items proposed in subscales that were proposed on the basis of frontal sys-
the original Apathy subscale loaded saliently on this fac- tems behavioral theory. That is, items from the individual
tor, as did one item from the Disinhibition subscale. FrSBe subscales tended to load together on each of three
Consistent with the notion that the three factors were corresponding factors, Apathy, Disinhibition, and Execu-
related to a similar underlying construct (i.e., frontal sys- tive Dysfunction. The Executive Dysfunction factor ac-
tems abnormality), the three factors were significantly (p < counted for the largest portion of the variance, but the
.01) correlated (Executive Dysfunction with Disinhibition Apathy and Disinhibition factors also emerged as impor-
r = .43, Executive Dysfunction with Apathy r = .43, tant in accounting for the patterns of responses. Thus, the
Disinhibition with Apathy r = .22). Such correlations can factor structure, in conjunction with the previous studies
be troubling when they are a result of a high level of item that have indicated construct validity of the scale, suggests
cross-loadings, because this indicates that items in the that the FrSBe is useful for assessing the severity of the
scale have such a high degree of overlap as to be ineffective three frontal syndromes in aggregate, as well as for assess-
for distinguishing the constructs targeted by the factors. ing these syndromes separately. Additional evidence of
However, only 2 of the 46 items had salient cross-loadings subscale utility has been obtained in clinical and research
as defined by .40 or greater, so item cross-loadings do settings. For example, in several studies, FrSBe subscales
not account for a significant portion of the factor were related to measures of independence in activities of
intercorrelations. daily living (Norton et al., 2001; Stout et al., 2001;
Zawacki et al., 2002).
Item Loading Characteristics The FrSBe has significant intercorrelations between
the factors, ranging from r = .22 to r = .43, a finding that is
Using the criterion of > .40 to indicate salient loading, expected when the constructs underlying the subscales are
29 of the 46 FrSBe items performed as predicted, loading related to a broader construct such as behavioral character-
saliently and solely on the expected factor. An additional 9 istics of frontal system dysfunction. Despite the interrela-
items showed strongest loadings on the expected factor, tionships, a significant level of unshared variance remains
but at a value lower than the criterion of .40. Thus, 38 of the in the factors, supporting the use of FrSBe subscales for
original 46 items loaded on the expected factor in the fac- differentiating specific patterns of behavior disturbances
tor analysis. For the remaining 8 items, 6 had their highest in individuals with frontal systems damage. Also of note,
loading on a factor other than the one corresponding only about 41% of the variance was accounted for by the
subscale to which they were assigned, and 2 had salient factor structure of the FrSBe. Thus, there is a substantial
cross-loadings both on the factor corresponding to their amount of variance in FrSBe scores that is also independ-
subscale assignment and an additional subscale (see Ta- ent of the three factors. Further studies will be necessary to
ble 2). determine whether that variance contributes to the mea-
Of the six items that loaded most highly on factors other surement of more general frontal syndromes.
than the one expected, only two had salient loadings, in- Only two of the items in the FrSBe cross-loaded
cluding Starts things but fails to finish them, which was strongly on more than one factor. Although these items
assigned to the Apathy subscale but which loaded saliently were written to measure part of a single construct, it ap-
on the Executive Dysfunction factor, and Is sensitive to pears that more than one process underlies the behaviors
the needs of other people, which was assigned to the tapped by these two items. Relatively more of the items
Disinhibition subscale but instead loaded saliently on the performed below optimal levels in the factor analysis be-
Executive Dysfunction factor and the Apathy factor, re- cause they loaded less saliently (less than .40) on any of the
spectively. The two items that failed to show specificity to three factors (17 items) or loaded saliently only on a factor
other than the one corresponding to the subscale for which points to the need for additional studies to determine the
they were proposed (2 items). There are several possible predictive validity of the subscales.
reasons for such findings. For example, a few items had
very low endorsement rates and restricted variance in our
sample (e.g., trouble with the law, does risky things, un- NOTE
concerned about incontinence), which may account for 1. Throughout the article, we refer to the scale as the Frontal Systems
their failure to covary with other items in a manner that Behavior Scale (FrSBe). In publications prior to this, the scale has been
would have resulted in a salient factor loading. Although consistently referred to as the Frontal Lobe Personality Scale (FLOPS).
their psychometric properties are not ideal, they may be
useful for clinical purposes. For example, trouble with
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tingtons disease, and schizophrenia.