aspirin + gliquidone

aspirin increases effects of gliquidone by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

aspirin + bisoprolol

aspirin decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1
wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

aspirin + insulin aspart

aspirin increases effects of insulin aspart by pharmacodynamic synergism. Modify Therapy/Monitor Closely.
Coadministration of insulin with high doses of salicylates (3 g/day or more) may increase risk for hypoglycemia.
Insulin dose adjustment and increased frequency of glucose monitoring may be required.

bisoprolol + aspirin

bisoprolol and aspirin both increase serum potassium. Use Caution/Monitor.

aspirin + ciprofloxacin

aspirin decreases levels of ciprofloxacin by Other (see comment). Use Caution/Monitor. Comment: Buffered
aspirin may decrease absorption of quinolones. Consider administering 2 hr before or 6 hr after, buffered
aspirin administration.

Minor

aluminum hydroxide + aspirin

aluminum hydroxide, aspirin. Mechanism: passive renal tubular reabsorption due to increased pH.
Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at
large doses (d/t increased renal excretion of unchanged salicylic acid).

aspirin + gliquidone

aspirin increases effects of gliquidone by plasma protein binding competition. Minor/Significance Unknown.
Large dose of salicylate.