Life Sciences

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Week 1

College 1 (inleiding)

cel replicatie gen duplicatie
archaebacteriën transcriptie horizontal transfer
eubacteriën RNA ortholoog
prokaryoten translatie paraloog
eukaryoten eiwit (protein) homoloog
DNA aminozuur genfamilie
chromosoom enzym reverse genetics
gen mutant haploid
genoom mutatie diploid

College 2 (DNA)
ribose thymine 3’ kant
deoxyribose thymidine waterstofbrug
nucleoside uracil basepaar
nucleotide uridine antiparallel
purine nucleoside monofosfaat minor groove
pyrimidine nucleoside difosfaat major groove
adenine nucleoside trifosfaat plasmide
adenosine ATP, GDP, dTTP, dCMP uitsmelten/denatureren
guanine etc hybridiseren/renaturere
guanosine fosfoanhydride band n
cytosine fosfodiester band
cytidine 5’ kant

College 3 (supercoiling)
topologie relaxed DNA karyotype
ontwinding van DNA topoisomerase I chromosome painting
positieve supercoiling topoisomerase II
negatieve supercoiling chromatine

1
Life Sciences
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Week 2

College 4 (Histonen)

chromatine euchromatine acetylering
histon heterochromatine methylering
nucleosoom epigenetica fosforylering
linker histon Barr body histon code
30 nm fiber chromatine remodeling
solenoid histon modificatie

College 5+6 (DNA synthese)
replicatie primer MutS
pyrofosfaat primase MutL
DNA polymerase RNase MutH
template DNA ligase Dam methylase
exonuclease DNA helicase hemimethylering
proofreading allosterisch effect origin
replicatievork SSB (single strand initiatie van replicatie
leading strand binding DnaA
synthese protein) bidirectionele replicatie
lagging strand sliding clamp terminatie van
synthese clamp loader replicatie
Okazaki fragment mismatch repair

2
Life Sciences
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Week 3

College 7 Replicatie in eukaryoten)

cel cyclus centromeer reader-writer complex
G1 fase ORC (origin recognition epigenetica
S fase complex) telomerase
G2 fase histon chaperone reverse transcriptase
M fase chromatin assembly t-loop
telomeer factor

College 8 (DNA repair)
DNA damage base excision repair nucleotide excision
depurinering DNA glycosylase repair
deaminering AP endonuclease bypass DNA
zuurstof radicalen fosfodiesterase polymerase
thymine dimeer translesion synthesis

College 9 (reparatie DNA breuken en homologe recombinatie)
enkelstrengs breuk KU eiwit hybridisatie
dubbelstrengs breuk scars heteroduplex
NHEJ (non homologous homologe recombinatie
end meiose Holliday junction
joining) RecA branch migration

3
RuvA en RuvB genconversie crossover

4
Life Sciences
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Week 4

meiose

College 10+11 (RNA synthese)
RNA vouwing coderende streng TFIIH
hairpin transcriptie unit CTD fosforylering
stem-loop promoter RNA processing
ribozym consensus RNA factory
mRNA transcriptie initiatie CAP
tRNA transcriptie elongatie polyA staart
rRNA RNA polymerase I polyA polymerase
G-U basepaar RNA polymerase II intron
transcriptie RNA polymerase III exon
RNA polymerase algemene transcriptie splicing
transcriptie bubble factoren alternatieve splicing
terminator TATA box exon skipping
template streng TBP

College 12 (eiwit synthese)
translatie anticodon aminoacyl-tRNA
genetische code T loop synthetase
codon D loop editing
reading frame wobble positie polypeptide keten
tRNA Inosine N-terminale kant

5
C-terminale kant

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Life Sciences
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Week 5

College 13 (ribosomen en eiwit synthese)

ribosoom peptidyl transferase initiator tRNA
ribosomale eiwitten translatie elongatie SD sequentie
rRNA factor polycistronische
kleine subunit EF-Tu (EF-1) messenger
grote subunit EF-G (EF-2) stopcodon
A-site startcodon release factor
P-site translatie initiatie polyribosoom
E-site factoren

College 14 + 15 (regulatie van gen expressie)
transcriptie factor ligand downstream
repressor lac operon Gal4 activator
activator lac repressor mediator
helix-turn-helix motief CAP (catabolite histon acetylering
dimeer activator histon deacetylering
zinc-finger motief protein) chromatine remodeling
leucine zipper motief cAMP coactivator
helix-loop-helix motief inducer corepressor
heterodimeer verschillende sigma enhancesome
operon factoren
operator enhancer
tryptofaan repressor upstream

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