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Our body comprises of millions of cell which perform thousands of functions which help our
body to run smoothly. These cells require steady amount of amino acids, vitamin and fats to
perform at optimum level. But in modern world its hard to have perfect diet which comprises of
all required nutrition required by body. Also, factors like stress, anxiety, sleep deprevation break
havoc on human body. Elixir is among first products in supplement market which focuses on
cellular health. This product was conceived by thinking there should be supplement beside
nutrition and exercise which could support overall health of cell in long term.
Composition of Elixir:
1. Niagen
2. Pteostilbene
Niagen is brand name sold by company called Chromadex. This company holds patent for
and formulate tablet consisting of 400mg of Niagen. NR is a form of vitamin B3. Studies have
shown that NR can increase expression of NAD+ in human being. NAD+ is the coenzyme used
by mitochondria (aka powerhouse of cell) to produce energy for all basic function of human
body. ATP produced by mitochondria is the most efficient source of energy for cells.
each tablet. Pterostilbene is naturally found in plants such as blueberries, grapes and Indian Kino
tree and has been long used to reduce inflammation and blood sugar. Its chemical structure is
similar to that of Resveratrol but it has much more half-life and better abruption than later.
Pterostilbene help in combating the effect of extracellular reactive oxygen species(ROS) which
are primarily responsible for cell damage and inflammation. This powerful polyphenol help cells
to protect itself from both internal and external stress. They also helps activating protein called
sirtuins which regulate expression of genes that regulate body response to stress.
Both of above ingredient work in synergistic ways to improve cellular health. NR helps in
increasing the level of NAD+; coenzyme for mitochondria to produce ATP and Pterostilbene
helps in combating oxidative stress to cells by producing protein (sirtuins). These protein are
again dependent upon NAD+ to get activated and regulate body response to cell damage and
stress.
NAD+ and sirtuins are both essential for good metabolic health of cell. Studies have shown that
mitochondria and cells nucleus. IT signal mitochondria to convert glucose and fatty acids to
produce ATP. But as we ages our cells loses capacity to generate enough NAD+ due to factor like
oxidative stress and nutrition deficient diet. As a result, communication between cells nucleus
ATP or energy by cells to carry out various biochemical reaction in our body. Over the period of
time this result in to various physiological condition such as disease, inflammation and
premature aging. Various studies have shown that NAD+ is also used in various biochemical
pathway which are responsible for protecting tissues, DNA repair and increasing life span.
NAD+ is also cofactor for enzymes called sirtuins. These are also known as longevity enzymes.
These enzymes are activated by NAD+ directly and resveratrol indirectly. Protein produced by
these enzymes SIRT1 and SIRT3 are directly responsible for activating genes which tend turns
off genes responsible for promoting age, storage of visceral fat and maintaining bodys blood
sugar level.
a. Damage to neuron of brain. This can result in loss of memory and coordinate movement
disorder.
e. Increased fatigue, lethargy and muscle loss.
To combat these consequences there are two ways of increasing intracellular NAD+ level. First
is calorie restriction. In this method, we take restricted calorie to limit energy production but we
make sure that our food is composed of all the nutrients required by our body. Second is by
administering NAD+ as a form of supplements. It has been found that vitamin B3 can boost
NAD+ production but in its standard form people have complained about side effects such as
irritation, flushing and rash. Whereas patented form of vitamin B3, NR is free of these
consequences and turn off gene responsible for aging, improves endurance and cognitive
function as well.
Another component of Elixir, Pterostilbene helps in balancing blood sugar level and blood lipids.
Studies have shown when then there is high level of glucose in blood, biochemical pathways
produce end product which have adverse effect on body tissue and develops resistance to insulin.
Pterostilbene is shown to metabolize increase blood sugar and helps in maintaining healthy sugar
level in blood. Studies have also shown that it protective effect on part of brain such as
Dosage:
We have decided to have 400 mg of NR and 60 mg of Pterostilbene in our Elixir tablet. This
formulation has based on scientific studies which compared the effect of different dosage of NR
on NAD+ in human bodies. Different dosage of NR 100mg, 300mg and 1000mg were
administered for a week. Their blood work showed that 300mg dose reached maximum NAD+
level at 24 hours. This gave us the benchmark for effective dosage of NR in our product. Another
study was carried out by our competitor Eysium which administered two dosages 250 mg and
500mg of NR to subjects for eight weeks. Results showed that 500 mg dosage showed significant
increase in NAD+ but after 4 weeks NAD+ reached it plateau and then showed decline in their
level. Which gave us fair idea that dosage should be higher than 250 mg but lower than 500 mg.
hence we finally decided have 400mg of NR in our product for most effective dosage.
Pterostlilbene has fixed at 60 mg per tablet which is highest dosage of this compound available
in market. This dosage should give us fair advantage over our competitor.
1. Restoration of muscle activity: Studies on mice have shown that it helps in overcoming
to muscle weakness. When administered to mice orally it was seen that it delays in
progression of myopathy.
2. Reduces chances of obesity and diabetes: Pterostilobene and NAD+ works
synergistically to help in metabolism of excessive blood sugar and fatty acids and hence
These enzyme produces protein which activate the turn-off gene responsible for aging.
degeneration and protecting nerve cells by activating metabolic pathway. This help
http://alivebynature.com/about-niagen/
https://www.elysiumhealth.com/basis
https://www.amazon.com/gp/product/B005ACNW5S/ref=oh_aui_detailpage_o08_s01?
ie=UTF8&th=1
http://www.lifeextension.com/magazine/2014/11/the-youth-restoring-benefits-of-nad/page-01
https://selfhacked.com/2016/08/29/nicotinamide-riboside/