Breakfast-skipping as an Intermittent Fasting Protocol ‘Tanya Zilberter, Infotonic conseil, France. Anti-aging Medicine World Congress, Monaco, April 5-8, 2017 Introduction “The widely aozopted notion of breakast (GF) asthe most important mel ofthe day has boon called into queston. Curent recommendation regarding BF Isnow saen as porhaps the most peremptory yet Ietabolaly groundless heath gues (Bets ts. 2016). Brown etal (2013) argued that the lk totwoen cbesty and BF skipping doesnot automaticaly mean causal elatonshipa, kis routnly State that skipping BF Is overcampensated wih increas energy consurgon lar during te day, “ach nol boon conimod in rect controled bats skipping BF caused no ovorempensaton of ‘alors intake later in the day (Gonzalez et al, 2014). On the ther hand, even a single overnight ast Feduees concentrations of nsuin and lucas, known Biomarkers of tronic dsease (Kobayashi 2018) Skipping Breakfast Decreases Daily Energy Intake Calor restriction has boon shown to have profound antiaging benefit shoul be mentioned thats humans, dung long-term aswell asshort-arm protocals, both ttl fasting and caloric recticton are hard to comply wh due to present hinge (Stole et al, 2007), Thi icy Isconidered purely psychological ature. In a within-subject experiment where two moals simian tasto and texture were adminisired one naining calles andthe oer not (lebermen atl, 2008), the ethers concluded Cogntve, performance, activ, seep, aed mood are not averslyafecied in heathy humans by 2 days of calorie ‘Seprivation when the subjects and investigators ao unaware of he calorie contnt of tho weatmets™. Daly nergy and fa nts ware reduced wih BF omssion, Moreover skiping BF resulted n nt energy det of out 200 kcal a. day (Levitsky & Pacanowsk, 2073). fener SSeaes 8 | hes 0 > eRe aene > energy rate | —>- obey sk 1 Danae | eee ae Sennen pectteen) Skipping BF Decreases the Risks of Diseases ait stdewe oe - tStres f= jes iz J wersmmsns 3 jo Mela) a an isc isteach ek ce pert ioumieranes Ina yea long study based on Japanese insurance sass, the accunation of ney sagnosed diseases was plied against varousifesyierlatod bt boases (eluding melabote ating and poorer heath was demonsrsted (Fig. C). Skinping BF may provide the neuroprctecive and cognively bbonetcal eects sinlar to that of TRF (Zibortr & Ziborer, 2014 and thus promot ho oath cognitive aging. Ou ‘elaled analysis of BF eating vrsus BF skipping effects revealed at oly tne only group benationg rom ary BF is Imainourshed chen and chidren with ow Is. Chien having high 0 showed better cognve teat ests after skpped BF. The most important finding ae: 1) habitual BF-skpping atu porto bot: witout BF and 2) habitual BF calor perform beter ater AF of pure at, nich means that her ovemight kos stat ls not interuped Intermittent Ketosis ‘Sleeping energy expendlure was higher wen BF was habiualy sipped Ideaing a prlongaton of ovemightKetoas {otsyashi et al, 2014). Indeed, he best cote performance was observed afta aBF of pre fal sche etal, 2001), ‘ion may melasoealy mime te efecs of sing BF atogeter byte same token a he ketogeri Set mimics the “tects of saration Longtarmetsa kalos are known fo be strongly neurogtetnve and cogrtvely Benet, or “Stancn cdr adn stds ofAshorers Soave (aber & aber 2013) Intermittent Fasting and Time-restricted Feeding Protnging the overnight fast habitually happens ona daly basis during the time-esticted feeding regimen (TRF). In animal tudes, TRF protocols restict food aval to 4-8 hour ‘very ereaaan cele (eg. dung dark phase in rodents). Arama tude have shown that iabole consequonces of TRF are metabolically favorabo independant of caloric take. Een soretenn TRF iervenion in ata lowed down age-aasocatad cognitive ‘ecine and improved cognitive fnctions (Singh et a, 2012). The elects on glucose ‘olerance ana insulin sonsitvy were moe pronounced compared to caloric esticton. Innumans, TRF is achieve by consistent eaucng daly meal count Sim, TRF has References 1 Bouts ot al. Proceedings ofthe Nutrition Society (2016) 1 2. Brown eal. Am J Clin Nutr (2013) 98(5)1298-308, dois103945/aen.1 53. Fontin-Lozano etal. (2008). Mol. Neurobiol 38, 167-177. doi 10.1007/s12035-008-8040-1 4, Gonzalez et al. Br J Nute(2013) 110 1-12 5. Jadiya etl (2011). Biochem. Biophys. Res. Commun. 13,306-310 6, Kobayashi etal Obes Res Clin Paci 2013) 8 (3)e249-e257, doi 10.1016) rep 2013 01.001 7 Levitsky & Pacanowski Physiol Behav 2013) 1199-16. been shown to be as etaboteallyfavorabein humans showing long-term neuroproactve eects, @.. 9 te prevention ot nesrodogensratvedscases Jaya et. 2017; Srivastava & Halgs, 2011), supposedly va improve synaptic plasty and Cogative function (Fontar-Lozano etl, 2008; Liu sta, 2013). TRF is @ one ofthe fos of Inarmitant fasting, the one wth superior adherence. Arecet Japanese tong term study of avery large cohort extracted rom 4-year long insurance recorés showed {hat BF shippers hada lower nedence of metabolic dizeases, hon conse isk factors for @eeacee of aging, recent Japanese long-term study of @ very large cohort extracted rom 4-year lng insurance records showed that SF skippers hada lower insaence of ‘metabo dssases, whch constuterisk actors for esases of aging. Reducng these isk factors can provide proucon against ‘ary onset of apng and proton heathy, active and happy aging (Okamoto ot, 2013} 8. Lieberman tal. (2008). Am. J. Clin, Nutr. 88, 667-676, 9-Liv etal 2013), Neuroscience. 238, 371-380, ‘Okamoto etal. J Nat! Inst Pubic Health(2013) 62 (1:13.30. UL Singh etal. 2012). Age 34, 917-98. do: 10.1007/11357-01 12. Srivastava & Haigis, M.C. (2011). Cur: Pharm. Des. 17, 3418-3433, 15, Stote etal. 2007). Am. J. Clin. Nutr. 85, 981-988 14 Zilbertr (2011) Front. Neurooner. 3% 15. Zilbeter & Zlberter (2013) Foot Hum. Neuse. 7631 16, Zilberter& Zlberte (2014) Foat. Public Health 2:59.