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Learning Objectives:
At the end of 3-hour leacture discussion, the students
will be able to:
Define rheology.
Provide examples of fluid pharmaceutical products
exhibiting various rheologic behaviors.
Describe the application of of rheology in the the
pharmacuetical science.
Undertsand anf define the different concepts in
rheology.
Appreciate the fundamentals of practical
determination of rheologic properties using the
four types of viscometers.
Content Outline:
Definition
Classification of Rheologic Systems
Thixothropy
Determination of Rheologic Properties
Application o Rheology in Pharmacy
Rheology
rheo to flow
logos science
Science of describing the flow and deformation of
matter under stress.
Viscosity ( )
- the resistance of fluid to flow
- the higher the viscosity, the greater the
resistance.
Significance
formulation of medicinal and cosmetic creams,
pastes and lotion.
formulation in emulsion, suspension, suppositories
and tablet coatings
fluidity of solutions for injection
in mixing and flow of materials, their packing into
containers, their removal prior to use ( whether by
pouring from a bottle, extrusion from a tube or
passage through a single syringe needle).
affect patient acceptability, physical stability and
even biological availability.
Classification of Rheologic Systems
Newtonian System
Non-Newtonian System
Newtons Laws
1. Every body continues in its state of rest or uniform
motion in a straight line unless it is acted upon by
another force.
Thixotropic coefficient, B
U1 - U2 plastic viscosities
t1 and t2 time, seconds
Measurement of Thixotropy
2 approaches
Second To determine the structural
breakdown due to increasing shear rate.
Rheopexy
Solid forms a gel more readily when gently
shaken or sheared than allowed to form a
gel while the materials is kept.