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CHEMOTHERAPY
K A I TLYN D I CK SO N
SEA M A R CH C D I ETETI C I N TERN
SI TE: SEA TTLE CA N CER CA RE A LLI A N CE
IN-SERVICE OBJECTIVES
To become familiar with fasting
strategies and perceived benefits
made by media and internet
claims
To review physiology of fasting
and the growth hormone/insulin
like growth factor 1 axis
To explore current research
related to short-term fasting
during chemotherapy
To assess the risk versus benefit
of fasting during chemotherapy https://www.washingtonpost.com/national/health-science/fasting-may-
protect-against-disease-some-say-it-may-even-be-good-for-the-
brain/2012/12/24/6e521ee8-3588-11e2-bb9b-288a310849ee_story.html
the abstinence or limitation
of food, drink or both
Practiced in many cultures and
religions
Fasting allows the body to focus on
energy and cleansing
Health Claims
Anti-aging
Brain health
Reduces inflammation and oxidative
stress
Weight loss
https://patriciadaly.com/intermittent-fasting/
FASTING STRATEGIES 7
Intermittent Fasting
Short-Term Fasting
Prolonged Fasting
Fasting-Mimicking Diet
DR. VALTER LONGO 7
http://www.derangedphysiology.com/main/required-
reading/endocrinology-metabolism-and-
nutrition/Chapter%203.1.8/physiological-adaptation-
prolonged-starvation
HUMAN GROWTH HORMONE 7
https://intensivedietarymanagement.com/how-
do-we-gain-weight-calories-part-1/
GH/IGF-1 AXIS 2,4
IGF-1
High blood levels suppress GH
secretion
Produced in the liver
48% amino acid sequence of
proinsulin
Major regulator of metabolism
Exerts powerful effects on
cellular proliferation and
apoptosis, angiogenesis and
metastasis
http://sageke.sciencemag.org/cgi/content-nw/full/2004/31/re5/F1
DIFFERENTIAL STRESS RESISTANCE EFFECT 5
Changhan L, Safdie F, et al. Reduced Levels of IGF-1 Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting
and Improve Chemotherapeutic Index. Cancer Research. 2010; 70(4); 1564-72
DorffT, Groshen S, et al. Safety and feasibility of fasting in combination with platinum based chemotherapy. BMC
Cancer. 2016. 16:360
DorffT, Groshen S, et al. Safety and feasibility of fasting in combination with platinum based chemotherapy. BMC Cancer. 2016. 16:360
ASSESSING RISK VS BENEFIT
https://www.dietdoctor.com/intermittent-fasting
REFERENCES
1. Changhan L, Safdie F, et al. Reduced Levels of IGF-1 Mediate Differential Protection of Normal
and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index. Cancer
Research. 2010; 70(4); 1564-72.
2. Clemmons, David. The relative roles of growth hormone and IGF-1 in controlling insulin
sensitivity.The Journal of Clinical Investigation 2004 Jan 1;113(1): 25-27
3. Dorff T, Groshen S, et al. Safety and feasibility of fasting in combination with platinum based
chemotherapy. BMC Cancer. 2016. 16:360.
4. Jin M, Buck E, Mulvihill MJ. Modulation of insulin-like growth factor-1 receptor and its signaling
network for the treatment of cancer: current status and future perspectives. Oncology Rev
2013. 22;7(1)e3.
5. Lee C, Longo V et al. Fasting vs dietary restriction in cellular protection and cancer treatment:
from model organisms to patients. Oncogene. 2011. 30;3305-3316.
6. Longo V, Mattson M. Fasting: Molecular Mechanism and Clinical Applications. Cell Metabolism.
2014. 19;181-192,
7. L-Nutra. l-nutra.com.Accessed: March 20 2016.
8. Norrelund H, Nair S et al. The Protein-Retaining Effects of Growth Hormone During Fasting
Involve Inhibition of Muscle-Protein Breakdown. Diabetes. 2001. 50(1): 96-104.