A partial list of afflictions and their effects follow:

Broken limbs: Obvious. Can't walk with broken legs, can only hobble with
one broken leg (takes a second to move, instead of being
instant). Can't use physical attacks with broken arms, etc.
Confusion: Causes some attacks to misfire, and prevents concentration.
Clumsiness: Gives a 33% chance of missing with some physical attacks.
Epilepsy: Throws you off balance now and then due to seizures.
Paralysis: Cannot move, cannot attack, cannot get herbs from pocketbelts.
Aeon: Causes one second lag on all your commands until cured.
Voyria: Kills in about 15 seconds if not cured.
Darkshade: Causes allergy to sunlight. While in the sun, you will start
Taking damage and eventually you will die.
Vomiting: Causes you to occasionally vomit, which makes you become
hungry. If you grow too hungry, you will go unconscious.
Asthma: Cannot smoke while you have this. Moving around too quickly
will cause you to take damage.
Dizziness: Can send you in a random direction when you move.
Slickness: Prevents the application of salves.
Anorexia: Prevents you from eating or drinking things.
Disfigurement: Turns your mobile allies against you.
Weakness: Causes you to do less physical damage
Recklessness: Your health and mana can be displayed on your prompt. This will
cause them to always appear as full.
Shivering: You will shiver now and then, making you lose equilibrium.
You must concentrate to regain it.
Webbed: Cannot move or do most physical attacks until you have writhed
out (takes a few seconds).
Bound: Like web, but it takes longer to writhe out of.
Sleep: Cannot do anything except type wake. It takes a few seconds to
wake up.
Thin blood: A nasty affliction that will cause toxic relapses. Every time
you are hit with a venom, it will hit you again a few seconds
later.
Sensitivity: Causes you to take about 33% more damage than normal.
Fear: Will cause you to run about in panic until you COMPOSE
yourself.
Shyness: Gives fear every few seconds that you are in a room with
someone else.
Claustrophobia: Gives fear when indoors.
Agoraphobia: Gives fear when outdoors.
Stunned: Cannot do anything until this wears off. Usually only lasts
a couple seconds.
Fallen: Fallen to the ground. Cannot move or do many attacks until you
STAND. Your legs must not be crippled if you wish to stand up.
Deafness: Prevents you from hearing other people. This is also a defence
against some sound-based attacks.
Blindness: Can't see your location too well.
Stupidity: Garbles about 25% of your commands
Amnesia: Wipes out the next command entered.
Concussion: Gives amnesia every second or two. Very nasty.
Deadening: Drastically decreases the amount of time it takes for a monk to
get a mind lock on you.
Blacked out: You don't receive most text for a few seconds.
Clamped: Your health and mana maximums are temporarily decreased.
Vertigo: Unable to fly or go up generally.
Mercy: An inability to deliver a killing blow.