Conde, Ryan Carlo P.

September 20, 2015

BS BIOLOGY III Sir. Wilfredo Barerra

Transcript and protein expression decoupling reveals RNA binding proteins and
miRNA as potential modulator of human aging
Yu-Ning Wei, Hai-Yang Hu, Gang-Cai Xie, Ning Fu, Zhi-Bin Ning, Rong Zeng and Philipp Khaitovich

The article, Transcript and protein expression decoupling reveals RNA binding proteins and
miRNA as potential modulator of human aging by Yu-Ning Wei, Hai-Yang Hu, Gang-Cai Xie, Ning Fu,
Zhi-Bin Ning, Rong Zeng and Philipp Khaitovich seeks to know how transcript and protein expression
decoupling reveals RNA binding proteins and miRNA as potential modulator of human aging. The
research problem being addressed as the expression of many genes that has undergone drastic changes
in mRNA and protein levels and the connection between RNA and protein expression level changes, as
well as the role of posttranscriptional regulation in controlling expression level changes in postnatal
development and aging that has remain unexplored.

It is clear from the abstract of the article that this is an important discovery of mankind that will
lead to longer life. In fact the article is directly to the point. The authors started by describing the
regulation of gene expression and its critical roles in controlling biological processes and then followed by,
describing the human genome and its RNA-binding domains. Another critical point in this is the
posttranscriptional regulation that has been repeatedly implicated in the control of gene expression
changes in a number of species. Furthermore, the results were presented neatly as it presents the cause
of the increased decoupling of mRNA and protein expression levels in human brain aging. As for the
conclusion, the author mentioned that the directions of aging dependent expression changes are
observed at the protein level that further suggest the potential role of posttranscriptional regulation in
countering the effects of aging decline.

To such a complicated issue the author sums the research up well by saying that genes targeted
and predicted to be targeted by the aging-dependent posttranscriptional regulation can be associated with
biological processes known to play important roles in aging and lifespan extension, mTOR pathway,
mitochondrial function and Alzheimers disease.