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Korn et al $elpimtcry ffas{rt? ?013' 1i}25

#^o*"dkHlE:Iffi$*
Severe and uncontrolled adutrt asthrna is
issociaredwrth viramin D and ittff,ffiy
deficiency Lktr*b,ny,
5rephanie Kornl', Marisa llubnerl, Mailhias
Jungl, ['laria Ble$net' and Rolald Buhll

Abstract
lfii DD ttst, . vltamirt
has effects on t.e innate an<l aciaptive
immune system' ln asrl-:matic chiidren low
Eackgrourd:'vitamin
Dieveisareas*ciatedwithpoorasihmaco,.,rrol.reducect.tr.:ngfunction,increasedmedicationintake,and
with as{hma sevetity and
in adult asrhma pStients or iG assrxialiol
exacerixtlons. Linle is knoro,,il ahour vitamin D
contral.
ar-rd ?5-hydrcxyviiamin D t25(oi-t)D]
serurr concerlrarions '*ere
Metheds: cii*icai parari.isiers of asthma control FLVi r 233%' 559,5 severe', 5 I7c
(rnean t 5D: 45'0 = 1 3'8 yrs'' 4096 male' 74'9
evaluate<l in 28{} aduil asthma padents
unconiroiied)
insufficiency or
were low (25'6 tl i'B nglml} and vitamin D
Hesults: 25{o|1lD ccncentrations in aijult a$hmatics (inierr*irienr:
:s(oir)D ievels.uere ieiaied ro asihn:a ser,eriiy
deficiency ivitamin D <30 ng/mi) was common ie;,it). p=0'e46} ancl
31.,i r 1:.0 nglml, r*iid: ir.{rri"snqr*t,
morJ";;i"';tt;:i.o ng/mi, severe:24'0* i1'8 nqlmi,
1''S;g/nri, uncotrtroiled: 24'2 t
'1
i '8 nglr:"ri' p = t
0'C3C)'
conrroi (ccnrrolld: 29.5 + 12.5 nglr,--:i. oa.tiy .onr*ri*j
25.9
qaiienls se,ete or unccntr-oiled
-i*e irequency cf vita,:*r, ;*:ufi*--., *r Oeficlenq was sigt'iflcanril] nigiot in
f r"'r'-1h

FlVl i'- o'' }30 *r'r/t-':i ;'3 + 0'9 Lvs' }-'7 i '0 L' p
{':luinin
:0'0S6i' iligh*r:
asihrna and was associaled wiih a i*'/se| "t=0
ieveisoiexhaiedt'lCi45*46ppbvs'3'1+37ppi:**=**::i'ahighernf"ti{:A':+6'}!'j!'i5'l:3'?'p'l'*'L\}ii'and *'a;
'i
p *'o.c*r}. oi crrai co{i(csiercids cr sfui'J.l ecsir"l*ph'iia
i?r.iiJrn eosinophilia {5. i t- 1 : .bg'* rrr. 0.5 :r .0?$. 3u .;sJ
uxamin O iniufflcienry or deficiency'
assoc;aied wi;h a 2fft or 40,1i hlgher risk of 1'Yiii-r palietlls
reveis i:eiorv 30 pglmi are comrr}on in adi-lir aslhma anc mosi.pronquqcid,l;r
csrxlusinnE: zs{ort}D D:iatus rniqht ne
hypcihesis ilai iirp:clvrrrq scnoptirr':al vira|nin
seve,,e and/or r.rnrontrollec aslirma, supccrtirrg the
effeciive tn preventon anC irealmeat of asthma;'
Keywords: Asii':rr:a, 3i*1. Cortrrosl*'o:du, !::' *55::
pr{ii$tei$
inadequately c*ntrulled patients with severe
BackEround risk af exacerbations and
the most conlmon chlanlic asth** are at high seYere
Ail!** reprtss*ffifte-sf u*it,iu-.*frted mirtality' These patiats represent'the
B'$rldl!'ide
aiu*uruu urrd i, u m$ou)gbli hgdtLptoblem
conlrol of altl"rma as gr"**o unmet medicaL need among the as*r:natic
i11. In ttrc. mai6i--ity of patients
be with loug-tertn populati*:r todaY.
is iucrtasingiy rec*giiie*d il
dfinea by guidelines can achieved ' vitr*in D iniufficiency
maitrtenancl meclic;rtioirs i1]' HrlrteveL a srrbstantial
tire general populaticrn, aad has beer largely attrihuted
propcrtion af patie*ts do not achieve opti*al as$x:ra \\thile
despite even high sl*se treatment' 1* particular
,r-a?-*r"l', 1ifut44* and behavioral changes l2'3i'
io,.i*i its muscirloskeletal consequelces are well established' a

,r** links asthrna to subat*ral '-itami:r l)

t ypoti',usis
i '' ^ l' .' : ' i-.** if-g:. Vitamin D has several effects ou IJre inaateitt
i.r,,,',i'.,'i,j,,,,,.,,' ::'-, I 7;;1-1 ';; ;r7 1'1
and ajaptive kndrune $ystems that might
l:e relevant
'1' 1'
'Pttu;i.;t Uep;c,r:i,i, ll.ri.'7 uri',ii51:y ii;:i:1:;::' lar:;r*i-':ti!:in::t3
it* pri*ury prevention of asth$a' in the prote{tio$
i5I 3i, i,,,:nir)7, ce.ariny
f"ll'i:i: .,,,t,"t ,lflrrr'.':icll i; a"?:lri"it a: :hc ci:ir atiljl:
"l ''i'i
:"1'G:::f:::"::':;i':iJl';*' ,:
{ _} *no**cenrrar *l,' *i;i;*r'',*1i:;itfi':,'