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WEEK 1: CHECK-IN & ORIENTATION CM3102

Check-in & Orientation


Objectives
To get to know each other
Tointroducegeneralinformationandpolicyofthecourse
Tointroduceevaluationpolicy
Toremindgenerallabsafety
Tointroduce(1)labdataprocessingand(2)labtechniques

References
1.Laboratory manual for principles of general chemistry (8th Edn), J. A. Beran, 2009, Wiley
& Sons
2.LaboratoryExperiment,J.H.Lelson,K.C.Kemp,2009,PearsonEducationInc.
3.Anintroductiontoerroranalysis(2ndEdn),J.R.Taylor,1997,UniversityScienceBooks.
4.AnintroductiontoExperimentalPhysics,C.Cooke,1996,UCLPress
5.PracticalPhysics(4thEdn),G.L.Squires,2001,CambridgeUniversityPress
6.Experimental Physics, R. A. Dunlap, 1988, OUP

Introduction
Course number: CM3102
Hours:5hours
Credit:3credit
Courseoutline:Thiscourseoffersstudentstopracticesynthesisoftypicalorganicand
inorganiccompoundsinlaboratories.Eachexperimentincludesunderstandingofphysical
andchemicalpropertiesofreactantsandproducts,preparationofreactants,designand
setupofareactor,analysisofproducts,anddiscussionofreactionmechanism.
Prerequisite:GeneralChemistryExperimentIandII(GS1211andGS1212)
Instructors:Prof.JiwonSeo(jseo@gist.ac.kr),
Prof.WonJinChung(wjchung@gist.ac.kr)
Teaching Assistants:
TUE: (ywj426@gist.ac.kr),
(monster37@gist.ac.kr), (jjs@gist.ac.kr)
FRI: (leeyeonjae@gist.ac.kr),
(ojy@gist.ac.kr), (ssm1228@gist.ac.kr)

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Schedule
Week 1 (3/2-3/3): Check-in & orientation
Week2(3/63/10):Extractionandrecrystallization
Week3(3/133/17):Distillation
Week4(3/203/24):GrignardreactionI
Week5(3/274/31):GrignardreactionII
Week6(4/34/7):MonomersynthesisI(DielsAlderreaction/NMR)
Week7(4/104/14):MonomersynthesisII
Week8(4/174/21):Midtermweek
Week9(4/244/28):MonomersynthesisIII
Week10(5/15/5):Purificationofmonomer(recrystallization)
Week11(5/85/12):ROMP(ringopeningmetathesispolymerization)
Week12(5/155/19):ROMPpolymercharacterization(GPC,NMR)
Week13(5/225/26):SolidphasepeptidesynthesisI
Week14(5/296/2):SolidphasepeptidesynthesisII
Week15(6/56/9):SolidphasepeptidesynthesisII
Week16(6/126/16):FinalWeek

Evaluation
1.Pre-lab quiz: Background (10 points)
2.Attitude(50points)
Labsafety(15points)
Cleaning/Cleanliness(10points)
Lateness(5points)
Technique/Comprehension(5points)
Concentration(5points)
Labnote(10points)
3.Laboratoryreports(40points)
Results(20points)
Quantitativeresults;Data&Calculation
Table&GraphsQualitativeresults:Observations

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Discussion(20points)
Assessingtheresults;Conclusions
All the written communications (i.e., reports, quiz) must be made in English.
Oral communications including pre-lab lectures can be delivered in Korean.
You must sign the 'student agreement form' to be checked in to this course.
Week 1 (check-in & orientation): Pre-lab quiz (50 pts)+ Attitude (50 pts), no report.

Laboratory Safety and General Guidelines


(reference: An introduction to Experimental Physics, Cooke C., UCL Press, 1996
Practical Physics (4th Edn), Squires, G. L., Cambridge University Press, 2001
ExperimentalPhysics,DunlapR.A.,OUP,1988.)
"Laboratory safety should come first all the time when you plan and carry out an
experiment."Everystudentmustbeextremelycarefulinhandling,storing,anddisposingof
chemicals.Laboratorysafetyshouldbeaconstantconcernandpracticeforeveryoneinthe
laboratory.
Besurethatyouandyourpartnerspracticelaboratorysafetyandfollowbasiclaboratory
rules.Itisyourresponsibility,nottheinstructor'snortheTA's,toplayitsafe.Alittleextra
effortonyourpartwillassureothersthatthechemistrylaboratorycontinuestobesafe.
Accidentsdoandwilloccur,butmostoftentheyarecausedbycarelessness,thoughtlessness,
orneglect.

Self-protection
1.Safety goggles must be worn at all times. Contact lenses should be replaced with
prescriptionglasses.Wherecontactlensesmustbeworn,eyeprotection(safetygoggles)
is absolutely necessary. A person wearing prescription glasses must also wear safety
gogglesoraneyeshield.
2.Highheeledshoes,opentoedshoes,andsandalsarenotpermitted.
3.Shortpantsarenotpermitted.
4.Labcoatsmustbeworninthelaboratory.
5.Safety gloves are to be worn to protect the hand when handling corrosive liquids (I
recommendyoutowearsafetyglovesanytimeyouhandlechemicals,organicsolvents,or
acids).Latexandnitrilegloveswillbeprovided.Ifyouareallergictolatexgloves,use
nitrilegloves.
6.Jewelry should be removed. Chemicals can cause a severe irritation, if concentrated,
underaring,wristwatch,orbracelet.Itisjustagoodpracticeoflaboratorysafetyto
removejewelry.
7.Securelonghairandremove(orsecure)necktiesandscarves.

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8.Nevertaste,smell,ortouchachemicalorsolutionunlessspecificallydirectedtodoso.
Individualallergicorsensitivityresponsestochemicalscannotbepredicted.Poisonous
substancesarenotalwayslabeled.
9.Washyourhandsoftenduringthelaboratory.Alwayswashyourhandswithsoapand
water before leaving the laboratory. Dangerous chemicals may be inadvertently
transferredtotheskinandfromtheskintothemouth.

Laboratory rules
1.Smoking,drinking,eating,andchewing(includinggum)arenotpermittedatanytime
becausechemicalsmayenterthemouthorlungs.Yourhandsmaybecontaminatedwith
anunsafechemical.
2.Donotworkinthelaboratoryalone.Thelaboratoryinstructormustbepresent.
3.Donotleaveyourexperimentunattendedduringthelabperiod.Accidenthappenswhen
unattended.
4.Inquisitivenessandcreativenessinthelaboratoryareencouraged.However,variationsor
alterations oftheExperimental Procedure areforbiddenwithoutpriorapprovalofthe
laboratory instructor. Ifyour chemical intuition suggests further experimentation, first
consultwithyourlaboratoryinstructor.
5.Maintainacleanlaboratoryspace.Immediatelycleanupallchemicalspills,paperscraps,
andglassware.DiscardwastesasdirectedbyyourlaboratoryTA/instructor.
6.Donotbringyourbooks,bags(backpacks,purses()),orotherunnecessaryitems
inthelab.Labnotebooks,pens,andcalculatorsareallowedinthelab.
7.Attheendofthelaboratoryperiod,completelyclearthelabbenchandhood,andclean
thelabsinks.Alsocleanallglasswareusedintheexperiment.Youcanleavethelabonly
aftertheTAinspectsyourareaandsaysyes.
8.Beawareofyourneighbors'activities;youmaybeavictimoftheirmistakes.Advise
themofimpropertechniquesorunsafepractices.Ifnecessary,telltheTAorinstructor.
9.Mostofall,listentoyourTA!

Laboratory accidents
1.Know where to find and how to use the laboratory safety equipment such as fire
extinguishers,firstaidkits,andsafetyshowers.
2.Reportallaccidentsorinjuries,evenifconsideredminor,immediatelytoyourTAor
instructor.
3.Ifanaccidentoccurs, donotpanic! AlertthelabTAandinstructorimmediately.Ifa
personisinjured,provideorseekaidimmediately;clothingandbookscanbereplaced
andexperimentscanbeperformedagainlater.
4.Wheneveryourskincomesintocontactwithchemicals,quicklyflushtheaffectedareafor
severalminuteswithtapwaterfollowedbythoroughwashingwithsoapandwater.Get

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helpimmediately.Donotrubtheaffectedarea,especiallythefaceoreyes,withyour
handsbeforewashing.
Forchemicalsintheeye:Getimmediatehelp.Ifachemicalgetsinyoureyes,you
mustwashyoureyesasquicklyasyoucan.Acrucialpointabouteyewashingisthat
theirrigationshouldbeginattheearliestpossiblemomentaftertheaccidentbecause
thefirstsecondsarethemostimportant.Insomecases,noamountofwashingcansave
youreyesifyoudelayevenalittle.Irrigatetheeyesaminimumof15minutesfor
acids and most other chemicals, and at least 30 minutes for bases. Do not use
neutralizesintheeyes.
Remember, leavecontactlensesathome. However,ifchemicals dogetinyoureyes
whilewearingcontacts,removethemasquicklyaspossibleandirrigateyoureyes.
Softlensesareespeciallydangerousbecausetheycanabsorbandretainmanyorganic
chemicals.Alwayskeepgogglesonwhileyouareinthelab.
5.Chemicalspillsoveralargepartofthebodyrequireimmediateaction.Usingthesafety
shower,floodtheaffectedareaforatleast5minutes.Removeallcontaminatedclothingif
necessary.Useamilddetergentandwateronly.Getmedicalattentionasdirectedbyyour
instructor.
6.Incaseoffire,
Students: (1) if it occurs in the hood, close the sash and report to your TA and
instructor,(2)ifitoccursoutofthehood,reporttoyourTAandinstructorfirst,and
evacuatethelab.
TA:(1)dischargeafireextinguisheratthebaseoftheflamesandmoveitfromone
sidetotheother.(2)smallflamescanbesmotheredwithawatchglass,largebeaker,
orsimilarglassware(donotuseatowel,itmaycatchonfire).(3)donotdischargea
fireextinguisherwhenaperson'sclothingisonfireusethesafetyshower.
Oncethefireappearstobeoutofcontrol,immediatelyevacuatethelaboratoryand
report119.
7.Forcuts(i.e.,onyourfinger),Stopbleedingbycompressionand/orusepressurepoints.
Allcutsshouldbeexaminedbycollegehealthservicepersonnel()
todetermineseverityofcut.
Forburns,theaffectedareashouldbesubmergedinanice/waterbath,and/orplacedunder
runningwaterforseveralminutestowithdrawheatfromtheburnedarea.Moreserious
burnsrequireimmediatemedicalattention.Anyfurthertreatmentshouldbegivenonly
afterconsultingwiththeTAorinstructor.
8.Handlechemicalspillsinthelaboratoryasfollows:
AlertyourneighborsandthelaboratoryTA/instructor.
Clean up the spill as directed by the laboratory TA/instructor. Use spill kit when
necessary.
Ifthesubstanceisvolatile,flammable,ortoxic,warneveryoneoftheaccident.
9.Inordertopreventfireandotheraccidents,

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Considerallchemicalstobehazardousunlessinstructedotherwise.
Many common reagents (for example, alcohols, acetone, and especially ether) are
highly flammable. Do not use them anywhere near open flames. You must pay
particularattentionwhenyouheatthemonthehotplate.
Performinthefumeexhausthoodanyreactionsinvolvingskinirritatingordangerous
chemicals,orunpleasantodors.
10.Waste disposal (solvents, solids, glass, sharps, gloves, and other wastes) should be
separated.

Preparing for and working in the laboratory


1.Yourtotalconcentrationontheexperimentisrequiredforasafe,meaningfullaboratory
experience.Youmaysocializewithothersinthelab,butdonothaveaparty!Youare
expectedtomaintainalearning,scientificenvironment.
2.Scientistslearnmuchbydiscussionwithoneanother.Itisencouragedtohavediscussion
withyourclassmatesandTA.However,nevercopyfromyourclassmate'sreport.
3.Prepareforeachexperiment.
Review the Objectives and Introduction to understand the "chemistry" of the
experiment,thechemicalsystem,thestoichiometryofthereactions,thecolorchanges
toanticipate,andthecalculationsthatwillberequired.
Consultchemicalhandbooks(Merckhandbook,CRChandbook,andetc)tobefamiliar
withthePhysical/chemicalpropertiesofchemicalsintheexperiment.Youcanaccess
handbooksinthelibrary(3rdfloor)'reservedbook'sectionand'chemistry'section.
Athoroughknowledgeoftheexperimentwillmakethelabexperimentmoretime
efficientandscientificallymoremeaningful(andresultinabettergrade!).Complete
theprelaboratoryassignments.
4.Reviewtheexperimentalprocedure.
Trytounderstandthepurposeofeachstep.
Determinewhatdataaretobecollectedandhowitistobeanalyzed(calculations,
graphs,etc).
Reviewthelaboratorytechniquesandthesafetycautions.
5.Useofreagents
Disposeofexcessreagentsasinstructedbyyourinstructor. NEVERRETURNTHE
EXCESSREAGENTSTOTHEREAGENTBOTTLE.
Leavereagentbottlesontheshelfwhereyoufoundthem.
Useonlytheamountofreagentcalledfor;avoidexcesses.
Wheneverinstructedtousewaterintheseexperiments,usepurifiedwater(notthetap
water)unlessinstructedotherwise.

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6.Aboveall, enjoy thelaboratory experience! Beprepared, observe,think, discuss,and


anticipateduringthecourseoftheexperiment.Youwillberewarded.

Writing tips for lab notebook and reports


Writeallnotesandreportsinhand,notwithcomputer.Yourwritingsmustbewritten
clearly,soyourTAscanevaluateyourreports.
Whywewritethelabnote
Thepurposeofascientistslabnoteistorecordwhatwasdoneinanexperiment,together
withresults.Theyshouldbeunderstandablebythewriterorsomebodyelseatalaterdate,
whenwritingthemupforaformalreport.Thenoteshouldalsoenableyoutorecreate
accuratelytheexperimentatalaterdateifmoreresultsareneeded.

Notes
1.Titleanddates
Whenyoustartanexperiment,recorditstitleandthedate.
2.Objectives
3.Introductions
Write down the concept, mathematical description, and definitions for doing
experiment.
4.Materials
Put the apparatus and materials (chemicals) needed for experiments. Survey the
chemicalandphysicalpropertiesofthematerials(forexample,mp,bp,pKa,toxicity,
etc.)Estimatetheamountofchemicalsyouneeded.
5.Methods
Writedowneachstepoftheexperiment.Ifyouchangeafewstepsfromyourclass
manual,clearlymarkthem.
6.Results(observation,measurements,data(TLC,yield,colorandshapeofproducts,
spectra)...)
Put findings and observation during the experiments in this section. Also if you
measureanyvalue,clearlywritedownthemassoonasyoumeasure.
7.Discussion
Write the way how you induce your idea from the results and discuss about the
uncertainty of the measurement and meaning of the results. Think about how to
improvetheexperimentalsteps.

AdvicesfromSwathmore
http://www.swarthmore.edu/NatSci/cpurrin1/notebookadvice.htm

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Whywewriteaformalreport
Communicationoftheresultsandconclusiontootherscientistandthemediaisavery
importantforscientistsandengineers.Inordertopreparemoreprofessionalreportsof
scientificworks,youshouldpracticewritingaformalreport.
Reports should make clear what has been measured, discuss experimental techniques,
includeresultsandwhatconclusionsyouhavereached.
FinalReports
1.Title
2.Introduction(Objectives)
Puttheprinciple,reactionmechanism,reactionequationetc.Youdontneedtowrite
same thing (same sentences) with your references. After you fully understand the
concept,reorganizeyourideawithyourthinking.
Writedownwhatyouwanttoknow(orprove)bydoingthisexperiment.
3.Experimental(Materialsandmethods)
Withnumbers,puteachstepwhatyouperformduringtheexperiment.Writetheexact
amountofreagentsyouusedfortheexperiment.Ifanythingisdifferentfromyour
classmanual,clearlywritedownthem.
4.Results
Ifyoucan,summarizeyourresultswithatableoragraph.Ifyoudosomecalculations,
givethemwithanerroranalysis.Thereisnoneedtoshowthedetailedworkingwhenit
isobvious.
Ifyouhaveanyquestionfromyourclassmanual,keepinmindtoanswerthose.

Programs, Search programs, Databases


ChemDraw (Download from GIST IT service)
SciFinder (GIST Library E-Resources)

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