TETRACYCLINE (3)

Tetracycline, also called Deschloro Biomycin, is a naphthalene (a white crystalline

compound) antibiotic that discovered in 1940s and is produced by the Streptomyces genus of
Actinobacteria (Gaillard, T., 2015). Its work as blocking the Aminoacyl-tRNA that about to
bind to the ribosome acceptor site during protein synthesis. Therefore, the bacteria couldnt
synthesis the protein which is essential to them. Tetracycline is generally used to treat a wide
variety of infections caused by bacteria such as skin, intestines, respiratory tract, acne etc.
(Tetracycline, 2017).

PROPERTIES (1)
 APPLICATIONS (2)

Tetracycline is a member of the tetracycline family its useful for antimicrobial action. Its
usually used to treating infections caused that by streptococci, staphylococci, Gram-negative
bacilli, rickettsiae, and certain protozoans and viruses. Tetracycline can also produced
biosynthetically by fermentation with a strain of Streptomyces aureofaciens or chemically
produced by hydrogenolysis of chlortetracycline. Tetracyclines are the stopper for bacterial
protein synthesis by binding to the 30S ribosomal subunit. Tetracycline will act as an
inhibitor of growth (bacteriostatic) rather than a killer of the infectious agent (bactericidal)
and it is only effective against multiplying microorganisms.

Tetracycline antibiotics include;

Chlortetracycline (CAS # : 57-62-5)

Demeclocycline Hydrochloride (CAS # : 64-73-3)
Demethylchlortetracycline (CAS # : 127-33-3)
Dihydrostreptomycin Sesquisulfate (CAS # : 5490-27-7)
Doxycycline (CAS # : 564-25-0)
Duramycin (CAS # : 1391-36-2)
Meclocycline Sulfosalicylate (CAS # : 73816-42-9)
Methacycline Hydrochloride (CAS # : 3963-95-9)
Minocycline (CAS # : 10118-90-8)
Neomycin (CAS # : 1404-04-2)
Oxytetracycline (CAS # : 6153-64-6)
Streptomycin (CAS # : 57-92-1)
Tetracycline (CAS # : 60-54-8)
Vancomycin (CAS # : 123409-00-7)
 REFERENCES
1. Tetracycline. (2017). Retrieved May 14, 2017,
fromhttps://pubchem.ncbi.nlm.nih.gov/compound/tetracycline#section=Top
2. (n.d.). Retrieved May 21, 2017, from
http://www.chemicalland21.com/lifescience/phar/TETRACYCLINE%20HYDROCH
LORIDE.htm
3. Gaillard, T., Madamet, M., & Pradines, B. (2015). Tetracyclines in malaria. Malaria
Journal, 14(1). doi:10.1186/s12936-015-0980-0