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March 20, 2015

MONSANTO

--- March 20, 2015 MONSANTO Dr. Margaret Chan Director-General World Health Organization Avenue Appia 20 1211

Dr. Margaret Chan Director-General World Health Organization Avenue Appia 20 1211 Geneva 27 Switzerland Telephone:+ 41 22 791 2111 Facsimile(fax): + 41 22 791 3111

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Dear Dr. Chan:

It has come to our attention that the International

Agency fo r Research on Cancer (IARC)has

classified glyphosate as a probable human carcinogen (Group 2A). Dur ing its

understanding that

publically available regulatory assessments t hat support the conclus ion that glyphosa te does not pose a human health risk.

review, it is our

IARCpart icipants purposefully chose t o disregar d dozens of studies and

IARC'sfindings are contrary to robus t scientific assessments conducted by regulatory agencies in the EU,Canada,US,Japan and even other bodies w ith in the Wo rld Health Organization. All of

these agenciesconcluded glyphosate is not a carcinogen . It is doubtful tha t a scientific process

could have reached a conclusion t hat so dramatically differs globe.

from regulatory agencies around the

Conclusionsabout a herbicide such as glyphosaite, the most widely used crop protection product in the world, which is used on crops grown for food and feed purposes, must be non-biased, thorough and based on quality science t hat adheres to internationally recognized standards. As a manufact urer of glyphosate, we would like to req uest an urgen t meeting with appropriate personnel from your organization to address the fo llowing:

What steps can be immed iately taken to rectify this highly questionable review and conclusion as compared to all othe r reviews tha t have been conducted with regulatory agencies around t he glo be;

An account i ng of all studies tha t were conside red dur ing t he rev iew process, and equally as important, an account ing of those studies tha t were disregarded;

An understand ing as to why glyphosate was selected

made known to the public in Septembe r 2014; An understa nding of how part icipants and specialists were selected for participation in this monograph; and An accounting of all funding for the classificat ion of glyphosate by IARC,including donors.

for review in April 2014, but only

Dr. Margaret

Chan

March 20, 2015

Page 2

Safety is our number one priority , and we know that IARC's conclusions will likely cause a great deal of concern w ith growers and consumers alike . We are very anxious to determ ine a path

forward to address these clear inconsistencies . I will be in contact with your office to inqu ire

who may be available to meet with me, and potential your assistance .

dates and times . Thank you very much for

Sincerely,

. dates and times . Thank you very much for Sincerely, ·' Dr.Phil,:. Miller '/; '

·' Dr.Phil,:.Miller '/;

'

: VicePresident , Global Regulatory Affairs

Cc:

Dr.Christopher P. Wild , IARC Director IARC,Office of the Director 150Cours Albert Thoma s 69372 Lyon CEDEX08, France

Tel:+33 {0)4 72 73 84 85 Fax:+33 (0)4 72 73 85 75

Dr. FrancisS. Coll ins, M .D., Ph.D., Director of the National Institutes of Health NationalInstitutes of Health {NIH), Office of the Director

BG1 RM 126

l CENTERDR BETHESDAMD 20814 francis.colllns@nih.gov

Dr.HaroldVarmus, M .D., Director of the National Cancer Institute NCI(National Cancer Insti t ute)

BG31 RM11A48

MailStop:2590

31CENTERDR

BETHESDAMO 20814

haro1d.varmus@nih.gov

2590 31CENTERDR BETHESDAMO 20814 haro1d.varmus@nih.gov Jose Grazianoda Silva, Director -Genera, Food and

JoseGrazianoda Silva, Director -Genera, Food and Agriculture Organization of the United Nations FoodandAgriculture Organization of the United Nations VialedelleTerme di Caracalla

00153Rome,Italy

Tel:(+39)06 57051