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Reprinted by permission from British Dental Journal: Evidence based dentistry. Br Dent J. 1995 Oct 7;179(7):270-3.

1995 Macmillan Publishers Ltd.

Personal View

Evidence based dentistry


D Richards,* BDS, DDPHRCS (Eng), FDSRCPS (Glasg),
A Lawrence,** BDS, DDPHRCS

We live in an age of information, innovation and change. Clinical decision making based on good
quality evidence should lead to more effective and efficient treatments. Each practitioner has a
role in assessing this information. This paper outlines this role, together with the advantages and
problems of introducing an evidence based approach to dentistry.

There is world-wide interest in The problems of introducing trials by commercial concerns


making health services more evidence based dentistry could result in non-publication of
effective and containing health negative or unhelpful findings. Sir
care costs without compromising amount of evidence 4
Robert Boyles in 1661 pointed
quality of evidence
quality of care in the face of practice based on authority
out that 'Many excellent notions
technological advances, rather than evidence or experiments are, by sober and
demographic change and modest men suppressed,' and
increasing public expectation. there seems to have been little
However, comparatively few Advantages of evidence change.
decisions in the health services based dentistry
are made as a result of good Dissemination of evidence
evidence. Shaw1 pointed out in it improves the effective use Unless good methods of
his recent leader on the Cochrane of research evidence in dissemination are available even
clinical practice
Collaboration that even when where there is good evidence it
it uses resources more
there is good evidence for a effectively can take many years for a
particular intervention or therapy, it relies on evidence rather particular treatment to become
it is often many years before it than authority for clinical the norm.
comes into general use. He decision making
it enables practitioners to
quotes the use of corticosteroids monitor and develop
Practice based on authority rather
to reduce neonatal mortality in clinical performance. than evidence
premature birth.2 Cumulative The use of techniques or
systematic review could have therapies based on the views of
shown 20 years ago that the use There are about 500 journals authority rather than evidence
of intravenous streptokinase in related to dentistry. Clearly not all may lead to the wrong treatment
acute myocardial infarction was a of these articles are relevant to all being performed. lain Chalmers
life saving measure.3 areas of dental practice, nor can and Brian Haynes in their paper5
one hope to read any more than a give the example of the Oxford
What are the problems of small minority. textbook of clinical medicine6
introducing evidence based which stated 'the clinical benefits
dentistry? Quality of evidence of thrombolysis (in treating
The aim of evidence based Much of the ever increasing patients with myocardial
dentistry is to encourage the volume of evidence is produced infarcts)... remains to be
ordinary dental practitioner in to enhance career prospects established'. This was several
primary dental care to look for rather than to increase years after the publication of the
and make sense of the evidence knowledge. This can compromise study noted above.3
available in order to apply it to quality. A number of publications
everyday clinical problems. that are widely read in dentistry What is evidence based
However, making clinical are not subject to peer review and dentistry?
decisions based on evidence even when they are there is the Evidence based dentistry (EBD)
does pose several problems for tendency for publication bias. This is a process that restructures the
the dental practitioner. bias may not be explicit but there way in which we think about
is a tendency both by the clinical problems. It is an
Amount of evidence researchers and editors to publish approach to clinical problem
Currently over 2 million positive reviews. Negative trials solving that has evolved from a
biomedical articles are published can be equally valuable, and self-directed and problem based
annually in some 20,000 journals. concerns have been raised that approach to learning rather than
increasing sponsorship of medical the more traditional didactic form.

BRITISH DENTAL JOURNAL


Reprinted by permission from British Dental Journal: Evidence based dentistry. Br Dent J. 1995 Oct 7;179(7):270-3.
1995 Macmillan Publishers Ltd.

This problem based method of


learning has been extensively Identify clinical problem
developed at McMaster University
Medical School in Hamilton,
Canada. The department of
community dental health at the
faculty of dentistry, University of Search for evidence
Toronto is also using these
methods and they are being
adopted in many other medical Discard
schools throughout the world. A
useful introduction to the methods
employed is in the textbook by Make sense of Update evidence
7
Sackett et al., Clinical Evidence
epidemiology. A basic science for
clinical medicine.
EBD is the process of making
decisions based on known Store
evidence. Figure 1 outlines the
main stages in the process. The
first stage is to identify the clinical
Act on Evidence
problem, after which, evidence to
help solve the problem must be
located.
Fig. 1 The process of evidence based dentistry in order to make clinical decisions
What constitutes evidence?

Our own clinical examination, (RCTs). However, this is not the currently available dentifrice
including specific findings from only evidence and a list of levels formulations, and a meta-analysis
history and results from tests of evidence is shown in figure 2 by Hayes et al.9 of systemic
constitutes evidence. Research (level one being the best). tetracycline use in chronic adult
evidence will usually be based on Systematic reviews efficiently periodontitis.
a much larger number and variety integrate existing information and
of clinical interventions and thus provide data to establish whether Finding the evidence
becomes an important aid for scientific findings are consistent
clinical decision making, since it and can be generalised across Having identified a clinical
extends beyond our individual populations, settings and problem where can good
experience. treatment variations. Meta- evidence be found? There are
Research evidence helps us as analysis is a form of systematic four basic routes:
clinicians decide which review that looks at all the
interventions are most effective. It relevant literature whether good, 1 ask someone
should not replace our clinical bad or indifferent. The next stage 2 consult a textbook
findings from the history and is to work out a grading and a 3 find a relevant article in your
examination, but harness our conclusion for each trial. The own reprint file
clinical intuition from years of results are then combined with 4 use a bibliographical database
experience. What research more weight being given to larger such as MEDLINE.
should do is enable us as studies. This produces a single
clinicians to maximise our estimate of the clinical Asking a consultant or a
experience by recognising gaps effectiveness. The advantage of a colleague is an efficient way of
and uncertainties in our meta-analysis is that it getting an answer to a problem,
knowledge rather than waiting for summarises the available particularly if you are unlikely to
the next patient to expose our evidence and because of its encounter it again. There are,
inadequacies. systematic nature it can be however, a number of drawbacks
appraised rapidly and the results to this approach. Experts often
What is good evidence? applied to patient care. disagree, they may not be up to
Some recent examples of dental date in that particular area of the
The gold standard for evidence systematic reviews are DePola et subject, or they may not agree
is strong evidence from at least al.8 on the relative anticaries with the latest evidence. The best
one published systematic review effectiveness of sodium method of using an expert is to
of multiple well-designed monofluorophosphate and ask them for a specific reference
randomised controlled trials sodium fluoride, as contained in so that you can appraise the

BRITISH DENTAL JOURNAL


Reprinted by permission from British Dental Journal: Evidence based dentistry. Br Dent J. 1995 Oct 7;179(7):270-3.
1995 Macmillan Publishers Ltd.

evidence for yourself. In this way any of the commercial databases design, subjects, intervention,
you do not abdicate your role in currently available on CD-ROM. main outcome measures, results
assessing whether your patient This is a relatively inexpensive and conclusions.
would benefit from the approach option that should be considered
suggested by the expert. by practitioners now. Action
Textbooks are only as current as
their most recent reference. They Making sense of the evidence Following appraisal of the
can also suffer from the problem evidence there are four courses
identified earlier of the authors Finding the evidence is just the of action. We can act on it,
not accepting the latest evidence. first stage in the process. The discard it or store it, but we
Personal references files are next stage is appraisal, that is should be aware that new
unlikely to be large or cover the making sense of the evidence. evidence is always emerging so
wide variety of problems This appraisal should be critical, we need to continually update it.
encountered in everyday practice. that is systematically considering
Using a library is an alternative its validity, results and relevance What are the advantages of this
approach for accessing textbooks to our own work. For an approach?
and journals but there is little introduction to the type of skills
evidence of great use of these required for the critical reading of It improves the effective use of
facilities by dental practitioners. articles, the BDJ article by research evidence in clinical
10
The final route is the electronic Bulman is a useful starting practice
one, in these days of increasing point, while Milne and The clinical problem solving
use of computers this is fast Chambers11 provide a number of approach to dentistry favours the
becoming the quickest and guidelines for assessing review early uptake of new and better
simplest way of accessing articles. treatments, or results in the early
information. MEDLINE is There are also a series of rejection of ineffective treatments.
available in many local and articles in the British Medical
regional medical libraries, and Journal on systematic reviews It uses resources more effectively
5,12,13,14,15,16
also to members of the BDA that give more insight Systematic reviews of materials,
through the BDA library. It also to the process. The Cochrane for example, may lead to the
features an after-hours dial-up Collaboration and other agencies earlier adoption of the most
service accessible using a such as the Centre for Reviews effective ones. This in turn should
modem. and Dissemination in York also lead to a reduction in replacement
Going on-line is a relatively have an important role in levels thereby saving resources.
inexpensive option and becoming reviewing and disseminating
cheaper every month. Many evidence. A step in the right It relies on evidence rather than
practices now have computers direction would be the making of authority for clinical decision
and the simple addition of a CD- journal abstracts more informative making
ROM drive would allow rapid along the lines of those adopted Regular reviewing of the
personal access in the surgery to by the BMJ, giving objectives, currently available evidence
should develop us as
practitioners so that we have the
Type and strength of evidence skills to evaluate evidence for
ourselves based on our own
Better clinical practice and assessment
1. strong evidence from at least one published systematic review of multiple of the evidence, rather than
well-designed randomised controlled trials textbooks or authorities who may
2. strong evidence from at least one published properly designed randomised not be up to date. This appraisal
controlled trial of appropriate size and in an appropriate clinical setting of evidence is necessary to aid
3. evidence from published well-designed trials without randomisation, single the approach to clinical decision
group pre, post, cohort, time series or matched case controlled studies making as described by Kay and
17
Nuttal in their recent series of
4. evidence from well-designed experimental studies from more than one
articles in the British Dental
centre or research group
Journal.
5. opinions of respected authorities, based on clinical evidence, descriptive
studies or reports of expert consensus committees. Monitor and develop clinical
Worse performance

Use of the skills outlined should


enable us to monitor and develop
Fig. 2 A list of levels of evidence our own clinical performance.
This has been previously carried

BRITISH DENTAL JOURNAL


Reprinted by permission from British Dental Journal: Evidence based dentistry. Br Dent J. 1995 Oct 7;179(7):270-3.
1995 Macmillan Publishers Ltd.

out by peer review. The success The pressure of practice tends administration before preterm
delivery: an overview of the evidence
of this has resulted in clinical to make dentists switch off the
from controlled trials. Br ] Obstet
audit being introduced to general 'learn mode' but there is a need to Gynaecol 1990; 97: 11-25.
dental practice on an switch the learn mode on again. 3. Lau J, Antman E M, Jimenz-Silva J,
experimental basis. This provides The experience in Canada that Kupelnick B, Mosteller F, Chalmers T
C. Cumulative meta-analysis of
an ideal opportunity for audit to evidence based doctors are
therapeutic trials for myocardial
be structured on an evidence happier doctors and transferring infarction. Engl J Med 1992; 327:
based framework. The proposed this satisfying and effective 248-254.
clinical audit facilitators in dental practice to dentistry can be a 4. Hall M B. In defence of the
experimental essay. In Boyle R.
practice could be key people in market asset in the new world of
Natural philosophy, pp 119-131.
encouraging EBD which would dentistry. Being able to offer up- Bloomington: Indiana University
improve the quality and focus of to-date information based on Press, 1965.
audit. properly evaluated evidence must 5. Chalmers I, Haynes B. Reporting,
updating, and correcting systemic
help with increasing demands of reviews of the effects of health care.
Conclusions patients. It also helps dentists to Br Med] 1994; 309: 862-865.
test claims of representatives of 6. Weatherall D J, Ledingham J G G,
In order to use this approach various dental and drug Warrell D A, Oxford textbook of
medicine. 2nd ed. London: Oxford
there is a need for the companies. University Press, 1987.
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identifying clinical problems, Evidence based dentistry H, Tugwell P. Clinical epidemiology.
literature searching, using initiatives A basic science for clinical medicine.
2nd ed. Little, Brown and Co., 1991.
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8. DePaula P F, Soparkar P M, Triol C,
means and critical appraisal. The evidence based approach Volpe A R, Garcia L, Duffy J, Vaughn
Ideally this would involve has already moved into medicine B. The relative anticaries
everyone in the profession but in this country and there are a effectiveness of sodium
monofluorophosphate and sodium
initially we need to develop the number of initiatives in dentistry
fluoride as contained in currently
skills of a core of enthusiasts who including the establishment of the available dentrifice formulations. Am
can then encourage its spread Cochrane Oral Health Group in J Dent 1993; 6: S7-S22.
through the profession. 1993. Recently a workshop on 9. Hayes C, Angelillo I, Antczak-
Bouckoms A A. Quality assessment
This approach needs to take evidence based dentistry in
and meta-analysis of systemic
place not only amongst the ranks Oxford was well received by tetracyline use in chronic adult
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Obtaining data from randomised
technique oriented; these have a care. They will feel much happier
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