Clog P dengan Aktivitas ( Log 1/IC50)

Regression

Variables Entered/Removeda

Variables Variables
Model Entered Removed Method

1 ClogPb . Enter

a. Dependent Variable: log1IC50

b. All requested variables entered.

Model Summary

Adjusted R Std. Error of the

Model R R Square Square Estimate

1 ,314a ,098 -,014 ,49515

a. Predictors: (Constant), ClogP

ANOVAa

Model Sum of Squares df Mean Square F Sig.

1 Regression ,214 1 ,214 ,873 ,377b

Residual 1,961 8 ,245

Total 2,175 9

a. Dependent Variable: log1IC50

b. Predictors: (Constant), ClogP

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients

Model B Std. Error Beta t Sig.

1 (Constant) -1,027 ,269 -3,815 ,005

ClogP -,071 ,076 -,314 -,935 ,377

a. Dependent Variable: log1IC50

tPSa dengan Aktivitas ( Log 1/IC50)

Regression

Variables Entered/Removeda

Variables Variables
Model Entered Removed Method

1 tPSab . Enter

a. Dependent Variable: log1IC50

b. All requested variables entered.

Model Summary

Adjusted R Std. Error of the

Model R R Square Square Estimate

1 ,531a ,282 ,192 ,44192

a. Predictors: (Constant), tPSa

ANOVAa

Model Sum of Squares df Mean Square F Sig.

1 Regression ,613 1 ,613 3,139 ,114b

Residual 1,562 8 ,195

Total 2,175 9

a. Dependent Variable: log1IC50

b. Predictors: (Constant), tPSa

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients

Model B Std. Error Beta t Sig.

1 (Constant) -2,010 ,461 -4,361 ,002

tPSa ,010 ,006 ,531 1,772 ,114

a. Dependent Variable: log1IC50

pKa dengan Aktivitas ( Log 1/IC50)

Regression

Variables Entered/Removeda

Variables Variables
Model Entered Removed Method

1 pKab . Enter

a. Dependent Variable: log1IC50

b. All requested variables entered.

Model Summary

Adjusted R Std. Error of the

Model R R Square Square Estimate

1 ,771a ,595 ,544 ,33195

a. Predictors: (Constant), pKa

ANOVAa

Model Sum of Squares df Mean Square F Sig.

1 Regression 1,294 1 1,294 11,743 ,009b

Residual ,882 8 ,110

Total 2,175 9

a. Dependent Variable: log1IC50

b. Predictors: (Constant), pKa

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients

Model B Std. Error Beta t Sig.

1 (Constant) -10,687 2,761 -3,870 ,005

pKa ,666 ,194 ,771 3,427 ,009

a. Dependent Variable: log1IC50

Etotal dengan Aktivitas ( Log 1/IC50)

Regression

Variables Entered/Removeda

Variables Variables
Model Entered Removed Method

1 Etotalb . Enter

a. Dependent Variable: log1IC50

b. All requested variables entered.

Model Summary

Adjusted R Std. Error of the

Model R R Square Square Estimate

1 ,404a ,164 ,059 ,47692

a. Predictors: (Constant), Etotal

ANOVAa

Model Sum of Squares df Mean Square F Sig.

1 Regression ,356 1 ,356 1,565 ,246b

Residual 1,820 8 ,227

Total 2,175 9

a. Dependent Variable: log1IC50

b. Predictors: (Constant), Etotal

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients

Model B Std. Error Beta t Sig.

1 (Constant) -,838 ,349 -2,399 ,043

Etotal -,014 ,011 -,404 -1,251 ,246

a. Dependent Variable: log1IC50

BM dengan Aktivitas ( Log 1/IC50)

Regression

Variables Entered/Removeda

Variables Variables
Model Entered Removed Method

1 BMb . Enter

a. Dependent Variable: log1IC50

b. All requested variables entered.

Model Summary

Adjusted R Std. Error of the

Model R R Square Square Estimate

1 ,061a ,004 -,121 ,52049

a. Predictors: (Constant), BM

ANOVAa

Model Sum of Squares df Mean Square F Sig.

1 Regression ,008 1 ,008 ,030 ,866b

Residual 2,167 8 ,271

Total 2,175 9

a. Dependent Variable: log1IC50

b. Predictors: (Constant), BM

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients

Model B Std. Error Beta t Sig.

1 (Constant) -1,399 ,974 -1,437 ,189

BM ,000 ,003 ,061 ,174 ,866

a. Dependent Variable: log1IC50

Regression

Variables Entered/Removeda

Variables Variables
Model Entered Removed Method

1 ClogP2, ClogPb . Enter

a. Dependent Variable: log1IC50

b. All requested variables entered.

Model Summary

Adjusted R Std. Error of the

Model R R Square Square Estimate

1 ,369a ,136 -,111 ,5181437

a. Predictors: (Constant), ClogP2, ClogP

ANOVAa

Model Sum of Squares df Mean Square F Sig.

1 Regression ,296 2 ,148 ,552 ,599b

Residual 1,879 7 ,268

Total 2,175 9

a. Dependent Variable: log1IC50

b. Predictors: (Constant), ClogP2, ClogP

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients

Model B Std. Error Beta t Sig.

1 (Constant) -,922 ,340 -2,707 ,030

ClogP -,183 ,216 -,802 -,844 ,427

ClogP2 ,017 ,031 ,526 ,553 ,598

a. Dependent Variable: log1IC50