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Dr. Zerrudo: BREAST/MALE c.

Colloidcarcinoma
d. Tubular carcinoma
1. Fibrocystic change usually occurs at 10. This lesion is characterized by neoplastic cells
a. Before 30 years of age arranged in single files
b. 20-40 years of age a. Invasive lobular carcinoma
c. After 40 years b. Mucinous carcinoma
d. 6th decade c. Tubular carcinoma
2. Most common benign tumor of the female d. Medullary carcninoma
breast 11. This breast lesion is characterized by marked
lymphocytic infiltration
a. Fibroadenoma a. Medullary carcinoma
b. Benign phylloides tumor b. Tubular carcinoma
c. Galactocele c. Invasive lobular carcinoma
d. Tubular adenoma d. Mucinous carcinoma
3. Most common congenital anomaly 12. This lesion is characterized by islands of
a. Supernumerary nipples neoplastic cells floating in lakes of mucin
b. Accessory axillary breast tissue a. Tubular carcinoma
c. Congenital inversion of nipples b. Invasive lobular carcinoma
d. Mammary duct ectasia c. Mucinous carcinoma
4. All of the following are inflammatory d. Medullary carcinoma
conditions, except 13. This lesion is characterized by well-formed
a. Acute mastitis tubules lined by single layer of cells with
b. Supernumerary nipples apocrine snouts
c. Galactocele a. Invasive lobular carcinoma
d. Silicone breast implants b. Mucinous carcinoma
5. Mimics carcinoma clinically and on c. Medullary carcinoma
mammogram d. Tubular carcinoma
a. Fat necrosis 14. Most important prognostic factor in breast
b. Mammary duct ectasia carcinoma
c. Galactocele a. Axillary lymph node status
d. A and B b. Histologic subtype
6. Which of the following is the most common c. Tumor size
type of breast carcninoma d. Tumor histologic grade
a. Invasive ductal carcinoma 15. The stage where there is an invasive CA 2 cm or
b. Mucinous carcninoma less in size including microinvasion with
c. Medullary carcinoma negative nodes and no distant metastases.
d. Invasive lobular carcinoma a. Stage I
7. Genetic factors usually involved in Breast b. Stage II
Carcinoma, except c. Stage III
a. Li-Fraumeni syndrome d. Stage IV
b. BRCA-1, BRCA-2 mutations 16. Cryptorchidism/testicular atrophy-
c. Chromosome 11q mutation UNDESCENDED TESTES
d. Heterozygous ATM gene mutation 17. Epididymis- much more affected than testes
8. This lesion is characterized by solid sheets of proper
high-grade malignant cells with central necrosis 18. TESTICULAR NEOPLASMS- MALIGNANT!!!, most
a. Pagets disease important cause of painless testicular
b. Cribriform variant enlargement.
c. Medullary carcninoma 19. 95% of ALL TESTICULAR NEOPLASMS- from
d. Comedocarcinoma GERM CELLS; 5%- from SUPPORT CELLS
9. Well circumscribed mass lacking desmoplastic 20. SEMINOMA- ~dysgerminoma IN OVARY, NO
response HEMORRHAGE/NECROSIS
a. Pagets disease a. Large cells with clear cytoplasm
b. Medullary carcinoma b. Fibrous septae
c. Mild lymphocytic infiltrate 10. SQUAMOUS CELL CARCINOMA- 95% of tumors,
d. (-) A-fetoprotein/ HCG chronic inflammatory cell dermal infiltrate
e. (+) placental alkaline phosphatase 11. MALIGNANT
21. EMBRYONAL CARCINOMA- INVASIVE masses MELANOMA/MELANOCARCINOMA- 2nd most
with HEMORRHAGE and NECROSIS ; neoplastic common malignant tumor
cells are ANGRY LOOKING, hyperchromatic 12. CLUE CELLS- G. vaginalis, cytoplasm covered
nuclei, prominent nucleoli by organisms.
a. May be positive for hcg/afp 13. BOTRYOID RHABDOMYOSARCOMA
22. YOLK SAC TUMOR- most COMMON PRIMARY (Sarcoma botryoides)- BUNCH OF GRAPES;
TESTICULAR NEOPLASM in children <3 years of Cambium Layer: subepithelial dense zone
age- GOOD PROGNOSIS
14. Hallmark of HPV-
a. CHILDREN- pure
KOILOCYTOSIS/KOILOCYTOTIC ATYPIA
b. ADULTS- mixed with EC.
15. CERVICAL INTRAEPITHELIAL NEOPLASIA
c. (+) AFP (CIN) 1- Including Condyloma, the
23. CHORIOCARCINOMA- trophoblastic
superficial cell layers (koilocytes), with
differentiation from TOTIPOTENTIAL GERM
CELLS preservation of epithelial maturation.
a. (+) HCG 16. ASCUS- Atypical squamous cell of
24. TERATOMA- MORE THAN ONE germ layer type. undetermined significance: nuclear
enlargement 2.5-3x nucleus, variation in nuclear
a. ADULT- ALL MALIGNANT size, shape, and nucleation, mild
b. OVARY- BENIGN hyperchromasia
25. MIXED GERM CELL TUMORS- 50-60% 17. HYDATID CYST OF MORGANI- Paratubal cyst, 1-
a. Teratocarcinoma- most common 2 cm, SEROUS FLUID, PAPER-THIN WALL,
b. columnar to cuboida.
18. POLYCYSTIC OVARY- Stein- Levinthal Syndrome,
polycystic ovary associated with AMENORRHEA,
ANOVULATION, OBESITY 40%, HIRSUTISM 50%,
Dr. Layda: FEMALE REPRODUCTIVE SYSTEM VIRILISM
19. ENDOMETRIOSIS in OVARY- blood lakes in
1. CANDIDA- white curdly material TRANSPLANTATION AREA: CHOCOLATE CYSTS
2. HPV- Condyloma Acuminata (venereal 20. ENDOMETRIOTIC CYSTS:
Warts) a. Endometrial glands
3. MOSSCUM CONTAGIOSUM Pox virus, b. Endometrial stroma
producing a characteristic lesion c. Hemosiderin laden macrophages/
4. HSV 2- HERPETIC Ulcer development: macules, histiocytes
papules, vesicles, very painful but do not 21. Serous: MALIGNANT SURFACE EPITHELIAL
actually leave any serious sequelae TUMORS- SEROUS CYSTADENOCARCINOMA: (+)
5. BARTHOLINS DUCT CYST- lined by PSAMMOMA BODIES, you are sure that you are
TRANSITIONAL CELLS which sometimes become dealing with SEROUS TYPE
METAPLASTIC, hence sometimes it becomes 22. BRENNER TUMORS- uncommon
STRATIFIED SQUAMOUS EPITHELIAL LINING
adenofibromas in which the epithelial
6. LICHEN SCLEROSIS (CHRONIC VULVITIS)- elderly
component consists of NESTS OF
females, THINNED OUT SKIN with underlying
TRANSITIONAL CELL resembling URINARY
SUBEPITHELIAL FIBROSIS
BLADDER.
7. CONDYLOMA LATUM/LATA- T. pallidum:
23. GRANULOSA CELL TUMORS- Adult type: CALL
SYPHILLIS (CHANCRE).
EXNER-BODIES/ Juvenile type: no nuclear
8. KOILOCYTES- squamous cells with NUCLEAR
grooving, teratomas (immature/mature), yolk
ATYPIA and PERINUCLEAR CLEARING/halo by a
sac tumors
dense rim of cytoplasm; NUCLEUS is raisinoid
24. FIBROMA- Meigs syndrome: fibroma, ascites,
9. PAGETS DISEASE- large anaplastic tumor cells
pleural effusion
with perinuclear clearing or halo, confined to
25. GERMINOMAS/DYSGERMINOMA- Most
the basal layer up to the middle.
radiosensitive of ovarian tumors, separated by
delicate bands of FIBROUS TISSUE WITH b. MALIGNANT:
LYMPHOCYTES (-sensitive to radiation),
ADENOSQUAMOUS CA
monotonous population of germ cells with
prominent nucleoli. 44.GRADE III: solid tumor cells
26. DERMOID CYSTS/ CYSTIC TERATOMAS- from predominate over the glandular areas
3 GERM LAYERS!!! (poorly differentiated).
27. STRUMA OVARI- composed of ENTIRELY
MATURE THYROID TISSUE
28. METASTATIC OVARIAN TUMORS-
KRUKENBERG TUMOR: Bilateral metastasis
composed of mucin producing SIGNET RING
CANCER.
29. COMPLETE HYDATIDIFORM MOLE- Grossly
swollen chorionic villi, BUNCH OF GRAPES,
Haploid 23X duplicates to 46XX.
30. CHORIOCARCINOMA- mass with CENTRAL
NECROSIS and HEMORRHAGE, from
TROPHOBLAST, high serum HCG
31. BATTLEDOR PLACENTA- True marginal
insertion of placenta, cord inserted marginally
32. PROLIFERATIVE PHASE- ESTROGEN
33. SECRETORY PHASE- saw-toothed appearance
34. PREGNANCY- Arias Stella Reaction
35. PILL ENDOMETRIUM- Asynchronous or
discordant pattern
36. CHRONIC ENDOMETRITIS- (+) PLASMA CELLS
37. ADENOMYOSIS/ ENDOMETRIOSIS
INTERNA- whorls and trabeculated appearance
38. SIMPLE HYPERPLASIA- without atypia, aka
CYSTIC HYPERPLASIA or SWISS CHEESE
HYPERPLASIA
39. LEIOMYOMA- aka UTERINE FIBROIDS, MOST
COMMON TUMOR of the UTERUS, smooth
muscle tumor
40. MALIGNANT MIXED MULLERIAN TUMORS
(MMT)- ALL COMPONENTS derived from
MESODERM, also called CARSINOSARCOMA
41. Type 1 endometrial CA: present
unopposed estrogen and hyperplasia, pre
and PERIMENOPAUSAL status
42.ADENOCARCINOMA- also called
ADENOCARCINOMA with SQUAMOUS
METAPLASIA, with nests of benign
squamous cells
43.ADENOSQUAMOUS CA- BOTH glands and
squamous cells are MALIGNANT, often
with CLEAR and SQUAMOUS CELLS
a. BENIGN: ADENOACANTHOMA