MgSO4

(selective a2 adrenergic agonist)

It prevents seizures in pre-eclampsia and doesnt treat hypertension.

In eclampsia, it is given as soon as the convulsion has ended.
It causes :
vasodilation,
increases cerebral,
uterine and
renal blood flow
decreased cerebral edema.

PREPARATION OF MAGNESIUM SULPHATE PREPARATION OF MAGNESIUM SULPHATE

IV REGIME IM REGIME
(low dose/Zuspan regime) (high dose/Pritchard regime)
1 Amp (5ml) = 2.47g/ ~2.5g of 50% MgSO4 1 Amp (5ml) = 2.47g/ ~2.5g of 50% MgSO4
2 Amp = 10mls = ~ 5.0g 2 Amp = 10mls = ~ 5.0g
1mls = ~ 0.5g 1mls = ~ 0.5g

LOADING DOSE LOADING DOSE

4g of 20% MgSO4 IV slow bolus over 15-20mins 1) 4g of 20% MgSO4 IV slow bolus over 15-20mins

Required? 4g (4g/0.5g) = 8mls MgSO4 Required? 4g (4g/0.5g) = 8mls MgSO4

mixed with mixed with
12ml NS in 20ml syringe 12ml NS in 20ml syringe
= 20ml of 4g of 20% MgSO4 = 20ml of 4g of 20% MgSO4

2) Followed immediately by IM 10g MgSO4- to upp

MAINTENANCE DOSE quadrant of each buttock in zigzag manner
1g/hour IV infusion run @ 10mls/hour (5g injection to each buttock)
*1ml of 2% lignocaine (LA) if needed

10mls MgSO4 (5g)

mixed with
40ml NS in 50ml syringe
*should stop once baby is delivered
*max length of infusion 24H

MAINTENANCE DOSE
IM 5gm MgSO4 every 4H for 24H
(total 6 injection and 2.5gm injection to each buttock)

CAUTION!!
WATCH OUT FOR MgSO4 TOXICITY!!!
HOURLY!
1) Knee jerk
2) Urine output > 25ml/hour
3) Respiratory rate > 16/min
4) Pulse rate/BP

INDICATIONS:

HTAA Jan17 Yana

HTAA Jan17 Yana