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A Haberdashers Askes Occasional Paper.

All
rights reserved.
1

Haberdashers Askes School


Occasional Papers Series in the
Sciences
Occasional Paper Number Nine
Could Sickle Cell Anaemia save your life?
Exploring the intersection of
heterozygote advantage with
population genetics
Aske Project Winning Paper 2016
Sohum Patel
PAT500@habsboys.org.uk
February
201
7
A Haberdashers Askes Occasional Paper. All
rights reserved.
2
Haberdashers Askes Occasional Paper Number
Nine
February 2017
All rights reserved
Could Sickle Cell Anaemia save your
life?
Exploring the intersection of heterozygote
advantage with
population genetics.
Sohum Patel
Abstract
This paper will consider the paradoxical relationship between sickle
cell anaemia
and malaria, two diseases ostensibly far removed from one
another, but which in
reality have greatly influenced one another through the centuries.
Why is it that
Nigerians dont get malaria quite as much as you might expect?
The answer lies in
the increased prevalence of sickle cell anaemia and sickle cell trait
in the country,
which affords individuals relative immunity to the infectious disease.
In this paper,
I analyse the frequency of the allele which makes all of this possible
in a Nigerian
population, creating a mathematical model based on evolutionary
game
theory
which aims to predict the rate at which sickle cell anaemia will
progress through
society over the coming centuries.