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1995

WORTH Elswier Science Ltd for BES

EINEMANN

Printed in Great Britain

13504533(95)000194 1550-45x3:95 $10.00 + 0.00

mechanics: a numerical study of the motion of an

isolated particle freely suspended in channel flow

G. Dubini, R. Pietrabissa and F. M. Montevecchi

ABSTRACT

In this paper a problem belonging to the moving boundary class is tackled with a 2-D application of computational

fluid dynamics techniques. The motion of an isolated rigid particle free[]y suspended in an incompressible Newtonian

fluid in a narrow channel is studied numerically at a low Reynolds number, yet different from zero. The actual

problem consists of two coupled problems: the motion of the viscous jluid and that of the rigid particle suspended

and convected with thejuid. Thefull Navier-Stokes equations (i.e. both transient and convective terms are included)

are solved in the fluid domain by means of the finite element method, while the motion of the particle is determined

on the basis of a rigid act of motion. Results from simulations corresponding to dtff erential initial positions of the

particle are shown in this paper: they allow one to study the rotational motions of the particle as well as its displuce-

ments. The goal of the paper is to analyse the lateral displacement behaviour of the particle, already observed in

experimental studies in microcirculation. In particular, lateral migrations are supposed to be due to inertial forces

acting in the Juid around the moving particle combined with the proximity of the resting wall (wall effect). Prelimi-

nary results are in fairly good agreement with those available in the literature.

lation

eter is 0.3 mm or below. In these circumstances

Fluid-structure interaction problems are fre-

experimental studies** put in evidence phenom-

quently met in bio-fluid mechanics. In this field,

ena of fluid dynamic nature that may be explained

theoretical approaches, either analytical or

only taking into account blood structure. As a mat-

numerical, often require the adoption of several

ter of fact, the whole blood is not a homogeneous

proper simplifications to overcome difficulties

fluid since it is composed of cellular particles

such as complex 3-D geometries, highly visco-elas-

(mainly red cells) suspended in a Newtonian and

tic materials, non-Newtonian and/or non-homo-

homogeneous fluid (the plas,ma). Due to the

geneous fluids. In the case of fluid-structure inter-

small dimensions of the red blood cell (RISC), less

action problems, an additional major difficulty

than 8 pm, the effects of its presence are not sig-

arises, since the position of interfaces between

nificant when the blood flows in tubes whose

fluid and structure is unknown; they passively

diameter is greater than 0.3 mm, since in these

move due to fluid forces, and hence their position

cases the viscosity is not influenced by the pres-

depends upon local stress distribution (moving

ence of RBCs.

boundary problem).

Typical regions where the presence of RBCs

Usually, when studying and modelling the car-

within plasma cannot be neglected are those of

diovascular system and its behaviour from the

capillaries (diameter of about 10 pm) and small

fluid dynamic point of view, blood is considered as

arterioles (diameter of about 100 pm). The study

an incompressible, homogeneous and Newtonian

fluid. This approximation, which is quite good in of blood flow in capillaries leads to knowledge of

the exchanges of fluids and other materials

most cases, may lead to severe errors if the system

between the blood and the tissue surrounding the

Correspondence to: Dr Riccardo Pietrabissa, Dipartimento di Bioing-

vessels, while the fluid dynamic behaviour in

egncria. Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 arterioles may explain the blood and RBC distri-

Milano, Italy. Tel. (N-2-2643 4300: Fax (39)-2-2643 430?. bution in different capillary branches. Hence the

Motion of a rigid particle in channelpow: G. Dubini et al.

study of blood rheology, beyond giving a deeper while for the movement of the particle the finite

knowledge of blood properties, helps us in under- difference method is adopted. In order to evalu-

standing the microcirculation and its regulation. ate the role played by local inertial forces around

A first approach to model blood viscous proper- the suspended particle, the full Navier-Stokes

ties consists of considering blood as a homo- equations are solved in this study (assuming that

geneous fluid with non-Newtonian behaviou?s4s5. gravity effects per unit volume can be discarded):

This approach allows one to properly describe the

blood properties at low shear rate and high hema-

(1)

tocrit. but it does not take into consideration the

structure of blood. The above models are purely

Results from two simulations are reported here,

phenomenological. When the presence of RBCs

corresponding to two different initial conditions

becomes important not only for global behaviour,

with reference to the distance of the particle from

but also for local phenomena, blood may no

the wall. The results show quite a good agreement

longer be considered homogeneous. Further-

with the experimental observations reported in

more, since the first experiments on blood flow6,

the literature.

a corpuscle-free region near the vessel walls was

noticed, whose radial thickness becomes signifi-

cant for very small vessels (diameter below DESCRIPTION OF THE MODEL

0.3 mm). These observations indicate that the

For the numerical evaluation of the movement of

assumption of blood homogeneity neglects not

the RBCs transported by plasma we refer to a sim-

only the presence of RBCs, but also in some cases

plified model. It consists of a 2-D system shaped

their non-uniform distribution on the cross-sec-

as the longitudinal section of a straight, rigid,

tion of the vessel, too.

impermeable conduit with a diameter

The study of the motion of particles suspended

D = 100 pm. The internal side of the conduit is

in a flowing fluid has been faced mainly with

filled with homogeneous, incompressible, New-

experimental set-ups-, but some analytical-

tonian fluid. The fluid density is

and more recently some numerica120-25 studies

p = 1.03*10 kg-m- and the fluid viscosity is

have been published as well.

p = 1.2.10-s Pas. The fluid domain contains one

Among the experimental studies, some have

isolated 2-D particle model, which is shown in Fig-

put in evidence that particles in dilute suspensions

ure 1. Its dimensions are: maximum diameter

show radial displacements towards either the wall

a = 8 pm, minimum diameter b = 2.4 pm. It is sup-

of the conduit or the axis, depending on the

posed to be rigid and to have the same density as

deformability of the particle and the local fluid

the surrounding fluid. This hypothesis allows one

dynamics. Two different mechanisms have been

to assume that buoyancy forces are equal to zero.

suggested in order to explain these migrations:

Since the motion of the particle is rigid and 2-

the former deals with the inertial forces acting in

D, it may be fully described by the trajectory of its

the fluid surrounding the particle, while the latter

centre of mass C and by the rotation around the

refers to the so-called wall effect. This consists axis through C. In a fixed Cartesian frame of ref-

of the alteration of the fluid dynamic field around erence, the motion is described by the time

the moving particle due to the presence of a

courses of the co-ordinates x, and y of the centre

resting wall in the proximity of the particle itself. of mass and that of the rotation angle (Y of the

The present work describes a numerical

particle around C. These functions are obtained

approach to study the motion of a single particle

by means of a double integration of the corre-

in a narrow channel flow. Some approximations

sponding acceleration functions with respect to

have been considered, such as rigid wall vessel,

time.

rigid particle and planar geometry. For the numerical solution, we consider a finite

The solution of the Navier-Stokes equation

time step At in which the three acceleration

allows one to describe the fluid dynamic behav-

components are kept constant. Hence the equa-

iour of the fluid, but time-varying boundary con-

ditions due to the particles movements must be

taken into account. On its side, the particle moves ---I.

according to the fluid dynamic forces exerted by

the surrounding fluid. It is a typical problem of

fluid-structure interaction in which a fluid flow

and a solid body motion influence each other.

The problem may be disconnected into two prob-

lems - the fluid dynamics of the fluid of suspen-

sion and the motion of the particle - that are

linked by considering the solution of one as a

boundary condition of the other.

The numerical technique is based on an iterat-

ive algorithm that allows one to reach the conver-

gence of the solution of the two problems. For

the solution of the fluid dynamics of the fluid of Figure 1 The finite element mesh of the fluid domain model with

suspension a commercial computer code is used, the particle. The magnification shows the particle model and the

which is based on the finite element method, nodes on its edge

610

tions describing the motion of the particle, for the

k-th time step where tk 5 t 5 tk + At, are: M= (5)

x,.(t) = hgk)(t-t,) + jc,(t,)(t-t,)tx,(t,)

where 1 is the total length of the edge of the par-

y<(t) = +j; (k) (t-t,) + j&(4) (t-t,) + y&J ticle, Jcand j the co-ordinates of a generic point

a(t) = k?(k)(t-t,) t &(t,)(t-t,) + CY (t/J. (2) on the edge of the particle in a Cartesian frame

moving with the particle and centred in C.

The accelerations in equations (2) are pro-

The approach adopted is clearly different from

portional to the resultant forces and couple acting

the most commonly used-, based on the

on the particle (according to Newtons second hypothesis that neither external forces nor

law) as follows:

moment act on the particle and that the effect of

inertia forces can be neglected in the fluid and

on the particle (zero-drag conditions). The

assumption is based on the observation that in

microcirculation viscous forces are usually greater

than inertial ones and flow may be assumed to be

steady. It allows one to solve the Stokes equations

(characterised by zero Reynolds and Womersley

(3) numbers) instead of the Navier-Stokes equations.

As regards boundary conditions, they include

where m is the mass;j is the inertial polar moment both steady-state (along the boundary of the

of the particle around the rotation axis; &,, &, and conduit) and time-varying conditions (along the

M are the forces and the couple acting on the boundary of the moving particle). In detail we

particle, respectively. adopted the following boundary conditions for

The evaluation of force and couple resultants the conduit: zero velocity at the wall of the con-

requires knowledge of the distribution of local duit (no-slip conditions) ; parabolic velocity profile

forces acting on the edge of the particle and, at the inlet section of the conduit; and uniform

hence, of the fluid dynamic stresses exerted by the pressure on the outlet section of the conduit.

fluid on the particle. On the edge of the particle, no-slip conditions

The full description of the stress state in the are adopted. Since the particle moves in a plane

fluid domain is given by the fluid dynamic stress as a rigid body, the velocity at a generic point P of

tensor in the generic points belonging to the fluid the particle is governed by the following equation

domain. The components of this tensor are: (F&we 2) :

v, = v, + iu x r,,, (6)

where rp is the vector from the centre C to the

point P of the particle. When the point P lies on

the edge, vp is a boundary condition for the fluid

dynamic problem. ciffure 3 shows the boundary

conditions adopted m the model.

(4)

COMPUTATIONAL TECHNIQUE

where p is the viscosity of the fluid, p the pressure

and U, u the velocity components at the point of The fluid flow and the motion of the particle rep-

co-ordinates X, y. resent a strictly coupled problem, but, since the

The solution of the Navier-Stokes equation simultaneous solution is very difficult, we chose

gives velocity vectors and pressure fields in the to decouple them. The computational technique

fluid domain, including those points which adopted faces each problem separately and util-

belong to the edge of the rigid particle. From ises an iterative algorithm for the convergence of

these values the components of the stress tensor the solutions.

can be calculated by means of equations (4). Cau-

thys formula allows one to calculate the stress vec-

tor components (k, f) acting at each point on

the edge of the particle (depending on the local

orientation of the edge) in the same Cartesian

frame of reference adopted for the components

of the stress tensor. Integration of stress vectors

along the whole edge of the particle gives force

and couple resultant components. It yields:

R = t,ds

0

& = t&

0

611

Motion of a rigid particle in channel flow: G. Dubini et al.

- V(t)=0

3. it calculates the tentative distribution of velo-

L city on the edge of the particle for t = tk + At/2;

4. it updates the fluid dynamic model with the

description of the mesh and of the boundary

conditions at the edge of the particle;

5. it runs FIDAP which performs the transient

fluid dynamic simulation along the time step

with initial conditions set equal to those at the

end of the previous time step;

6. it calculates the resultants of the fluid dynamic

forces acting on the particle at the end of the

time step;

Figure 3 Boundary conditions of the model

7. it calculates the acceleration components of

the particle;

8. it compares tentative and calculated acceler-

The fluid dynamics has been studied by means ation components at the end of the time step

of FIDAP (FDI, Evanston, IL, USA) which is a and evaluates the errors;

commercial general purpose code based on the 9. it iterates the procedure using new tentative

finite element method and especially developed acceleration components based on errors or

for the study of incompressible viscous fluid and goes to the next time step.

thermal problems. FIDAP has the capability of

simulating some flow problems which involve The errors in 8 are the differences between tenta-

moving boundary surfaces, but only if the speci- tive and calculated acceleration components. The

fied moving boundary displays minor shape or algorithm to reduce these mismatches utilises the

position changes. Hence this capability cannot be sensitivity approach briefly outlined in the follow-

utilised for the study of the motion of the particle. ing, where, for more general notation, the three

The finite element discretization of the fluid acceleration components are indicated as aj (j= 1,

domain consists of 341 nine-node quadrilateral 2, 3).

elements for a total of 1374 nodes. The edge of The sensitivity of the quantity A to the quantity

the particle is divided into 20 three-node bound- B, indicated with the operator symbol S(A/B), is

ary elements displaying 40 nodes in all, as shown usually expressed in terms of relative variations

in Figure 1. Within each time step a transient fluid as follows:

dynamic calculation is performed having, as initial

conditions, nodal velocity vectors coming from

the solution in the previous time step. FIDAP (7)

solves the 2-D Navier-Stokes equations consider-

ing transient and convective terms and applying In the algorithm adopted we utilise a different

the quasi-Newton method with an implicity time definition of sensitivity, which refers to absolute

integration (trapezoid rule). variations:

We have developed a program for the simul-

ation of the rigid body motion

to interact with FIDAPs and performing

(RIBOMO), able

different

p0; 2. (8)

tasks. It solves equation (5)) (3) and (2) using the

stress tensor components given by FIDAP, and, The sensitivities of the acceleration errors to the

under the hypothesis that the three acceleration accelerations are calculated imposing a pertur-

components are constant during each time step, bation aaj to each of the three acceleration

it calculates the boundary conditions and defines components and evaluating the corresponding

the mesh for the fluid dynamic problem. The pro- errors de,. Hence our sensitivity operator works as

gram also compares the solutions of the two prob- a partial derivative and, from the definition of the

lems and applies an iterative algorithm to reach total differential of a function of three variables,

their convergence. Both FIDAP and RIBOMO in finite terms we may write for errors 2,

work under a UNIX shell control and are (il, 2,3):

implemented on a Tektronix XD88/10 work-

station. [ (z)Aaj] = $[ F(:)Aaj] = AZi (ix I,2,3).

The developed iterative algorithm, which brings

to convergence both the problems, has the flow-

chart representation shown in Figure 4 and works

as follows: Equation (9) forms a linear system in which

Ae, are the global error variations required for the

1. it defines the tentative acceleration compo- convergence, Aaj are the unknown acceleration

nents of the particle, in first approximation variations and the nine sensitivities SYF(e,/a.) are

assumed equal to the final values of the pre- calculated by means of simulations in w hic h the

vious time step; three fixed aaj are applied separately. The sol-

2. it calculates the tentative motion of the particle ution of the system enables us to calculate the new

in the time step, particularly the position of C tentative acceleration components. With these

for t= tk + At and t= tk + At/2; values a new simulation is performed and, if the

612

;L

Tentative acceleration

- components of the

particle

__-__ 7-~.--- .__~ - 1

-- ~~ -A ~ -.~~~~

I

Motion of the

particle [Eqs.2]

1

4. ~ _-~--

Velocity vectors

I on the particle

1 .med6e[Eq~61 .~ -2

----v-.-- -..~~~

; Description of the fluid

dynamic model (mesh

1

~ and boundary conditions

- at the particle~~ edge)

__.__~_. __---

~~ -L- ~~~ .~-

I

Transient fluld New tentative acceleration

1-Time increment

h -I

I

dynamic simulation

[Fidap]

1

components based on errors

Fluid dynamic I

I forces acting on the

particle edge [Eqs.4, 51 I

I.

..p--..~-~Y r-- ~~~~ d

~--__-

Calculated acceleration :

I components of the

particle [Eqs 31 ~

L- ~~~-~~ ~~~

r ~~~~~--

~~_ -Y ~-~ ~~~ __~

r---

Comparison of tentative and

calculated accelerations

and error evaluations [Eq 81

-~ ~~~~

Y

1

/ Are the errors . , -

\ admlsslble ,

/

\, ,,_

yes

Figure 4 Flow chart of the program for the simulation of the rigid particle motion (RIBOMO)

three new errors are within the pre-set tolerance, the initial condition the major axis of the particle

we proceed to the following time step. is aligned with the axis of the conduit (a(0) = 0)

and the particle does not rotate (h(O) = 0) , but

RESULTS AND DISCUSSION only translates in the axial direction (j,(O) = 0).

The axial velocity of the centre of mass is set equal

Two different simulations have been performed to the fluid velocity at the same distance from the

in order to evaluate the lateral displacement of conduit axis. The velocity boundary condition at

the particles centre of mass. This displacement is the inlet section of the conduit is a parabolic pro-

induced by the nonequilibrium of the forces act- file with v,,,,, = 1 mmes-; hence Reynolds number

ing on the edge of the particle. It should depend for the channel flow is &= 0.057.

on both local inertial forces and the distance of The time interval adopted for the simulations

the particles centre of mass from the wall of the is At = 0.01 s, but shorter time increments are used

conduit, which is responsible for the wall effect. to reach a faster convergence of the solution when

The two simulations have different initial con- the acceleration gradient is very high and at the

ditions: distance of the particles centre of mass beginning of the simulation if the initial con-

from the conduit wall IC = 25 pm for the first ditions do not match the dynamic equilibrium for

simulation and IC = 10 pm for the second one. In the fluid-structure system. Reported results refer

613

Motion of a rigid particle in channel jlow: G. Dubini et al.

between the two panels in Figure 6 indicates that

the second simulation (where the particle is closer

to the wall) shows a higher angular velocity, being

the angular velocity strongly dependent on the

axial velocity gradient displayed by the fluid in the

lateral direction (au/@). Such a gradient

increases from the axis to the wall, hence

inducing a higher angular velocity for the particle

closer to the wall of the conduit. It is interesting

to compare these results with those analytically

obtained by Jeffery . He studied the motion of

an ellipsoidal rigid particle transport by an

unbounded (infinite) Couette flow (characterised

by a constant shear rate) and suggested that the

rotation period of the particle major axis may be

calculated as follows:

T= 271.(4l + a>

(10)

G

Figure 5 Velocity vectors plotted by FIDAP post processor in a gen-

eric time step where s,, is the particles axis ratio and G is the

shear rate. In our model the axis ratio is

to a complete rotation of the particle s, = b/a = 0.3 and the two simulations give the fol-

(0 I (Y 5 2~). During each time step FIDAF calcu- lowing results: G=20s- and T= 1.24s for

lates the velocity vectors and the pressure values IC = 25 pm; G= 32 s-l and T= 0.692 s for

in all the nodes of the fluid domain and has the IC = 10 pm. The corresponding periods of

graphic capability to plot them as shown in Figure rotation calculated by means of equation (10) are

5. The magnification in Figure 5 illustrates the pat- T= 1.14s and T=0.713s and hence our results

tern of the velocity vectors in the proximity of the match them very well. For a better comparison

edge of the particle. with the results obtained by Jeffery we refer to

F@.M~ 6 shows the time courses of the rotation Karnis et aLg who calculated the time courses of

angle and the angular velocity for the two simula- the rotation angle of two differently shaped par-

tions. The peak values of the angular velocity refer ticles. Figure 7 shows their results.

to angles (Y= 7r/2 and a = 3~/2 with respect to Time courses of the longitudinal (v,) and the

lateral (v,) velocities of the centre of mass of the

particle are shown in Figure 8 as functions of the

.a(rad) IC=25 pm &(rad/s) rotation angle. The longitudinal velocity of the

2x' /40 particle is highest when its major axis is aligned

with the direction of flow (a = 0, 7~, 2~) and low-

est when it is perpendicular to the flow direction.

The lateral velocity shows a more complex pat-

tern, with roughly periodic oscillations and major

abrupt changes in direction at (Y= 7r/2 and 37r/2.

As regards lateral displacements, Figure 9 shows,

a (rad)

a

2n .--40

a .30

3/2n ,,disc particle

i.

a /

-rod particle

x .20

nl2 .I0

/',, HA.

/ ,l' OL

I. In 0 0.25 0.5 0.75 1

'0 0.1 0.2 0.3 0.4 0.5 0.6 0.7"

t/l

t (s)

b Figure 7 Experimental results showing the variation of the angle (Y

with time in Poiseuille flow for a rigid disc and a rigid rod. The solid

Figure 6 Time courses of the rotation angles and angular velocities lines have been drawn according to Jeffety (redrawn from Karnis

for the simulation with IC= 25 pm (a) and for that with et aL9). Compare the behaviour of the disc with our results shown

IC = 10 wrn (b) in Figure 6

614

Motion of n rigid particle in rhnnnrl /lout: G. Ilubini et al.

0.002 0.76

I 25.1

IC = 25 pm

/

24.9 ;,, :

/ ,/

24.7 -

a

v y (mm/s) IC = 10 pm ~~ vx (mm/s)

10.1 IC = 10 pm

0.006

I

9.9 i

OQ

-0.003

1

Figure 8 Time courses of the longitudinal (v,) and lateral (v,) velo- angle a (rad)

cities as functions of the rotation angle a of the particle for the simul-

ation with IC = 25 /.~rn (a) and for that with IC = 10 pm (h) Figure 9 Distance from the wall of the particles centre as a function

of the rotation angle for both simulations

for both the simulations and as a function of the of reference (directions x and y) to identify the

rotati0.n angle, the distance of the particles cen- contributions given by the different portions of

tre from the wall of the conduit. The simulation the edge of the particle to the lateral motion.

with IC = 25 pm shows that the particle moves Each plot depicts the rigid particle in the actual

towards the wall, with regular oscillations. On the angular position, while the stress components on

other hand the simulation with IC = 10 pm shows each half-perimeter of the edge are plotted on the

a motion towards the axis of the conduit. These sides of an ideal square frame around the particle.

results are in agreement with some experimental For a quantitative evaluation, the same stress

findings, particularly those reported by SegrC and components are plotted in Figure II as functions

Silberberg and recently confirmed14. They of the curvilinear abscissa s along the edge of the

observed that rigid spheres transported in Poiseu- particle. This figure indicates that the stress

ille flow through a tube are subject to radial forces components are always much lower than 0.3 Pa.

which tend to carry them to an equilibrium pos- In this regard, one should note that Goldsmith*

ition at about 0.6 tube radii from the axis. This experimentally found that in a dilute suspension

phenomenon has been termed tubular pinch of normal RBCs a cell moves without apparent

effect and its origin was supposed to lie in the deformation, provided that the shear stress acting

inertia of fluid around the moving spheres com- on its surface is lower than 0.28 Pa (2.8 dyncm- ,

bined with the proximity of the wall. In our model which corresponded to a shear rate of about

(conduit width D = 100 pm) the equilibrium pos- 200 s-l in Goldsmiths experimental set-up*).

ition, according to Segre and Silberberg, should Hence the hypothesis of rigid particle, which

be at a distance from the axis equal to 30 pm, sounds quite drastic and is generally unacceptable

which corresponds to a distance of 20 pm from if applied to RBCs, can be reasonably utilised in

the wall. This means that the equilibrium position an idealised model to study micro fluid dynamics

is just between the two calculated trajectories; of RBCs in in vitro experiments with either normal

hence the obtained trends look reasonably cor- cells or cells whose deformability has been

rect. impaired.

In F@~re 10 longitudinal (c) and lateral (4,) It is interesting to compare our results about

components of the stress vector t acting along the velocities and displacements of the centre of mass

edge of the rigid particle are plotted for different of the article with those obtained by Sugihara-

angular positions (0 I (Y I V) extracted from the Se~2.B , who studied the motion of an isolated

second simulation (IC = 10 pm). Stress compo- elli tical particle and an isolated doublet in a 2-

nents are evaluated in the fixed Cartesian frame D i! ounded Poiseuille flow. Although the rigid

615

Motion of a rigid particle in channel&o: G. Dubini et al.

t, Pa)

0.4[

-0.41

a

4 Pa)

0.4r

-0.41

b

Figure 11 Stress components as functions of the cutilinear absi-

cissa s along the edge of the particle. Data refer to the simulation

with IC = 10 pm. Longitudinal component t, (a) and lateral compo-

nent 4 (b)

adopted to study single-file or multifile arrange-

a= 138 ments of RBCs in capillaries22, to study the relative

motion of two circular particles representing a red

Figure 10 Longitudinal (.!.J and lateral (f) stress components act- blood cell and a white blood cell*l and to study

ing along the edge of the particle. Data refer to the simulation with

IC = 10 pm. At each angular position of the particle the stress the motion of differently shaped rigid par-

DCles23,25.

components acting on the edge of the particle are plotted on the

sides of an ideal square frame. The perimeter of the particle is split

into two equal portions and related stress components are plotted

along two opposite sides of the ideal frame CONCLUSIONS

The model presented has been developed as a

particles studied are differently shaped, a qualiti- first step towards a better understanding of local

ative comparison can be made. The main differ- effects of fluid dynamics of particles in a highly

ence in the two approaches is that our model dilute suspension flowing in narrow tubes or chan-

includes local inertial effects, both for the fluid nels. In particular, our goal was to investigate the

and the particle, according to experimental effects on the movements (translation and

results in the literature8,14. Results from our simul- rotation) of a particle suspended in a channel

ations clearly show not only complex changes in flow.

lateral velocity as well as a periodic lateral The model faces the fluid-structure system solv-

migration (both already described by Sugihara- ing separately the two problems - fluid dynamics

Seki23,24), but also the existence of a global lateral and particle motion - and finds the convergence

drift leading to a different lateral position at the of the two solutions using an iterative procedure.

end of the period of rotation with respect to the Several approximations have been considered to

initial one. We agree with Sugihara-Seki23p24 in simplify the model complexity; they are: rigid par-

attributing periodic changes in lateral velocity and ticle, rigid wall of the vessel, rectilinear vessel, 2-

in lateral position of the centre of the particle to D geometry. Furthermore we have considered the

the presence of the walls of the conduit (wall presence of only one particle. Under the above

effect). In our opinion the net displacement of hypotheses the model allows one to describe some

the particle shown by our model is due to a combi- particular features of the motion of a single par-

nation of local inertial forces with the proximity ticle. As regards lateral displacements, the results

of the walls of the conduit. agree with experimental observations8,14 con-

As regards the 2-D approximation, it is quite a firming that the proximity to the wall establishes

common assumption in published papers dealing the direction of the lateral displacement of the

with numerical studies of the RBC motion. Owing particle. Furthermore results suggest that the role

to its great complexity, 3-D geometry is adopted of local inertial forces is relevant in causing a net

only together with the assumption of axisymmetry lateral drift of the particle, which leads to a new

of the problem2, even if 3-D non-axisymmetric lateral position at the end of each period of

models have been recently developedlg**, based rotation. The results are also in fairly good agree-

616

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approach. tube flow. Fed Proc 1971; 30: 5, 1578-88.

14. Uijttewaal WSJ, Nijhof E-J, Heethaar RM. Lateral

migration of blood cells and microspheres in two-dimen-

sional Poiseuille flow: a laser-Doppler study. ,/ Biomerh

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617

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