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ABSTRACT
Introduction: Type 2 diabetes has become a worldwide issue with the dramatic increase in incidence and prevalence
over the past two decades. As the epidemiological burden of diabetes increases, the economic burden on individuals
and nation is expected to rise. Obesity being one of the major risk factor for development of T2DM and its complica-
tion, glycemic control is crucial for management of diabetes. HbA1c is an index of long term glycemic status of dia-
betic subjects and has become the gold standard test around the world for initiation of treatment in diabetics. Aims:
The aim of this study was to determine the association of obesity with T2DM and to correlate dysglycemia with obe-
sity. Material and Methods: A total of 100 type 2 diabetics were enrolled for the study. The subjects were catego-
rized based on the revised consensus guidelines for India for generalized obesity and abdominal obesity. Results: The
results of the study showed that gender wise there was no significant difference of the various clinical and biochemi-
cal characteristics except for the duration of diabetes. Subjects of this study were mostly overweight and obese hav-
ing abdominal obesity. A significant correlation was seen between the glycemic and metabolic status of the diabetic
study population. Conclusion: Overall an increasing trend of dysglycemia in diabetic subjects with normal BMI, over-
weight to obese was observed. The prevalence of both central and peripheral obesity was increased in the diabetic
subjects.
Correspondence: Dr. Shabana Shireen, Professor of Biochemistry, Address: 12-2-48, Station Road, Panja centre,
Wynchpet, Vijayawada-520001. Email: shabanashireen2000@yahoo.com
Table 1. Clinical and biochemical characteristics in Table 2. Characteristics of types of obesity in T2DM
T2DM based on gender
Types of Female Males
Total (n=100)
Characteristics Females Males obesity (57) (n=43)
Nos 57 (57) 43 (43) Generalised
42(73.7) 30(69.8) 72(72)
Family history 40 (70.2) 26 (60.5) Obesity
Hypertension 20 (35.1) 16 (37.2) Abdominal
56(98.2) 24(55.8) 80(80)
Thyroid disorder 6 (10.5) 0 (0) Obesity
Alcohol 1 (1.8) 24 (55.8) Combined
42(73.7) 23(53.5)) 63(63)
Smoking 1 (1.8) 21 (48.8) Obesity
Anti-diabetics Data presented as number of patients with
percentages in parentheses
OHA 44 (77.2) 41 (95.3)
OHA & Insulin 13 (22.8) 2 (4.7)
Table 3. Clinical and biochemical characteristics in
Diet female and male diabetics
Vegetarian 1 (1.8) 1 (2.3)
Females Males
Mixed 56 (98.2) 42 (97.7) Characteristics p value
(n=57) (n=43)
Habitation Age (yrs) 48.499.47 52.049.29 0.0643
Rural 34 (59.6) 26 (60.5) Age of onset (yrs) 43.637.23 44.237.67 0.6899
Urban 23 (40.4) 17 (39.5)
Duration of DM
Occupation 4.843.7 7.025.33 0.017*
(yrs)
Housework 34 (59.6) 0 (0) SBP(mm/Hg) 127.8914.73 131.8617.4 0.2202
Daily Wage 15 (26.3) 7 (16.3)
DBP(mm/Hg) 79.6510.17 80.934.87 0.4482
Agriculturer 7 (12.3) 12 (27.9)
WC(cm) 98.6310.25 94.9311.27 0.09
Teacher 1 (1.8) 4 (9.3) 2
office/disability 0 (0) 6 (13.9) BM I(kg/m ) 28.585.02 26.644.87 0.0531
Shop owner 0 (0) 5 (11.6) FPG (mg%) 151.0252.2 164.9550.1 0.183
driver 0 (0) 3 (7.0) HbA1c (%) 8.311.68 8.11.6 0.4528
carpenter/painter 0 (0) 6 (13.9) Data presented as Mean SD, *P<0.05
HbA1c
<7% 18 (31.6) 15 (34.9)
>7% 39 (68.4) 28(65.1)
WC
F <80 cm 1 (1.8) ----
F >80 cm 56 (98.2) ----
M <90 cm ----- 19 (44.2)
M >90 cm ----- 24 (55.8)
BMI
18.0-22.9 kg/m2 3 (5.3) 11 (25.6)
Figure 2. Correlation between BMI and WC in male Figure 5. Correlation between WC and HbA1c in female
diabetes diabetics
Figure 3. Correlation between BMI and HbA1c in Figure 6. Correlation between WC and HbA1c in male
female diabetics diabetics
Table 4. Clinical and biochemical characteristics in female and male diabetics based on BMI
How to Cite this article: Shabana S, Ramya K, Sasisekhar T.V.D, Santosh Kumar A. HbA1c as an Index of Glycemic Status in
Obese Type 2 Diabetics. Int. j. clin. biomed. res. 2017;3(3): 34-39.