MECHANISISM SIDE EFFECTS/ NURSING

DRUG NAME OF ACTION INDICATION CONTRAINDICATION ADVERSE EFFECTS CONSIDERATIONS

Generic Name: Bacteriostatic or Initial treatment of Contraindicated with Dermatologic: Assessment:

Pyrazinamide bactericidal active TB in allergy to Rashes, History:
against adults and pyrazinamide, acute photosensitivity Allergy to
Brand Name: mycobacterium children with hepatic disease, Gastro Intestinal: pyrazinamide, acute
Tebrazid tuberculosis combined with lactation, acute gout. Hepatotoxicity, hepatic disease, gout,
other Use cautiously with nausea, vomiting, diabetes mellitus,
Classification: antituberculotic diabetes mellitus, diarrhea, anorexia acute intermittent
Antituberculotic Treatment of acute intermittent Hematologic: porphyria, pregnancy.
drug-resistant TB porphyria, pregnancy. Sideroblastic Physical:
Dosage: as part of an anemia, Skin color, lesions,
15 to 30 mg/kg once individualized thrombocytopenia, joint status, TB, liver
daily regimen. adverse effects on evaluation, LFTs,
clotting mechanism serum and urine uric
Route: or vascular integrity acid levels, blood and
Oral Other: urine glucose, CBC.
Active gout
Intervention:
Administer only in
conjunction with
other
antituberculotics.
Administer once a
day.
Discontinue drug if
liver damage or
hyperuricemia in
 conjunction with
acute gouty
arthritis occurs.

Teaching pionts:
Take drugs once a
day, it will need to
be taken with other
tuberculosis drugs.
Take drugs
regularly, avoid
missing doses.
Do not discontinue
drug without first
consulting
healthcare
provider.
Have regular,
periodic medical
check-ups,
including blood test
to evaluate drug
effects.
Report fever,
malaise loss of
appetite, nausea,
vomiting, darkened
urine, yellowing of
skin and eyes,
severe pain in
great toe or wrist.