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Datasheet of Miquelianin (Quercetin 3-O-glucuronide)

Description:.
Miquelianin shows an antioxidant effect in human plasma. At 50 M, miquelianin suppresses the consumption of the t
hree antioxidants lycopene, -carotene and -tocopherol significantly[1]. In vitro studies indicate that miquelianin is able
to reach the central nervous system from the small intestine[2]. Miquelianin significantly reduces the generation of -a
myloid (A) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of i
nterfering with the initial protein-protein interaction of A140 and A142 that is necessary for the formation of neur
otoxic oligomeric A species[3]. Treatment with 0.1 M miquelianin suppresses ROS generation, cAMP and RAS activ
ation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses in
vasion of MDA-MB-231 breast cancer cells and MMP-9 induction, and inhibits the binding of [3H]-NA to b2-AR. Mi
quelianin may function to suppress invasion of breast cancer cells by controlling b2-adrenergic signaling, and may be a
dietary chemopreventive factor for stress-related breast cancer[4].Miquelianin treatment, compared to vehicle-control treat
ment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term poten
tiation[3]. A flavonoid fraction obtained from a crude extract of Hypericum perforatum (St. John's wort) is remarkably
active in the forced swimming test. Miquelianin is one of the compound separated from the fraction[5].

Chemical Information

Catalog DC10152

Purity of current batch: >98%

Molecular Weight (MW) 478.36

Molecular Formula C21H18O13

CAS No. 22688-79-5

Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.