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Datasheet of KRN633

KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-
2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. Selectivity profiling with recombinant
tyrosine kinases showed that KRN633 is highly selective for VEGFR-1, -2, and -3. KRN633 inhibits
tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung,
colon, and prostate, in athymic mice and rats. KRN633 also causes the regression of some well-
established tumors and those that had regrown after the cessation of treatment. KRN633 was well
tolerated and had no significant effects on body weight or the general health of the animals. KRN633
might be useful in the treatment of solid tumors and other diseases that depend on pathologic
Chemical Information
Catalog DC10454

Purity of current batch: >98%

Molecular Weight (MW) 416.86

Molecular Formula C20H21ClN4O4

CAS No. 286370-15-8

Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.