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CAUSES
Absence of lactase, which is the enzyme that digests sugar in milk
After age 3, making of lactase starts to decrease and by teen years we are left with about 5 to 10 percent of lactase
activity.
o Only a small number of people in the world retain enough lactase to digest and absorb lactose well
Large intakes of lactose for people who have little lasting lactase enzyme or with GI problems can cause loose stools or
diarrhea
METABOLIC PATHWAY
Lactose normally gets broken down into glucose and galactose
in the small intestine
o Lactose is not absorbed reaches large intestine
Not enough of the lactase enzyme
o Lactose is not broken down, therefore lactose collects in
the gut
Some people may be more sensitive to lactose in large
quantities, varies person to person
TESTS
Lactose hydrogen breath test
o Given standard dose of lactose after fasting
o Breath hydrogen is measured
o If lactose is not digested in the small intestine, it passes into colon and converted to hydrogen
o Hydrogen is absorbed into blood stream and exhaled through lungs
o Shows increased levels 60 to 90 minutes after lactose ingestion
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Lactose intolerance test
o Lactose is given, if someone has enough lactase enzyme, blood sugar will rise, showing the breakdown of
lactose to galactose and glucose
o If lactose intolerant, blood sugar will not raise because lactose is not absorbed
Passes into the colon and GI symptoms can appear
DIET
SOURCES
Boyle, M. A., & Holben, D. H. (2013). Community Nutrition in Action: An Entreprenurial Approach ( 6th ed.) Belmont. CA:Wadsworth
Byrd-Brednenner, C., Moe, G., Beshgetoor, D., Berning, J. (2013). Wardlaws Perspectives In Nutrition (9th ed.) New York, NY:
McGraw-Hill.
Rolfes, S. R., & Whitney, E. (2011). Understanding Nutrition (12th ed.) Belmont. CA: Wadsworth.
Vandenplas, Y. (2015). Lactose intolerance. Asia Pacific Journal of Clinical Nutrition, 24 Suppl 1S9-S13.
doi:10.6133/apjcn.2015.24.s1.02