Diabetes Mellitus Type 2 Pathophysiology

Diabetes Type 2
Predisposing Contributing
-Age 57 y/o -sedentary lifestyle
Insulin Resistance -Increased intake of sweet
foods
Hyperglycemia

Blood Blood Blood sugar exceeds Glucose cannot Gluconeogenesis

Osmolality viscosity renal threshold enter cell activation

Fluid shifting Blood Favors Glycosuria Cellular Lipolysis CHON breakdown

from Flow bacterial Starvation
intracellular to growth
extracellular
Accumulation Muscle Wasting and poor
Osmotic Sensation of of by product wound healing
Tissue Infection Diuresis hunger
Intracellular Perfusion
DHN

Urine Polyphagia Fatty Ketones Toxic to Brain tissue

Output Acid
Thirst Wound s
Sensation Healing
Acetone
Polyuria Atherosclerosis Metabolic Breath
acidosis
Polydipsia
Ketonuria
Gangrene Micropathy
Formation Macropathy
Diabetic
Ketoacidosis
Amputation CVA, MI, PVD Neuropathy Retinopathy Nephropathy

Loss of Sensation Loss of vision ESRD

Tingling/numbness Blindness
Weakness
Source: Nurselabs