John H.

Alexander MD, MHS, FACC

DCRI Faculty Associate Director

DCRI Director, Cardiovascular Research
Vice Chief for Clinical Research, Division of Cardiology, Duke Department of Medicine
Professor of Medicine, Cardiology

Biography

John H. Alexander, MD, MHS, FACC, is a cardiologist and professor of medicine in the
Department of Medicine and Division of Cardiology at Duke University Medical Center, as well
as the Vice Chief for Clinical Research in the Division of Cardiology. He is the director of
cardiovascular research at the DCRI where he oversees a large group of clinical research faculty
and a broad portfolio of cardiovascular clinical trials and other clinical research programs.

Dr. Alexanders clinical interests are in acute and general cardiovascular disease, valvular heart
disease, and echocardiology. His research focuses on the translation of novel therapeutic
concepts into clinical data through clinical trials, specifically on the therapeutics of acute
coronary syndromes and chronic coronary artery disease, on antithrombotic therapies, and on
novel methodological approaches to clinical research.

Dr. Alexander has published extensively and has served on the steering committee and as the
principal investigator of numerous multicenter clinical trials. He serves on steering committee of
the Clinical Trial Transformation Initiative (CTTI).

EDUCATION
MD, University of Pennsylvania School of Medicine, 1993
MHS, Duke University School of Medicine, 2001
RESIDENCY
Internal Medicine, Brigham and Women's Hospital (Massachusetts), 1993-1996
FELLOWSHIP
Cardiovascular Disease, Duke University Medical Center, 1996-2000
BOARD CERTIFICATION
American Board of Internal Medicine, Cardiovascular Disease

Peter K. Smith, MD

EDUCATION
MD, Duke University School of Medicine, 1977
RESIDENCY
Surgery, Duke University Medical Center, 1977-1987 6(Chief Resident, 1986)
Thoracic Surgery, Duke University Medical Center, 1986-1987
FELLOWSHIP
AHA Clinician Scientist Awardee, Duke University Medical Center, 1980-1983
BOARD CERTIFICATION
American Board of Thoracic Surgery, Surgery, Thoracic
Biff Palmer, M.D.
Professor

Department Internal Medicine

Biography

Biff Franklin Palmer, MD, is Professor of Internal Medicine at UT Southwestern Medical

Center, Dallas, Texas. He is board certified in internal medicine and nephrology.

Dr. Palmer received his medical degree from UT Southwestern Medical School and completed
his residency in internal medicine at Walter Reed Army Medical Center, Washington, D.C. He
then went on to complete a research fellowship in the Department of Nephrology at the Walter
Reed Army Institute of Research and a clinical fellowship in the Division of Nephrology at UT
Southwestern Medical Center-Parkland Memorial Hospital.

Dr. Palmer has authored more than 190 articles and chapters. In addition to his work as an
author, Dr. Palmer serves as editor for the Southwestern Internal Medicine Conference in the
American Journal of Medical Sciences. He is an Associate editor for the American Journal of
Nephrology and is on the editorial board of Clinical Nephrology and the American Journal of
Kidney Disease. He is a member of the Nephrology subspecialty board for the American Board
of Internal Medicine.

A Fellow of the American College of Physicians and the American Society of Nephrology, Dr.
Palmer is also a member of the Texas Medical Association, the International Society of
Nephrology, the American Society of Nephrology, and the Southern Society for Clinical
Investigation. He has received numerous teaching awards to include the Regents Outstanding
Teaching award from the University of Texas and the Parkland Memorial Hospital Internal
Medicine Housestaff Outstanding Teacher Award. He is a member of the Southwestern
Academy of Teachers and has been designated as a Distinguished Teaching Professor by the
University.

Education
Internship
Walter Reed Army Medical Center (1982), Internal Medicine
Medical School
UT Southwestern Medical School (1982)
Residency
Walter Reed Army Medical Center (1984), Internal Medicine
Fellowship
Walter Reed Army Medical Center (1988), Nephrology
Research Fellowship
UT Southwestern Medical Center - Nephrology (1989), Nephrology
Specialty Areas

Chronic Kidney Diseases

Kidneys (Nephrology)

Clinical Interest
Acute Kidney Injury
Acute Renal Failure
Chronic Kidney Disease
Electrolyte Abnormalities & Disorders
General Nephrology
Hemodialysis
Kidney Disease
Renovascular (Secondary) Hypertension Management
Publications

Featured Publications

Regulation of Potassium Homeostasis.

Palmer BF Clin J Am Soc Nephrol 2014 Apr
Ascent to altitude as a weight loss method: The good and bad of hypoxia inducible factor
activation.
Palmer BF, Clegg DJ Obesity (Silver Spring) 2013 Apr
Evaluation and Treatment of Respiratory Alkalosis.
Palmer BF Am. J. Kidney Dis. 2012 Aug
Metabolic complications associated with use of diuretics.
Palmer BF Semin. Nephrol. 2011 Nov 31 6 542-52
A physiologic-based approach to the evaluation of a patient with hypokalemia.
Palmer BF Am. J. Kidney Dis. 2010 Dec 56 6 1184-90
A physiologic-based approach to the evaluation of a patient with hyperkalemia.
 Palmer BF Am. J. Kidney Dis. 2010 Aug 56 2 387-93
Physiology and pathophysiology with ascent to altitude.
Palmer BF Am. J. Med. Sci. 2010 Jul 340 1 69-77
Recent advances in the prevention and management of intradialytic hypotension.
Palmer BF, Henrich WL J. Am. Soc. Nephrol. 2008 Jan 19 1 8-11
Proteinuria as a therapeutic target in patients with chronic kidney disease.
Palmer BF Am. J. Nephrol. 2007 27 3 287-93
Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic
kidney disease.
Palmer BF Am. J. Med. Sci. 2004 Dec 328 6 330-43

Deborah Clegg, PhD

Deborah Clegg, PhD, is a professor in the Cedars-Sinai Division of General Internal Medicine
and Department of Biomedical Sciences. Her research focus is on understanding the impact of
sex hormones on energy homeostasis, metabolic function and adipose tissue distribution.
Specifically, her lab researches whether androgens and estrogens are involved in the modulation
of the major bioenergetic or biosynthetic pathways that normally support energy homeostasis and
adipose tissue function. There are sex differences with respect to body fat distribution and
prevalence of the metabolic syndrome. Disease prevalence changes over the course of the
lifespan due to fluctuations in sex hormone levels. During her postdoctoral education at the
University of Cincinnati, Clegg obtained strong guidance in intermediary metabolism, and her
research focused on the consequences of impaired metabolism to energy homeostasis. Clegg
mastered techniques to evaluate physiology in cells and whole animals. As an assistant professor
at the University of Cincinnati, she applied this expertise in physiology where she established
methods to interrogate novel aspects of sex hormones and their impact on metabolism. This work
was funded by a National Institutes of Health R01 grant, which focuses on the role of estrogen in
the central nervous system to regulate food intake and body weight. Clegg's work was later
funded by Society for Women's Health Research's Interdisciplinary Studies in Sex-Differences
Networks. These funds were to be used to focus on sex differences in gene expression in adipose
tissues. New principles emerging from this work suggest that specific metabolic pathways are
influenced by sex hormones and are necessary for the development of adipose tissue function
and metabolism. In July 2014, Clegg joined the faculty at Cedars-Sinai, where she has
established her independent laboratory.

Education

Undergraduate: Oregon State University, 1986

Doctorate: University of Georgia, 2000
Cedars-Sinai Affiliations

Cancer Institute (Samuel Oschin Comprehensive Cancer Institute)

Department of Biomedical Sciences
Diabetes & Obesity Research Institute

Awards & Activities

Outstanding Teacher Award, University of Texas Southwestern Medical Center, 2014

Distinguished Researcher Award, University of Texas Southwestern Medical Center,
2010

Publications

Neinast MD, Frank AP, Zechner JF, Li Q, Vishvanath L, Palmer BF, Aguirre V, Gupta
RK, Clegg DJ. Activation of natriuretic peptides and the sympathetic nervous system
following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning.
Mol Metab. 2015;4(5):427-436.
Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol.
2015;402:113-119.
Morselli E, Fuente-Martin E, Finan B, Kim M, Frank A, Garcia-Caceres C, Navas CR,
Gordillo R, Neinast M, Kalainayakan SP, Li DL, Gao Y, Yi CX, Hahner L, Palmer BF,
Tschp MH, Clegg DJ. Hypothalamic PGC-1 protects against high-fat diet exposure by
regulating ER. Cell Rep. 2014;9(2):633-645.
Kamel S. Kamel, MD

FRCP(C), MB BCh

Research Interests

Dysnatremias, dyskalemias, metabolic acidosis, metabolic alkalosis, nephrolithiasis

Research Activities

1. Clinical disorders of fluid and electrolytes and acid-base balance

2. Metabolic regulation and acid-base balance
3. Pathophysiology of nephrolithiasis

Mitchell L. Halperin

MD, McGill University

Emeritus Professor, Medicine, St. Michael's Hospital

Clinical Specialty

Nephrology

Research Interests

Renal physiology, acid base homeostasis, metabolic regulation

Research Activities

I am an emeritus professor of medicine at the University of Toronto. My areas of interest are in

renal and integrative physiology, metabolic regulation, and medical education. My research
includes laboratory and clinical studies which have made significant contributions in the areas of
acid-base balance, potassium, sodium and water physiology, and in the field of metabolic
regulation. I developed many of the diagnostic tests used today at the bedside to reveal
mechanisms of disease in these areas.

Other Activities

1. MD Honoris Causa, Universite de Montreal, 1998

2. Elected membership in the Royal Society of Canada, 2002
3. MD Honoris Causa, Universite de Clermont, France, 2008
Christopher E Forsmark, M.D. - Background

Education

Medical School
Johns Hopkins University

Residency
University of California - Internal Medicine

Fellowship

University of California - Gastroenterology

Research Fellowship

University of California - Gastroenterology

Board Certifications

Internal Medicine
Gastroenterology

Honors and Awards

President - American Pancreatic Association (2006-2007)

Councilor - American Pancreatic Association (2001-2004)
President - Florida Gastroenterologic Society (2002-2003)
Treasurer - Florida Gastroenterologic Society (1999-2002)
Chairman - Pancreatic Disorders Section of the American Gastroenterological
Association (1996-1997)
Postgraduate Course Director - American Gastroenterological Association (1998)
Editor - Pancreas, Clinical Gastroenterology and Hepatology, Techniques in
Gastrointestinal Endoscopy, International Journal of Pancreatology
Santhi Swaroop Vege, M.D.

Location
Rochester, Minnesota
Contact
Vege.Santhi@mayo.edu Clinical Profile

SUMMARY

I have published over 75 peer- reviewed manuscripts.I am interested in pancreatic diseases in

general and acute pancreatitis in particular from a clinical research point of view.I have compiled
a data base of 200+ patients with severe acute pancreatitis over a 10-yr period treated at Mayo,
from which presentations and publications have resulted.Currently, i am prospectively following
all acute pancreatitis admissions for over 8 months under MIDAS protocol.If any fellow in GI or
resident is interested in analyzing some aspects of the disease, they may contact me.

PUBLICATIONS

See my publications

PROFESSIONAL DETAILS

Academic Rank

1. Professor of Medicine

EDUCATION

1. Resident - Internal Medicine Mayo Clinic in Rochester

2. Fellow - DM in Gastroenterology Postgraduate Institute of Medical Education &
Research
3. Resident - Internal Medicine (MD) Government General Hospital, Guntur
4. Internship Government General Hospital, Guntur
5. MB BS Guntur Medical School
6. Other - Pre University Course Andhra Loyola College

C. Mel Wilcox, MD, Professor, Division Director

Dr. Wilcox has been serving as Professor of Medicine and the Division Director since
joining UAB in 2001. During this time, Dr. Wilcox has guided the Division into becoming
one of the leaders in the treatment of gastrointestinal and digestive disorders in the
region. He is a leading expert in the treatment of Zollinger-Ellison syndrome and disorders
relating to pancreatiobiliary disease. Dr. Wilcox serves on several editorial boards of
scholarly journals including Clinical Gastroenterology and Hepatology (editor) and
American Journal of Medicine (associate editor) among others. He is active in
instruction with fellowship program as well as providing lectures and presentations on the
treatment and procedures available for gastrointestinal disorders. Dr. Wilcox received his
medical degree from the Medical College of Georgia. He completed his internship and
residency at UAB and fellowship training in gastroenterology at UCSF. His current research
interests include includes the role of endoscopic therapy in the treatment of
pancreaticobiliary diseases.

Physician Provider Profile

Recent Publications

1. Progress in the management of necrotizing pancreatitis.

Wilcox CM, Varadarajulu S, Morgan D, Christein J.
Expert Rev Gastroenterol Hepatol. 2010 Dec;4(6):701-8
2. Treatment strategies for Zollinger-Ellison syndrome.
Wilcox CM, Hirschowitz BI. Expert Opin Pharmacother. 2009 May;10(7):1145-57.
3. CGH receives high impact factor.
Wilcox CM. Clin Gastroenterol Hepatol. 2009 Jan;7(1):6. Epub 2008 Nov 24
4. Should patients undergoing ERCP be placed in the prone or supine position?
Wilcox CM. Nat Clin Pract Gastroenterol Hepatol. 2008 Sep;5(9):488-9.
5. Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison
syndrome and
other acid hypersecretors receiving long-term acid suppression with lansoprazole.
Wilcox CM, Martin T, Phadnis M, Mohnen J, Worthington J, Hirschowitz BI. BMC
Gastroenterol. 2008 May 28;8:18
6. Exploring the use of the sham design for interventional trials: implications for endoscopic
research.
Wilcox CM. Gastrointest Endosc. 2008 Jan;67(1):123-7.
Philip E. Cryer, MD

Professor of Endocrinology and Metabolism in Medicine

Biography

A Phi Beta Kappa and Alpha Omega Alpha graduate of Northwestern University and its Medical
School, Philip E. Cryer came to Barnes Hospital as a house officer in medicine in 1965. After
house staff training and a fellowship in endocrinology and metabolism, and two years at the
Naval Medical Research Institute in Bethesda, Maryland, Dr. Cryer became Chief Resident in
Medicine at Barnes and joined the Washington University faculty as an Instructor in 1971. He
rose to the rank of Professor of Medicine in 1981 and served as the Irene E. and Michael M. Karl
Professor of Endocrinology and Metabolism from 1985 until he became Emeritus in 2014. He
headed the Washington University General Clinical Research Center (and led it through six NIH
site visits) from 1973 to 2006 and was Director of the Division of Endocrinology, Diabetes and
Metabolism from 1985 to 2002.

Although he taught in the clinical setting throughout, Dr. Cryers major focus was on research in
humans. He developed a sensitive method for the measurement of epinephrine and studied the
sympathoadrenal system extensively. With Jack Gerich he discovered the physiology of glucose
counterregulation, the mechanisms that normally prevent or rapidly correct hypoglycemia. He
then studied its pathophysiology leading to iatrogenic hypoglycemia in people with diabetes. The
latter studies culminated in his novel concept of hypoglycemia-associated autonomic failure in
diabetes and his international leadership in the field.

Dr. Cryers research was recognized by his membership in the American Society for Clinical
Investigation (which he served as vice president) and the Association of American Physicians
and by his receipt of the Banting Medal for Scientific Achievement of the American Diabetes
Association, the Claude Bernard Medal of the European Society for the Study of Diabetes and an
honorary doctorate from the University of Copenhagen. He held NIH R01 research support for
three decades, the last as a MERIT Award, and served on the NIH Metabolism Study Section.
Dr. Cryer is the only person in the 75 year history of the ADA to receive its Banting Medal for
Scientific Achievement, serve as editor-in-chief of its prestigious journal Diabetes and be elected
its President. At the time of his retirement he was honored by the decision of the William and
Elaine Wolff family to endow the Philip E. and Carolyn E. Cryer Professor of Endocrinology
and Metabolism at Washington University.

Dr. Cryer consistently acknowledged his research sponsors, mentors, collaborators, technicians,
research nurses and colleagues, and particularly the 42 postdoctoral fellows who did the bulk of
the work and made it better.

Research Interests

The themes of Dr. Cryers translational research are studies of the physiology of glucose
counterregulation the mechanisms that normally prevent or rapidly correct hypoglycemia and
of its pathophysiology in type 1 and type 2 diabetes, and the relationship of the latter to clinical
hypoglycemia in diabetes.
Dr. Robert C. Brunham

Position:

Professor

Division:

Infectious Diseases

Education:
University of British Columbia, MD
Recent Publications:

Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, and Plummer FA. Identification of
Four Novel HLA-A Alleles from an East African Population by High-Resolution Sequence-
Based Typing. Hum. Immunol. 2006. 67:833-838.
Keynan Y, Luo M, Lacap P, Brunham R, Plummer FA. Identification of two novel HLA-C
alleles, Cw*070105 and Cw*1408, from East African women. Hum Immunol. 2006;67:359-362.
Mak A, Rahmanian R, Lei V, Lawrence D, Krajden M, Brunham RC, Skowronski D, Li Y,
Booth T, Goh SH, Petric M. Longitudinal Analysis of Genotype Distribution of Influenza A
Virus from 2003 to 2005. J Clin Microbiol 2006. 44(10):3583-3588.
Patrick DM, Petric M, Skowronski DM, Guasparini R, Booth TF, Krajden M, McGeer P,
Bastien N, Gustafson L, Dubord J, MacDonald D, David ST, Srour L, Parker R, Andonov A,
Isaac-Renton J, Loewen N, McNabb G, McNabb A, Goh S, Henwick S, Astell C, Guo JP, Drebot
M, Tellier R, Plummer F, Brunham RC. An outbreak of human coronavirus OC43 infection and
serological cross-reactivity with SARS coronavirus. Can J Infect Dis Med Microbiol 2006;
17(6): 330-336.
See HR, Zakhartchouk AN, Petric M, Lawrence EJ, Mok CPY, Hogan RJ, Rowe T, Zitzow LA,
Karunakaran KP, Hitt MM, Graham FL, Prevec L, Rini JM, Tingle AJ, Scheifele DW,
Skowronski DM, Patrick DM, Voss TG, Babiuk LA, Gauldie J, Roper RL, Brunham R, Finlay
BB. Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine
candidates in mice challenged with SARS coronavirus. J Gen Virol. 2006;87:641-650.
Skowronski D, Woolcott JC, Tweed SA, Brunman R, Marra F. Potential cost-effectiveness of
annual influenza immunization for infants and toddlers: Experience from Canada. Vaccine. 2006
May 8;24:4222-4232.
Rey-Ladino J, Jiang X, Gabel BR, Shen C, and Brunham RC. Survival of Chlamydia
muridarum within Dendritic Cells. Infect. Immun. 2007;75(8): 3707-3714.
Skowronski DM, Li Y, Tweed SA, Tam TWS, Petric M, David ST, Marra F, Bastien N, Lee
SW, Krajden M, Brunham RC: Protective measures and human antibody response during an
avian influenza H7N3 outbreak in poultry in British Columbia, Canada. CMAJ 2007; 176(1): 47-
53.
Zaharik ML, Nayar T, White R, Ma C, Vallance BA, Straka N, Jiang X, Rey-Ladino J, Shen C,
Brunham RC. Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated
Chlamydia muridarum reveals marked differences in CXC chemokine profiles. Immunology.
2007 Feb;120(2):160-72.
Zakhartchouk AN, Sharon C, Satkunarajah M, Auperin T, Viswanathan S, Mutwiri G, Petric M,
See RH, Brunham RC, and Finlay BB et al. Immunogenicity of a receptor-binding domain of
SARS coronavirus spike protein in mice: Implications for a subunit vaccine. Vaccine 2007. 25,
136-143.
Brunham, RC and Rekart, ML. The arrested immunity hypothesis and the epidemiology of
Chlamydia control. Sex. Transm. Dis. 2008; 35(1):53-4.
Gnther OP, Ogilvie G, Naus M, Young E, Patrick DM, Dobson S, Duval B, Nol PA, Marra F,
Miller D, Brunham RC, Pourbohloul B. Protecting the next generation: what is the role of the
duration of human papillomavirus vaccine-related immunity? J Infect Dis. 2008 Jun
15;197(12):1653-61.
Jiang X, Shen C, Rey-Ladino J, Yu H, and Brunham RC. Characterization of a murine dendritic
cell line (JAWS II) and primary bone marrow derived dendritic cells (BMDCs) in Chlamydia
antigen presentation and induction of protective immunity. Infect Immun. 2008; Jun;76(6):2392-
401.
Karunakaran, KP, Rey-Ladino, J, Stoynov, N, Berg K, Shen C, Jiang X, Gabel BR, Yu H,
Foster LJ, Brunham RC. Immunoproteomic discovery of novel T cell antigens from the obligate
intracellular pathogen Chlamydia. J Immunol. 2008; 180(4):2459-65.
Marra F, Marra CA, Sadatsafavi M, Morn-Mendoza O, Cook V, Elwood RK, Morshed M,
Brunham RC, Fitzgerald JM. Cost-effectiveness of a new interferon-based blood assay,
QuantiFERON-TB Gold, in screening tuberculosis contacts. Int J Tuberc Lung Dis. 2008;
12(12):1414-24.
Ness RB, Shen C, Bass D, Jackson C, Moysich K, Edwards R, Brunham RC. Chlamydia
trachomatis serology in women with and without ovarian cancer. Infec Dis Obstet Gynecol
2008;2008:219672.
Ness, RB, Soper DE, Richter HE, Randall H, Peipert JF, Nelson DB, Schubeck D, McNeeley
SG, Trout W, Bass DC, Hutchison K, Kip K and Brunham RC. Chlamydia antibodies,
Chlamydia heat shock protein, and adverse sequelae after pelvic inflammatory disease: the PID
Evaluation and Clinical Health (PEACH) Study. Sex Transm Dis. 2008; 35(2): 129-135.
Peterson TA, Luo M, Mao X, Brunham RC, Plummer FA. Identification of novel DPA1 allele,
DPA1*010602, in an East African population. Hum Immunol. 2008; 69(12):885-6.
Rekart, ML and Brunham, RC. Debate. Epidemiology of Chlamydial infection: Are we losing
ground? Sex. Transm. Infect. 2008; 84: 87-91.
Nol PA, Davoudi B, Brunham RC, Dub LJ, Pourbohloul B. Time evolution of epidemic
disease on finite and infinite networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2
Pt 2):026101.
Ondondo BO, Brunham RC, Harrison WG, Kinyari T, Sheth PM, Mugo NR, Cohen CR.
Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein
60-stimulated interferon gamma responses in peripheral blood mononuclear cells and
endometrial biopsy samples from women with high exposure to infection. J Infect Dis. 2009 Jun
15;199(12):1771-9.
Brunham RC, Rekart ML. Considerations on Chlamydia trachomatis disease expression. FEMS
Immunol Med Microbiol. 2009; 55(2):162-6.
Brunham RC. Infectious disease prevention and control: remember 1908 and imagining 2108.
Can J Public Health. 2009; 100(1):5-8.
Pourbohloul B, Ahued A, Davoudi B, Meza R, Meyers L, Skowronski D, Villasenor I, Galvan
F, Cravioto P, Earn D, dushoff J, Fisman D, Edmunds WJ, Hupert N, Scarpino S, Trujillo J,
Lutzow M, Morales J, Contreras A, Chavez C, Patrick D, Brunham RC. Initial human
transmission dynamics of the pandemic (H1N1) 2009 virus in North America. Influenza and
Other Respiratory Viruses. 2009; 3(5):215-222.
Yu H, Jiang X, Shen C, Karunakaran KP, Brunham RC. Novel Chlamydia muridarum T cell
antigens induce protective immunity against lung and genital tract infection in murine models. J
Immunol. 2009; 182(3):1602-8.
Pourbohloul B, Ahued A, Davoudi B, Meza R, Meyers LA, Skowronski DM, Villaseor I,
Galvn F, Cravioto P, Earn DJ, Dushoff J, Fisman D, Edmunds WJ, Hupert N, Scarpino SV,
Trujillo J, Lutzow M, Morales J, Contreras A, Chvez C, Patrick DM, Brunham RC. Initial
human transmission dynamics of the pandemic (H1N1) 2009 virus in North America. Influenza
Other Respi Viruses. 2009 Sep;3(5):215-22.
Jiang X, Shen C, Yu H, Karunakaran P, Brunham RC. Differences in innate immune responses
correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection.
Immunology. Sept 11 2009; (published online ahead of print).
Myers GS, Mathews SA, Eppinger M, Mitchell C, OBrien KK, White OR, Benahmed F,
Brunham RC, Read TD, Ravel J, Bavoil PM, Timms P. Evidence that human Chlamydia
pneumoniae was zoonotically acquired. Journal of Bacteriology. 2009 Dec;191(23):7225-33.
Xie F, Hu Y, Turvey SE, Magee LA, Brunham RM, Choi KC, Krajden M, Leung PC, Money
DM, Patrick DM, Thomas E, von Dadelszen P. Toll-like receptors 2 and 4 and the cryopyrin
inflammasome in normal pregnancy and pre-eclampsia. BJOG 2010 Jan;117(1):99-108.
Skowronski D, De Serres G, Crowcroft N, Janjua N, Boulianne N, Hottes T, Rosella L,
Dickinson J, Gilca R, Sethi P, Ouhoummane N, Willison D, Rouleau I, Petric M , Fonseca K,
Drews S, Rebbapragada A, Charest H, Hamelin M, Boivin G, Gardy J, Li Y, Kwindt T, Patrick
D, Brunham R, for the Canadian SAVOIR Team. Association between the 2008-09 Seasonal
Influenza Vaccine and Pandemic H1N1 Illness during Spring-Summer 2009: Four Observational
Studies from Canada. PLoS Medicine. 7(4): e1000258. April 2010.
Gardy J, Brunham RC. Navigating Transmission Networks with Genomics & Phylogenetic
Trees. Future Virology. May 2010;5(3):251-253.
Mitchell C, Hutton S, Myers G, Brunham R, Timms P. Chlamydia pneumoniae is genetically
diverse in animals and appears to have crossed the host barrier to humans on (at least) two
occasions. PLoS Pathogens. May 2010;6(5):1-11.
Yu H, Jiang X, Shen C, Karunakaran K, Jiang J, Rosin N, Brunham RC. Chlamydia muridarum
T cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that
correlates with a high frequency of Gamma Interferon (IFN-)/Tumor Necrosis Factor Alpha and
IFN-/Interleukin-17 double positive CD4+ T cells. Infection and Immunity. May
2010;78(5):2272-2282.
Gottlieb S, Brunham R, Byrne G, Martin D, Xu F, Berman S. Introduction: The Natural History
and Immunobiology of Chlamydia trachomatis Genital Infection and Implications for Chlamydia
Control. Journal of Infectious Diseases. June 2010;201(Suppl 2):S85-S87.
Gottlieb S, Martin D, Xu F, Byrne G, Brunham R. Summary: The Natural History and
Immunobiology of Chlamydia trachomatis Genital Infection and Implications for Chlamydia
Control. Journal of Infectious Diseases. June 2010;201(Suppl 2):S190-S204.
Meza R, Pourbohloul B, Brunham RC. Birth cohort patterns suggest that infant survival predicts
adult mortality rates. Journal of Developmental Origins of Health and Disease. June
2010;1(3):174-183.
Karunakaran K, Yu H, Foster L, Brunham R. Development of a Chlamydia trachomatis T cell
Vaccine. Human Vaccines. 2010;6(10):1-5.
Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T,
Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho
O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE. Mapping the
protein interaction network in methicillin-resistant Staphylococcus aureus. J Proteome Res. 2011
Mar 4;10(3):1139-50.
Yu H, Karunakaran KP, Kelly I, Shen C, Jiang X, Foster LJ, Brunham RC. Immunization with
live and dead Chlamydia muridarum induces different levels of protective immunity in a murine
genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1
cells. J Immunol. 2011 Mar 15;186(6):3615-21. Epub 2011 Feb 4.
Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze
RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L,
Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE.
Antimicrob Agents Chemother. 2011 May;55(5):2042-53.
Collingro A, Tischler P, Weinmaier T, Penz T, Heinz E, Brunham RC, Read TD, Bavoil PM,
Sachse K, Kahane S, Friedman MG, Rattei T, Myers GS, Horn M. Unity in varietythe pan-
genome of the chlamydiae. Mol Biol Evol. 2011 Dec;28(12):3253-70. Epub 2011 Jun 20.
Gardy JL, Johnston JC, Ho Sui SJ, Cook VJ, Shah L, Brodkin E, Rempel S, Moore R, Zhao Y,
Holt R, Varhol R, Birol I, Lem M, Sharma MK, Elwood K, Jones SJ, Brinkman FS, Brunham
RC, Tang P. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak.
N Engl J Med. 2011 Feb 24;364(8):730-9. Erratum in: N Engl J Med. 2011 Jun 2;364(22):2174.
DSouza C, Kronstad J, Taylor G, Warren R, Yuen M, Hu G, Jung W, Sham A, Kidd S, Tangen
K, Lee N, Zeilmaker T, Sawkins J, McVicker G, Shah S, Gnerre S, Griggs A, Zeng Q, Bartlett
K, Li W, Wang X, Heitman J, Stajich J, Fraser J, Meyer W, Carter D, Schein J, Krzywinski M,
Kwon-Chung K, Varma A, Wang J, Brunham R, Fyfe M, Ouellette B, Siddiqui A, Marra M,
Jones S, Holt R, Birren B, Galagan J, Cuomo C. Genome variation in Cryptococcus gattii, an
emerging pathogen of immunocompetent hosts. mBio. 2011. (in press).
Zoraghi R, Warroll L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD,
Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka
NC, Andersen RJ, Reiner NE. MRSA pyruvate kinase as a target for bis-indole alkaloids with
antibacterial activities. J Biol Chem. 2011 Oct 26.
Jorma Paavonen, LKT

Professor

Department of Obstetrics and Gynecology, University of Helsinki

Address:
Department of Obstetrics and Gynecology
University Hospital
Haartmaninkatu 2
00029 Helsinki
Finland

Education:
Matric Exam 1966 (Mntsln Yhteiskoulu)
M.D. 1973 (University of Helsinki)
Academic Dissertation 1979 (University of Helsinki)
Board certified in Obstetrics and Gynecology 1979 (Ministry of Health)

Employment:
1975-79 Resident, Department of Obstetrics and Gynecology, University Hospital, Helsinki
1980 Research Associate, Department of Virology, University of Helsinki
1981-82 Visiting Scientist, Department of Obstetrics and Gynecology, University of
Washington, Seattle
1982-84 Instructor, Department of Clinical Sciences, University of Tampere
1984-86 Acting Assistant Professor, Department of Obstetrics and Gynecology, University of
Washington, Seattle, Washington, USA
1986 Acting Associate Professor, Department of Obstetrics and Gynecology, University of
Washington, Seattle, Washington, USA
1987-89 Senior Research Fellow, Medical Research Council, Academy of Finland
1987-1991 Assistant Physician-in-Chief, Department of Obstetrics and Gynecology, University
Hospital, Helsinki
1994-1995 Senior Scientist, Medical Research Council, Academy of Finland
1991-98 Associate Professor in Obstetrics and Gynecology, University of Helsinki

Current position:
1998- (ongoing) Professor in Obstetrics and Gynecology, University of Helsinki
1998- (ongoing) Physician-in-Chief, Department of Obstetrics and Gynecology, University
Hospital, Helsinki

Professional Organizations:
Board member of several national or international societies.
President and organizer of 2 international conferences
Editorial Activities:
Referee of several international journals; Editorial Board Member of 3 international journals
Associate Editor of 2 international journals

Teaching activities:
Supervisor of 11 completed academic dissertation programs
Supervisor of 6 ongoing academic dissertation programs
Official opponent of 9 academic dissertations
Official reviewer of 5 academic dissertation programs

Publications:
335 original scientific publications or reviews in peer reviewed journals in English
114 scientific publications in Finnish or in Swedish
 Nicholas J. Talley, M.D., Ph.D.

Location: Rochester, Minnesota | Jacksonville, Florida

PROFESSIONAL DETAILS

Academic Rank

1. Professor of Epidemiology
2. Professor of Medicine

EDUCATION

1. MMedSc - Genetic and molecular epidemiology University of Newcastle

2. MD University of New South Wales
3. Research Fellowship - Gastroenterology Mayo Clinic in Rochester
4. PhD University of Sydney
5. Professorial Registrar - Medicine and Gastroenterology Royal North Shore Hospital
6. Research Scholar - Gastroenterology Royal North Shore Hospital
7. Medical Registrar Prince Henry/Prince of Wales Hospitals
8. Resident Prince Henry/Prince of Wales Hospitals
9. Internship Prince Henry/Prince of Wales Hospitals
10. BS University of New South Wales
11. MB University of New South Wales
12. Elective Term - Internal Medicine Addenbrooks Hospital

Publications

1. Absah I, Rishi A, Talley NJ, Katzka D, Halland M. Rumination syndrome:

pathophysiology, diagnosis, and treatment. Neurogastroenterol Motil 2016 Oct 20 [Epub
ahead of print] View PubMed
2. Raslau D, Herrick LM, Locke GR, Schleck CD, Zinsmeister AR, Almazar A, Talley NJ,
Saito YA. Irritable bowel syndrome and the perinatal period: lower birth weight increases
the risk. Neurogastroenterol Motil 2016 Oct; 28 (10):1518-24 Epub 2016 May 18
View PubMed
3. Talley NJ. Board Review Vignette: Irritable Bowel Syndrome. Am J Gastroenterol 2016
Sep; 111 (9):1223-5 Epub 2016 Aug 16 View PubMed
4. Clark K, Lam LT, Talley NJ, Quinn J, Blight A, Byfieldt N, Currow DC. Assessing the
Presence and Severity of Constipation with Plain Radiographs in Constipated Palliative
Care Patients. J Palliat Med 2016 Jun; 19 (6):617-21 Epub 2016 May 20 View PubMed
5. Choung RS, Rey E, Richard Locke G 3rd, Schleck CD, Baum C, Zinsmeister AR, Talley
NJ. Chronic constipation and co-morbidities: A prospective population-based nested
case-control study. United European Gastroenterol J 2016 Feb; 4 (1):142-51 Epub 2015
Nov 11 View PubMed
6. Holtmann GJ, Ford AC, Talley NJ. Pathophysiology of irritable bowel syndrome The
Lancet Gastroenterology and Hepatology 2016; 1 (2):133-46
7. Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, Schmidt PT,
Pedersen NL, Magnusson P, Talley NJ, Holliday EG, Houghton L, Gazouli M,
Karamanolis G, Rappold G, Burwinkel B, Surowy H, Rafter J, Assadi G, Li L, Papadaki
E, Gambaccini D, Marchi S, Colucci R, Blandizzi C, Barbaro R, Karling P, Walter S,
Ohlsson B, Tornblom H, Bresso F, Andreasson A, Dlugosz A, Simren M, Agreus L,
Lindberg G, Boeckxstaens G, Bellini M, Stanghellini V, Barbara G, Daly MJ, Camilleri
M, Wouters MM, D'Amato M. Exploring the genetics of irritable bowel syndrome: a
GWA study in the general population and replication in multinational case-control
cohorts. Gut 2015 Nov; 64 (11):1774-82 Epub 2014 Sept 23 View PubMed
8. Choung RS, Rubio-Tapia A, Lahr BD, Kyle RA, Camilleri MJ, Locke GR 3rd, Talley
NJ, Murray JA. Evidence Against Routine Testing of Patients With Functional
Gastrointestinal Disorders for Celiac Disease: A Population-based Study. Clin
Gastroenterol Hepatol 2015 Nov; 13 (11):1937-43 Epub 2015 May 16 View PubMed
9. Paula H, Grover M, Halder SL, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ.
Non-enteric infections, antibiotic use, and risk of development of functional
gastrointestinal disorders. Neurogastroenterol Motil 2015 Nov; 27 (11):1580-6 Epub
2015 Aug 24
View PubMed
10. Herrick LM, Locke GR 3rd, Schleck CD, Zinsmeister AR, Treder V, Talley NJ.
Dyspepsia in the community: value of a community-based mailed survey to identify
potential participants for a randomized clinical trial. Scand J Gastroenterol 2015 Aug; 50
(8):959-64 Epub 2015 Mar 11 View PubMed
11. Crowell MD, Umar SB, Lacy BE, Jones MP, DiBaise JK, Talley NJ. Multi-Dimensional
Gastrointestinal Symptom Severity Index: Validation of a Brief GI Symptom Assessment
Tool. Dig Dis Sci. 2015 Aug; 60(8):2270-9. Epub 2015 Apr 05. View PubMed
12. Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW, Lacy BE,
DiBaise JK, Prather CM, Abraham BP, El-Serag HB, Moayyedi P, Herrick LM, Szarka
LA, Camilleri M, Hamilton FA, Schleck CD, Tilkes KE, Zinsmeister AR. Effect of
Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized
Controlled Study. Gastroenterology 2015 Aug; 149 (2):340-9.e2 Epub 2015 Apr 25
View PubMed
13. Brummond NR, Locke GR 3rd, Choung RS, Chang JY, Schleck CD, Zinsmeister AR,
Talley NJ. Effects of Birth Cohorts on the Irritable Bowel Syndrome Support Early-Life
Risk Factors. Dig Dis Sci. 2015 Jul; 60(7):2112-8. Epub 2015 Feb 14. View PubMed
14. Chang JY, Locke GR III, Schleck CD, Zinsmeister AR, Talley NJ. Lack of familial
aggregation in chronic constipation excluding irritable bowel syndrome: a population-
based study. Dig Dis Sci. 2015 May; 60(5):1358-65. View PubMed
15. Keshteli AH, Feizi A, Esmaillzadeh A, Zaribaf F, Feinle-Bisset C, Talley NJ, Adibi P.
Patterns of dietary behaviours identified by latent class analysis are associated with
chronic uninvestigated dyspepsia. Br J Nutr 2015 Mar 14; 113 (5):803-12 Epub 2015 Feb
17 View PubMed
16. Knight JR, Locke GR 3rd, Zinsmeister AR, Schleck CD, Talley NJ. Family history of
mental illness or alcohol abuse and the irritable bowel syndrome. J Psychosom Res 2015
Mar; 78 (3):237-41 Epub 2014 Dec 03 View PubMed
17. Elias MK, Kopacova J, Arora AS, Dierkhising RA, Enders FT, Katzka DA, Kryzer LA,
Halland M, Smyrk TC, Talley NJ, Alexander JA. The diagnosis of esophageal
 eosinophilia is not increased in the summer months. Dysphagia 2015 Feb; 30 (1):67-73
Epub 2014 Oct 07 View PubMed
18. Cho SY, Choung RS, Saito YA, Schleck CD, Zinsmeister AR, Locke GR 3rd, Talley NJ.
Prevalence and risk factors for dysphagia: a USA community study. Neurogastroenterol
Motil 2015 Feb; 27 (2):212-9 Epub 2014 Nov 06 View PubMed
19. Gentile N, Katzka D, Ravi K, Trenkner S, Enders F, Killian J, Kryzer L, Talley NJ,
Alexander J. Oesophageal narrowing is common and frequently under-appreciated at
endoscopy in patients with oesophageal eosinophilia. Aliment Pharmacol Ther 2014 Dec;
40 (11-12):1333-40 Epub 2014 Oct 07 View PubMed
20. Barboza JL, Talley NJ, Moshiree B. Current and emerging pharmacotherapeutic options
for irritable bowel syndrome. Drugs. 2014 Oct; 74(16):1849-70. View PubMed
21. Gupta M, Beebe TJ, Dunagan KT, Schleck CD, Zinsmeister AR, Talley NJ, Locke GR
3rd, Iyer PG. Screening for Barrett's esophagus: results from a population-based survey.
Dig Dis Sci. 2014 Aug; 59(8):1831-50. Epub 2014 Mar 21. View PubMed
22. Pleyer C, Bittner H, Locke GR 3rd, Choung RS, Zinsmeister AR, Schleck CD, Herrick
LM, Talley NJ. Overdiagnosis of gastro-esophageal reflux disease and underdiagnosis of
functional dyspepsia in a USA community. Neurogastroenterol Motil. 2014 Aug;
26(8):1163-71. Epub 2014 Jun 11. View PubMed
23. Halland M, Almazar A, Lee R, Atkinson E, Larson J, Talley NJ, Saito YA. A case-
control study of childhood trauma in the development of irritable bowel syndrome.
Neurogastroenterol Motil. 2014 Jul; 26(7):990-8. Epub 2014 May 11. View PubMed
24. Beyder A, Mazzone A, Strege PR, Tester DJ, Saito YA, Bernard CE, Enders FT, Ek WE,
Schmidt PT, Dlugosz A, Lindberg G, Karling P, Ohlsson B, Gazouli M, Nardone G,
Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G,
Camilleri M, Locke GR 3rd, Talley NJ, D'Amato M, Ackerman MJ, Farrugia G. Loss-of-
function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with
irritable bowel syndrome. Gastroenterology 2014 Jun; 146 (7):1659-68 Epub 2014 Mar
05 View PubMed
25. Choung RS, Locke GR 3rd, Francis DD, Katzka D, Winkle PJ, Orr WC, Crowell MD,
Devault K, Harmsen WS, Zinsmeister AR, Talley NJ. Novel partial 5HT3 agonist
pumosetrag reduces acid reflux events in uninvestigated GERD patients after a standard
refluxogenic meal: a randomized, double-blind, placebo-controlled pharmacodynamic
study. Neurogastroenterol Motil. 2014 Jan; 26(1):13-20. Epub 2013 Sep 03.
View PubMed
26. Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ. The effects of
ageing on the onset and disappearance of unexplained abdominal pain: a population-
based study. Aliment Pharmacol Ther 2014 Jan; 39 (2):217-25 Epub 2013 Dec 04
View PubMed
27. Talley NJ, Napthali KE. Endoscopy in symptomatic gastroesophageal reflux disease:
Scoping out whomto target. JAMA Internal Medicine. 2014; 174(3):465-6. View
PubMed
28. Guerin A, Mody R, Fok B, Lasch KL, Zhou Z, Wu EQ, Zhou W, Talley NJ. Risk of
developing colorectal cancer and benign colorectal neoplasm in patients with chronic
constipation. Aliment Pharmacol Ther. 2014; 40(1):83-92. View PubMed
29. Vazquez-Elizondo G, Ngamruengphong S, Khrisna M, Devault KR, Talley NJ, Achem
SR. The outcome of patients with oesophageal eosinophilic infiltration after an eight-
 week trial of a proton pump inhibitor. Aliment Pharmacol Ther. 2013 Nov; 38(10):1312-
9. Epub 2013 Oct 05.
View PubMed
30. Ludvigsson JF, Aro P, Walker MM, Vieth M, Agreus L, Talley NJ, Murray JA,
Ronkainen J. Celiac disease, eosinophilic esophagitis and gastroesophageal reflux
disease, an adult population-based study. Scand J Gastroenterol. 2013 Jul; 48(7):808-14.
Epub 2013 May 14.
View PubMed
31. Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Talley NJ. Associations between
medication use and functional gastrointestinal disorders: a population-based study.
Neurogastroenterol Motil 2013 May; 25 (5):413-9, e298 Epub 2013 Jan 29 View
PubMed
32. Topazian M, Camilleri M, Enders FT, Clain JE, Gleeson FC, Levy MJ, Rajan E, Nehra
V, Dierkhising RA, Collazo-Clavell ML, Talley NJ, Clark MM. Gastric antral injections
of botulinum toxin delay gastric emptying but do not reduce body weight. Clin
Gastroenterol Hepatol 2013 Feb; 11 (2):145-50.e1 Epub 2012 Oct 09 View PubMed
33. Leggett CL, Nelsen EM, Tian J, Schleck CB, Zinsmeister AR, Dunagan KT, Locke GR
3rd, Wang KK, Talley NJ, Iyer PG. Metabolic syndrome as a risk factor for Barrett
esophagus: a population-based case-control study. Mayo Clin Proc 2013 Feb; 88 (2):157-
65 View PubMed
34. Flook NW, Moayyedi P, Dent J, Talley NJ, Persson T, Karlson BW, Ruth M. Acid-
suppressive therapy with esomeprazole for relief of unexplained chest pain in primary
care: a randomized, double-blind, placebo-controlled trial. Am J Gastroenterol. 2013 Jan;
108(1):56-64. Epub 2012 Nov 13. View PubMed
35. Choung RS, Locke GR III, Schleck CD, Ziegenfuss JY, Beebe TJ, Zinsmeister AR,
Talley NJ. A low response rate does not necessarily indicate non-response bias in
gastroenterology survey research: A population-based study. Journal of Public Health
(Germany). 2013; 21(1):87-95.
36. Rajan E, Gostout CJ, Aimore Bonin E, Moran EA, Locke RG, Szarka LA, Talley NJ,
Deters JL, Miller CA, Knipschield MA, Lurken MS, Stoltz GJ, Bernard CE, Grover M,
Farrugia G. Endoscopic full-thickness biopsy of the gastric wall with defect closure by
using an endoscopic suturing device: survival porcine study. Gastrointest Endosc 2012
Nov; 76 (5):1014-9 View PubMed
37. Saito YA, Larson JJ, Atkinson EJ, Ryu E, Almazar AE, Petersen GM, Talley NJ. The
role of 5-HTT LPR and GNbeta3 825C>T polymorphisms and gene-environment
interactions in irritable bowel syndrome (IBS). Dig Dis Sci 2012 Oct; 57 (10):2650-7
Epub 2012 Aug 02 View PubMed
38. Bennett C, Vakil N, Bergman J, Harrison R, Odze R, Vieth M, Sanders S, Gay L, Pech O,
Longcroft-Wheaton G, Romero Y, Inadomi J, Tack J, Corley DA, Manner H, Green S, Al
Dulaimi D, Ali H, Allum B, Anderson M, Curtis H, Falk G, Fennerty MB, Fullarton G,
Krishnadath K, Meltzer SJ, Armstrong D, Ganz R, Cengia G, Going JJ, Goldblum J,
Gordon C, Grabsch H, Haigh C, Hongo M, Johnston D, Forbes-Young R, Kay E, Kaye P,
Lerut T, Lovat LB, Lundell L, Mairs P, Shimoda T, Spechler S, Sontag S, Malfertheiner
P, Murray I, Nanji M, Poller D, Ragunath K, Regula J, Cestari R, Shepherd N, Singh R,
Stein HJ, Talley NJ, Galmiche JP, Tham TC, Watson P, Yerian L, Rugge M, Rice TW,
Hart J, Gittens S, Hewin D, Hochberger J, Kahrilas P, Preston S, Sampliner R, Sharma P,
 Stuart R, Wang K, Waxman I, Abley C, Loft D, Penman I, Shaheen NJ, Chak A, Davies
G, Dunn L, Falck-Ytter Y, Decaestecker J, Bhandari P, Ell C, Griffin SM, Attwood S,
Barr H, Allen J, Ferguson MK, Moayyedi P, Jankowski JA. Consensus statements for
management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on
a Delphi process. Gastroenterology. 2012 Aug; 143(2):336-46. Epub 2012 Apr 24. View
PubMed
39. Talley NJ. Dietary modification as a treatment for irritable bowel syndrome.
Gastroenterol Hepatol (N Y). 2012 Aug; 8(8):552-4. View PubMed
40. Alexander JA, Jung KW, Arora AS, Enders F, Katzka DA, Kephardt GM, Kita H, Kryzer
LA, Romero Y, Smyrk TC, Talley NJ. Swallowed fluticasone improves histologic but
not symptomatic response of adults with eosinophilic esophagitis. Clin Gastroenterol
Hepatol. 2012 Jul; 10(7):742-749.e1. Epub 2012 Apr 01. View PubMed
41. Myasoedova E, Matteson EL, Talley NJ, Crowson CS. Increased incidence and impact
of upper and lower gastrointestinal events in patients with rheumatoid arthritis in Olmsted
County, Minnesota: a longitudinal population-based study. J Rheumatol 2012 Jul; 39
(7):1355-62 Epub 2012 Apr 01 View PubMed
42. Lacy BE, Talley NJ, Locke GR 3rd, Bouras EP, DiBaise JK, El-Serag HB, Abraham BP,
Howden CW, Moayyedi P, Prather C. Review article: current treatment options and
management of functional dyspepsia. Aliment Pharmacol Ther. 2012 Jul; 36(1):3-15.
Epub 2012 May 16.
View PubMed
43. Choung RS, Locke GR 3rd, Rey E, Schleck CD, Baum C, Zinsmeister AR, Talley NJ.
Factors associated with persistent and nonpersistent chronic constipation, over 20 years.
Clin Gastroenterol Hepatol 2012 May; 10 (5):494-500 Epub 2012 Jan 28 View PubMed
44. Lee J, Huprich J, Kujath C, Ravi K, Enders F, Smyrk TC, Katzka DA, Talley NJ,
Alexander JA. Esophageal diameter is decreased in some patients with eosinophilic
esophagitis and might increase with topical corticosteroid therapy. Clin Gastroenterol
Hepatol 2012 May; 10 (5):481-6 Epub 2012 Feb 03 View PubMed
45. Talley NJ, Locke GR 3rd, Herrick LM, Silvernail VM, Prather CM, Lacy BE, DiBaise
JK, Howden CW, Brenner DM, Bouras EP, El-Serag HB, Abraham BP, Moayyedi P,
Zinsmeister AR. Functional Dyspepsia Treatment Trial (FDTT): a double-blind,
randomized, placebo-controlled trial of antidepressants in functional dyspepsia,
evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.
Contemp Clin Trials 2012 May; 33 (3):523-33 Epub 2012 Feb 10 View PubMed
46. Herrick LM, Locke GR 3rd, Zinsmeister AR, Talley NJ. Challenges and lessons learned
in conducting comparative-effectiveness trials. Am J Gastroenterol 2012 May; 107
(5):644-9 View PubMed
47. Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ. Overlap of
dyspepsia and gastroesophageal reflux in the general population: one disease or distinct
entities? Neurogastroenterol Motil 2012 Mar; 24 (3):229-34, e106 Epub 2011 Dec 12
View PubMed
48. Adibi P, Keshteli AH, Esmaillzadeh A, Afshar H, Roohafza H, Bagherian-Sararoudi R,
Daghaghzadeh H, Soltanian N, Feinle-Bisset C, Boyce P, Talley NJ. The study on the
epidemiology of psychological, alimentary health and nutrition (SEPAHAN): overview
of methodology. Journal Of Research In Medical Sciences. 2012 Mar; 17:S292-8.
49. Choung RS, Locke GR 3rd, Lee RM, Schleck CD, Zinsmeister AR, Talley NJ. Cyclic
vomiting syndrome and functional vomiting in adults: association with cannabinoid use
in males. Neurogastroenterol Motil 2012 Jan; 24 (1):20-6, e1 Epub 2011 Sept 27 View
PubMed
50. Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ.
Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. Am
J Gastroenterol 2012 Jan; 107 (1):82-8 Epub 2011 Nov 15 View PubMed
51. Rey E, Choung RS, Schleck CD, Zinsmeister AR, Talley NJ, Locke GR 3rd. Prevalence
of hidden gastroparesis in the community: the gastroparesis "iceberg". J
Neurogastroenterol Motil 2012 Jan; 18 (1):34-42 Epub 2012 Jan 16 View PubMed
52. Tack J, Talley NJ. [In process citation]. Arq Gastroenterol. 2012; 49 Suppl 1:21-7. View
PubMed
53. Brook RA, Kleinman NL, Choung RS, Smeeding JE, Talley NJ. Excess comorbidity
prevalence and cost associated with functional dyspepsia in an employed population. Dig
Dis Sci. 2012 Jan; 57(1):109-18. Epub 2011 Jul 13
View PubMed
54. Chang JY, Talley NJ, Locke GR 3rd, Katzka DA, Schleck CD, Zinsmeister AR,
Dunagan KT, Wu TT, Wang KK, Prasad GA. Population screening for barrett esophagus:
a prospective randomized pilot study. Mayo Clin Proc 2011 Dec; 86 (12):1174-80 View
PubMed
55. van Zanten SV, Wahlqvist P, Talley NJ, Halling K, Vakil N, Lauritsen K, Flook N,
Persson T, Bolling-Sternevald E, STARS II Investigators. Randomised clinical trial: the
burden of illness of uninvestigated dyspepsia before and after treatment with
esomeprazole--results from the STARS II study. Aliment Pharmacol Ther. 2011 Oct;
34(7):714-23. Epub 2011 Aug 17. View PubMed
56. Walker MM, Talley NJ. Clinical value of duodenal biopsies--beyond the diagnosis of
coeliac disease. Pathol Res Pract. 2011 Sep 15; 207(9):538-44. Epub 2011 Sep 22. View
PubMed
57. Jung KW, Talley NJ, Romero Y, Katzka DA, Schleck CD, Zinsmeister AR, Dunagan
KT, Lutzke LS, Wu TT, Wang KK, Frederickson M, Geno DM, Locke GR, Prasad GA.
Epidemiology and natural history of intestinal metaplasia of the gastroesophageal
junction and Barrett's esophagus: a population-based study. Am J Gastroenterol 2011
Aug; 106 (8):1447-55; quiz 1456 Epub 2011 Apr 12 View PubMed
58. Ravi K, Talley NJ, Smyrk TC, Katzka DA, Kryzer L, Romero Y, Arora AS, Alexander
JA. Low grade esophageal eosinophilia in adults: an unrecognized part of the spectrum of
eosinophilic esophagitis? Dig Dis Sci. 2011 Jul; 56(7):1981-6. Epub 2011 Feb 06. View
PubMed
59. Katz KD, Rashtak S, Lahr BD, Melton LJ, Krause PK, Maggi K, Talley NJ, Murray JA.
Screening for celiac disease in a North American population: sequential serology and
gastrointestinal symptoms. Am J Gastroenterol. 2011 Jul; 106(7):1333-9. Epub 2011 Mar
01. View PubMed
60. Achem SR, Almansa C, Krishna M, Heckman MG, Wolfsen HC, Talley NJ, DeVault
KR. Oesophageal eosinophilic infiltration in patients with noncardiac chest pain. Aliment
Pharmacol Ther. 2011 Jun; 33(11):1194-201. Epub 2011 Apr 05. View PubMed
61. Talley NJ. Irritable bowel syndrome: rational therapy. Consultant. 2011 Jun; 51(6):341-
7.
62. Pittock SJ, Lennon VA, Dege CL, Talley NJ, Locke GR 3rd. Neural autoantibody
evaluation in functional gastrointestinal disorders: a population-based case-control study.
Dig Dis Sci 2011 May; 56 (5):1452-9 Epub 2010 Dec 23 View PubMed
63. Choung RS, Ruff KC, Malhotra A, Herrick L, Locke GR 3rd, Harmsen WS, Zinsmeister
AR, Talley NJ, Saito YA. Clinical predictors of small intestinal bacterial overgrowth by
duodenal aspirate culture. Aliment Pharmacol Ther. 2011 May; 33(9):1059-67. Epub
2011 Mar 13. View PubMed
64. Wang YR, Talley NJ, Picco MF. Overlap irritable bowel syndrome, inflammatory bowel
disease, and diverticular disease. J Clin Gastroenterol. 2011 Apr; 45(Suppl 1):S36-42.
65. Ford AC, Achkar JP, Khan KJ, Kane SV, Talley NJ, Marshall JK, Moayyedi P. Efficacy
of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis. Am J
Gastroenterol. 2011 Apr; 106(4):601-16. Epub 2011 Mar 15. View PubMed
66. Ford AC, Kane SV, Khan KJ, Achkar JP, Talley NJ, Marshall JK, Moayyedi P. Efficacy
of 5-aminosalicylates in Crohn's disease: systematic review and meta-analysis. Am J
Gastroenterol. 2011 Apr; 106(4):617-29. Epub 2011 Mar 15. View PubMed
67. Talley NJ, Abreu MT, Achkar JP, Bernstein CN, Dubinsky MC, Hanauer SB, Kane SV,
Sandborn WJ, Ullman TA, Moayyedi P, American College of Gastroenterology IBD
Task Force. An evidence-based systematic review on medical therapies for inflammatory
bowel disease. Am J Gastroenterol. 2011 Apr; 106 Suppl 1:S2-25; quiz S26. View
PubMed
68. Beebe TJ, Ziegenfuss JY, St Sauver JL, Jenkins SM, Haas L, Davern ME, Talley NJ.
Health Insurance Portability and Accountability Act (HIPAA) authorization and survey
nonresponse bias. Med Care 2011 Apr; 49 (4):365-70 View PubMed
69. Dinning PG, Jones M, Hunt L, Fuentealba SE, Kalanter J, King DW, Lubowski DZ,
Talley NJ, Cook IJ. Factor analysis identifies subgroups of constipation. World J
Gastroenterol. 2011 Mar 21; 17(11):1468-74. View PubMed
70. Spergel JM, Book WM, Mays E, Song L, Shah SS, Talley NJ, Bonis PA. Variation in
prevalence, diagnostic criteria, and initial management options for eosinophilic
gastrointestinal diseases in the United States. J Pediatr Gastroenterol Nutr. 2011 Mar;
52(3):300-6. View PubMed
71. Ang D, Talley NJ, Simren M, Janssen P, Boeckxstaens G, Tack J. Review article:
endpoints used in functional dyspepsia drug therapy trials. Aliment Pharmacol Ther.
2011 Mar; 33(6):634-49. Epub 2011 Jan 12. View PubMed
72. Talley NJ. Rumination syndrome. Gastroenterol Hepatol (N Y). 2011 Feb; 7(2):117-8.
View PubMed
73. Choung RS, Shah ND, Chitkara D, Branda ME, Van Tilburg MA, Whitehead WE,
Katusic SK, Locke GR 3rd, Talley NJ. Direct medical costs of constipation from
childhood to early adulthood: a population-based birth cohort study. J Pediatr
Gastroenterol Nutr 2011 Jan; 52 (1):47-54 View PubMed
74. Choung RS, Branda ME, Chitkara D, Shah ND, Katusic SK, Locke GR 3rd, Talley NJ.
Longitudinal direct medical costs associated with constipation in women. Aliment
Pharmacol Ther 2011 Jan; 33 (2):251-60 Epub 2010 Nov 22 View PubMed
75. Chang JY, Talley NJ. An update on irritable bowel syndrome: from diagnosis to
emerging therapies. Curr Opin Gastroenterol. 2011 Jan; 27(1):72-8. View PubMed
76. Jung KW, Gundersen N, Kopacova J, Arora AS, Romero Y, Katzka D, Francis D,
Schreiber J, Dierkhising RA, Talley NJ, Smyrk TC, Alexander JA. Occurrence of and
 risk factors for complications after endoscopic dilation in eosinophilic esophagitis.
Gastrointest Endosc. 2011 Jan; 73(1):15-21. Epub 2010 Nov 09. View PubMed
77. Myasoedova E, Talley NJ, Manek NJ, Crowson CS. Prevalence and risk factors of
gastrointestinal disorders in patients with rheumatoid arthritis: results from a population-
based survey in olmsted county, Minnesota. Gastroenterol Res Pract 2011; 2011:745829
Epub 2011 Nov 17 View PubMed
78. Lacy BE, Talley NJ, Camilleri M. Functional dyspepsia: time to change clinical trial
design? Am J Gastroenterol. 2010 Dec; 105(12):2525-9. View PubMed
79. Choung RS, Herrick LM, Locke GR 3rd, Zinsmeister AR, Talley NJ. Irritable bowel
syndrome and chronic pelvic pain: a population-based study. J Clin Gastroenterol 2010
Nov-Dec; 44 (10):696-701 View PubMed
80. Aro P, Ronkainen J, Storskrubb T, Vieth M, Engstrand L, Johansson SE, Bolling-
Sternevald E, Bolinder G, Alving K, Talley NJ, Agreus L. Use of tobacco products and
gastrointestinal morbidity: an endoscopic population-based study (the Kalixanda study).
Eur J Epidemiol. 2010 Oct; 25(10):741-50. Epub 2010 Jul 29.
View PubMed
81. McElhiney J, Lohse MR, Arora AS, Peloquin JM, Geno DM, Kuntz MM, Enders FB,
Fredericksen M, Abdalla AA, Khan Y, Talley NJ, Diehl NN, Beebe TJ, Harris AM,
Farrugia G, Graner DE, Murray JA, Locke GR, Grothe RM, Crowell MD, Francis DL,
Grudell AM, Dabade T, Ramirez A, Alkhatib M, Alexander JA, Kimber J, Prasad G,
Zinsmeister AR, Romero Y. The Mayo Dysphagia Questionnaire-30: documentation of
reliability and validity of a tool for interventional trials in adults with esophageal disease.
Dysphagia. 2010 Sep; 25(3):221-30. Epub 2009 Oct 24. View PubMed
82. Chang JY, Choung RS, Lee RM, Locke GR 3rd, Schleck CD, Zinsmeister AR, Smyrk
TC, Talley NJ. A shift in the clinical spectrum of eosinophilic gastroenteritis toward the
mucosal disease type. Clin Gastroenterol Hepatol. 2010 Aug; 8(8):669-75; quiz e88.
Epub 2010 May 06. View PubMed
83. Chang JY, Talley NJ. Current and emerging therapies in irritable bowel syndrome: from
pathophysiology to treatment. Trends Pharmacol Sci. 2010 Jul; 31(7):326-34. Epub 2010
Jun 01. View PubMed
84. Walker MM, Murray JA, Ronkainen J, Aro P, Storskrubb T, D'Amato M, Lahr B, Talley
NJ, Agreus L. Detection of celiac disease and lymphocytic enteropathy by parallel
serology and histopathology in a population-based study. Gastroenterology. 2010 Jul;
139(1):112-9. Epub 2010 Apr 13. View PubMed
85. Beebe TJ, Rey E, Ziegenfuss JY, Jenkins S, Lackore K, Talley NJ, Locke RG 3rd.
Shortening a survey and using alternative forms of prenotification: impact on response
rate and quality. BMC Med Res Methodol 2010 Jun 08; 10:50 Epub 2010 June 08 View
PubMed
86. Rey E, Locke GR, Jung HK, Malhotra A, Choung RS, Beebe TJ, Schleck CD,
Zinsmeister AR, Talley NJ. Measurement of abdominal symptoms by validated
questionnaire: a 3-month recall timeframe as recommended by Rome III is not superior to
a 1-year recall timeframe. Aliment Pharmacol Ther. 2010 Jun; 31(11):1237-47. Epub
2010 Mar 06. View PubMed
87. Walker MM, Salehian SS, Murray CE, Rajendran A, Hoare JM, Negus R, Powell N,
Talley NJ. Implications of eosinophilia in the normal duodenal biopsy - an association
 with allergy and functional dyspepsia. Aliment Pharmacol Ther. 2010 Jun; 31(11):1229-
36. Epub 2010 Mar 04. View PubMed
88. Brook RA, Kleinman NL, Choung RS, Melkonian AK, Smeeding JE, Talley NJ.
Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin
Gastroenterol Hepatol. 2010 Jun; 8(6):498-503. Epub 2010 Mar 19. View PubMed
89. Gururatsakul M, Holloway RH, Talley NJ, Holtmann GJ. Association between clinical
manifestations of complicated and uncomplicated peptic ulcer and visceral sensory
dysfunction. J Gastroenterol Hepatol. 2010 Jun; 25(6):1162-9. View PubMed
90. Walter SA, Kjellstrom L, Nyhlin H, Talley NJ, Agreus L. Assessment of normal bowel
habits in the general adult population: the Popcol study. Scand J Gastroenterol. 2010
May; 45(5):556-66. View PubMed
91. Rubio-Tapia A, Talley NJ, Gurudu SR, Wu TT, Murray JA. Gluten-free diet and steroid
treatment are effective therapy for most patients with collagenous sprue. Clin
Gastroenterol Hepatol 2010 Apr; 8 (4):344-349.e3 Epub 2010 Jan 06 View PubMed
92. Chang JY, Locke GR 3rd, McNally MA, Halder SL, Schleck CD, Zinsmeister AR,
Talley NJ. Impact of functional gastrointestinal disorders on survival in the community.
Am J Gastroenterol 2010 Apr; 105 (4):822-32 Epub 2010 Feb 16 View PubMed
93. Leise MD, Locke GR 3rd, Dierkhising RA, Zinsmeister AR, Reeder GS, Talley NJ.
Patients dismissed from the hospital with a diagnosis of noncardiac chest pain: cardiac
outcomes and health care utilization. Mayo Clin Proc. 2010 Apr; 85(4):323-30. Epub
2010 Mar 01. View PubMed
94. Tack J, Talley NJ. Gastroduodenal disorders. Am J Gastroenterol. 2010 Apr; 105(4):757-
63. View PubMed
95. Saito YA, Petersen GM, Larson JJ, Atkinson EJ, Fridley BL, de Andrade M, Locke GR
3rd, Zimmerman JM, Almazar-Elder AE, Talley NJ. Familial aggregation of irritable
bowel syndrome: a family case-control study. Am J Gastroenterol 2010 Apr; 105 (4):833-
41 Epub 2010 Mar 16
View PubMed
96. Jung HK, Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ.
Diarrhea-predominant irritable bowel syndrome is associated with diverticular disease: a
population-based study. Am J Gastroenterol 2010 Mar; 105 (3):652-61 Epub 2009 Oct 27
View PubMed
97. Gururatsakul M, Holloway RH, Adam B, Liebregts T, Talley NJ, Holtmann GJ. The
ageing gut: diminished symptom response to a standardized nutrient stimulus.
Neurogastroenterol Motil. 2010 Mar; 22(3):246-e77. Epub 2009 Oct 08. View PubMed
98. Haag S, Senf W, Tagay S, Heuft G, Gerken G, Talley NJ, Holtmann G. Is there any
association between disturbed gastrointestinal visceromotor and sensory function and
impaired quality of life in functional dyspepsia? Neurogastroenterol Motil. 2010 Mar;
22(3):262-e79. Epub 2009 Oct 08. View PubMed
99. Powell N, Walker MM, Talley NJ. Gastrointestinal eosinophils in health, disease and
functional disorders. Nat Rev Gastroenterol Hepatol. 2010 Mar; 7(3):146-56. Epub 2010
Feb 02. View PubMed
100. Moayedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ,
Quigley EM. The efficacy of probiotics in the treatment of irritable bowel syndrome: a
systematic review. Gut. 2010 Mar; 59(3):325-32. Epub 2008 Dec 17. View PubMed
Professor Alexander Ford

Professor of gastroenterology and consultant gastroenterologist

MBChB MD FRCP

Practising at Spire Leeds Hospital

Clinical Interests
Gastroenterology
Bowel disease
Colonoscopy
Endoscopy
Inflammatory bowel disease
Motility disorder
Gastrointestinal

I have a special clinical interest in irritable bowel syndrome, dyspepsia, gastro-oesophageal

reflux disease, Barretts oesophagus, peptic ulcer disease, coeliac disease and chronic
constipation.

Qualification and professional memberships

MBChB / University of Leeds / 1997

Bachelor of Medicine and Bachelor of Surgery

MD / University of Leeds / 2006

Medical Doctor

FRCP / Royal College of Physicians, London / 2012

Fellow of the Royal College of Physicians

Professional memberships

Royal College of Physicians

British Society of Gastroenterology
American Gastroenterological Association
Medical Protection Society
The Rome Foundation
Professional leadership

Secretary, Neurogastroenterology Section of the British Society of Gastroenterology

Current NHS posts

Professor of gastroenterology, Leeds University

Consultant gastroenterologist, Leeds Teaching Hospitals Trust

Awards received

ASNEMGE Rising Star of Gastroenterology 2008

Cochrane collaboration Bill Silverman Prize 2010

Publications

1. Ford AC, Brenner DM, Schoenfeld PS. Efficacy of pharmacological therapies for the
treatment of opioid-induced constipation: Systematic review and meta-analysis. Am J
Gastroenterol 2013 (in press). Impact factor: 7.553
2. Billioud V, Ford AC, Del Tedesco E, Colombel J-F, Roblin X, Peyrin-Biroulet L. Preoperative
use of anti-TNF therapy and postoperative complications in inflammatory bowel disease: A
meta-analysis. J Crohns Colitis 2013 (in press). Impact factor: 3.385
3. Ford AC, Peyrin-Biroulet L. Opportunist infections with anti-tumor necrosis factor- therapy
in inflammatory bowel disease: Meta-analysis of randomized controlled trials. Am J
Gastroenterol 2013;108:1268-1276. Impact factor: 7.553
4. Power AM, Talley NJ, Ford AC. Association between constipation and colorectal cancer:
Systematic review and meta-analysis of observational studies. Am J Gastroenterol
2013;108:894-903. Impact factor: 7.553
5. Sainsbury A, Sanders DS, Ford AC. Prevalence of irritable bowel syndrome-type symptoms in
patients with celiac disease: A meta-analysis. Clin Gastroenterol Hepatol 2013;11:359-365.
Impact factor: 6.648