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ABSTRACT
It has been conducted a study to determine the effectiveness of the ethanol extract
of the cooperleaf herb (Acalypha indica L.) in decreasing blood glucose levels
which is compared with metformin. This study used male rat (Mus musculus) as
much as 20 head, divided into 4 groups. The first group was given a Na-CMC
(negative control), the second group was given metformin (positive control), the
third group was given ethanol extract of the cooperleaf herb dose of 3 g/kg body
weight and the fourth group was given a dose of ethanol extract of 6 g/kg body
weight for 5 days. All treatments were given orally. Blood glucose of mouse is
induced by using a dose dexamethasone 3 mg/kg body weight/day orally for 8
days. The result showed that the percentage decrease in blood glucose levels in
male rat were given a dose of ethanol extract of 6 g/kg body weight of 72.93%
and the group of male rat given metformin amounted to 54.44%. LSD test results
showed that the percentage decrease in blood glucose levels are significantly
different. So the ethanol extract of the cooperleaf herb and mouse dose of 6 g/kg
had a reduction in the effectiveness of blood glucose levels better than metformin.