SRINIVASA NAGA RAJA, M.D.

DEMOGRAPHIC INFORMATION

Current Appointments
Professor, Department of Anesthesiology/Critical Care Medicine, Division of Pain Medicine
Director, Division of Pain Medicine, Department of Anesthesiology/Critical Care Medicine
Director of Pain Research, Department of Anesthesiology/Critical Care Medicine

Personal Data
Department of Anesthesiology & Critical Care Medicine
The Johns Hopkins University School of Medicine
600 N. Wolfe St., Osler 292
Baltimore, Maryland 21287, U.S.A.

phone: (410) 955-1822 / fax: (410) 614-2019 / e-mail: sraja@jhmi.edu

Education and Training

1974 Prince of Wales Medical College,
Patna University, India Medicine/Surgery M.B.B.S.
1976-77 Middlesex General Hospital,
New Brunswick, NJ Surgery Internship
1977-79 Univ. of Washington Affiliated
Hospitals, Seattle Anesthesiology Residency
1979-81 Univ. of Virginia School of Medicine, Pharmacology/
Charlottesville Neurophysiology Postdoctoral

Research Training
July, 1979 to June, 1981Mentor, Dr. P.G. Guyenet, Ph.D., Department of Pharmacology
University of Virginia School of Medicine as a Research Fellow (N.I.G.M.S. Research Training
Grant, University of Virginia School of Medicine).

Professional Experience
July 1981 - April 1990 Assistant Professor
Department of Anesthesiology/Critical Care Medicine
The Johns Hopkins University School of Medicine
May 1990-April 1997 Associate Professor
Department of Anesthesiology/Critical Care Medicine
The Johns Hopkins University School of Medicine
May 1997- present Professor
Department of Anesthesiology/Critical Care Medicine
Division of Pain Medicine
The Johns Hopkins University School of Medicine

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RESEARCH ACTIVITIES

Publications (in peer-reviewed journals)

1. Raja SN, Guyenet PG. The effects of phencyclidine on the spontaneous activity of
mono-aminergic neurons. European Journal of Pharmacology. 1980;63:229-233.

2. Raja SN, Guyenet .G. Action of phencyclidine on synaptic transmission in the

hippocampus. Brain Research. 1982;236:289-304.

3. Raja SN, Moscicki MS, Woodside JR, DiFazio CA. The effect of acute phencyclidine
administration on cyclopropane requirement (MAC) in rats. Anesthesiology.
1982;56:275-279.

4. Raja SN, Meyer RA, Campbell JN, Burke R. The response of nociceptive afferents in
the peripheral nerve to cutaneous heat stimuli is altered by general anesthetics.
Anesthesia and Analgesia 1983;62:279-280.

5. Campbell JN, Raja SN, Meyer RA Halothane sensitizes cutaneous nociceptors in

monkey. Journal of Neurophysiology. 1984;52:762-770.

6. Raja SN, Campbell JN, Meyer RA. Evidence for different mechanisms of primary and
secondary hyperalgesia following heat injury to the glabrous skin. Brain 1984;107:1179-
1188.

7. Meyer RA, Raja SN, Campbell JN. Coupling of action potential activity between
unmyelinated fibers in the peripheral nerve of monkey. Science 1985;227:184-187.

8. Meyer RA, Raja SN, Campbell JN, Mackinnon SE, Dellon AL. Neural activity
originating from a neuroma in the baboon. Brain Research 1985;325:255-260.

9. Raja SN, Geller H. Another potential source of major gas leak. Anesthesiology
1986;64:297-298.

10. Raja SN, Meyer RA, Campbell JN, Khan AA. Narcotics do not alter the heat response of
unmyelinated primary afferents in monkey. Anesthesiology 1986;65:468-473.

11. Raja SN, Meyer RA, Campbell JN. Peripheral mechanisms of somatic pain.
Anesthesiology 1988;68:571-590.

12. Meyer RA, Campbell JN, Raja SN. Antidromic nerve stimulation in monkey does not
sensitize unmyelinated nociceptors to heat. Brain Research 1988;441:168-172.

13. Campbell JN, Raja SN, Meyer RA, MacKinnon SE. Myelinated afferents signal the
hyperalgesia associated with nerve injury. Pain 1988;32:89-94.
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14. Campbell JN, Khan AA, Meyer RA, Raja SN. Responses to heat of C-fiber nociceptors
in monkey are altered by injury in the receptive field but not by adjacent injury. Pain
1988;32:327-332.

15. Berkowitz ID, Raja SN, Bender KS, Kopits SE. Dwarfs: Pathophysiology and anesthetic
implications. Anesthesiology, 73:739-759, 1990.

16. Raja SN, Treede R-D, Davis KD, Campbell JN. Systemic alpha-adrenergic blockade
with phentolamine: A diagnostic test for sympathetically maintained pain.
Anesthesiology 1991;74(4):691-698.

17. Manning DC, Raja SN, Meyer R., Campbell JN. Pain and hyperalgesia following
intradermal injection of bradykinin in humans. Clinical Pharmacology and Therapeutics
1991;50:721-729.

18. Davis KD, Treede R-D, Raja SN, Meyer R., Campbell JN. Topical application of
clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain
1991;47:309-318.

19. Raja SN, Davis KD, Campbell JN. The adrenergic pharmacology of sympathetically
maintained pain. J. of Reconstructive Microsurgery 1992;8:63-69.

20. Valley MA, Raja SN. Relief of intractable pain from metastic multiple myeloma using
epidural phenol injections. Journal of Pain and Symptom Management 1992;7:179-181.

21. Khan AA, Raja SN, Manning DC, Campbell JN, Meyer RA. The Effects of bradykinin
and sequence-related analogs on the response properties of nociceptors. Somatosensory
and Motor Research 1992;9:97-106.

22. Treede R-D, Meyer RA, Raja SN, Campbell JN. Peripheral and central mechanisms of
cutaneous hyperalgesia. Progress in Neurobiology 1992;38:397-421.

23. Campbell JN, Meyer RA, Raja SN. Is nociceptor activation by alpha-1 adrenoreceptors
the culprit in sympathetically maintained pain? American Pain Society Journal 1992;1:3-
11.

24. Meyer RA, Treede R-D, Raja SN, Campbell JN. Peripheral versus central mechanisms
for secondary hyperalgesia: Is the controversy resolved? American Pain Society Journal
1992;1(2):127-131.

25. Treede R-D, Davis KD, Campbell JN, Raja SN. The plasticity of cutaneous hyperalgesia
during sympathetic ganglion blockade in patients with neuropathic pain. Brain
1992;115:607-621.

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26. Meyer RA, Davis K., Raja SN, Campbell JN. Sympathectomy does not abolish
bradykinin-induced cutaneous hyperalgesia in man. Pain 1992;51:323-327.

27. Raja SN, Campbell JN, Meyer RA, Colman RW. Role of kinins in pain and
hyperalgesia: psychophysical studies in a patient with kininogen deficiency. Clinical
Science 1992;83:337-341.

28. Raja SN, Dickstein RE, Johnson CA. Comparison of postoperative analgesic effects of
intraarticular bupivacaine and morphine following arthroscopic knee surgery.
Anesthesiology 1992;77:1143-1147.

29. Raja SN. Reflex sympathetic dystrophy: pathophysiological basis for therapy. Pain
Digest 1992;2:274-280.

30. Valley MA, Bourke DL, Hamill MP, Raja SN. Time course of sympathetic blockade
during epidural anesthesia: laser Doppler flowmetry studies of regional skin perfusion.
Anesthesia and Analgesia 1993;76:289-294 1993.

31. Valley MA, Bourke DL, McKenzie AM, Raja SN. Quantitative testing of sympathetic
function with laser Doppler flowmetry. Journal of Clinical Monitoring 1993;9(4):252-
256.

32. Shir Y, Cameron LB, Raja SN, Bourke DL. The safety of intravenous phentolamine
administration in patients with neuropathic pain. Anesthesia and Analgesia
1993;76:1008-11.

33. Shir Y, Raja SN. Indigo carmine-induced severe hypotension in patients undergoing
radical prostatectomy. Anesthesiology 1993;79:378-381.

34. Raja SN, Meyer RA, Campbell JN. Clonidine: effects on pre- vs. post-junctional
adrenoceptors. Pain 1993;54:361-362.

35. Shir Y, Raja SN, Frank SM. The effect of epidural vs general anesthesia on postoperative
analgesic demand in patients undergoing radical prostatectomy. Anesthesiology 1994;80
(1):49-56.

36. Valley MA, McKenzie AM, Bourke DL, Raja SN. Effects of epidural test dose volume
on skin perfusion and temperature, and reflex vasoconstriction. Regional Anesthesia
1994;19 (1):52-58.

37. Fleisher LA, Frank SM, Shir Y, Estafanous, M, Kelly S., Raja SN. Cardiac
sympathovagal balance and peripheral sympathetic vasoconstriction: Epidural versus
general anesthesia. Anesthesia and Analgesia 1994;79:165-171.

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38. Frank SN, Shir Y, Raja SN, Fleisher LA, Beattie C. Core hypothermia and skin surface
temperature gradients: epidural vs. general anesthesia and the effects of age.
Anesthesiology 1994;80 (3):502-508.

39. Pappagallo M. Raja SN, Haythornthwaite J, Clark M, Campbell JN. Oral opioids in the
management of post-herpetic neuralgia: A prospective survey. Analgesia 1994;1:51-55.

40. Shir Y, Frank SM, Brendler CM, Raja SN. Postoperative morbidity is similar in patients
anesthetized with either epidural vs. general anesthesia for radical prostatectomy.
Urology 1994;44:232-236.

41. Frank SM, Raja SN. Reflex cutaneous vasoconstriction during cold pressor test is
mediated by an -adrenergic mechanism. Clinical Autonomic Research 1994;4:257-262.

42. Raja SN, North RB. Highlight on Paraplegia in a patient with an intrathecal catheter and
a spinal cord stimulator by Aldrete et al. Anesthesiology 1994;81:27A-28A.

43. Treede RD, Meyer RA, Raja, SN, Campbell JN. Evidence for two different heat
transduction mechanisms in nociceptive primary afferents innervating monkey skin.
Journal of Physiology 1995;483:747-758.

44. Raja SN. Role of the sympathetic nervous system in acute pain and inflammation.
Annals of Medicine 1995;27:241-248.

45. Shir Y, Raja SN, Brendler CB, Frank S. M. Intraoperative blood loss during radical
retropubic prostatectomy: epidural vs. general anesthesia. Urology 1995;45:993-999.

46. Campbell JN, Raja SN. Reflex sympathetic dystrophy. Neurology 1995;45:1235-1236.

47. Raja SN, Choi Y, Asano Y, Holmes C, Goldstein DS. Arteriovenous differences in
plasma concentrations of catechols in rats with neuropathic pain. Anesthesiology
1995;83:1000-1008.

48. Frank SM, El-Gamal N, Raja SN, Wu PK, Afifi O. Role of -adrenoceptors in the
maintenance of core temperature in humans. Clinical Science 1995;89:219-225.

49. Frank SM, El-Gamal N, Raja SN, Wu PK, Afifi O. -Adrenoceptor mechanisms of
thermoregulation during cold challenge in humans. Clinical Science 1996;91:627-631.

50. Raja SN, Turnquist JL, Meleka S, Campbell JN. Monitoring adequacy of a-adreneceptor
blockade following systemic phentolamine administration. Pain 1996;64:197-204.

51. Lam HD, Hanley DF, Trapp BD, Saito S, Raja SN, Dawson TM, Yamaguchi H.
Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in
the rat hind paw. Neuroscience Letters 1996;210:201-204.
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52. Choi Y, Raja SN, Moore LC, Tobin JR. Neuropathic pain in rats is associated with
altered nitric oxide synthase activity in neural tissue. Journal of Neurological Sciences
1996;138: 14-20.

53. Frank SM, Raja SN, Wu PK, El-Gamal N. -Adrenergic mechanisms of

thermoregulation in humans. Annals N.Y. Acad. Sciences 1996;813:101-110.

54. Wesselmann U, Raja SN. Reflex sympathetic dystrophy and causalgia. Anesthesiology
Clinics of North America 1997;15: 407-427.

55. Raja SN. Peripheral modulatory effects of catecholamines in inflammatory and

neuropathic pain. Advances in Pharmacology 1998;42:567-571.

56. Haythornthwaite JA, Raja SN, Fisher B, Frank SM, Brendler CB, Shir Y. Pain and
quality of life following radical retropubic prostatectomy. The Journal of Urology
1998;160:1761-1764.

57. Shir Y, Ratner A, Raja SN, Campbell JN, Seltzer Z. Neuropathic pain following partial
nerve injury in rats is suppressed by dietary soy. Neuroscience Letters 1998;240:73-76.

58. Ringkamp M, Grethel EJ, Choi Y, Meyer RA, Raja SN. Mechanical hyperalgesia after
spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of
adrenergic antagonists. Pain 1999;79:135-141.

59. Ringkamp M, Eschenfelder S, Grethel EJ, Hbler H-J, Meyer .A, Jnig W, Raja SN.
Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like
behavior in rats with L5 spinal nerve injury. Pain 1999;79:143-153.

60. Fuchs PN, Ringkamp M, Shiotani M, Raja SN. Sympathectomy decreases formalin-
induced nociceptive responses independent of changes in peripheral blood flow.
Experimental Neurology 1999;155:95-102.

61. Fuchs PN, Roza C, Sora I, Uhl G, Raja SN. Characterization of mechanical withdrawal
responses and effects of -, - and -opioid agonists in normal and -opioid receptor
knockout mice. Brain Research 1999;821:480-486.

62. Mansikka H, Shiotani M, Winchurch R, Raja SN. Neurokinin-1 receptors are involved
in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia
in mice. Anesthesiology 1999;90:1643-1649.

63. Frank SM, Raja SN, Bulcao C, Goldstein D. Relative contribution of core and cutaneous
temperatures to thermal comfort and autonomic responses in humans. J. Appl. Physiol.
1999;86:1588-1593.

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64. Clark MR, Heinberg LJ, Haythornthwaite JA, Quatrano-Piacentini AL, Pappagallo M,
Raja SN. Psychiatric symptoms and distress differ between patients with post-herpetic
neuralgia and peripheral vestibular disease. J. Psychosom. Res. 2000;48:51-57.

65. Pappagallo M, Oaklander AL, Quatrano-Piacentini AL, Clark MR, Raja SN.
Heterogenous patterns of sensory dysfunction in postherpetic neuralgia suggest multiple
pathophysiological mechanisms. Anesthesiology 2000;92:691-698.

66. Bulcao CF, Frank SM, Raja SN, Tran KM, Goldstein DS. Relative contribution of core
and skin temperatures to thermal comfort in humans. J. Therm. Biol. 2000;25:147-150.

67. Mansikka H, Sheth RN, De Vries C, Lee H, Winchurch R, Raja SN. Nerve injury-
induced mechanical but not thermal hyperalgesia is attenuated in neurokinin-1 receptor
knockout mice. Exp. Neurol. 2000;162:343-349.

68. Gupta N, Frank SM, Ghoneim N, El-Rahmany HK, Talamini MA, Zacur HA, Raja SN.
Thermoregulation and hormone replacement in postmenopausal women. J. Therm. Biol.
2000;25:165-169.

69. Tran KM, Frank SM, Raja SN, El-Rahmany HK, Kim LJ, Vu B. Lumbar sympathetic
block for sympathetically maintained pain: Changes in cutaneous temperatures and pain
perception. Anesthesia & Analgesia 2000;90:1396-1401

70. Frank SM, Raja SN, Bulcao C, Goldstein DS. Age-related thermoregulatory differences
during core cooling in humans. Am. J. Physiol. 2000;279:R349-R354.

71. Ali Z, Raja SN, Wesselmann U, Fuchs P, Meyer RA, Campbell JN. Intradermal
injection of norepinephrine evokes pain in patients with sympathetically maintained pain.
Pain 2000;88:163-170.

72. Frank SM, El-Rahmany H.K, Tran KM, Vu B, Raja SN. Comparison of lower extremity
cutaneous temperature changes in patients receiving lumbar sympathetic ganglion blocks
versus epidural anesthesia. J. Clin. Anesth. 2000;12:525-530.

73. Fuchs PN, Meyer RA, Raja SN. Heat, but not mechanical hyperalgesia, following
adrenergic injections in normal human skin. Pain 2001;90:15-23.

74. Shir Y, Sheth R, Campbell JN, Raja SN, Seltzer Z. Soy-containing diet suppresses
chronic neuropathic sensory disorders in rats. Anesthesia & Analgesia 2001;92:1029-
1034.

75. Weng H-R, Mansikka H, Winchurch R, Raja SN, Dougherty PM. Sensory processing in
the deep spinal dorsal horn of neurokinin-1 receptor knockout mice. Anesthesiology
2001;94:1105-1112.

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76. Shir Y, Raja SN, Weissman CS, Campbell JN, Seltzer Z. Consumption of soy diet prior
to nerve injury preempts the development of neuropathic pain in rats. Anesthesiology
2001;95:1238-1244.

77. Wu CL, Tella P, Staats PS, Vaslav R, Kazim D, Wesselmann U, Raja SN. Analgesic
effects of intravenous lidocaine and morphine on post-amputation pain: A randomized
double-blind, active-placebo-controlled, crossover trial. Anesthesiology 2002;96:841-8.

78. Raja SN, Grabow T. Complex Regional Pain Syndrome I (Reflex Sympathetic
Dystrophy). Anesthesiology 2002;96:1254-60.

79. Mansikka H, Zhou L, Donovan DM, Pertovaara A, Raja SN. The role of -opioid
receptors in inflammatory hyperalgesia and 2-adrenoceptor mediated antihyperalgesia.
Neuroscience, 2002;113:339-349.

80. Raja SN, Haythornthwaite JA, Pappagallo M, Clark MR, Travison TG, Sabeen S, Royall
RM, Max MB. Opioids versus antidepressants in postherpetic neuralgia: a randomized
placebo-controlled trial. Neurology 2002;59:1015-1021.

81. Shir Y, Campbell JN, Raja SN, Seltzer Z. The correlation between dietary soy
phytoestrogens and neuropathic pain behavior in rats after partial denervation. Anesthesia
& Analgesia 2002;94:421-6.

82. Tao F, Tao Y-X, Mao P, Zhao C, Li D, Liaw W-J, Raja SN, Johns .A. Intact
carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.
Neuroscience 2003;120:847-54.

83. Tao Y-X, Rumbaugh G, Wang G, Petralia RS, Zhao C, Kauer FW, Tao F, Zhuo M.
Wenthold RJ, Raja SN, Huganir RL, Bredt DS, Johns RJ. Impaired NMDA receptor-
mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in
mice lacking PSD-93 protein. Journal of Neuroscience 2003;23:6703-12.

84. Pogatzki EM, Raja SN. A mouse model of incisional pain. Anesthesiology
2003;99:1023-7.

85. Grabow TS, Tella PK, Raja SN. Spinal cord stimulation for complex regional pain
syndrome: an evidence-based medicine review of the literature. Clinical Journal of Pain
2003;19:371-83.

86. Haythornthwaite JA, Clark MR, Pappagallo M, Raja SN. Pain coping strategies play a
role in the persistence of pain in post-herpetic neuralgia. Pain 2003;106:453-60.

87. Zhao C-S, Tao Y-X, Tall JM, Donovan DM, Meyer RA, Raja SN. Role of -opioid
receptors in formalin-induced pain behavior in mice. Exp Neurol 2003 184:839-45.

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88. Tall JM, Raja SN. Dietary constituents as novel therapies for pain. Clinical Journal of
Pain 2004;20:19-26.

89. Wu CL, Hsu W, Richman J, Raja SN. Postoperative cognitive function as an outcome of
regional anesthesia and analgesia. Regional Anesthesia and Pain Medicine 2004;29:257-
68.

90. Zhao C., Tall JM, Meyer RA, Raja SN. Anti-allodynic effects of systemic and
intrathecal morphine in the spared nerve injury model of neuropathic pain in rats.
Anesthesiology 2004;100:905-11.

91. Mansikka H, Zhao C, Sheth R, Sora I, Uhl G, Raja SN. Nerve injury induces a tonic
bilateral -opioid receptor mediated inhibitory effect on mechanical allodynia in mice.
Anesthesiology 2004;100:912-21.

92. Zhao C, Wacnik PW, Tall JM, Johns DC, Wilcox GL, Meyer RA, Raja SN. Analgesic
effects of a soy-containing diet in three murine bone cancer-pain models. Journal of Pain
2004;5:104-10.

93. Tall JM, Seeram NP, Zhao C, Nair MG, Meyer RA, Raja SN. Tart cherry anthocyanins
suppress inflammation-induced pain behavior in rat. Behavioural Brain Research
2004;153:181-8.

94. Tao Y-X, Raja SN. Synaptic MAGUK proteins and chronic pain. Trends in
Pharmacological Sciences 2004;25:397-400.

95. Francis JA, Raja SN, Nair MG. Bioactive terpenoids and guggulusteroids from
commiphora mukul gum resin of potential anti-inflammatory interest. Chemistry and
Biodiversity 2004;1:1842-53.

96. Tao F, Tao Y-X, Zhao C, Dor S, Liaw W-J, Raja SN, Johns RA. Differential roles of
neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory
hyperalgesia. Neuroscience 2004;28:421-30.

97. Pogatzki-Zahn EM, Shimizu I, Caterina M, Raja SN. Heat hyperalgesia after incision
requires TRPV1 and is distinct from pure inflammatory pain. Pain 2005;115:296-307.

98. Shimizu I, Iida T, Guan Y, Zhao C, Raja SN, Jarvis MF, Cockayne DA, Caterina M.
Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain 2005;116:96-
108.

99. Chu Y-C, Guan Y, Skinner J, Raja SN, Johns RA, Tao Y-X. Effect of genetic knockout
or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's
adjuvant-induced persistent pain. Pain 2005;119(1-3):113-23.

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100. Lin EE, Horasek S, Agarwal S, Wu CL, Raja SN. Local administration of norepinephrine
in the stump evokes dose-dependent pain in amputees. Clinical Journal of Pain. 2006 (in
press).

101. Guan Y, Borzan J, Meyer RA, Raja SN. Windup in dorsal horn neurons is modulated by
endogenous spinal mu-opioid mechanisms. Journal of Neuroscience. 2006;26(16):4298-
4307.

102.

103.
104. Kudel, I., Edwards, R., Kozachik, S., Block, BM., Agarwal, S., Heinberg, LJ.,
Haythorthwaite, J., Rja, SN. Predictors and Consequences of Multiple Persistent Post-
Mastectomy Pains. Journal of Pain Symptom Management (In press).
Editorials
1. Raja SN. Diagnosis of sympathetically maintained pain: The past, present and future.
Editorial. European Journal of Pain 1993;14:45-48.

2. Raja SN. Is an ounce of preoperative local anesthetic better than a pound of

postoperative analgesic? Editorial, Regional Anesthesia 1996;21:277-280.

3. Raja SN. Nerve blocks in the evaluation of chronic pain. A plea for caution in their use
and interpretation. Anesthesiology 1997;86:4-6.

4. Raja SN. Highlight: Assessment of the potency and efficacy of systemic versus
intrathecal opioids in rats by Abram S.E. et al., Anesthesiology 1997;87:27A-29A.

5. Raja SN, Wesselmann U. Sympathetically maintained pain: Confusing classification, ill-

defined diagnostic criteria, and puzzling pathophysiology. Commentary, Behavioral and
Brain Sciences 1997;20:462.

6. Raja SN, Haythornthwaite JA. Anesthetic management of the elderly: Measuring

function beyond the immediate perioperative horizon. Editorial, Anesthesiology
1999;91:909-911.

7. Raja SN, Campbell JN. Risk-benefit ratio for surgical sympathectomy: Dilemmas in
clinical decision making. Commentary, The Journal of Pain 2000;1:261-264.

8. Raja SN, Dougherty PM. Reversing tissue injury-induced plastic changes in the spinal
cord: The search for the magic bullet. Editorial, Regional Anesthesia and Pain Medicine
2000;25:441-444.

9. Wu CL, Raja SN. Optimizing postoperative analgesia: the use of global outcome
measures. Anesthesiology 2002;97:533-4.

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10. Berde CB, Brennan TJ, Raja SN. Opioids: more to learn, improvements to be made.
Editorial in Anesthesiology 2003;98 (6):1309, 2003.

11. Gottschalk A, Raja SN. Severing the link between acute and chronic pain: the
anesthesiologists role in preventive medicine. Anesthesiology 2004;101:1063-5.

12. Raja SN, Haythornthwaite JA. Combination therapy for neuropathic pain which
drugs, which combination, which patients? NEJM 2005;352;13:1373-5.

13. Raja SN, Brennan TJ. Special issue on plasticity in postoperative pain: select reports
from the Journal-sponsored symposium. Anesthesiology 2006;104:

Review Articles
1. Kissin I, Raja SN. Preemptive analgesia, concepts, controversies and caveats. Pain
Digest 1995;5:5-8.

2. Gupta R, Raja SN. Chronic pain: Pathophysiology and its therapeutic implications.
Current Review of Pain 1996;1:1-9.

3. Raja SN. Evidence for a role of adrenoceptors in the signaling of pain in humans. PSNS
SIG (IASP Newsletter), November 2000: 2-4.

4. Fuchs PN, Raja SN, Meyer RA. Topical capsaicin for the treatment of neuropathic pain.
Anesthesia & Analgesia 2000;5:1-8.

5. Raja SN, Haythornthwaite JA. Managing chronic noncancer pain with opioids: The gap
between basic science and clinical studies (Review). Clin. J. Pain 2000;16:270-274.

6. OGorman DA, Raja SN. Drug infusions for the diagnosis and treatment of chronic pain.
Current Pain and Headache Reports 2002;6 (6):452-9.

7. Panlilio LM, Christo PJ, Raja SN. Current Management of Postherpetic Neuralgia. The
Neurologist 2002; 8:339-350.

8. Christo PJ, Grabow TS, Raja SN. Opioid effectiveness, addiction, and depression in
chronic pain. Adv Psychosom Med 2004; 25:123-37.

9. Grabow TS, Christo PJ, Raja SN. Complex regional pain syndrome: diagnostic
controversies, psychological dysfunction, and emerging concepts. Adv Psychosom Med
2004; 25:89-101.

10. Block BM, Hurley RW, Raja SN. Mechanism-based therapies for pain. Drug News and
Perspectives 2004 17:187-94.

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11. Meyer RA, Ringkamp M, Campbell JN, Raja SN. Neural mechanisms of hyperalgesia
after tissue injury. Johns Hopkins APL Technical Digest 2005; 26:56-66.

12. Sharma A, Williams K, Raja SN. Advances in treatment of complex regional pain
syndrome: recent insights on the perplexing disease. Current Opinion in Anaesthesiology
2006,19-000-000.

Book Reviews
1. Raja SN. The management of pain, Second Edition by John J. Bonica a book review.
Anesthesiology 1990;73:1298.

2. Raja SN, Veloso K. Practical management of pain, Second Edition by Prithvi Raj - a
book review. Anesthesiology 1992;76:871.

3. Raja SN, Haythornthwaite JA. Quality of life assessment in medicine. A CD-ROM for
Windows, Issue 2. Anesthesiology 1998;89:1043-1044.

4. Raja SN, Grabow T. Anesthesiology, 2002. Complex Regional Pain Syndrome, Vol. 22.
(Eds., Harden et al.) IASP Press, 2001.

5. Sharma A, Raja SN. CRPS: Current Diagnosis and Therapy; Wilson, PR, Stanton-
Hicks M, Harden RN. (Eds.) Progress in Pain Management Research, Vol 32. IASP
Press, 2005. Book Review. Clinical Journal of Pain 2006;22:225.

Book Chapters
1. Meyer RA, Campbell JN, Raja SN. Peripheral neural mechanisms of cutaneous
hyperalgesia, in: Advances in Pain Research and Therapy, Vol. 9 Proceedings of the IV
World Congress on Pain, HL Fields, R Dubner and F Cervero (eds.), Raven Press, New
York, 1985, pp. 53-72.

2. Meyer RA, Campbell JN, Raja SN. Hyperalgesia following peripheral nerve injury, in:
Effects of Injury on Spinal and Trigeminal Somatosensory Systems, LM Pubols and BJ
Sessle (eds.), Alan R. Liss, Inc., New York, 1987, pp. 383-388.

3. Frost SA, Raja SN, Campbell JN, Meyer RA, Khan AA. Does hyperalgesia to cold
stimuli characterize patients with sympathetically maintained pain (Reflex Sympathetic
Dystrophy)?, in: R. Dubner, G.S. Gebhart, M.R. Bond, (eds.), Pain Research and Clinical
Management, Vol. 3 Proceedings of the Vth World Congress on Pain, Elsevier Science
Publishers, Amsterdam, 1988, pp. 151-156.

4. Campbell JN, Raja SN, Meyer RA. Painful sequelae of nerve injury, in: R.
Dubner, GS Gebhart, and MR Bond (eds.), Pain Research and Clinical Management,
vol. 3, Proceedings of the Vth World Congress on Pain, Amsterdam, Elsevier Science
Publishers, 1988, pp. 135-143.
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5. Campbell JN, Raja SN, Cohen RH, Manning DC, Khan AA, Meyer RA. Peripheral
neural mechanisms of nociception, In: Textbook of Pain, 2nd Edition, Wall and Melzack
(eds.), Churchill Livingston, New York, 1989, pp. 22-45.

6. Raja SN, Campbell JN, Meyer RA. Hyperalgesia and sensitization of primary afferent
fibers, In: Pain Syndromes in Neurological Practice, HL Fields (ed.), Butterworth,
London, 1990, pp. 19-45.

7. Meyer RA, Campbell JN, Raja SN. The role of nociceptors and low-threshold
mechanoreceptors in the pain to light touch observed in sympathetically-maintained pain,
In: Lesions of Primary Afferent Fibers as a Tool for the Study of Clinical Pain, G
Guilbaud and JM Besson (eds.), Elsevier Science Publishers, 1991, pp. 307-314.

8. Campbell JN, Raja SN, Meyer RA. How should sympathetically maintained pain be
diagnosed: A case study, In: Lesions of primary afferent fibers as a tool for the study of
clinical pain, G Guilbaud and JM Besson (eds.), Elsevier Science Publishers, 1991, pp.
45-51.

9. Treede R-D, Raja SN, Davis KD, Meyer RA, Campbell JN. Evidence that peripheral
alpha-adrenergic receptors mediate sympathetically maintained pain, in: Proceedings VIth
World Congress on Pain, MR Bond, JE Charlton, CJ Woolf (eds.), Elsevier Science
Publishers, 1991, pp. 377-382.

10. Meyer RA, Raja SN, Treede R-D, Davis KD, Campbell JN. Neural mechanisms of
sympathetically maintained pain, In: Pathophysiological Mechanisms of Reflex
Sympathetic Dystrophy, W Janig and R Schmidt (eds.), 1992, pp. 141-150.

11. Campbell JN, Meyer RA, Davis KD, Raja SN. Sympathetically maintained pain: A
unifying hypothesis, In: Hyperalgesia, WD Willis (ed.), Raven Press, New York 1992.

12. Raja SN, Hendler N. Sympathetically maintained pain. In: Current Practice in
Anesthesiology, MC Rogers (ed.), B.C. Decker, Inc., Philadelphia, 1992, pp. 421-425.

13. Raja SN, Meyer RA, Campbell JN. Intravenous phentolamine: A placebo-controlled
diagnostic test for sympathetically maintained pain In: Pain and the Sympathetic Nervous
System Newsletter, 1992, pp. 2-3.

14. Campbell JN, Raja SN, Meyer RA. Pain and the sympathetic nervous system connecting
the loop. In: New Trends in Referred Pain and Hyperalgesia, Eds. Lvecchiet, D Alle-
Iessard, Ulindblum, MA Gianberardino, Elsevier Science Publisher, 1993, pp. 99-108.

13
15. Campbell JN, Raja SN, Selig DK, Belzberg AJ, Meyer RA. Diagnosis and management
of sympathetically maintained pain. In: Progress in Pain Research and Management,
Vol.1, Edited by HL Fields, JC Liebeskind, 1994, pp. 85-100.

16. Campbell JN, Raja SN, Belzberg AJ, Meyer RA. Hyperalgesia and the sympathetic
nervous system. In Touch, temperature and pain in Health and Disease: Mechanism and
Assessments. In: Progress in Pain Research and Management Vol.3, Edited by Bovie J,
Hanson P, Lindblom U. IASP Press, Seattle, 1994, pp. 249-264.

17. Frank SM, Raja SN, Fleischer LA, Beattie C, Higgins MS, Breslow MJ. Cardiovascular
and adrenergic manifestations of cold stress. In: Thermal Balance in Health and
Disease, Advances in Pharmacological Sciences, 1994, pp. 325-331.

18. Meyer A, Campbell JN, Raja SN. Peripheral neural mechanisms of nociception. In:
Textbook of Pain, 3rd Edition, Wall and Melzack (eds.), Churchill Livingston, New York,
1994, pp. 13-44.
19. Manning D, Churcher A, Raja SN. Diagnosis of reflex sympathetic dystrophy and
therapeutic strategies based on pathophysiology. In: Current Review of Pain, Ed. P Raj
Current Medicine, Philadelphia, 1994, pp. 195-208.

20. Choi Y, Raja SN, Chronic Pain: Pathophysiology and Rationale for Treatment. In:
Management of Pain: A World Perspective, P Raj, S Erdine, D Niv, SN Raja (eds.)
Monduzzi Editore, Bologna, Italy, 1995, pp. 95-105.

21. Wesselmann U, Raja SN, Campbell JN. Sympathetic maintained pain in autonomic
nervous system in physical medicine and rehabilitation: State of the art reviews. Eds.
RW Teassell, Hanley and Belfus, Philadelphia, Vol 10, 1996, pp. 137-151.

22. Meyer RA, Raja SN, Campbell JN. Neural mechanisms of primary hyperalgesia. In:
Neurobiology of Nociceptors, Belmonte C, Cervero F (eds.), Oxford University Press,
1996, pp. 370-389.

23. Choi Y, Raja SN. Chronic Pain: pathophysiology and rationale for treatment. In: Pain
Management-A World Perspective, Raj PP, Erdine S, Niv D, Raja SN, (eds.) Monduzzi
Editore, Bologna, Italy, 1996, pp. 95-104.

24. Haythornthwaite JA, Raja SN. Commentary: What is a successful outcome of pain. In:
Pain Treatment Centers at a Crossroads: A Practical and Conceptual Reappraisal,
Progress in Pain Research and Management, edited by MJ Cohen and JN Campbell,
IASP Press, Seattle, Vol. 7, 1996, pp. 203-207.

25. Shir Y, Ratner A, Raja SN, Campbell JN, Seltzer Z. The effect of diet on neuropathic
pain expression in rats. In: Pain Mechanisms and Management, edited by SA
Ayrapetyan, AV Apkarian, Ios Press, New York, 1997, pp 139-158.
14
26. Raja SN, Meyer RA, Campbell JN. Transduction properties of the sensory afferent
fibers. In: Anesthesia: Biological Foundations, T L Yaksh, C Lynch, WM Zapol, M
Maze, JF Biebuyck, LJ Saidman (eds). Lippincott-Raven Press, Philadelphia, 1998, pp.
515-530.

27. Raja SN. Sympathetically maintained pain. In: Atlas of Anesthesiology, edited by RD
Miller, Current Medicine, Philadelphia, Vol. VI, 1998, pp. 6.1-6.14.

28. Raja,SN, Dougherty PM. Pain and the neurophysiology of somatosensory processing.
In: Essentials of Pain Medicine and Regional Anesthesia, (eds.) HT Benzon, SN Raja, D
Borsook, RE Molloy, G. Strichartz, Churchill Livingstone, Philadelphia, 1999, pp. 2-6.

29. Dougherty PM, Raja SN. Pain and the neurochemistry of somatosensory processing. In:
Essentials of Pain Medicine and Regional Anesthesia, edited by HT Benzon, SN Raja, D
Borsook, RE Molloy, G Strichartz, Churchill Livingstone, Philadelphia, 1999, pp. 7-9,.

30. Mitchell VC, Raja SN. Preemptive analgesia-Pathophysiology. In: Essentials of Pain
Medicine and Regional Anesthesia, edited by HT Benzon, SN Raja, D Borsook, RE
Molloy, G Strichartz, Churchill Livingstone, Philadelphia, 1999, pp. 140-141.

31. Mitchell VC, Raja SN. Preemptive analgesia-Clinical studies. In: Essentials of Pain
Medicine and Regional Anesthesia, edited by HT Benzon, SN Raja, D Borsook, RE
Molloy, G Strichartz, Churchill Livingstone, Philadelphia, 1999, pp. 143-146.

32. Guarino A, Raja SN. Terminology and pathophysiology of complex regional pain
syndromes. In: Essentials of Pain Medicine and Regional Anesthesia, edited by HT
Benzon, SN Raja, D Borsook, RE Molloy, G Strichartz, Churchill Livingstone,
Philadelphia, 1999, pp. 245-247.

33. Guarino A, Raja SN. Diagnosis of complex regional pain syndrome. In: Essentials of
Pain Medicine and Regional Anesthesia, edited by HT Benzon, SN Raja, D Borsook, RE
Molloy, G Strichartz, Churchill Livingstone, Philadelphia, 1999, pp. 248-251.

34. Raja SN. Phentolamine infusion test. In: Essentials of Pain Medicine and Regional
Anesthesia, edited by HT Benzon, SN Raja, D Borsook, RE Molloy, G Strichartz,
Churchill Livingstone, Philadelphia, 1999, pp. 252-254.

35. Raja SN, Meyer RA, Ringkamp M, Campbell JN. Peripheral neural mechanisms of
nociception. In: Textbook of Pain, 4th Edition, edited by P. Wall and R. Melzack,
Churchill Livingstone, New York, 1999, pp. 11-57.

15
36. Gupta MA, Haddox JD, Raja SN. Complex regional pain syndromes and
sympathetically maintained pain. In: The Pain Clinic Manual, 2nd Edition, (eds.) SE
Abram, JD Haddox. Lippincott Williams & Wilkins, Philadelphia, 2000, pp. 177-184.

37. Shir Y, Campbell JN, Raja SN, Seltzer Z. Pre- but not postoperative consumption of soy
suppresses pain behavior following partial sciatic ligation in rats. Proceedings of the 9th
World Congress on Pain, Vol. 16, IASP Press, Seattle, 2000, pp 477-483.

38. OGorman DA, Raja SN. Infusion Tests and Therapies in the Management of Chronic
Pain. In: Practical Management of Pain, 3rd Edition, edited by Raj PP. Mosby Inc., St.
Louis, 2000, pp. 723-731.

39. Walia K, Raja SN. Complex Regional Pain Syndromes (Reflex Sympathetic Dystrophy
and Causalgia). In: Current Therapy in Neurological Diseases, 6th Edition, edited by
Johnson RT, Griffin JW, McArthur JC. Mosby, Inc., St. Louis, 2001, pp. 71-74.

40. Baron R, Raja SN. Role of adrenergic transmitters and receptors in nerve and tissue
injury related pain. In: Mechanisms and Mediators of Neuropathic Pain, Chaplan SR,
Malmberg A. Birkhauser Verlag, 2002.

41. Panlilio L, Tella P, Raja SN. Neuropathic pain: Outcome studies on the role of nerve
blocks. In: Textbook of Regional Anesthesia, edited by Raj PP. W.B. Saunders Churchill
Livingstone, Philadelphia, 2002, pp 969-987.

42. Raja SN, Benzon HT. Phantom pain. In: Essentials of Pain Medicine and Regional
Anesthesia, 2nd Edition, edited by HT Benzon, SN Raja, RE Molloy, S Liu, SM Fishman.
W.B. Saunders Company, New York, 2005, pp. 394-8.

43. Raja SN, Dougherty PM. The anatomy and physiology of somatosensory and pain
processing. In: Essentials of Pain Medicine and Regional Anesthesia, 2nd Edition, edited
by HT Benzon, SN Raja, RE Molloy, S Liu, SM Fishman. W.B. Saunders Company,
New York, 2005, pp. 1-6.

44. Dougherty PM, Raja SN. The neurochemistry of somatosensory and pain processing. In:
Essentials of Pain Medicine and Regional Anesthesia, 2nd Edition, edited by HT Benzon,
SN Raja, RE Molloy, S Liu, SM Fishman, W.B. Saunders Company, New York, 2005,
pp. 6-14.

45. Grabow TS, Guarino AH, Raja SN. Complex regional pain syndrome (CRPS):
terminology and pathophysiology. In: Essentials of Pain Medicine and Regional
Anesthesia, 2nd Edition, edited by H.T. Benzon, SN Raja, RE Molloy, S Liu, SM
Fishman, W.B. Saunders Company, New York, 2005, pp. 376-9.

16
46. Grabow TS, Guarino AH, Raja SN. Complex regional pain syndrome (CRPS): diagnosis
and treatment. In: Essentials of Pain Medicine and Regional Anesthesia, 2nd Edition,
edited by HT Benzon, SN Raja, RE Molloy, S Liu, SM Fishman, WB Saunders
Company, New York, 2005, pp. 380-5.

47. Vaidyaramaman M, Raja SN. Central pain states. In: Essentials of Pain Medicine and
Regional Anesthesia, 2nd Edition, edited by H.T. Benzon, SN Raja, RE Molloy, S Liu,
SM Fishman, WB Saunders Company, New York, 2005, pp. 399-406.

48. Meyer RA, Ringkamp M, Campbell JN, Raja SN. Peripheral mechanisms of cutaneous
nociception. In: Textbook of Pain, 5th Edition, edited by McMahon S, Koltzenburg M.
Elsevier, London, 2005.

49. Hord ED, Haythornthwaite JA, Raja SN. Comprehensive evaluation of the patient with
chronic pain. In: The Neurologic Basis of Pain, edited by M. Pappagallo, McGraw Hill,
New York 2005, pp. 209-18.

50. Raja SN, Baron R: Pain, Sympathetically maintained pain in CRPS II: Human
Experimentation. In: Encyclopedic Reference of Pain. Schmidt, R.F. and Willis, W.D.
(Eds), Springer-Verlag, Berlin 2006.

51. Raja SN, Agarwal S. Opioids in the management of complex regional pain syndrome.
In: Encyclopedic Reference of Pain. Schmidt, R.F. and Willis, W.D. (Eds), Springer-
Verlag, Berlin 2006.

52. Borzan J, Shir Y, Raja SN. Dietary variables in neuropathic pain. In: Encyclopedic
Reference of Pain. Schmidt, R.F. and Willis, W.D. (Eds), Springer-Verlag, Berlin 2006.

53. Tella PK, Agarwal S, Klick B, Max MB, Haythornthwaite JA, Raja SN. Do the analgesic
effects of opioids and tricyclic antidepressants differ in subtypes of patients with
postherpetic neuralgia? Proc. of the 11th World Congress on Pain. IASP Press, Seattle,
2006 (in press).

Books/Textbooks
1. Raj P, Erdine S, Niv D, Raja SN, Editors, Management of Pain: A World Perspective,
Sixth International Congress Pain Clinic, Monduzzi Editore, Bologna, Italy, 1995.

2. Benzon HT, Raja SN, Borsook D, Molloy RE, Strichartz G, Editors, Essentials of Pain
Medicine and Regional Anesthesia, Churchill Livingstone, Philadelphia, 1999.

3. Benzon HT, Raja SN, Molloy RE, Liu S, Fishman SM. Editors, Essentials of Pain
Medicine and Regional Anesthesia, Second Edition, W.B. Saunders Company, New
York, 2005.

17
Other Media/Electronic Publication
1. Tella P, Raja SN. (2002, Feb 28). Is Complex Regional Pain Syndrome a regional
syndrome? Editorial. MD Consult: Pain Medicine, Perspectives on contemporary Topics.
Retrieved on June 23, 2004 from http://www.mdconsult.com

2. Tall JM, Raja SN. (2002, Dec 20). Could some soy each day keep the pain doctor away?
Editorial. MD Consult: Pain Medicine, Perspectives on contemporary Topics. Retrieved
on March 24, 2003 from http://www.mdconsult.com

3. Raja, SN. (2004, June 23). Is postherpetic neuralgia a preventable disease? Editorial.
MD Consult: Pain Medicine, Perspectives on contemporary Topics. Retrieved on June
23, 2004 from http://www.mdconsult.com

4. Sharma A., Raja SN. Gender differences in the perception of chest pain. Commentary.
MD Consult: Pain Medicine, Perspectives on contemporary Topics. Retrieved on January
5, 2005 from http://www.mdconsult.com

5. Sharma A, Raja SN. Use and abuse of opioids: the eternal debate. Original article. MD
Consult: Pain Medicine, Perspectives on contemporary Topics. Retrieved on February 7,
2005 from http://www.mdconsult.com

Extramural Sponsorship

GRANTS
Current
2 R01 NS026363-16A1 (Raja) 4/1/89-2/29/11 22% effort
NIH/NINDS $215,645/current yr. Total direct $1,932,450
Injury-Induced Pain: Chemical Modulation of Nociceptors
The major goals of this project are to understand the role of mu-opioid neurokinin-1 and
adrenergic receptor mechanisms in the pathophysiology of neuropathic pain.
Role: Principal Investigator

1P50 AT00437 (Dobs) 9/30/00-7/31/06 15% effort

NIH/NCCAM Project 2 $80,000/current yr.
Johns Hopkins Center for Cancer Complementary Medicine
This proposal will examine the analgesic effects of soy and tart cherry as dietary supplements in
four different well-established animal models of chronic pain which represent different aspects of
pain associated with cancer: inflammation, nerve injury, cytotoxic neuropathy, and bone cancer
pain.
Role: Principal Investigator Project 2

1R01 DE13906-01 (Haythornthwaite) 9/15/01-8/31/06 5% effort

National Institutes of Health $337,881/current yr.
18
Pain Management in Temporomandibular Joint Disorders
This is a clinical trial that will compare the separate and combined effects of psychological and
pharmacological interventions in reducing pain and depression and improving function in
individuals with TMD. One of the psychological interventions is a self-help intervention that
will be tested.
Role: Co-Investigator

1 R01 NS051551-01 (Caterina) 6/1/05-5/31/10 5% effort

NIH/NINDS $208,125
Role of TRPV channel in pain and temperature sensation
Role: Co-Investigator

Pending
1 R01 NS048067-01A1 (Tao) 1/1/06-12/31/09 5% effort
NIH/NINDS Yr. 1/$150,000
Role of spinal glutamate transporter in chronic pain
Role: Co-Investigator

(Dore) 9/1/06-8/31/11 15% effort

CERC/NCCAM Yr. 1/$736,115 ($148,226/Project 1)
Flavonoids and CAM (Project 1: Flavonoids and Pain)
Role: Co-Investigator, P.I. Project 1

(Haythornthwaite) 9/1/06-3/31/11 5% effort

NIDA Yr.1/$499,489 Total Costs $4,092,549
Prescription Opioid Use and Abuse in the Treatment of Pain
Role: Co-Investigator

(Raja) 7/1/06-6/30/07 1% effort

California Table Grape Commission Total Direct/$20,833
Freeze-dried Grape Powder as a Potential Adjuvant in the Treatment of Arthritis
Role: Principal Investigator

Previous
(Campbell) 1982-1985
N.I.H.
Effects of Anesthetic on Primary Afferents.
Role: Co-Investigator

NS20845 (Campbell) 1983-1995 20% effort

National Institute of Neurologic and Communicate Disorders and Stroke
Neurophysiological and Psychophysical Studies of Pain
Role: Co-Investigator

(Raja) 1984-1987
19
National Institute of General Medical Sciences, N.I.H.
New Investigator Research Award

(Keith Lillemoe, M.D.) 1993-1996

N.I.H.
Pain Relief in Pancreatic Cancer: A Randomized Trial
Role: Co-Investigator

(Stuart Grossman, M.D.) 1993-1996

N.I.H.
Improved Dissemination of Cancer Pain Information
Role: Co-Investigator

(Campbell) 1994-1999 20% effort

NINCDS Total Direct $3,178,12
Studies of Neuropathic Pain Total Direct Project 4 $352,314
Role:Principal Investigator of Project 4

(Steve M. Frank, M.D.) 1996-1997 1% effort

IARS Clinical Scholar Research Award Total Direct/$37,500
Determinates of the Adrenergic and Metabolic Responses to Core Hypothermia
Role: Co-Investigator

5P01HD3399004 (Barbara de Lateur, M.D) 1996-2001 20% effort

National Center for Medical Rehabilitation Research, NIH Total Direct/$500,998
Pain Management in Persons with Disabilities
Role: Principal Investigator of Project 2 and Co-Investigator in Project 3

(Raja) 1999-2000
United States-Israel Binational Science Foundation Grant
Mechanisms of Neuropathic Pain Modulation by Diet
Role: Principal Investigator in U.S.A.

(Raja) 2002-2004 5% effort

Janssen Extramural Research Grant
Efficacy of Transdermal Fentanyl for Chronic Neuropathic Pain
Role: Principal Investigator

CONTRACTS
Current
CC-5013-CRPS-002 (Raja) 3/7/05-12/1/07 1% effort
Celgene Corporation $68,156 current yr.
Multicenter, Double-blind Placebo-controlled Study to Evaluate the Efficacy of and Safety of
Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1
Role: Principal Investigator
20
CC-5013-RAD-001 (Christo) 10/1/05-9/30/06 2% effort
Celgene Corporation $88,022 current yr.
Multicenter, Double-blind Placebo-controlled Study to Evaluate the Efficacy of and Safety of
Lenalidomide in the Treatment of Painful Lumbar Radiculopathy
Role: Co-Investigator

Previous
CC-5013-CRPS-001 (Raja) 2003-2005 1% effort
Celgene Corporation
Multicenter, Double-blind Placebo-controlled Study to Evaluate the Efficacy of and Safety of
CC-5013 in the Treatment of Complex Regional Pain Syndrome
Role: Principal Investigator

EDUCATIONAL ACTIVITIES
Teaching

1981-2003 Fulfilled general teaching activities.

Fall 2004 Pain Fellows/Residents Pathophysiology of Pain.

Fall 2004 Residents
Fall 2004 Blaustein Lecture Gunshot Wound to the Neck: Weir Mitchell Revisited
Fall 2004 Undergrads/AS 080.355 The Neuroscience of Pain, Cancer Pain.
Fall 2004 Pain Journal Club
Fall 2005 Pain Fellows/Residents Sympathetic Blocks
Fall 2005 Pain Fellows/Residents Opioids
Fall 2005 Residents Journal Club and CRPS.
Fall 2005 Undergrads/AS 080.355 The Neuroscience of Pain, Cancer Pain.
Fall 2005 Pain Journal Club
Fall 2005 Pain Journal Club
Spring 2006 Pain Fellows/Residents Dietary constituents

CME Instruction
Co-Director of CME Course: 11th Annual Pain Medicine Update, Johns Hopkins
University School of Medicine, December 2005
Director, CME Course: American Conference on Pain Medicine, Institute of Applied
Science & Medicine and Johns Hopkins Medicine, April 2006

Mentoring

Advisees:
1. Gabriel Koschorke, M.D., 1987-1989
4. Donald M. Manning, M.D., Ph.D., 1987-1989, Celgene Corporation
5. Marc A. Valley, M.D., 1989-1990
21
6. Karen D. Davis, Ph.D., 1988-1991, Professor, University of Toronto
7. Yoon Choi, MD, Postdoctoral, 1993-1995, MD/U. Seoul, Korea/1992, Injury-induced
pain: chemical modulation of nociceptors, Pain Medicine/Private Practice.
8. Zahid Ali, PhD, Postdoctoral, 1994-1996, PhD/U. Bristol, UK/1994, Injury-induced pain:
chemical modulation of nociceptors, Sr. Research Pharmacologist/ GlaxoSmithKline.
9. Matthias Ringkamp, MD, PhD, Postdoctoral, 1995-1997, PhD/U. Erlangen-Nuremberg,
Germany/1993 Injury-induced pain: chemical modulation of nociceptors, Assistant
Professor/JHU.
10. Nandini Kiri, MBBS, Postgraduate, 1995-1996, MBBS/India, 1994, Studies of
neuropathic pain, Internist/Private Practice.
11. Perry Fuchs, PhD, Postdoctoral, 1996-1998, PhD/U. Texas-Arlington/1996, Injury-
induced pain: chemical modulation of nociceptors, Associate Professor/ U. Texas-
Arlington.
12. Heikki Mansikka, MD, PhD, Postdoctoral, 1998-2000, PhD/U. Helsinki, Finland/1998,
Injury-induced pain: chemical modulation of nociceptors, Associate Director/Pfizer, Ltd.,
Sandwich, Kent, UK.
13. Prabhav Tella, MBBS, MPH, Postgraduate, 2000-2003, MPH/JHSPH/2000, Pain
management in persons with disabilities, Resident/Hahnemann Hospital.
14. Jill M. Tall, PhD, Postdoctoral, 2001-2003, PhD/NE Ohio U COM/200, Complementary
therapies for cancer pain, Assistant Professor/Youngstown State University.
15. Chengshui Zhao, PhD, Postdoctoral, 2000-2004, PhD/Peking University/2000, Injury-
induced pain: chemical modulation of nociceptors, Postdoctoral Fellow/Washington
University.
16. Shefali Agarwal, MBBS, MPH, Postgraduate, 2002-present, MPH/JHSPH/2002, Efficacy
of transdermal fentanyl, Clinical coordinator/JHU.
17. Yun Guan, PhD, Postdoctoral, 2002-present, PhD/UMD-Baltimore/2002, Injury-induced
pain: chemical modulation of nociceptors, Postdoctoral Fellow/JHU.
18. Jasenka Borzan, PhD, Postdoctoral, 2003-present, PhD/U. Texas-Arlington/2003,
Complementary therapies for cancer pain, Postdoctoral Fellow/JHU.

During the last decade, an average of three Clinical Fellows per year has been trained in Pain
Medicine, and several have continued in academic careers.

Thesis Committee:
Wendy P. Blakely, MN, RN, PhD, The behavioral consequences of spinal nerve ligation: a model
of chronic neuropathic pain, 2003.

Editorial Activities

22
 1989-present Reviewer for the following journals: Anesthesiology, Anesthesia and
Analgesia, Neuroscience, Pain, Muscle and Nerve, Somatosensory and Motor Research,
Archives of Ophthalmology, Journal of Clinical Anesthesia, The Clinical Journal of Pain,
Journal of Neuroimmunology, Molecular Brain Research
1991-present Associate Editor, Pain Digest
1993-present Associate Editor, Anesthesiology
1998- 2006 Editor, Anesthesiology
1999-present Associate Editor, Pain
1999-2006 Section Editor, Classic Papers Revisited, Anesthesiology
2002-present Clinical Trials Editor, MD Consult Pain Medicine

CLINICAL ACTIVITIES
Certification
Licensed to practice Medicine in the State of Maryland #D21130
E.C.F.M.G. examination, July 1975; F.L.E.X. examination, 1977
Diplomate of the American Board of Anesthesiology, 1982
The American Board of Anesthesiology, 1993
Added Qualifications in Pain Management, Recertified 2003

ORANIZATIONAL ACTIVITIES
Institutional Administrative Appointments
1985-89 Member, Anesthesia Pharmacy Advisory Committee, Department of
Anesthesiology and Critical Care Medicine
1990-92 Chairman, Clinical Research Committee, Department of Anesthesiology
and Critical Care Medicine
1991-93 Co-Director, Pain Management Services, Department of Anesthesiology
and Critical Care Medicine
1993-present Member, Clinical Competence Committee, Department of
Anesthesiology/Critical Care Medicine
1993-94 Director, Division of Pain Medicine, Department of Anesthesiology and
Critical Care Medicine
1997-present Member, Grant Review Committee, Blaustein Pain Center
1997-present Member, Department of Anesthesiology and Critical Care Medicine,
Promotions Committee
2000-present Member, Admissions Committee, School of Medicine
2004-present Member of Professional Promotion Committee, School of Medicine
2004-present Member of Service Executive Committee, Department of Anesthesiology
and Critical Care Medicine
2005-present Member of Dermatology Chair Search Committee

Professional Societies
American Pain Society
American Society of Anesthesiologists
Association of University Anesthesiologists
23
 International Association for the Study of Pain
Society for Neuroscience
Amputee Coalition of America
Reflex Sympathetic Dystrophy Association of America

Advisory Committees/Review Groups

1986 President, Neurosciences Division of the Association of Scientists of Indian
Origin in America

1989 Reviewer, Special Study Section, NIH

1989 Ad-hoc Reviewer, Surgery, Anesthesiology and Trauma Study Section, NIH

1989-1994 Member, Surgery, Anesthesiology and Trauma Study Section, NIH

1989, 1990, 1994 Member, Scientific Program Committee, Annual Meeting of American
Pain Society, Scientific Chair, International Update on Reflex Sympathectomy
Dystrophy, sponsored by RSDSA, Tampa, 2002

1993-present Reviewer, United States-Israel Binational Science Foundation Research Grants

1993-1995 Member, Scientific Program Committee, American Pain Society

1994-2004 Consultant, Anesthesia and Respiratory Devices Panel, FDA

1995 Chairman, Professional Development Courses, Annual Meeting of the American

Pain Society, Los Angeles

2000 Member, Scientific Review Board, Center for Medicinal Cannabis Research

2001 Ad-hoc Reviewer, Surgery, Anesthesiology and Trauma Study Section, National
Institutes of Health

2002-present National Initiative on Pain Control (NIPC), Scientific Advisory Board

2002 Co-Chair, Scientific Advisory Board, Reflex Sympathetic Dystrophy Syndrome

Association (RSDSA)

2002 Ad-hoc Reviewer, Surgery, Integrative Functional and Cognitive Neuroscience

Review Group, National Institutes of Health

2005 Section Head, Faculty of 1000 Medicine

2005-2008 Member, Scientific Program Committee, IASP 12th World Congress on Pain

24
2006 Member of FDA Anesthetic and Life Support Drugs Advisory Committee
2006 Member of IASP Ad Hoc Committee on Young Investigators
2006-2009 Director-at-Large, American Pain Society Board of Directors (elected)

RECOGNITION
Honors
1972-1973 Patna University Merit Scholarship

1979-1981 National Research Service Award, National Institute of General Medical Sciences,
at the University of Virginia

1982-1983 Outstanding Teacher Award, Department of Anesthesiology and Critical Care

Medicine, Johns Hopkins University School of Medicine

2000 Citation Poster Award, American Pain Society

2002 Selected for Marquis Whos Who in Medicine and Healthcare, 4th Edition

Invited Talks
1987-1989
Invited speaker at St. Joseph's Hospital, Baltimore, "Pediatric Anesthesia Circuits," 1987.
Speaker at a panel on Reflex Sympathetic Dystrophy at the Joint Meeting of the
American and Canadian Pain Society, Toronto, November 1988.
Invited speaker at St. Agnes Hospital, Baltimore, "Anesthesia Equipment and Anesthetic
Mishaps," August 1989.

1990
Invited speaker, symposium on "Sympathetically Maintained Pain," 6th World Congress
on Pain, Adelaide, Australia, April 1990.
Invited speaker, symposium on Animal Pain and Its Control, Cornell University, New
York; "Role of peripheral alpha-adrenergic receptors in chronic pain," June 1990.
Invited speaker at the Update and Advances in Pain Management, University of Texas
Health Science Center at Houston, "Update on basic research on pain mechanisms,"
Houston, September 1990.

1991
Invited Speaker, Conference on Sympathetically Maintained Pain, Mensana Clinic,
"Diagnosis of Sympathetic Maintained Pain," Baltimore, April 1991.
Invited speaker, Anesthesiology Grand Rounds, St. Joseph's Hospital, Baltimore, MD,
"Recent Advances in Pain Management," November 1991.

25
1992
Invited speaker, Annual Meeting of the American Society for Regional Anesthesia,
Tampa, March 1992
Invited speaker, Second International Pain Symposium, Atlanta, April 1992
Invited speaker, University of Tsukuba, Japan, August 1992.
Panel member, Chronic Pain Management: Current Clinical Issues. Annual meeting of
the American Society of Anesthesiologists, New Orleans, October, 1992.

1993
Invited speaker, Neuropathic Pain: Basic mechanisms In a2 Adrenergic Mechanisms in
Spinal Analgesia, Lucerne, Switzerland, August 1993.
Panel member, Chronic Pain Management. Annual meeting of the American Society of
Anesthesiologists, Washington, DC, October 1993.
Panel member, Drug Infusions and Nerve Blocks in Pain Diagnosis at the Annual
meeting of the American Pain Society, Florida, November 1993

1994
Invited speaker, The Pain & Rehabilitation Clinic of Chicago and Department of Physical
Medicine and Rehabilitation of Northwestern University Medical School, Chicago,
Illinois, "Pathophysiology of RSD: Advances in the Last 5 Years With Emphasis on
Peripheral and Central Mechanisms," January 1994.
Invited speaker, 6th International Congress Pain Clinic, Chronic Pain: Pathophysiology
and Rationale for Treatment, Atlanta, April 1994
Invited speaker, Paulo Symposium on Modern Trends in Postoperative Pain Control,
Hanasaari, Finland, September 1994
Panel speaker, Clonidine in the Treatment of Neuropathic Pain/Reflex Sympathetic
Dystrophy. Annual meeting of the American Pain Society, Florida 1994

1995
Invited speaker, Satellite Symposium to the Association of University Anesthetists
meeting, "The afferent message in man," May 1995
Panel chair, "Pain Therapies Based on Mechanisms of Hyperalgesia and
Antinociception," Annual Meeting of American Pain Society, Los Angeles, November
1995
Panel member, Symposia on "Diagnostic Techniques for Sympathetically Maintained
Pain," Annual Meeting of American Pain Society, Los Angeles, November 1995
Invited speaker, "Comprehensive Review of Pain Management," American Pain Society
for Regional Anesthesia, New Orleans, November 1995
Invited speaker, "Current Concepts in Acute, Chronic, and Cancer Pain Management,"
The World Foundation for Pain Relief and Research Inc., New York, December 1995

1996
Invited speaker, "Diagnosis and Treatment of Reflex Sympathetic Dystrophy," Annual
Meeting of the American Society for Regional Anesthesia, San Diego, March 1996
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 Panel member, Symposia on "Monoamines in Pain Modulation," International
Association for Study of Pain, 8th World Congress of Pain, Vancouver, August 1996
Chairperson, Panel on Catecholamines and Pain, 8th International Congress on
Catecholamines, Asilomar, September 1996.
Panel speaker, Neuropathic Pain: Diagnosis and Management, Second Annual
Multidisciplinary Pain Medicine Update, Baltimore, September 1996.
Invited speaker, Reflex Sympathetic Dystrophy, International Seminar on Pain,
Santiago, Chile, October 1996.
Panel Member, Diagnosis of Sympathetically Maintained Pain, Annual Meeting of
American Pain Society, Washington, DC, November 1996.

1997
Speaker, Postherpetic Neuralgia, The Johns Hopkins School of Medicine Biennial
Meeting, June 1997.
Invited speaker, Meeting of the Tamil Nadu Chapter of the Indian Association of
Anesthesiologists, Madras, India, August 1997.
Invited speaker, Professional Development Course, Role of Sympathetic Blocks in the
Diagnosis and Management of Somatic and Visceral Pain States, Annual Meeting of the
American Pain Society, New Orleans, October 1997.
Grand Rounds speaker, Neuropathic Pain: Rational Basis for Therapy, Department of
Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions,
December 1997.
Invited speaker, Current Concepts in the Diagnosis and Treatment of Sympathetically
Maintained Pain, Postgraduate Course: Current Concepts in Acute, Chronic and Cancer
Pain Management, World Foundation for Pain Relief and Research, New York City,
December, 1997.

1998
Invited speaker, Clinical Trials on Neuropathic Pain, Blaustein Conference, The Johns
Hopkins Medical Institutions, January 1998.
Invited speaker, Complex Regional Pain Syndromes and Postamputation Pain
Syndromes, 7th John J. Bonica Vail Winter Pain Conference, Vail, Colorado, March,
1998
Invited speaker, 1st International Conference on Mechanisms and Treatment of
Neuropathic Pain, Rochester, N.Y., June 1998
Invited speaker, Complex Regional Pain Syndromes, 4th Annual Pain Update Mtg.,
Rochester, N.Y., August 1998
Invited speaker, Annual Meeting of the American Pain Society, San Diego, CA,
November, 1998

1999
Grand Rounds speaker, Opioids for Chronic Noncancer Pain? Department of
Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions,
February 1999
27
 Invited speaker, Complex Regional Pain Syndromes: Changing Concepts and Puzzling
Pathophysiology, San Diego County Society of Anesthesiologists, March 1999
Invited speaker, Alternatives in Pain Management, Howard County General Hospital,
Columbia, Maryland, April 1999
Invited speaker, Nerve Block Controversies, 2nd International Conference on
Mechanisms and Treatment of Neuropathic Pain, Washington, D.C., June 1999
Invited speaker, Pharmacological dissection of neuropathic pain: Intravenous infusions
as diagnostic and therapeutic tools, 9th World Congress on Pain, Vienna, Austria, August
1999.
Invited speaker, Pain Management - Guidelines for Gastroenterologists 5th Annual
Johns Hopkins Hepato-Biliary Update Mtg., Ocean City, MD, September 1999.
Panel speaker, Common Fatal Flaws - Panel on Perils of Publishing or What Do
Those Editors Want, Anyway? American Society of Anesthesiologists Annual Mtg,
Dallas, TX, October 1999.
Invited speaker, CRPS Type I & II: Current Trends, Asian and Oceanic Society of
Regional Anaesthesia. 5th Biennial Congress, New Delhi, India, October 1999.
Invited speaker, Peripheral Neural Mechanisms of Somatic Pain, Asian and Oceanic
Society of Regional Anaesthesia. 5th Biennial Congress, New Delhi, India, October 1999.
Faculty participant, Paravertebral Lumbar Sympathetic Plexus Block, Workshop on
Regional Anesthesia Techniques, Asian and Oceanic Society of Regional Anaesthesia. 5th
Biennial Congress, New Delhi, India, October 1999.
Invited speaker, Current concepts in diagnosis and diagnostic tools for complex regional
pain syndrome, World Foundation for Pain Relief and Research, New York, December
1999.

2000
Invited speaker, State of the art cancer pain management, First Annual Pain
Management Symposium, Columbia University College of Physicians & Surgeons, New
York, April 2000
Invited speaker,Opioids and chronic pain: Two centuries of controversies, Blaustein
Lecture Series, University of Maryland School of Medicine, Baltimore, MD, May 2000.
Invited speaker, Role of opioids in pain management: Two centuries of controversies
and concerns, Purdue Pharma LP, Norwalk, CT, August 2000.
Invited speaker, Opioids for chronic pain: What is the controversy? St. Joseph Medical
Center, Towson, Maryland, August 2000.
Invited speaker, Sympathetic Blocks, Sixth Annual Multidisciplinary Pain Medicine
and Regional Anesthesia Update, Baltimore, MD, August 2000
Moderator, Phantom pain after amputation: A perceptual correlate of thalamic and
cortical reorganization, American Pain Society Annual Meeting, Atlanta, November
2000.
Invited speaker, Pain management, Kernan Hospital, Amputee Support Group,
Baltimore, MD, December 2000.

2001
28
 Invited participant, Symposium: Pain Management for the New Millenium - Challenges
and Solutions, Albert Einstein Medical Center, Philadelphia, PA, January 2001.
Invited speaker, Symposium: Ageing and anaesthesia: Anaesthetic management of the
elderly, European Society of Anaesthesiologists, Gothenburg, Sweden, April 2001.
Panel speaker: Peripheral Nerve Blocks, American Society of Anesthesiologists, Annual
Meeting, New Orleans, October 2001.
Guest Lecture, Design of Clinical Studies and Drug Trials, Stanley Medical College,
India, November 2001.
Invited participant, Workshop: Reflex sympathetic dystrophy/complex regional pain
syndrome (CRPS): state-of-the-art-science, National Institutes of Health, Bethesda,
December 2001.

2002
Invited speaker, International Update on RSD/CRPS, Guidelines for Therapy: Research
Outcomes vs Expert Opinions, Tampa, Florida, February 2002.
Invited speaker, American Pain Society Symposium, Evidence for Alternative Therapies
for Pain from Arthritis and Related Diseases, Baltimore, Maryland, March 2002.
Invited speaker, American Pain Society Meeting, Grand Rounds for the Basic Scientist:
Live Case Presentations of Patients with Chronic Pain, Baltimore, Maryland, March
2002.
Invited speaker, Southern Pain Conference, Complex Regional Pain Syndromes:
Refining Diagnostic Criteria and Defining Therapeutic Goals, Lexington, Kentucky,
April 2002.
Invited speaker, Danish Pain Research Seminar, Pharmacological strategies towards the
sympathetic nervous system, Hindsgavl Slot, Denmark, June 2002.
Invited speaker, IASP Symposium, Sympathetically Maintained Pain, San Diego,
California, August 2002.
Invited speaker, Neurology Grand Rounds, Postherpetic Neuralgia: Clinical Trials and
Tribulations, The Johns Hopkins University, Baltimore, Maryland 2002.
Invited speaker, 5th International Conference Mechanisms and Treatment of Neuropathic
Pain, Opioid Analgesics, Bermuda, November 2002.

2003
Invited speaker, The American Geriatrics Society Annual Scientific Meeting, Baltimore,
Maryland, Additional therapies for postherpetic neuralgia: opioid analgesics and
interventional strategies, May 2003.
Invited speaker, JHUSOM 9th Annual Multidisciplinary Pain Medicine Update Meeting,
and 7th Annual American Neuromodulation Society Meeting, Efficacy of Opioids in
Pain Management, Neuropathic Pain & CRPS, Orlando, May 2003
Invited speaker, Johns Hopkins University, Blaustein Lecture,
Case Presentation of a Patient with Neuropathic Pain after an Upper Extremity
Traumatic Amputation, Baltimore, June 2003.
Invited speaker, 6th International Conference Mechanisms and Treatment of Neuropathic
Pain, Antidepressants and neuropathic pain, Bermuda, November 2003.
29
2004
Invited speaker, JHUSOM 10th Annual Multidisciplinary Pain Medicine Update Meeting,
and American Pain Medicine Meeting, Neuropathic Pain, Sympathetic Blocks,
Baltimore, August 2004
Co-director and speaker, International update on RSD/CRPS, CRPS: clinical
presentations & diagnostic workshops, San Diego, September 2004.
Invited speaker, 7th International Conference Mechanisms and Treatment of Neuropathic
Pain, Pharmacologic treatments for neuropathic pain and their implications for
understanding mechanisms Bermuda, November 2004.
Invited speaker, Clinical Education Series, Pennsylvania Academy of Family Physicians,
Reflex sympathetic dystrophy (CRPS) - current concepts in diagnosis and management
Hershey, November 2004.

2005
Invited speaker, American Academy of Pain Medicine CRPS I: role of interventional
strategies in diagnosis and treatment, Palm Springs, February 23-27, 2005.
Invited symposium participant, American Pain Society Allodynia vs. Hyperalgesia:
Whats the difference and why should we care? Boston, March 30-31, 2005.
Invited speaker, International Life Sciences Institute North America Special Conference
presented at Experimental Biology 2005 Dietary components and pain therapy San
Diego, April 1-3, 2005.
Invited Plenary Lecture, Chinese Association for the Study of Pain Complex regional
pain syndromes (CRPS 1; Reflex Sympathetic Dystrophy, RSD) an update of a
challenging disease Shandong, China, June 17-21, 2005.
Invited participant, 3rd Annual Comprehensive Pain Board Review Symposium CRPS
Madison, Wisconsin, August 2-5, 2005.
Workshop Organizer and chair, 11th Annual IASP World Congress on Pain, Sydney,
Australia, Opioids for chronic non-cancer pain: bench to bedside, August 21-26, 2005.
Workshop Participant, 11th Annual IASP World Congress on Pain, Sydney, Australia,
Side effects of common antineuralgic medication: their frequency and nature and what to
do about them, August 21-26, 2005.

Visiting Professorships
1989
University of Pennsylvania, "Sympathetically Maintained Pain.
University of Virginia, Charlottesville, "Peripheral Mechanisms of Pain: Recent
Advances.
University of Texas Health Sciences Center at Houston, "Peripheral and Spinal
Modulation of Pain.

1993

30
 Department of Anesthesia, The Bowman Gray School of Medicine, "Preemptive
Analgesia - Is an ounce of prevention worth a pound of care."
Hvidovre Hospital, University of Copenhagen, Denmark, "Pain and the Sympathetic
Nervous System.

1994
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India,
"Management of Cancer Pain."
Department of Clinical Neurophysiology, Huddinge University Hospital, Karolinska
Institute, Huddinge, Sweden, "Studies in an Animal Model of Neuropathic Pain."
University Hospital Uppsala, Sweden "Pathophysiology of Sympathetically Maintained
Pain."
Orebr Medical Center, Orebr, Sweden, "General vs. Regional Anesthesia for Radical
Prostatectomy: Pros and Cons."

1995
Department of Anesthesiology, Massachusetts General Hospital, "Is Chronic Pain Acute
Pain that Persists."
New York Hospital, Cornell Medical Center, "Current Concepts in the Pathophysiology
of Acute and Chronic Pain."

1996
Vanderbilt University, Is Chronic Pain Acute Pain that Persists.

1997
Southwestern Medical Center at Dallas, The University of Texas, Neuropathic Pain.
Department of Anaesthesia, National University of Singapore, Neuropathic Pain and Its
Treatment.
Department of Anesthesiology, Sri Ramachandra Medical College and Research Institute,
Madras, India Complex Regional Pain Syndrome.

1998
Hadassah University, Israel.
Benjamin Franklin Medical Center, Freie Universitt Berlin, Germany, Value of Nerve
Blocks and Infusion Tests in the Diagnosis of Chronic Pain

1999
Department of Anesthesiology, University of California, San Diego, Chronic Pain: Is it
Acute Pain that Persists? and Herpes Zoster Infections and Its Sequelae.
Department of Anesthesiology, Columbia University, New York, NY, Mechanisms of
Neuropathic Pain: Lessons from Transgenic Mice.

2002

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 Distinguished Visiting Professor, Department of Anesthesiology, Mayo Clinic, Rochester,
Minnesota Poppies and Pain: A Tale of Two Centuries.
Department of Anesthesiology, Duke University School of Medicine, Durham, North
Carolina, Poppies and Pain: A Tale of Two Centuries.

2003
Department of Anesthesiology, Duke University Medical Center, Genetics of Pain Series,
Durham, North Carolina, The Yin and Yang of Pain: Altered Central Modulation in
Neuropathic Pain.
New York Neurological Institute, Department of Neurology, Columbia University, New
York, NY, Post-herpetic Neuralgia: Controversies Over the Role of Opioids.

2005
UW Department of Anesthesiologys 45th Anniversary Celebration Poppies and pain: an
ongoing controversy Seattle.

2006
New York University
Washington University, St. Louis

ABSTRACTS AND PRESENTATIONS

International Meetings
Over the last 25 years, 40 Abstracts have been presented at international meetings such as the
IASP World Congress on Pain, the International Conference on the Mechanisms and Treatment
of Neuropathic Pain, the World Congress of Anesthesiologists, the Joint Scientific Meeting of
the American and Canadian Pain Society, and the Proceedings of the Pharmacology of
Thermoregulation.

National Meetings
Over the last 25 years, 108 Abstracts have been presented at national meetings such as the
Society for Neuroscience, the American Pain Society, the American Society of Anesthesiologists,
the American Society of Regional Anesthesia, the Society for Obstetric Anesthesia Practice, and
the American Society of Gastroenterology.

32